Abstract:
:Specific methylated derivatives of anthracene are mutagenic in S. typhimurium and have tumor-initiating activity on mouse skin. In this study, the mutagenic activities of 1-, 2-, and 9-methylanthracene, 2,9- and 9,10-dimethylanthracene, 2,9,-10-trimethylanthracene, 2,3,9,10-tetramethylanthracene, and the photo-oxide of 9,10-dimethylanthracene were determined in S. typhimurium TA98 and TA100. The relative tumor-initiating activities of these compounds were also evaluated. These bioassays indicate that increased mutagenic potency and tumor-initiating activity are associated with the presence of a methyl substituent at both the 9- and 10- position of anthracene. Metabolism studies suggest that the biological activity of specific methylated anthracenes may be related to the formation of a simple epoxide adjacent to a peri-methyl substituent.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
La Voie EJ,Coleman DT,Rice JE,Geddie NG,Hoffmann Ddoi
10.1093/carcin/6.10.1483subject
Has Abstractpub_date
1985-10-01 00:00:00pages
1483-8issue
10eissn
0143-3334issn
1460-2180journal_volume
6pub_type
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