Inhibition of 7,12-dimethylbenz[a]anthracene-induced lung tumorigenesis in A/J mice by food restriction is reversed by adrenalectomy.


:Prior work has demonstrated that food restriction of mice markedly suppresses 12-O-tetradecanoylphorbol-13-acetate (TPA) promotion of skin papillomas and adrenalectomy prior to initiating food restriction completely reverses the tumor inhibitory effect of underfeeding. In the present experiment the effect of food restriction, with or without prior adrenalectomy, on 7,12-dimethylbenz[a]anthracene (DMBA)-induced lung tumor development in A/J mice was explored. Food restriction (27%), beginning 3 weeks after a single oral dose of 0.5 mg DMBA and continued for the duration of the experiment (14 weeks), significantly inhibited lung adenoma development, whereas adrenalectomy 2 weeks before initiating food restriction abolished the tumor inhibitory effect of underfeeding and also enhanced tumor development in the ad libitum fed mice. Plasma corticosterone levels were significantly elevated in food-restricted A/J mice, whereas plasma dehydroepiandrosterone (DHEA) levels showed no apparent change. These studies suggest that adrenal gland secretory products may play a general role in the tumor preventive effect of food restriction in laboratory mice.






Pashko LL,Schwartz AG




Has Abstract


1996-02-01 00:00:00












  • Evidence for a 2,3-epoxide as an intermediate in the microsomal metabolism of 6-nitrobenzo[a]pyrene.

    abstract::The rat liver microsomal metabolism of 3-deutero-6-nitrobenzo(a)pyrene ([3-2H]6-NO2-BaP) was studied. The metabolites were separated by h.p.l.c. The 500 MHz 1H n.m.r. spectral analysis of the metabolites indicated that the 3-hydroxy-6-NO2-BaP and 6-NO2-BaP-3,9-hydroquinone each retained 33% of the deuterium label at t...


    pub_type: 杂志文章


    authors: Chou MW,Evans FE,Yang SK,Fu PP

    更新日期:1983-01-01 00:00:00

  • Differential transformation efficiency but not AP-1 induction under anchorage-dependent and -independent conditions.

    abstract::The JB6 mouse epidermal cell system has been extensively used as an in vitro model for the study of tumor promotion. The present study aimed to assess the relevance of monolayer measurements to the process of transformation, which is induced more efficiently under anchorage-independent (AI) conditions. Although it wou...


    pub_type: 杂志文章


    authors: Dong Z,Cmarik JL,Wendel EJ,Colburn NH

    更新日期:1994-05-01 00:00:00

  • Nafenopin-induced rat liver peroxisome proliferation reduces DNA methylation by N-nitrosodimethylamine in vivo.

    abstract::The hypolipidaemic drug nafenopin (NAF) has been shown to enhance the hepatocarcinogenic effect of N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine in rats. We have investigated whether the NAF-induced peroxisome proliferation in hepatocytes interferes with NDMA's metabolism and interaction with DNA. Adult male...


    pub_type: 杂志文章


    authors: Wiestler OD,Schmerold I,Fringes B,Volk B,Kleihues P

    更新日期:1985-09-01 00:00:00

  • Aphidicolin: an inhibitor of DNA repair in human fibroblasts.

    abstract::Aphidicolin is a specific inhibitor of DNA polymerase alpha. Its influence of DNA repair has been studied in both normal and excision deficient xeroderma pigmentosum cells exposed to u.v. irradiation at 254 nm. Single strand DNA breaks accumulated in u.v. irradiated normal cells when the inhibitor was present. Such br...


    pub_type: 杂志文章


    authors: Waters R

    更新日期:1981-01-01 00:00:00

  • Catalysis of nitrosation in vitro and in vivo in rats by catechin and resorcinol and inhibition by chlorogenic acid.

    abstract::Measurements were made of the effects of phenolic compounds, some of which are present in the human diet, on the nitrosation of proline by nitrite to give N-nitrosoproline (NPRO). In vitro, resorcinol, catechin, p-nitrosophenol and phenol were catalysts and chlorogenic acid an inhibitor; guaiacol showed a marginal cat...


    pub_type: 杂志文章


    authors: Pignatelli B,Bereziat JC,Descotes G,Bartsch H

    更新日期:1982-01-01 00:00:00

  • A new synthetic route to nucleotide adducts derived from N-acetylated and unacetylated 4-aminobiphenyl.

    abstract::The carcinogen N-acetoxy-N-2-acetylaminofluorene reacts with dG and dG-containing nucleotides to give good yields of the C-8 adducts, but the analogous 4-aminobiphenyl derivative does not. Replacement of the N-acetoxy group by 2,6-dichlorobenzoyloxy circumvents this difficulty. This reaction is shown to be generally a...


    pub_type: 杂志文章


    authors: Underwood GR,Price MF,Shapiro R

    更新日期:1988-10-01 00:00:00

  • Metabolism of benzo[f]quinoline by rat liver microsomes.

    abstract::The metabolism of [1,3-14C]benzo[f]quinoline (BfQ) by liver microsomes from control, 3-methylcholanthrene (3-MC)-pretreated and phenobarbital (PB)-pretreated rats has been investigated in order to gain insights into the effect of mixed function oxidase inducers on the types and levels of specific metabolites as formed...


    pub_type: 杂志文章


    authors: Kandaswami C,Kumar S,Dubey SK,Sikka HC

    更新日期:1987-12-01 00:00:00

  • Focal and non-focal hepatic expression of placental glutathione S-transferase in carcinogen-treated rats.

    abstract::Carcinogenesis develops in stages that have been operationally defined as initiation, promotion and progression. Although morphological end points have been described for detection and quantitation of these stages, to date initiation has been assessed only in the context of clonal growth in response to certain promoti...


    pub_type: 杂志文章


    authors: Dragan YP,Campbell HA,Baker K,Vaughan J,Mass M,Pitot HC

    更新日期:1994-11-01 00:00:00

  • Pyruvate kinase isoenzyme shift from L-type to M2-type is a late event in hepatocarcinogenesis induced in rats by a choline-deficient/DL-ethionine-supplemented diet.

    abstract::Rats received a choline-deficient diet containing 0.1% (w/w) DL-ethionine (CDE) for 4, 10, 14 or 22 weeks. A separate group was treated for 4 weeks with CDE and then received a normal diet for 4 weeks. The L and M2 isoenzymes of pyruvate kinase were immunocytochemically demonstrated in liver sections. L-PK expression ...


    pub_type: 杂志文章


    authors: Hacker HJ,Steinberg P,Bannasch P

    更新日期:1998-01-01 00:00:00

  • Lower levels of urinary 2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline (MeIQx) in humans with higher CYP1A2 activity.

    abstract::Heterocyclic aromatics amines (HAAs), such as 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), are metabolically activated by cytochrome P4501A2 (CYP1A2) and N-acetyltransferase (NAT2). We examined the relationship between CYP1A2 and NAT2 activity and the excretion of total unconjugated MeIQx in 66 healthy subje...


    pub_type: 杂志文章


    authors: Sinha R,Rothman N,Mark SD,Murray S,Brown ED,Levander OA,Davies DS,Lang NP,Kadlubar FF,Hoover RN

    更新日期:1995-11-01 00:00:00

  • Increased formation of hepatic N2-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase 2-knockout mice treated with ethanol.

    abstract::N2-ethylidene-2'-deoxyguanosine (N2-ethylidene-dG) is a major DNA adduct induced by acetaldehyde. Although it is unstable in the nucleoside form, it is relatively stable when present in DNA. In this study, we analyzed three acetaldehyde-derived DNA adducts, N2-ethylidene-dG, N2-ethyl-2'-deoxyguanosine (N2-Et-dG) and a...


    pub_type: 杂志文章


    authors: Matsuda T,Matsumoto A,Uchida M,Kanaly RA,Misaki K,Shibutani S,Kawamoto T,Kitagawa K,Nakayama KI,Tomokuni K,Ichiba M

    更新日期:2007-11-01 00:00:00

  • Inhibitory effect of a flavonoid antioxidant silymarin on benzoyl peroxide-induced tumor promotion, oxidative stress and inflammatory responses in SENCAR mouse skin.

    abstract::In this communication, we investigate the preventive effect of a flavonoid antioxidant, silymarin, on free radical-generating skin tumor promoting agent benzoyl peroxide (BPO)-induced tumor promotion, oxidative stress and inflammatory responses in SENCAR mouse skin. Topical application of silymarin at a dose of 6 mg p...


    pub_type: 杂志文章


    authors: Zhao J,Lahiri-Chatterjee M,Sharma Y,Agarwal R

    更新日期:2000-04-01 00:00:00

  • XPC protects against smoking- and carcinogen-induced lung adenocarcinoma.

    abstract::Cigarette smoke (CS) contains hundreds of carcinogens and is a potent inducer of oxidative and bulky DNA damage, which when insufficiently repaired leads to activation of DNA damage response and possibly mutations. The DNA repair protein xeroderma pigmentosum group C (XPC) is primed to play an important role in CS-ind...


    pub_type: 杂志文章


    authors: Zhou H,Saliba J,Sandusky GE,Sears CR

    更新日期:2019-05-14 00:00:00

  • Candida albicans as a promoter of oral mucosal neoplasia.

    abstract::A model of oral mucosal carcinogenesis using the water-soluble carcinogen 4-nitroquinoline-1-oxide (4NQO) was combined with a model of oral mucosal candidosis to examine the ability of Candida albicans to promote the development of neoplasia in suitably initiated epithelium. Sprague-Dawley rats were initiated by the a...


    pub_type: 杂志文章


    authors: O'Grady JF,Reade PC

    更新日期:1992-05-01 00:00:00

  • Hepatic and extrahepatic bioactivation and GSH conjugation of aflatoxin B1 in sheep.

    abstract::Whole-body autoradiography of [3H]aflatoxin B1 ([3H]AFB1) in lamb showed a localization of bound labelling, in addition to the liver, in the nasal olfactory and respiratory mucosa, in the mucosa of the nasopharynx, pharynx, oesophagus, larynx, trachea, bronchi and bronchioles and in the palpebral and bulbar conjunctiv...


    pub_type: 杂志文章


    authors: Larsson P,Busk L,Tjälve H

    更新日期:1994-05-01 00:00:00

  • Cell cycle kinase inhibitor expression and hypoxia-induced cell cycle arrest in human cancer cell lines.

    abstract::Flow cytometric analysis of fibroblasts, normal breast epithelial cells and breast or other cancer cell lines identified variation in the abilities of cell lines to undergo cell cycle arrest as a response to hypoxia. Human mammary epithelial cells (HMEC), normal fibroblasts (Hs68 and WI38), HeLa cervical carcinoma and...


    pub_type: 杂志文章


    authors: Box AH,Demetrick DJ

    更新日期:2004-12-01 00:00:00

  • Bile acids do not form adducts when incubated with DNA in vitro.

    abstract::Bile acids have been implicated in the aetiology of colon cancer. We have previously found, using 32P-postlabelling, that bile from control patients and from patients with familial adenomatous polyposis (FAP) produces DNA adducts when incubated with salmon sperm DNA in vitro. In the present study we have incubated the...


    pub_type: 杂志文章


    authors: Scates DK,Spigelman AD,Venitt S

    更新日期:1994-12-01 00:00:00

  • Tissue protein turnover during liver carcinogenesis.

    abstract::Overall rates of tissue protein degradation in vivo during chemical hepatocarcinogenesis were estimated by a double-isotope method as well as from the accumulation of peptide intermediates in protein degradation induced by bestatin. Several parameters estimating rates of cell proliferation and cell loss have been meas...


    pub_type: 杂志文章


    authors: Canuto RA,Tessitore L,Muzio G,Autelli R,Baccino FM

    更新日期:1993-12-01 00:00:00

  • Butylated hydroxyanisole-induced alterations in cell kinetic parameters in rat forestomach in relation to its oxidative cytochrome P-450-mediated metabolism.

    abstract::Four groups of six male Wistar rats (85 +/- 7 g) were fed a diet containing 0% (control) or 2% of the carcinogenic food antioxidant butylated hydroxyanisole (BHA) for 2 weeks. In this experiment, feeding 2% BHA is equivalent to a dose of 2.1 +/- 0.3 g BHA/kg/day. One 0% BHA and one 2% BHA-fed group of rats were daily ...


    pub_type: 杂志文章


    authors: Verhagen H,Furnée C,Schutte B,Hermans RJ,Bosman FT,Blijham GH,ten Hoor F,Henderson PT,Kleinjans JC

    更新日期:1989-10-01 00:00:00

  • Nitric oxide induces cyclooxygenase expression and inhibits cell growth in colon cancer cell lines.

    abstract::The role of nitric oxide (NO) in colon cancer remains controversial. Inducible nitric oxide synthase (iNOS) has been reported to be up regulated and down regulated in colorectal cancer in both animal models and patient tissue samples. Cyclooxygenase-2 (COX-2) is important in colorectal carcinogenesis but its relations...


    pub_type: 杂志文章


    authors: Liu Q,Chan ST,Mahendran R

    更新日期:2003-04-01 00:00:00

  • Delayed expression of apoptotic and cell-cycle control genes in carcinogen-exposed bladders of mice lacking p53.S389 phosphorylation.

    abstract::Mice with non-phosphorylated serine 389 in p53 are susceptible for bladder tumors induced by 2-acetylaminofluorene (2-AAF). Since p53 is a transcription factor, this might well be preceded by differences in the regulation of gene expression. Microarray analysis was used to determine early transcriptional changes that ...


    pub_type: 杂志文章


    authors: Bruins W,Jonker MJ,Bruning O,Pennings JL,Schaap MM,Hoogervorst EM,van Steeg H,Breit TM,de Vries A

    更新日期:2007-08-01 00:00:00

  • Over-expression of glutathione S-transferase Yp isozyme and concomitant down-regulation of Ya isozyme in renal cell carcinoma of rats induced by ferric nitrilotriacetate.

    abstract::An iron chelate, ferric nitrilotriacetate (Fe-NTA), induces renal proximal tubular damage, a consequence of iron-catalysed Fenton-like reactions, that finally leads to a high incidence of renal cell carcinoma (RCC) in rodents. Glutathione S-transferase (GST) is a family of enzymes that play an important role in detoxi...


    pub_type: 杂志文章


    authors: Tanaka T,Nishiyama Y,Okada K,Satoh K,Fukuda A,Uchida K,Osawa T,Hiai H,Toyokuni S

    更新日期:1998-05-01 00:00:00

  • Redox-dependent toxicity of diepoxybutane and mitomycin C in sea urchin embryogenesis.

    abstract::The effects and mechanisms of action of diepoxybutane (DEB) and mitomycin C (MMC) were investigated on sea urchin embryogenesis, (Sphaerechinus granularis and Paracentrotus lividus). DEB- and MMC-induced toxicity was evaluated by means of selected end-points, including developmental defects, cytogenetic abnormalities ...


    pub_type: 杂志文章


    authors: Korkina LG,Deeva IB,De Biase A,Iaccarino M,Oral R,Warnau M,Pagano G

    更新日期:2000-02-01 00:00:00

  • Association of KRAS polymorphisms with risk for lung adenocarcinoma accompanied by atypical adenomatous hyperplasias.

    abstract::The pulmonary adenoma susceptibility 1 (Pas1) gene affects susceptibility to the development of lung adenomas in mice with a subset of the adenomas progressing to adenocarcinoma (ADC). In this study, genotype distributions for 10 polymorphisms in the human counterparts for three mouse candidate Pas1 genes, KRAS, CASC1...


    pub_type: 杂志文章


    authors: Kohno T,Kunitoh H,Suzuki K,Yamamoto S,Kuchiba A,Matsuno Y,Yanagitani N,Yokota J

    更新日期:2008-05-01 00:00:00

  • Role of copper accumulation and metallothionein induction in spontaneous liver cancer development in LEC rats.

    abstract::The LEC rat spontaneously develops liver cancer after suffering chronic liver injury caused by abnormal copper accumulation in the liver, but the role of copper accumulation in the induction of liver cancer remains obscure. We histochemically and biochemically examined the content of copper and metallothionein (MT), a...


    pub_type: 杂志文章


    authors: Sawaki M,Enomoto K,Hattori A,Tsuzuki N,Sugawara N,Mori M

    更新日期:1994-09-01 00:00:00

  • Xeroderma pigmentosum group A gene action as a protection factor against 4-nitroquinoline 1-oxide-induced tongue carcinogenesis.

    abstract::To test the hypothesis that nucleotide excision repair (NER) plays a protective role in chemical carcinogenesis in internal organs, xeroderma pigmentosum group A gene-deficient (XPA(-/-)) mice, heterozygous (XPA(+/-)) and wild-type (XPA(+/+)) mice were orally administered 0.001% 4-nitroquinoline 1-oxide (4NQO) in thei...


    pub_type: 杂志文章


    authors: Ide F,Oda H,Nakatsuru Y,Kusama K,Sakashita H,Tanaka K,Ishikawa T

    更新日期:2001-04-01 00:00:00

  • A novel experimental model for human mixed acinar-ductal pancreatic cancer.

    abstract::Pancreatic cancer has remained refractory to treatment. In large part, this results from the lack of an animal model that mimics pancreatic cancer in man. We describe a novel experimental model of pancreatic cancer that shares the genetic background, histologic features and natural history of human mixed acinar-ductal...


    pub_type: 杂志文章


    authors: Doiron B,DeFronzo RA

    更新日期:2018-02-09 00:00:00

  • Inhibitory effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate-induced increase in ornithine decarboxylase mRNA in mouse epidermis.

    abstract::Application of 5 nmol 12-O-tetradecanoylphorbol-13-acetate (TPA) to the skin of female CD-1 mice led to a rapid increase in the concentration of epidermal ornithine decarboxylase (ODC) mRNA from an undetectable level in control mice to a high maximum level at 4-5 h after TPA administration. The concentration of epider...


    pub_type: 杂志文章


    authors: Lu YP,Chang RL,Huang MT,Conney AH

    更新日期:1993-02-01 00:00:00

  • The effects of dietary corn oil on the metabolism and activation of benzo[a]pyrene by the benzo[a]pyrene metabolizing enzymes of the mouse.

    abstract::Male ICR Swiss mice, weighing 16-20 g, were fed ad libitum either a fat-free diet or a diet containing 10% corn oil. After three weeks on these diets, the rates of benzo[a]pyrene (B[a]P) metabolite formation and metabolism to products which covalently bind with macromolecules were compared using hepatic nuclei and mic...


    pub_type: 杂志文章


    authors: Baker MT,Karr SW,Wade AE

    更新日期:1983-01-01 00:00:00

  • Modulation of homologous gap junctional intercellular communication of human dermal fibroblasts via a paracrine factor(s) generated by squamous tumor cells.

    abstract::Loss of gap junctional intercellular communication (GJIC) is a characteristic of cancer cells. Since a coordinated interaction of epithelial tumor cells with stromal cells is a prerequisite for tumor invasion and metastasis, the present study was designed to test the hypothesis that skin-derived tumor cells may modula...


    pub_type: 杂志文章


    authors: Stuhlmann D,Ale-Agha N,Reinehr R,Steinbrenner H,Ramos MC,Sies H,Brenneisen P

    更新日期:2003-11-01 00:00:00