Metabolism of aflatoxin B1 in the bovine olfactory mucosa.

abstract：:Metabolism and nucleic acid binding of the mammary gland carcinogen N-hydroxy-4-acetylaminobiphenyl (N-OH-AABP) was investigated using the human mammary epithelial cell line MCF 10A. Chromatographic analysis of the ethyl acetate extract of the media from cultured MCF 10A after 24 h exposure to N-OH-AABP revealed the f...

journal_title：Carcinogenesis

authors： Swaminathan S,Frederickson SM,Hatcher JF

更新日期：1994-04-01 00:00:00

abstract：:DNA mismatch repair defects in certain cell types confer resistance to the cytotoxic effects of alkylating agents, suggesting that a normally functioning DNA mismatch repair pathway can actually mediate alkylation-induced cell death. In eukaryotic cells this phenomenon is only observed in cells lacking adequate DNA me...

journal_title：Carcinogenesis

authors： Rasmussen LJ,Samson L

更新日期：1996-09-01 00:00:00

abstract：:DNA strand breage in response to damage produced by UV (254 nm) radiation was characterized after permeabilization of diploid normal and xeroderma pigmentosum variant fibroblasts. The breakage reaction required ATP, Mg2+ and sucrose for maximal activity and was inhibited by 150 mM Na+ or K+ and 1 mM N-ethylmaleimide. ...

journal_title：Carcinogenesis

authors： Kaufmann WK,Briley LP

更新日期：1990-01-01 00:00:00

abstract：:Previous studies had indicated that complete skin tumor promoters of the phorbol ester class induce epidermal transglutaminase and cornification in a subpopulation of cultured mouse epidermal basal cells in proportion to their promoting properties. This report describes the effect of promoting agents other than phorbo...

journal_title：Carcinogenesis

authors： Yuspa SH,Ben T,Hennings H

更新日期：1983-11-01 00:00:00

abstract：:Ovarian cancer is developed from a single layer of thin epithelial cells covering the surface of ovary, named human ovarian surface epithelial cells. Like all primary human cells, human ovarian surface epithelial cells have a finite life span and will go into senescence and eventually die when cultured in vitro. Immor...

journal_title：Carcinogenesis

authors： Yang G,Rosen DG,Mercado-Uribe I,Colacino JA,Mills GB,Bast RC Jr,Zhou C,Liu J

更新日期：2007-01-01 00:00:00

abstract：:We measured the mutation frequency and spectrum induced by exposure of the mutation reporter plasmid pSP189 in vivo to phorbol myristate acetate (PMA)-activated human polymorphonuclear leukocytes (PMNs). The mutation frequency induced in the supF tRNA gene of pSP189 transfected into human Ad293 cells by a 30 min expos...

journal_title：Carcinogenesis

authors： Akman SA,Sander F,Garbutt K

更新日期：1996-10-01 00:00:00

abstract：:The denitrosation of a novel nitrosourea, 1-(2-chloroethyl)-3-[(2-dimethylaminosulfonyl)-ethyl]-1-nitrosoure a, tauromustine (TCNU), has been investigated in liver cytosol from various species and with a pool of cytosolic rat liver glutathione transferases (GSTs). In addition, the denitrosation of related nitrosoureas...

journal_title：Carcinogenesis

authors： Tuvesson H,Gunnarsson PO,Seidegård J

更新日期：1993-06-01 00:00:00

abstract：:Inflammatory conditions in selected organs increase the risk of cancer. An inflammatory component is present also in the microenvironment of tumors that are not epidemiologically related to inflammation. Recent studies have begun to unravel molecular pathways linking inflammation and cancer. In the tumor microenvironm...

journal_title：Carcinogenesis

authors： Colotta F,Allavena P,Sica A,Garlanda C,Mantovani A

更新日期：2009-07-01 00:00:00

abstract：:Alterations of epigenetic modifications are promising targets for cancer therapy, and several epigenetic drugs are now being clinically utilized. At the same time, individual epigenetic modifications have physiological functions in normal cells, and cancer cell specificity is considered difficult to achieve using a dr...

journal_title：Carcinogenesis

authors： Takeshima H,Wakabayashi M,Hattori N,Yamashita S,Ushijima T

更新日期：2015-02-01 00:00:00

abstract：:Mutagenicity assays were carried out in the Salmonella/microsome test, using five S. typhimurium his(-) strains (TA1535, TA1537, TA1538, TA98 and TA100), both in the presence and absence of post-mitochondrial preparations from Aroclor-induced rat livers and suitable co-factors. Seven oil dispersants showed a wide rang...

journal_title：Carcinogenesis

authors： Petrilli FL,De Renzi GP,De Flora S

更新日期：1980-01-01 00:00:00

abstract：:The phylogenetically distant F344 and BN rat strains and their (BN x F344) F1 hybrids were compared for susceptibility to hepatocarcinogenesis using the 'resistant hepatocyte' model. Quantitative stereological analysis of frequency (number/liver) and size (mean volume and volume fraction) of placental form glutathione...

journal_title：Carcinogenesis

authors： Pascale RM,Simile MM,DeMiglio MR,Muroni MR,Gaspa L,Dragani TA,Feo F

更新日期：1996-08-01 00:00:00

abstract：:The liver-derived human cell line, Hep G2, has high benzo[a]pyrene-metabolizing activity and converts benzo[a]pyrene to intermediates that are mutagenic and that bind to DNA. This cell line will be useful for studying metabolic activation of polycyclic aromatic hydrocarbons and other xenobiotics by human tissue and as...

journal_title：Carcinogenesis

authors： Diamond L,Kruszewski F,Aden DP,Knowles BB,Baird WM

更新日期：1980-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the leading causes for cancer related mortality worldwide. Poor prognosis of HCC patients is mainly due to frequent metastasis and recurrence. Deregulation of metastasis suppressors in malignant cells plays critical roles during cancer metastasis. Thus, novel metastasis suppres...

journal_title：Carcinogenesis

authors： Luo Q,Wang C,Jin G,Gu D,Wang N,Song J,Jin H,Hu F,Zhang Y,Ge T,Huo X,Chu W,Shu H,Fang J,Yao M,Gu J,Cong W,Qin W

更新日期：2015-10-01 00:00:00

abstract：:Alcohol is a major risk factor for oesophageal squamous cell carcinoma (OSCC), the most prevalent histological subtype of oesophageal cancer (OC) worldwide. The metabolism of alcohol is regulated by specific enzymes whose activity and expression is influenced by genetic polymorphisms. We conducted a systematic review ...

journal_title：Carcinogenesis

authors： Matejcic M,Gunter MJ,Ferrari P

更新日期：2017-09-01 00:00:00

abstract：:To establish a cell culture model for lung carcinogenesis, independent populations of the human papillomavirus 18-immortalized human bronchial epithelial cell line BEP2D were treated with high linear energy transfer radon-simulated alpha-particles, expanded and xenotransplanted into Nu/Nu mice. Six independent cell li...

journal_title：Carcinogenesis

authors： Weaver DA,Hei TK,Hukku B,McRaven JA,Willey JC

更新日期：1997-06-01 00:00:00

abstract：:Multiple myeloma (MM) is characterized by a wide spectrum of genetic changes. Global hypomethylation of repetitive genomic sequences such as long interspersed nuclear element 1 (LINE-1), Alu and satellite alpha (SAT-alpha) sequences has been associated with chromosomal instability in cancer. Methylation status of repe...

journal_title：Carcinogenesis

authors： Bollati V,Fabris S,Pegoraro V,Ronchetti D,Mosca L,Deliliers GL,Motta V,Bertazzi PA,Baccarelli A,Neri A

更新日期：2009-08-01 00:00:00

abstract：:Isolated trout liver cells were treated with lysolecithin to produce an in situ system for characterizing DNA repair in teleosts. In this preparation, the integrity of the plasma membrane is altered, nuclei remain intact, and the concentrations of dNTPs and nucleotide analogs, which normally do not penetrate intact pl...

journal_title：Carcinogenesis

authors： Miller MR,Blair JB,Hinton DE

更新日期：1989-06-01 00:00:00

abstract：:Genomic alterations affecting components of the mechanistic target of rapamycin (mTOR) pathway are found rather frequently in cancers, suggesting that aberrant pathway activity is implicated in oncogenesis of different tumor types. mTOR functions as the core catalytic kinase of two distinct complexes, mTOR complex 1 (...

journal_title：Carcinogenesis

authors： Gkountakos A,Pilotto S,Mafficini A,Vicentini C,Simbolo M,Milella M,Tortora G,Scarpa A,Bria E,Corbo V

更新日期：2018-07-30 00:00:00

abstract：:An ongoing controversy exists on beneficial versus harmful effects of high beta-carotene (BC) intake, especially for the lung. To elucidate potential mechanisms, we studied effects of BC on lung gene expression. We used a beta-carotene 15,15'-monooxygenase 1 (Bcmo1) knockout mouse (Bcmo1(-/-)) model, unable to convert...

journal_title：Carcinogenesis

authors： van Helden YG,Godschalk RW,Heil SG,Bunschoten A,Hessel S,Amengual J,Bonet ML,von Lintig J,van Schooten FJ,Keijer J

更新日期：2010-08-01 00:00:00

abstract：:Breast cancer incidence is increased in women with both high and low birth weight. The latter is also associated with hyperglycaemia, insulin resistance and type-2 diabetes, each of which independently increases breast cancer risk. We showed previously in our model of poor early-growth that pregnancy estradiol levels ...

journal_title：Carcinogenesis

authors： Fernandez-Twinn DS,Ekizoglou S,Gusterson BA,Luan J,Ozanne SE

更新日期：2007-03-01 00:00:00

abstract：:Overexpression of the helix-loop-helix protein Id-1 has been reported in over 20 types of cancer. While a number of factors have been demonstrated to regulate Id-1 gene transcription, little is known about the mechanisms responsible for its degradation. In this study, we have demonstrated that Id-1 protein stability w...

journal_title：Carcinogenesis

authors： Ling MT,Kwok WK,Fung MK,Xianghong W,Wong YC

更新日期：2006-02-01 00:00:00

abstract：:Circulating microRNAs (miRNAs) are potential biomarkers for cancer diagnosis, screening and prognosis. This study aimed to identify serum miRNAs as predictors of survival in patients with advanced non-small cell lung cancer (NSCLC). We profiled serum miRNAs in a pilot set of four patients with good survival (>24 month...

journal_title：Carcinogenesis

authors： Zhang Y,Roth JA,Yu H,Ye Y,Xie K,Zhao H,Chang DW,Huang M,Li H,Qu J,Wu X

更新日期：2019-07-04 00:00:00

abstract：:A plant polysaccharide, Aloe gel extract, was reported to have an inhibitory effect on benzo[a]pyrene (B[a]P)-DNA adduct formation in vitro and in vivo. Hence, chemopreventive effects of plant polysaccharides [Aloe barbadensis Miller (APS), Lentinus edodes (LPS), Ganoderma lucidum (GPS) and Coriolus versicolor (CPS)] ...

journal_title：Carcinogenesis

authors： Kim HS,Kacew S,Lee BM

更新日期：1999-08-01 00:00:00

abstract：:The Manchester (England) Children's Tumour Registry is population-based with a high level of ascertainment. Pathologic review ensured diagnostic accuracy. Routine monitoring of annual incidence revealed a significant increase in germ cell tumours from approximately 1 per million person years to approximately 4. Analys...

journal_title：Carcinogenesis

authors： Birch JM,Marsden HB,Swindell R

更新日期：1982-01-01 00:00:00

abstract：:Mutations of the tumor suppressor gene p53 have been found in hepatocellular carcinomas (HCCs) from many countries where HCC is common, but p53 mutations detected by direct sequencing in HCCs from the United States (where HCC is uncommon) have been reported only rarely. p53 Exons 1 to 11 were analyzed by polymerase ch...

journal_title：Carcinogenesis

authors： Kazachkov Y,Khaoustov V,Yoffe B,Solomon H,Klintmalm GB,Tabor E

更新日期：1996-10-01 00:00:00

abstract：:Isothiocyanates are anticarcinogenic phytochemicals found in cruciferous vegetables that both induce and are substrates for the gluthatione S-transferases (GSTs). The GSTs are phase II metabolizing enzymes involved in metabolism of various bioactive compounds. Functional polymorphisms in GST genes have been identified...

journal_title：Carcinogenesis

authors： Steck SE,Gaudet MM,Britton JA,Teitelbaum SL,Terry MB,Neugut AI,Santella RM,Gammon MD

更新日期：2007-09-01 00:00:00

abstract：:Stimulation of cell proliferation caused by peroxisome proliferators was blocked by antibodies against TNF alpha and agents that inactivate Kupffer cells, a rich source of TNF alpha, which supports the hypothesis that Kupffer cells play a pivotal role in peroxisome proliferator-induced hyperplasia. Here, the ability o...

journal_title：Carcinogenesis

authors： Rusyn I,Tsukamoto H,Thurman RG

更新日期：1998-07-01 00:00:00

abstract：:Human Papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma (HPV+OPSCC) is increasing in prevalence in the United States, as are cases of patients with multiple HPV+OPSCCs (mHPV+OPSCC). mHPV+OPSCCs present a unique opportunity to examine HPV+OPSCC mutation acquisition and evolution. We performed sequenci...

journal_title：Carcinogenesis

authors： Faden DL,Langenbucher A,Kuhs K,Lewis JS,Mirabello L,Yeager M,Boland JF,Bass S,Steinberg M,Cullen M,Lawrence MS,Ferris RL

更新日期：2020-10-19 00:00:00

abstract：:O-Methylation of catecholestrogens catalyzed by catechol-O-methyltransferase provides a major route for the rapid metabolic clearance of these steroids. However, the metabolic clearance rate of 4-hydroxyestradiol (4-OH-E2) is considerably lower than that of 2-hydroxyestradiol, although 2- and 4-hydroxycatecholestrogen...

journal_title：Carcinogenesis

authors： Roy D,Weisz J,Liehr JG

更新日期：1990-03-01 00:00:00

abstract：:2-Hexenal is an alpha,beta-unsaturated carbonyl compound which is mutagenic, genotoxic and forms cyclic 1,N2-propanodeoxyguanosine adducts like similar propenals for which carcinogenicity was shown, e.g. acrolein or crotonaldehyde. Since humans have a permanent intake of 2-hexenal via vegetarian food this genotoxic co...

journal_title：Carcinogenesis

authors： Schuler D,Eder E

更新日期：1999-07-01 00:00:00