Reactions of methylnitrosourea, epichlorohydrin, styrene oxide and acetoxyacetylaminofluorene with polyamino acids.

abstract：:Liver DNA, obtained at various time intervals from rats chronically fed a choline-devoid diet, was analysed for the presence of aromatic or alkyl adducts by the 32P-postlabeling assay. Alkyl adducts were not detected. Aromatic DNA adduct lesions were revealed, but only at levels (1 adduct per 0.5-3 X 10(9) nucleotides...

journal_title：Carcinogenesis

authors： Gupta RC,Earley K,Locker J,Lombardi B

更新日期：1987-01-01 00:00:00

abstract：:Silicosis is an inflammatory lung disease induced by the inhalation of silica-containing dust particles. There is conflicting data on whether patients with silicosis are more susceptible to lung cancer induced by cigarette smoke. To examine this issue experimentally, a model was developed in which one of the most abun...

journal_title：Carcinogenesis

authors： Bode C,Kinjo T,Alvord WG,Klinman DM

更新日期：2014-05-01 00:00:00

abstract：:Serum-free cultures of normal human buccal epithelial cells were transfected with a plasmid containing the SV40 T-antigen (SV40T) gene. Two major lines developed that showed extended lifespans (between 30 and 40 weeks) as compared with the controls (approximately 6 weeks). Continued growth through one or two crises ge...

journal_title：Carcinogenesis

authors： Kulkarni PS,Sundqvist K,Betsholtz C,Höglund P,Wiman KG,Zhivotovsky B,Bertolero F,Liu Y,Grafström RC

更新日期：1995-10-01 00:00:00

abstract：:Aloe-emodin (AE), one of the main bioactive anthraquinones of Rheum palmatum, possesses potent antitumor properties. Our previous proteomic study revealed that AE-induced apoptosis was associated with oxidative stress and oxidation of many redox-sensitive proteins. In this study, we aimed to further dissect the cell d...

journal_title：Carcinogenesis

authors： Lu GD,Shen HM,Chung MC,Ong CN

更新日期：2007-09-01 00:00:00

abstract：:As renal cell carcinomas are characterized by the disappearance of the transcription factor LFB1, which is known to be primarily involved in gene regulation in the liver, we have measured the presence of LFB1 in rat hepatocellular carcinomas induced by diethylnitrosamine. The level of LFB1 binding activity in adenoid-...

journal_title：Carcinogenesis

authors： Stumpf H,Senkel S,Rabes HM,Ryffel GU

更新日期：1995-01-01 00:00:00

abstract：:The steroid hormone 1,25-dihydroxyvitamin D(3), [1,25(OH)(2)D(3), calcitriol], the active metabolite of vitamin D, exerts pleiotropic antitumor effects against several malignancies. However, the clinical use of this hormone is limited by hypercalcemia. 25-Hydroxyvitamin D(3), the prohormone of 1,25(OH)(2)D(3), is hydr...

journal_title：Carcinogenesis

authors： Schwartz GG,Eads D,Rao A,Cramer SD,Willingham MC,Chen TC,Jamieson DP,Wang L,Burnstein KL,Holick MF,Koumenis C

更新日期：2004-06-01 00:00:00

abstract：:The repair of u.v.-induced damage in human and rodent cells was investigated at the level of DNA loops attached to the nuclear matrix. After 2 h post-u.v. incubation, DNase I digestion studies revealed a 3- to 4-fold enrichment of repair-labeled DNA at the nuclear matrix in four xeroderma pigmentosum cell strains belo...

journal_title：Carcinogenesis

authors： Mullenders LH,van Kesteren AC,Bussmann CJ,van Zeeland AA,Natarajan AT

更新日期：1986-06-01 00:00:00

abstract：:Pleomorphic adenoma gene like-2 (PLAGL2), a member of the PLAG gene family, is a C2H2 zinc finger transcriptional factor that is involved in cellular transformation and apoptosis. In this report, we show that PLAGL2 is associated with the organization of stress fibers and with small guanosine triphosphatase (GTPase) a...

journal_title：Carcinogenesis

authors： Sekiya R,Maeda M,Yuan H,Asano E,Hyodo T,Hasegawa H,Ito S,Shibata K,Hamaguchi M,Kikkawa F,Kajiyama H,Senga T

更新日期：2014-09-01 00:00:00

abstract：:Prostate cancer (PCa) is the second cause of cancer deaths in men in the USA. When the cancer recurs, early stages can be controlled with hormone ablation therapy to delay the rate of cancer progression but, over time, the cancer overcomes its hormone dependence, becomes highly aggressive and metastasizes. Clinical tr...

journal_title：Carcinogenesis

authors： Wang L,Li W,Lin M,Garcia M,Mulholland D,Lilly M,Martins-Green M

更新日期：2014-10-01 00:00:00

abstract：:The possible effect of oral 13 cis retinoic acid (13-cis-RA) on the carcinogenic process induced by 28 weekly s.c. injections of 1,2-dimethylhydrazine (DMH) in 34 Wistar rats was investigated. Using immunohistology, precancerous and cancerous stages were compared with the same stages induced by DMH without additional ...

journal_title：Carcinogenesis

authors： Decaëns C,Rosa B,Bara J,Daher N,Burtin P

更新日期：1983-09-01 00:00:00

abstract：:It is widely believed that abnormal production of polypeptide growth factors, together with other molecular alterations, play an important role in neoplastic development. Transforming growth factor alpha (TGFalpha), hepatocyte growth factor (HGF) and acidic fibroblast growth factor (aFGF) are the three major growth fa...

journal_title：Carcinogenesis

authors： Hu Z,Evarts RP,Fujio K,Omori N,Omori M,Marsden ER,Thorgeirsson SS

更新日期：1996-05-01 00:00:00

abstract：:The genes that are involved in estrogen biosynthesis, cellular binding and metabolism may contribute to breast cancer susceptibility. We examined the effect of the CYP17 promoter T --> C polymorphism and its interactions with the reproductive history, exogenous hormone use and selected lifestyle risk factors on breast...

journal_title：Carcinogenesis

authors： Chen Y,Gammon MD,Teitelbaum SL,Britton JA,Terry MB,Shantakumar S,Eng SM,Wang Q,Gurvich I,Neugut AI,Santella RM,Ahsan H

更新日期：2008-04-01 00:00:00

abstract：:Several nitroarenes derived from benzo[a]pyrene and perylene and the parent hydrocarbons have been assayed for mutagenicity in the Salmonella microsome test and for affinity for the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-receptor protein in rat liver cytosol. 1- and 3-nitrobenzo[a]pyrene are mutagenic in the absen...

journal_title：Carcinogenesis

authors： Löfroth G,Toftgård R,Nilsson L,Agurell E,Gustafsson JA

更新日期：1984-07-01 00:00:00

abstract：:The effects of consumption of glucosinolate-containing Brussels sprouts on plasma and urinary glutathione S-transferase (GST) class-alpha and -pi were investigated. Five male and five female non-smoking volunteers were randomly assigned to two groups in a crossover design. Five persons started on a glucosinolate-free ...

journal_title：Carcinogenesis

authors： Nijhoff WA,Mulder TP,Verhagen H,van Poppel G,Peters WH

更新日期：1995-04-01 00:00:00

abstract：:Complementary DNA of marmoset CYP1A2 was isolated by means of screening the cDNA library and reverse-transcriptase polymerase chain reaction. The deduced amino acid sequence of marmoset CYP1A2 consisted of 516 residues and showed 88.2 and 90.0% identities to corresponding forms in human and cynomolgus monkey, respecti...

journal_title：Carcinogenesis

authors： Sakuma T,Igarashi T,Hieda M,Ohgiya S,Isogai M,Ninomiya S,Nagata R,Nemoto N,Kamataki T

更新日期：1997-10-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of galacto-oligosaccharides (GOS, Elix'or) on the development of aberrant crypt foci (ACF) and colorectal tumours in rats treated with azoxymethane (AOM). Two groups of 102 male Fischer 344 rats were injected twice with AOM to induce colorectal tumours, and f...

journal_title：Carcinogenesis

authors： Wijnands MV,Schoterman HC,Bruijntjes JB,Hollanders VM,Woutersen RA

更新日期：2001-01-01 00:00:00

abstract：:The transforming potential of acrylonitrile epoxide (ANO) was tested in a modified NIH3T3 transfection-transformation assay. This involves a new ras construct obtained by ligating a human c-Ha-ras-1 proto-oncogene to the pSV2neo mammalian vector. The new plasmid was allowed to react with ANO or an established carcinog...

journal_title：Carcinogenesis

authors： Yuan B,Wong JL

更新日期：1991-05-01 00:00:00

abstract：:3,3-[3H]Dimethyl-1-phenyltriazene, 1-(4-chlorophenyl)-3,3-[3H]dimethyltriazene and 3,3-[3H]dimethyl-1-(2,4,6-trichlorophenyl)-triazene methylate initiator tRNA in vitro only after pre-incubation with microsomal enzymes and NADPH. The finding confirms that procarcinogenic dialkyl aryltriazenes must be enzymatically con...

journal_title：Carcinogenesis

authors： Hradec J,Kolar GF

更新日期：1985-07-01 00:00:00

abstract：:Gene-environment interactions play an important role in folate metabolism, with a potential impact on human health. Deficiencies in the uptake of key micronutrients and variant genotypes can affect the folic acid cycle, modulating methyl group transfer in key processes and leading to increased cancer risk and Down syn...

journal_title：Carcinogenesis

authors： Zijno A,Andreoli C,Leopardi P,Marcon F,Rossi S,Caiola S,Verdina A,Galati R,Cafolla A,Crebelli R

更新日期：2003-06-01 00:00:00

abstract：:Hepatic microsomes of female F344 rats were capable of N,O-acyltransfer of N-hydroxy-N-acetyl-2-aminofluorene (N-OH-AAF) and N-hydroxy-N-formyl-2-aminofluorene (N-OH-FAF), N-deacetylation of N-OH-AAF and N-acetyl-2-aminofluorene (2-AAF), and O-deacetylation of 4-nitrophenyl acetate (NPA). The activity for N,O-acyltran...

journal_title：Carcinogenesis

authors： Wang CY,Zukowski K,Lee MS,Sone T

更新日期：1992-11-01 00:00:00

abstract：:To test the hypothesis that nucleotide excision repair (NER) plays a protective role in chemical carcinogenesis in internal organs, xeroderma pigmentosum group A gene-deficient (XPA(-/-)) mice, heterozygous (XPA(+/-)) and wild-type (XPA(+/+)) mice were orally administered 0.001% 4-nitroquinoline 1-oxide (4NQO) in thei...

journal_title：Carcinogenesis

authors： Ide F,Oda H,Nakatsuru Y,Kusama K,Sakashita H,Tanaka K,Ishikawa T

更新日期：2001-04-01 00:00:00

abstract：:An ongoing controversy exists on beneficial versus harmful effects of high beta-carotene (BC) intake, especially for the lung. To elucidate potential mechanisms, we studied effects of BC on lung gene expression. We used a beta-carotene 15,15'-monooxygenase 1 (Bcmo1) knockout mouse (Bcmo1(-/-)) model, unable to convert...

journal_title：Carcinogenesis

authors： van Helden YG,Godschalk RW,Heil SG,Bunschoten A,Hessel S,Amengual J,Bonet ML,von Lintig J,van Schooten FJ,Keijer J

更新日期：2010-08-01 00:00:00

abstract：:The tissue distribution and macromolecular binding of benzene was studied over a dose range spanning nine-orders of magnitude to determine the nature of the dose-response and to establish benzene's internal dosimetry at doses encompassing human environmental exposures. [14C]-Benzene was administered to B6C3F1 male mic...

journal_title：Carcinogenesis

authors： Creek MR,Mani C,Vogel JS,Turteltaub KW

更新日期：1997-12-01 00:00:00

abstract：:The metastasis suppressor, N-myc downstream regulated gene 1 (NDRG1), is negatively correlated with tumor progression in multiple neoplasms, being a promising new target for cancer treatment. However, the precise molecular effects of NDRG1 remain unclear. Herein, we summarize recent advances in understanding the impac...

journal_title：Carcinogenesis

authors： Sun J,Zhang D,Bae DH,Sahni S,Jansson P,Zheng Y,Zhao Q,Yue F,Zheng M,Kovacevic Z,Richardson DR

更新日期：2013-09-01 00:00:00

abstract：:The fetus and neonate are sensitive targets for chemically induced carcinogenesis. Few studies have examined the risk/benefit of chemoprotective phytochemicals, given in the maternal diet, against transplacental carcinogenesis. In this study, B6129 SF1/J (AHR(b-1/d)) and 129Sv/ImJ (AHR(d/d)) mice were cross-bred. The ...

journal_title：Carcinogenesis

authors： Yu Z,Mahadevan B,Löhr CV,Fischer KA,Louderback MA,Krueger SK,Pereira CB,Albershardt DJ,Baird WM,Bailey GS,Williams DE

更新日期：2006-10-01 00:00:00

abstract：:Chronic oral administration of the carcinogenic aminoazo dye N-methyl-4-aminoazobenzene (MAB) to rats is known to result in the induction of liver tumors. In order to assess the role of carcinogen-DNA adduct formation in MAB hepatocarcinogenesis, male rats were fed 0.06% [3'-3H]MAB in the diet for 1, 3 or 5 weeks. Gro...

journal_title：Carcinogenesis

authors： Tullis DL,Dooley KL,Miller DW,Baetcke KP,Kadlubar FF

更新日期：1987-04-01 00:00:00

abstract：:The phosphoinositide 3-kinase (PI 3-kinase) signaling pathway has been shown to play a pivotal role in intracellular signal transduction pathways involved in cell growth, cellular transformation and tumorigenesis. Analysis of several colon adenocarcinoma cell lines indicates that the PI 3-kinase signaling pathway is u...

journal_title：Carcinogenesis

authors： Khaleghpour K,Li Y,Banville D,Yu Z,Shen SH

更新日期：2004-02-01 00:00:00

abstract：:Covalent binding to haemoglobin, plasma proteins and DNA was determined after intraperitoneal administration of radiolabelled diethylnitrosamine to mice. The level of alkylation of DNA in liver--the main site of activation--was found to be about two orders of magnitude higher than the level of alkylation of haemoglobi...

journal_title：Carcinogenesis

authors： Osterman-Golkar S,Bergmark E

更新日期：1988-11-01 00:00:00

abstract：:Wnt signaling plays a central role in mammary stem cell (MaSC) homeostasis and in breast cancer. In particular, epigenetic alterations at different members of the Wnt pathway have been identified among triple-negative, basal-like breast cancers. Previously, we developed a mouse model for metaplastic breast adenocarcin...

journal_title：Carcinogenesis

authors： Monteiro J,Gaspar C,Richer W,Franken PF,Sacchetti A,Joosten R,Idali A,Brandao J,Decraene C,Fodde R

更新日期：2014-01-01 00:00:00

abstract：:Current procedures for diagnosis and biomarker examination of colorectal cancer (CRC) are invasive and unpleasant. There is a great need to identify sensitive and specific biomarkers for early diagnosis of CRC. Circulating microRNAs (miRNAs) are promising molecular markers for CRC prediction. We performed a comprehens...

journal_title：Carcinogenesis

authors： Du M,Liu S,Gu D,Wang Q,Zhu L,Kang M,Shi D,Chu H,Tong N,Chen J,Adams TS,Zhang Z,Wang M

更新日期：2014-12-01 00:00:00