Downregulation of Fzd6 and Cthrc1 and upregulation of olfactory receptors and protocadherins by dietary beta-carotene in lungs of Bcmo1-/- mice.

abstract：:7-Hydroxymethylbenz[a]anthracene (7-HBA) showed potent mutagenicity towards Salmonella typhimurium TA 98 in the presence of untreated rat liver cytosol fortified with the PAPS-generating system, sodium sulphate and ATP. No mutagenic activity was observed either when the cytosol was boiled or when sodium sulphate or AT...

journal_title：Carcinogenesis

authors： Watabe T,Hakamata Y,Hiratsuka A,Ogura K

更新日期：1986-02-01 00:00:00

abstract：:Wnt/β-Catenin signaling dysregulation is involved in tumorigenesis. Furthermore, epigenetic modification of the Dickkopf (DKK) family (DKK1-DKK4) has been shown to be important in Wnt signaling regulation. In this study, the role of DKK2, a Wnt antagonist, in epithelial ovarian cancer (EOC) was evaluated by examining ...

journal_title：Carcinogenesis

authors： Zhu J,Zhang S,Gu L,Di W

更新日期：2012-12-01 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) have been described to play critical roles in initiation, progression and metastasis of various cancers. However, the involvement of CAFs in oral cancer (OC) has not been well addressed. In this study, we demonstrate that CAFs, when cocultured with OC cells (OCCs), produce high lev...

journal_title：Carcinogenesis

authors： Li X,Xu Q,Wu Y,Li J,Tang D,Han L,Fan Q

更新日期：2014-06-01 00:00:00

abstract：:Phenobarbital and clofibrate, two non-genotoxic carcinogens, have been investigated regarding the relationship between reactive oxygen species, antioxidant enzyme expression and apoptosis in primary cultures of rat hepatocytes. Low toxicity concentrations, 200 and 100 microg/ml for phenobarbital and clofibrate respect...

journal_title：Carcinogenesis

authors： Díez-Fernández C,Sanz N,Alvarez AM,Wolf A,Cascales M

更新日期：1998-10-01 00:00:00

abstract：:Prostate cancer (CaP) is the second leading cause of cancer death in American men. Chronic inflammation has been one of several factors associated with the development of CaP. Single-nucleotide polymorphisms (SNPs) in cytokine genes have been associated with increased inflammation, increased cytokine production and po...

journal_title：Carcinogenesis

authors： Zabaleta J,Lin HY,Sierra RA,Hall MC,Clark PE,Sartor OA,Hu JJ,Ochoa AC

更新日期：2008-03-01 00:00:00

abstract：:DNA-demethylating agents activate tumor suppressor genes that are silenced by DNA methylation in cancer and are therefore emerging as a novel approach to cancer therapy. 5-azacytidine (VIDAZA), the first representative of this class of drugs was approved for treatment of myelodysplastic syndromes and is currently bein...

journal_title：Carcinogenesis

authors： Chik F,Machnes Z,Szyf M

更新日期：2014-01-01 00:00:00

abstract：:A number of distinct subtypes of neuroblastoma exist with different genetic abnormalities that are predicative of outcome. Whole chromosome gains are usually associated with low stage disease and favourable outcome, whereas loss of 1p, 3p and 11q, unbalanced gain of 17q and MYCN amplification (MNA) are indicative of h...

journal_title：Carcinogenesis

authors： McArdle L,McDermott M,Purcell R,Grehan D,O'Meara A,Breatnach F,Catchpoole D,Culhane AC,Jeffery I,Gallagher WM,Stallings RL

更新日期：2004-09-01 00:00:00

abstract：:Estrogen plays an important role in breast cancer development. While the mechanism of the estrogen effects is not fully elucidated, one possible route is by increasing the stem cell-like properties in the tumors. Tocopherols are known to reduce breast cancer development and progression. The aim of the present study is...

journal_title：Carcinogenesis

authors： Bak MJ,Furmanski P,Shan NL,Lee HJ,Bao C,Lin Y,Shih WJ,Yang CS,Suh N

更新日期：2018-07-30 00:00:00

abstract：:Oxidative stress has consistently been linked to breast carcinogenesis, and mitochondria play a significant role in regulating reactive oxygen species generation. In our previous study, we found that increased levels of mitochondrial DNA (mtDNA) copy number and the presence of mitochondrial length heteroplasmies in th...

journal_title：Carcinogenesis

authors： Shen J,Wan J,Song R,Zhao H

更新日期：2015-11-01 00:00:00

abstract：:The inhibitory effects of three phenolic compounds (ferulic, chlorogenic and ellagic acids) on benzo[a]pyrene- and 7,12-dimethylbenz[a]anthracene-induced neoplasia have been investigated in mice. Ellagic acid was the most potent antagonist of tumorigenesis since this compound is active, by i.p. administration or added...

journal_title：Carcinogenesis

authors： Lesca P

更新日期：1983-12-01 00:00:00

abstract：:The effects of retinol and retinoic acid on cytotoxicity and mutation expression at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus in Chinese hamster ovary (CHO) cells with or without exogenous metabolic activation were studied in the presence and absence of known chemical mutagens. Neither retinol ...

journal_title：Carcinogenesis

authors： Budroe JD,Schol HM,Shaddock JG,Casciano DA

更新日期：1988-07-01 00:00:00

abstract：:Aberrant crypt foci (ACF), putative preneoplastic lesions, are early morphological changes induced by the colon carcinogen azoxymethane (AOM). Although inbred mice differ markedly in their susceptibility to AOM carcinogenesis, we have previously shown that ACF develop in both resistant and sensitive mouse strains afte...

journal_title：Carcinogenesis

authors： Papanikolaou A,Wang QS,Papanikolaou D,Whiteley HE,Rosenberg DW

更新日期：2000-08-01 00:00:00

abstract：:The pulmonary adenoma susceptibility 1 (Pas1) gene affects susceptibility to the development of lung adenomas in mice with a subset of the adenomas progressing to adenocarcinoma (ADC). In this study, genotype distributions for 10 polymorphisms in the human counterparts for three mouse candidate Pas1 genes, KRAS, CASC1...

journal_title：Carcinogenesis

authors： Kohno T,Kunitoh H,Suzuki K,Yamamoto S,Kuchiba A,Matsuno Y,Yanagitani N,Yokota J

更新日期：2008-05-01 00:00:00

abstract：:To explore the potential role for estrogen in lung cancer susceptibility, candidate single-nucleotide polymorphism (SNPs) in tobacco and estrogen metabolism genes were evaluated. Population-based cases (n = 504) included women aged 18-74, diagnosed with NSCLC in metropolitan Detroit between November 2001 and October 2...

journal_title：Carcinogenesis

authors： Cote ML,Yoo W,Wenzlaff AS,Prysak GM,Santer SK,Claeys GB,Van Dyke AL,Land SJ,Schwartz AG

更新日期：2009-04-01 00:00:00

abstract：:Species differences in the metabolism of toxic chemicals can confound the extrapolation of experimentally determined risk data to man. However, it is often difficult to obtain reliable information on human metabolism, particularly of genotoxic agents. In this study, comparisons of chromatographic profiles of DNA adduc...

journal_title：Carcinogenesis

authors： Huckle KR,Smith RJ,Watson WP,Wright AS

更新日期：1986-06-01 00:00:00

abstract：:Garcinol, a polyisoprenylated benzophenone, from the fruit rind of Garcinia spp., has been shown to have anti-inflammatory and anticarcinogenic activities. To study its mechanism of action, we analyzed the effects of garcinol and its derivatives, including cambogin, garcim-1 and garcim-2, on arachidonic acid metabolis...

journal_title：Carcinogenesis

authors： Hong J,Sang S,Park HJ,Kwon SJ,Suh N,Huang MT,Ho CT,Yang CS

更新日期：2006-02-01 00:00:00

abstract：:The spectrum of mutations induced by N-acetoxy-N-acetyl-2-aminofluorene (N-AcO-AAF) was examined by the pZipHprtNeo shuttle vector in mammalian cells. The vector carries a cDNA of the human hypoxanthine phosphoribosyl transferase (hprt) gene, which is stably integrated into chromosomal DNA of a mouse cell line, VH12. ...

journal_title：Carcinogenesis

authors： Ogawa HI,Kimura H,Koya M,Higuchi H,Kato T

更新日期：1993-11-01 00:00:00

abstract：:Sulindac, a widely used non-steroidal anti-inflammatory drug (NSAID), has been shown to inhibit chemically induced carcinogenesis in animal models. In the present study, we have investigated the molecular mechanism by which sulindac affects the activity and expression of the enzymes that mediate the initial detoxifica...

journal_title：Carcinogenesis

authors： Ciolino HP,MacDonald CJ,Memon OS,Bass SE,Yeh GC

更新日期：2006-08-01 00:00:00

abstract：:The polypeptide hormone epidermal growth factor (EGF) has been shown to enhance adenovirus type 5 transformation of a cloned culture of rat embryo cells (CREF) and X-ray or u.v.-light induced transformation of 10T1/2 mouse embryo cells. In both systems, the degree of enhancement was quantitatively similar to that obse...

journal_title：Carcinogenesis

authors： Fisher PB,Mufson RA,Weinstein IB,Little JB

更新日期：1981-01-01 00:00:00

abstract：:The mutagenicities of 2-aminodipyrido [1,2-a:3',2'-d] imidazole (Glu-P-2, a mutagen obtained from pyrolysate of glutamic acid) and six methyl substituted derivatives of Glu-P-2 were tested with Salmonella typhimurium TA98 and TA100 with S-9 mix. Glu-P-1 (6-Me-Glu-P-2) was the strongest mutagen to TA98 and TA100. 3-Me-...

journal_title：Carcinogenesis

authors： Takeda K,Shudo K,Okamoto T,Nagao M,Wakabayashi K,Sugimura T

更新日期：1980-01-01 00:00:00

abstract：:Inactivation of the adenomatous polyposis coli (Apc) gene by loss of the wild-type Apc allele (LOH) is a prerequisite for the development of intestinal adenomas in Msh2 proficient Min (Apc+/-Msh2+/+) mice. In contrast, adenomas from Msh2 deficient Min (Apc+/-Msh2-/-) mice are not usually associated with LOH. Given the...

journal_title：Carcinogenesis

authors： Sohn KJ,Choi M,Song J,Chan S,Medline A,Gallinger S,Kim YI

更新日期：2003-02-01 00:00:00

abstract：:A diet deficient in choline when fed to rats for as few as 3 days resulted in liver DNA damage. The damage could be monitored as alkali-labile lesions using alkaline-sucrose gradients as well as alkaline elution technique. The DNA damage disappeared when the choline-deficient diet was replaced by a choline-supplemente...

journal_title：Carcinogenesis

authors： Rushmore TH,Farber E,Ghoshal AK,Parodi S,Pala M,Taningher M

更新日期：1986-10-01 00:00:00

abstract：:Some of the glutathione S-transferases (GSTs) are polymorphic and may play a role in lung cancer susceptibility. Our previous study in a French Caucasian study population suggested GSTM1 null genotype as a moderate risk factor for lung cancer. Here we extended the study to investigate the potential role of GSTT1 and G...

journal_title：Carcinogenesis

authors： Stücker I,Hirvonen A,de Waziers I,Cabelguenne A,Mitrunen K,Cénée S,Koum-Besson E,Hémon D,Beaune P,Loriot MA

更新日期：2002-09-01 00:00:00

abstract：:The expression of cytochrome (CYP) P450 enzymes in human oesophageal mucosa was investigated in a total of 25 histologically non-neoplastic surgical tissue specimens by using specific antibodies in immunoblots and by RT-PCR mRNA analysis. The presence of CYP1A, 2E1, 3A and 4A enzymes was demonstrated by both technique...

journal_title：Carcinogenesis

authors： Lechevrel M,Casson AG,Wolf CR,Hardie LJ,Flinterman MB,Montesano R,Wild CP

更新日期：1999-02-01 00:00:00

abstract：:The O6-methylguanine-DNA methyltransferase gene (MGMT) encodes the direct reversal DNA repair protein that removes alkyl adducts from the O6 position of guanine. Several single-nucleotide polymorphisms (SNPs) exist in the MGMT promoter/enhancer (P/E) region. However, the haplotype structure encompassing these SNPs and...

journal_title：Carcinogenesis

authors： Xu M,Nekhayeva I,Cross CE,Rondelli CM,Wickliffe JK,Abdel-Rahman SZ

更新日期：2014-03-01 00:00:00

abstract：:Occupational nitrosamine exposures from a rubber vehicle seal (VS) curing operation were compared with the peripheral blood lymphocyte concentrations of two nitrosamine-related DNA adducts, N(7)-methylguanine (N(7)mdG) and O(6)-methylguanine (O(6)mdG), and with the activity of the enzyme that repairs O(6)mdG adducts, ...

journal_title：Carcinogenesis

authors： Reh BD,DeBord DG,Butler MA,Reid TM,Mueller C,Fajen JM

更新日期：2000-01-01 00:00:00

abstract：:The kinetics of nuclear polyploidization in livers of CF-1 mice exposed to dieldrin were studied at concentrations of 0, 0.1, 1, 5 and 10 p.p.m. in the diet, in 'steady-state' situations (which are reached within a few weeks after initiation of treatment). Animals were killed at five time intervals (after 1.85, 3, 6, ...

journal_title：Carcinogenesis

authors： van Ravenzwaay B,Tennekes H,Stöhr M,Kunz W

更新日期：1987-02-01 00:00:00

abstract：:Isothiocyanates are anticarcinogenic phytochemicals found in cruciferous vegetables that both induce and are substrates for the gluthatione S-transferases (GSTs). The GSTs are phase II metabolizing enzymes involved in metabolism of various bioactive compounds. Functional polymorphisms in GST genes have been identified...

journal_title：Carcinogenesis

authors： Steck SE,Gaudet MM,Britton JA,Teitelbaum SL,Terry MB,Neugut AI,Santella RM,Gammon MD

更新日期：2007-09-01 00:00:00

abstract：:In order to investigate the modulatory effect of the immune response induced by recurrent carcinogen exposure, anti-2-acetylaminofluorene (anti-2-AAF) IgG were elicited in Swiss mice before subsequent carcinogen administration. The immunization schedule consisted of three weekly i.p. injections of 2-acetylaminofluoren...

journal_title：Carcinogenesis

authors： Verdina A,Zito R,Cortese G,Leopardi P,Marcon F,Zijno A,Crebelli R

更新日期：1996-08-01 00:00:00

abstract：:A diet that is deficient in methionine, choline, folic acid and vitamin B12 has been found to induce alterations rapidly in liver tRNA methylation in male Fischer rats. In vitro assays indicated that activity of N2-guanine tRNA methyltransferase II (NMG2) was increased to 150% of controls levels in 1 week and 300% of ...

journal_title：Carcinogenesis

authors： Wainfan E,Dizik M,Hluboky M,Balis ME

更新日期：1986-03-01 00:00:00