Altered tRNA methylation in rats and mice fed lipotrope-deficient diets.

abstract：:The arylamine carcinogen 3,2'-dimethyl-4-aminobiphenyl (DMABP) has been proposed to be metabolically activated to DNA-binding derivatives through the formation of an N-hydroxy intermediate. In this study, the subsequent activation of N-hydroxy-DMABP through acid catalysis or enzymatic esterification was examined. [Rin...

journal_title：Carcinogenesis

authors： Flammang TJ,Westra JG,Kadlubar FF,Beland FA

更新日期：1985-02-01 00:00:00

abstract：:Apigenin, a flavonoid abundant in various vegetables and fruits, including parsley and onions, has been reported to possess anticarcinogenic effects. However, the direct molecular target of apigenin and its chemopreventive effect on ultraviolet (UV)-induced skin inflammation are not understood fully. Herein, we examin...

journal_title：Carcinogenesis

authors： Byun S,Park J,Lee E,Lim S,Yu JG,Lee SJ,Chen H,Dong Z,Lee KW,Lee HJ

更新日期：2013-02-01 00:00:00

abstract：:The conformation of N-(deoxyguanosin-8-yl)-2-acetylaminofluorene and N-(deoxyguanosin-8-yl)-2-aminofluorene was investigated by 1H n.m.r. spectroscopy. There was rotation about the glycosyl bond and preference for either the anti or syn conformation depended on whether or not the 8-arylamino nitrogen was acetylated. T...

journal_title：Carcinogenesis

authors： Evans FE,Miller DW,Beland FA

更新日期：1980-01-01 00:00:00

abstract：:Effect of nicotine on PDGF AA and PDGF BB interaction with cervical cancer SiHa cells was tested. [125I]PDGF AA was internalized by cells and accumulated in the cytoplasm and nucleus (chromatin). In the absence of nicotine, maximal accumulation of [125I]PDGF AA inside the cells occurred after 1 day of incubation, whic...

journal_title：Carcinogenesis

authors： Rakowicz-Szulczynska EM,McIntosh DG,Perry M,Smith ML

更新日期：1996-09-01 00:00:00

abstract：:The N-hydroxylamine of the carcinogen 2-amino-3-methylimidazolo[4,5-f]quinoline (IQ) covalently bound to calf thymus DNA at pH 7, and the binding was 11% higher under acidic conditions (pH 5). The extent of N-hydroxy-IQ binding to single-stranded polynucleotides at neutral pH was in the following order: polyguanylic a...

journal_title：Carcinogenesis

authors： Snyderwine EG,Roller PP,Adamson RH,Sato S,Thorgeirsson SS

更新日期：1988-06-01 00:00:00

abstract：:Groups of male and female IF strain mice were fed a diet containing either 0.5% or 1.0% paracetamol for up to 18 months. Among male mice fed the higher dose, the total liver cell tumour incidence was 87%, 21.7% developing hepatocellular carcinomas: both yields were statistically significant. The corresponding incidenc...

journal_title：Carcinogenesis

authors： Flaks A,Flaks B

更新日期：1983-01-01 00:00:00

abstract：:Tobacco-specific nitrosamines are a group of carcinogens that are present in tobacco and tobacco smoke. They are formed from nicotine and related tobacco alkaloids. Two of the nicotine-derived nitrosamines, NNK and NNN, are strong carcinogens in laboratory animals. They can induce tumors both locally and systemically....

journal_title：Carcinogenesis

authors： Hecht SS,Hoffmann D

更新日期：1988-06-01 00:00:00

abstract：:The 14-3-3 proteins are associated with proto-oncogene and oncogene products. Here, we generated NIH 3T3 cells overexpressing the beta isoform of the 14-3-3 proteins (14-3-3 beta) to examine the function of this isoform in cellular proliferation and oncogenic transformation. Overexpression of 14-3-3 beta in NIH 3T3 ce...

journal_title：Carcinogenesis

authors： Takihara Y,Matsuda Y,Hara J

更新日期：2000-11-01 00:00:00

abstract：:Transforming growth factor-beta 1 (TGF-beta1) plays a significant role in regulating the proliferation and apoptosis of prostate epithelial and stromal cells. We explored the association between the T (Leu) to C (Pro) polymorphism at codon10 of the TGF-beta1 gene (TGFB1) and the risk of prostate cancer (PCa) or benign...

journal_title：Carcinogenesis

authors： Li Z,Habuchi T,Tsuchiya N,Mitsumori K,Wang L,Ohyama C,Sato K,Kamoto T,Ogawa O,Kato T

更新日期：2004-02-01 00:00:00

abstract：:Conversion of the 2'-deoxyguanosine (dG) residues in calf thymus DNA to 8-hydroxy-2'-deoxyguanosine (8-OH-dG) was achieved at physiological pH by treating the DNA with hydrogen peroxide (H2O2) in the presence of nickel(II) chloride (NiCl2). The effectiveness of this reaction was enhanced by L-histidine (His) which for...

journal_title：Carcinogenesis

authors： Dutta AK,Misra M,North SL,Kasprzak KS

更新日期：1992-02-01 00:00:00

abstract：:Two mutagenic compounds have been isolated and purified from commercial beef extract. These two compounds have chemical, chromatographic, spectroscopic and biological behavior indistinguishable from those of the two known mutagens 2-amino-3-methyl-imidazo-[4,5-f]-quinoline and 2-amino-3,8-dimethyl-imidazo-[4,5-f]-quin...

journal_title：Carcinogenesis

authors： Turesky RJ,Wishnok JS,Tannenbaum SR,Pfund RA,Buchi GH

更新日期：1983-01-01 00:00:00

abstract：:Arsenic is a human carcinogen whose mechanism of action is unknown. Previously, this laboratory demonstrated that arsenite acts as a comutagen by interfering with DNA repair, although a specific DNA repair enzyme sensitive to arsenite has not been identified. A number of stable arsenite-sensitive and arsenite-resistan...

journal_title：Carcinogenesis

authors： Rossman TG,Wang Z

更新日期：1999-02-01 00:00:00

abstract：:Checkpoint kinase (CHEK) 2, a tumor suppressor gene, plays an essential role in the DNA damage checkpoint response cascade. We first investigated two polymorphisms in the proximal promoter of the CHEK2 gene and evaluated their associations with the risk of lung cancer in a case-control study using 500 incident lung ca...

journal_title：Carcinogenesis

authors： Zhang S,Lu J,Zhao X,Wu W,Wang H,Lu J,Wu Q,Chen X,Fan W,Chen H,Wang F,Hu Z,Jin L,Wei Q,Shen H,Huang W,Lu D

更新日期：2010-07-01 00:00:00

abstract：:We hypothesized that superoxide from Kupffer cells (KC) contributes to hepatocarcinogenesis. p47phox(-/-) mice, deficient in phagocyte NADPH oxidase and superoxide generation, received a single dose of the hepatocarcinogen diethylnitrosamine (DEN). The following hepatic effects were observed at time points between 30 ...

journal_title：Carcinogenesis

authors： Teufelhofer O,Parzefall W,Kainzbauer E,Ferk F,Freiler C,Knasmüller S,Elbling L,Thurman R,Schulte-Hermann R

更新日期：2005-02-01 00:00:00

abstract：:Cigarette smoking is a major cause of human cancer at a variety of sites, although its carcinogenic mechanisms remains unestablished. Cigarette smoke can be divided into two phases, gas phase and particulate matter (tar). Both phases contain high concentrations of oxidants and free radicals, especially nitric oxide (N...

journal_title：Carcinogenesis

authors： Yoshie Y,Ohshima H

更新日期：1997-07-01 00:00:00

abstract：:CXCL5 is a member of the CXC-type chemokine family that may play a role in carcinogenesis and cancer progression. This study investigates the biological function and clinical significance of CXCL5 in intrahepatic cholangiocarcinoma (ICC). We demonstrated that CXCL5 was overexpressed in ICC cell lines and tumor samples...

journal_title：Carcinogenesis

authors： Zhou SL,Dai Z,Zhou ZJ,Chen Q,Wang Z,Xiao YS,Hu ZQ,Huang XY,Yang GH,Shi YH,Qiu SJ,Fan J,Zhou J

更新日期：2014-03-01 00:00:00

abstract：:Wildtype 10T1/2 cells and 42 clonally derived morphologically transformed 10T1/2 cell lines were evaluated for expression of p53 mRNA and protein. Wildtype 10T1/2 cells expressed detectable levels of p53 mRNA and multiple immunologically distinct forms of the p53 protein, including both PAb240- and PAb246-reactive con...

journal_title：Carcinogenesis

authors： Coleman WB,Grisham JW,Smith GJ

更新日期：1994-02-01 00:00:00

abstract：:Teleocidin, a new tumor promoter, increased incorporation of radioactive inorganic phosphate (32Pi) into phospholipids in HeLa cells. This effect was detected within 1 h on incubation of the cells in medium containing teleocidin. The half-maximum effective dose of teleocidin was approximately 10 ng/ml. The main effect...

journal_title：Carcinogenesis

authors： Nishino H,Fujiki H,Terada M,Sato S

更新日期：1983-01-01 00:00:00

abstract：:Reactive oxygen species (ROS) have been implicated in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance of many cancers. We evaluated the role of peroxiredoxin (Prx) I in TRAIL resistance governed by coupling of nicotinamide adenosine dinucleotide phosphate oxidase (Nox)-derived ROS signaling ...

journal_title：Carcinogenesis

authors： Song IS,Kim SU,Oh NS,Kim J,Yu DY,Huang SM,Kim JM,Lee DS,Kim NS

更新日期：2009-07-01 00:00:00

abstract：:Extensive tumorigenicity studies in rodents revealed that dibenzo[a,l]pyrene (DB[a,l]P) is the most potent carcinogen among all polycyclic aromatic hydrocarbons (PAHs) tested so far. The structure of the genotoxic metabolite(s) responsible for this exceptional carcinogenicity is unknown. The fjord-region syn- and anti...

journal_title：Carcinogenesis

authors： Luch A,Glatt H,Platt KL,Oesch F,Seidel A

更新日期：1994-11-01 00:00:00

abstract：:Adipocytokines are a group of adipocyte-secreted proteins that have significant effects on the metabolism of lipids and carbohydrates, as well as numerous other processes. A number of recent studies have indicated that some adipocytokines may significantly influence the proliferation of malignant cells in vitro, where...

journal_title：Carcinogenesis

authors： Miyamoto S,Yasui Y,Tanaka T,Ohigashi H,Murakami A

更新日期：2008-05-01 00:00:00

abstract：:Vinyl chloride (VC) is a carcinogen associated with human and animal cancers. The ultimate carcinogenic form of VC, 2-chloroacetaldehyde (CAA), has been suspected to be mutagenic and we confirmed the mutagenicity of CAA using a modified shuttle vector plasmid. Base sequence analyses of 109 mutant plasmids with mutatio...

journal_title：Carcinogenesis

authors： Matsuda T,Yagi T,Kawanishi M,Matsui S,Takebe H

更新日期：1995-10-01 00:00:00

abstract：:Hairless mice were given 5 topical applications of 470 nmol 20-methylcholanthrene (MCA) at one week intervals. In one experimental group the MCA was dissolved in reagent grade acetone alone, in another group it was dissolved in a mixture consisting of 50% acetone and 50% dimethyl sulfoxide (DMSO). A control group rece...

journal_title：Carcinogenesis

authors： Iversen OH,Thorud E,Volden G

更新日期：1981-01-01 00:00:00

abstract：:The tumor suppressor PTEN antagonizes phosphatidylinositol 3-kinase (PI3K), which contributes to tumorigenesis in many cancer types. While PTEN mutations occur in some melanomas, their precise mechanistic consequences have yet to be elucidated. We sought to identify novel downstream effectors of PI3K using a combinati...

journal_title：Carcinogenesis

authors： Packer L,Pavey S,Parker A,Stark M,Johansson P,Clarke B,Pollock P,Ringner M,Hayward N

更新日期：2006-09-01 00:00:00

abstract：:Antimutagenic effects of a novel lipophilic antioxidant, 1-O-hexyl-2,3,5-trimethylhydroquinone (HTHQ), and other known antioxidants against heterocyclic amine- or other mutagen-induced mutagenesis were examined in the Ames assay using Salmonella strain TA 98 to access the chemo-preventive effects of antioxidants on he...

journal_title：Carcinogenesis

authors： Hirose M,Iwata S,Ito E,Nihro Y,Takahashi S,Mizoguchi Y,Miki T,Satoh T,Ito N,Shirai T

更新日期：1995-09-01 00:00:00

abstract：:[3H]Benzo[a]pyrene (B[a]P) was administered to male Sprague-Dawley rats via intratracheal instillation, and bile was collected over a period of 6 h. Conjugated metabolites of B[a]P in bile were separated by paper chromatography or reversed-phase ion-pair HPLC and quantified by liquid scintillation spectrometry. In pap...

journal_title：Carcinogenesis

authors： Bevan DR,Sadler VM

更新日期：1992-03-01 00:00:00

abstract：:Studies have shown that fisetin, a small phytochemical molecule, has antitumor activity; however, its antiangiogenic activity has not yet been examined. Accordingly, herein, we investigated the antiangiogenic efficacy and associated mechanisms of fisetin in human umbilical vein endothelial cells (HUVECs). Fisetin (10-...

journal_title：Carcinogenesis

authors： Bhat TA,Nambiar D,Pal A,Agarwal R,Singh RP

更新日期：2012-02-01 00:00:00

abstract：:Chemical carcinogens are generally activated enzymatically to electrophiles that form covalently bound carcinogen-DNA adducts. Detoxifying enzymes are competing with the activating enzymes for these procarcinogenic chemical substrates. Wide person-to-person variations in these two types of enzymatic activities are fou...

journal_title：Carcinogenesis

authors： Harris CC

更新日期：1989-09-01 00:00:00

abstract：:3,4-Epoxy-1-butene (EB) is the major mutagenic metabolite of butadiene (BD), an important industrial chemical classified as a probable human carcinogen. Although the mechanism of carcinogenicity of EB is not known, its reactions with nucleophilic sites of DNA giving pro-mutagenic lesions are likely to constitute the e...

journal_title：Carcinogenesis

authors： Tretyakova N,Lin Y,Sangaiah R,Upton PB,Swenberg JA

更新日期：1997-01-01 00:00:00

abstract：:Eukaryotic 3'-end formation is a critical step for mRNA maturation and involves a requisite cleavage and polyadenylation event downstream of a polyadenylation signal. Recent discoveries suggest that in nearly 70% of human genes, cleavage and polyadenylation can occur at multiple locations through a process known as al...

journal_title：Carcinogenesis

authors： Masamha CP,Wagner EJ

更新日期：2018-01-12 00:00:00