Abstract:
:The N-hydroxylamine of the carcinogen 2-amino-3-methylimidazolo[4,5-f]quinoline (IQ) covalently bound to calf thymus DNA at pH 7, and the binding was 11% higher under acidic conditions (pH 5). The extent of N-hydroxy-IQ binding to single-stranded polynucleotides at neutral pH was in the following order: polyguanylic acid much greater than polyadenylic acid greater than polycytidylic acid = polyuridylic acid. The binding of the carcinogen to DNA, polyguanylic acid and polyadenylic acid at neutral pH was enhanced 6-, 4- and 2-fold respectively by the presumed in situ formation of N-acetoxy-IQ from N-hydroxy-IQ and acetic anhydride. N-(Deoxyguanosin-8-yl)-IQ was synthesized by reaction at pH 7 of N-acetoxy-IQ (formed in situ with N-hydroxy-IQ and acetic anhydride) with deoxyguanosine and the structure characterized by NMR, mass spectral and UV absorption spectral analyses. Reverse phase HPLC of enzymatically hydrolyzed DNA which had been reacted with N-hydroxy-IQ in vitro showed a major adduct which was chromatographically identical to synthetic N-(deoxyguanosin-8-yl)-IQ. In addition, N-acetoxy-IQ, generated chemically by acetic anhydride or enzymatically with mammalian acetyltransferase, formed one major adduct with DNA which was chromatographically identical to the synthetic N-(deoxyguanosin-8-yl)-IQ. The results indicate that N-hydroxy-IQ and N-acetoxy-IQ react with DNA forming primarily the N-(deoxyguanosin-8-yl)-IQ adduct.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Snyderwine EG,Roller PP,Adamson RH,Sato S,Thorgeirsson SSdoi
10.1093/carcin/9.6.1061subject
Has Abstractpub_date
1988-06-01 00:00:00pages
1061-5issue
6eissn
0143-3334issn
1460-2180journal_volume
9pub_type
杂志文章相关文献
CARCINOGENESIS文献大全abstract::Recent studies have revealed that 1,2,3,4,6-penta-O-galloyl-beta-d-glucose (PGG) has anti-tumorigenic activity in vitro. In the present work, we evaluated the in vitro and in vivo antiangiogenic and antitumor activities of PGG and examined its molecular mechanisms. PGG significantly inhibited the proliferation and tub...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgi097
更新日期:2005-08-01 00:00:00
abstract::A family of 2-amino-N-methylimidazoazaarene (AIA) mutagens are produced in meats by cooking, and are of concern as potential carcinogens in the human diet. These are potent genotoxins in bacterial mutation assays, but are present only in trace quantities in cooked foods. Conventional analytical chemistry methods have ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.1.153
更新日期:1988-01-01 00:00:00
abstract::Cancer of the stomach is one of the most commonly diagnosed malignancies and remains an important cause of mortality world wide. This type of cancer is not uniformly distributed among populations but shows a marked variation in both incidence and mortality. Although gastric cancer is declining in many parts of the wor...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/20.12.2195
更新日期:1999-12-01 00:00:00
abstract::Male outbred Sprague-Dawley rats were fed a choline-deficient diet containing 0.10% DL-ethionine for up to 30 weeks. Liver slices from rats killed 4, 6, 10, 14, 22 and 30 weeks after starting the treatment were histochemically analyzed for the following parameters: basophilia, expression of cytokeratin 19 (which in th...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.2.225
更新日期:1991-02-01 00:00:00
abstract::Benzene, a ubiquitous environmental pollutant, is known to cause leukemia and aplastic anemia in humans and hematotoxicity and myelotoxicity in rodents. Toxicity is thought to be exerted through oxidative metabolites formed in the liver, primarily via pathways mediated by cytochrome P450 2E1 (CYP2E1). Phenol, hydroqui...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/20.8.1511
更新日期:1999-08-01 00:00:00
abstract::Base excision repair pathway may play an important role in repairing DNA damage related to Helicobacter pylori-induced inflammatory process. To evaluate the association between genetic polymorphisms of X-ray repair cross-complementing group 1 (XRCC1, Arg194Trp and Arg399Gln), adenosine diphosphate ribosyl transferase ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgp018
更新日期:2009-03-01 00:00:00
abstract::We have measured the levels of thymine glycol (TG) and thymidine glycol (dTG) in human urine, using an HPLC method. The results show that all 30 specimens examined (including 10 non-neoplastic and 20 neoplastic human urines) contained significant amounts of TG and dTG, average levels (mean +/- SEM) were 0.376 +/- 0.02...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/14.7.1359
更新日期:1993-07-01 00:00:00
abstract::Syrian hamster embryo cells were treated with crocidolite asbestos at a dose (1 microgram/cm2) which was shown in previous studies to induce cell transformation and aneuploidy in these cells. Treatment of cells with asbestos induced a greater than 20-fold increase in the incidence of cells in anaphase with abnormaliti...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/6.3.473
更新日期:1985-03-01 00:00:00
abstract::Epidemiological evidence suggests a link between meat consumption and prostate cancer. In this study, benign prostatic hyperplasia tissues, obtained by transurethral resection or radical retropubic prostatectomy from UK-resident individuals (n = 18), were examined for CYP1 expression and for their ability, in short-te...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/21.9.1683
更新日期:2000-09-01 00:00:00
abstract::Breast cancer is a leading cause of cancer-related mortality in women. Triple-negative breast cancer (TNBC; HER2-, ER-/PR-) is an aggressive subtype prone to drug resistance and metastasis, which is characterized by high intratumor microvascular density (iMVD) resulting from angiogenesis. However, the mechanisms contr...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy090
更新日期:2018-10-08 00:00:00
abstract::The major mammalian apurinic/apyrimidinic (AP) endonuclease (APE1) plays a central role in the DNA base excision repair pathway (BER) in two distinct ways. As an AP endonuclease, it initiates repair of AP sites in DNA produced either spontaneously or after removal of uracil and alkylated bases in DNA by monofunctional...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:
更新日期:2000-07-01 00:00:00
abstract::The GTPase activating proteins (GAP) stimulate the intrinsic GTPase activity of ras-p21 thus converting the protein into its inactive form. We have now analyzed carcinogen-induced mouse liver tumors for the possible occurrence of mutational changes in one of the two known GAP genes, namely p120-GAP. RNA from a total o...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/13.10.1903
更新日期:1992-10-01 00:00:00
abstract::Desmosomes are intercellular junctions that confer strong cell-cell adhesion. Altered expression of desmocollin 3 (DSC3), a member of the desmosomal cadherin family, was found in various cancers; however, its functional involvement in carcinogenesis has not yet been elucidated. Expression/localization of DSC3 was anal...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs273
更新日期:2012-12-01 00:00:00
abstract::Chemopreventive agents are compounds that inhibit carcinogenesis when administered prior or subsequent to a course of carcinogen administration. The effects of dietary administration of crocin dyes on the hepatic damage induced by aflatoxin B1 (AFB1) and dimethylnitrosamine (DMN) in rats were investigated. Female Spra...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/7.4.595
更新日期:1986-04-01 00:00:00
abstract::The potential carcinogenic activity of 5,6-dimethoxysterigmatocystin (DMSC) was examined by oral administration in rats. In Experiment I, all of eight effective ACI/N rats given DMSC in the diet at a concentration of 50 p.p.m. developed neoplastic nodules of the liver. Five rats developed hepatocellular carcinomas and...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.6.1039
更新日期:1988-06-01 00:00:00
abstract::Colorectal tumors are continuously exposed to an inflammatory environment, which together with mitogenic signals sustain several cancer hallmarks. Nuclear factor-kappa B (NFκB) is a major regulator of inflammation and variation in NFκB-associated genes could potentially be used as biomarkers to identify patients with ...
journal_title:Carcinogenesis
pub_type: 杂志文章,随机对照试验
doi:10.1093/carcin/bgs256
更新日期:2012-11-01 00:00:00
abstract::We have compared the regulation of ornithine decarboxylase (ODC) gene expression in primary cultures of hamster embryo fibroblasts and in two independently transformed hamster embryo cell lines. Previous studies have demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) can greatly potentiate the serum growth f...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.1.157
更新日期:1989-01-01 00:00:00
abstract::DL-N-acetyl-N'-nitrosotryptophan (I) and its methyl ester (II), readily formed under mild conditions by the reaction of nitrite with N-acetyltryptophan or its methyl ester, are model compounds for the study of the nitrosation of alpha-amino acid side chains, considered relevant to possible role of nitrosation of pepti...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/1.6.523
更新日期:1980-06-01 00:00:00
abstract::The association between prostate cancer risk and dietary fat consumption is well documented and explained partly by accelerated lipid peroxidation. We explored the possible effects of high dietary cholesterol on carcinogenesis and oxidative stress in the prostate of ACI/Seg rats. The rats develop prostate cancer spont...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh105
更新日期:2004-06-01 00:00:00
abstract::LHX4 is a member of the LIM-homeobox family and plays a critical role in pituitary development and differentiation. Several lines of evidences have reported their aberrant expression in cancers. However, the exact roles of LHX4 in carcinogenesis remain unclear. In this study, LHX4 expression was analyzed in tumor and ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr219
更新日期:2011-12-01 00:00:00
abstract::Debrisoquine hydroxylase activity has been attributed to CYP2D6 and poor metabolizers of debrisoquine have a reduced relative risk of developing aggressive bladder cancer. Production of a proximate carcinogen could occur in liver or bladder mucosa. However, it is not known if CYP2D6 is expressed in human bladder mucos...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/15.9.1955
更新日期:1994-09-01 00:00:00
abstract::The tumor suppressor PTEN antagonizes phosphatidylinositol 3-kinase (PI3K), which contributes to tumorigenesis in many cancer types. While PTEN mutations occur in some melanomas, their precise mechanistic consequences have yet to be elucidated. We sought to identify novel downstream effectors of PI3K using a combinati...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgl016
更新日期:2006-09-01 00:00:00
abstract::Cancer health disparities remain stubbornly entrenched in the US health care system. The Affordable Care Act was legislation to target these disparities in health outcomes. Expanded access to health care, reduction in tobacco use, uptake of other preventive measures and cancer screening, and improved cancer therapies ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgaa121
更新日期:2020-11-13 00:00:00
abstract::We investigated, in a cloned hamster tracheal epithelial cell line HTE-B, the effects of inhibitors of DNA topoisomerase, novobiocin and nalidixic acid; of DNA polymerase, 1-beta-arabinofuranosylcytosine (ara-C) and 2',3'-dideoxythymidine; of ribonucleotide reductase, hydroxyurea; and of poly(ADP-ribose)synthetase, 3-...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/5.2.187
更新日期:1984-02-01 00:00:00
abstract::Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disorder, and prophylactic colectomy has been shown to decrease the incidence of colorectal cancer (CRC). Duodenal cancer and desmoids are now the leading causes of death in FAP. We evaluate whether 3 months of oral supplementation with a patented...
journal_title:Carcinogenesis
pub_type: 临床试验,杂志文章
doi:10.1093/carcin/bgw041
更新日期:2016-06-01 00:00:00
abstract::The reaction of chloroacetaldehyde, a reactive metabolic of the carcinogen vinyl chloride, with DNA produces in addition to the hitherto known adducts, 1,N6-ethenoadenine and 3,N4-ethenocytosine, an ethenoguanine adduct, namely N2,3-ethenoguanine. This adduct is formed in the reaction of chloroacetaldehyde with the fr...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.6.663
更新日期:1982-01-01 00:00:00
abstract::In order to test the controversially discussed hypothesis that oval cells are part of a liver stem cell compartment and can give rise to cholangiocellular as well as hepatocellular carcinomas in the course of liver carcinogenesis, we transfected an oval cell line established in our laboratory with an oncogenically act...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/17.12.2635
更新日期:1996-12-01 00:00:00
abstract::For a group of nine hydrocarbon and halogenated hydrocarbon epoxides, there is shown to be a good correlation between their abilities to inhibit epoxide hydrase and the quantity Vmin /Es, where Vmin is the most negative value of the molecule's electrostatic potential in the neighborhood of the epoxide oxygen and Es is...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/5.6.845
更新日期:1984-06-01 00:00:00
abstract::It is estimated that one-third of Americans use dietary herbal supplements on a regular basis. Diets rich in bioactive phytochemicals are associated with reduced risk of certain cancers, notably, colon cancer. Herbal supplements have not been directly tested as sources of bioactive cancer preventives. Hence, this stud...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgi089
更新日期:2005-08-01 00:00:00
abstract::The levels of S-adenosylmethionine (AdoMet) and of S-adenosylhomocysteine (AdoHcy) as well as the ratio of AdoMet/AdoHcy were determined in the liver, lungs, testes and kidneys of weanling male rats fed a commercial chow diet or 5 different amino acid-defined diets for 1-5 weeks. The amino acid-defined diets used were...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.8.1051
更新日期:1983-08-01 00:00:00