Relationships between the electrostatic potential, epoxide hydrase inhibition and carcinogenicity for some hydrocarbon and halogenated hydrocarbon epoxides.

abstract：:Diglycerides function as analogs of the phorbol ester tumor promoters. We compare here the activity of glycerol 1-myristate 2-acetate (GMA) with the corresponding phorbol 12-myristate 13-acetate (PMA). GMA inhibited phorbol ester binding to reconstituted protein kinase C, stimulated protein kinase C enzymatic activity...

journal_title：Carcinogenesis

authors： Sharkey NA,Blumberg PM

更新日期：1986-04-01 00:00:00

abstract：:The metabolism of zymosterol and mevalonic acid was studied in vitro using the skin homogenates of 3-methylcholanthrene (3MC), diazacholesterol-treated and untreated mice. In normal mouse skin only lathosterol was a major metabolite and the other metabolites, cholesta-5,7,24-trien-3 beta-ol, desmosterol, cholesterol a...

journal_title：Carcinogenesis

authors： Tanimoto Y,Fukao K,Yoshiga K,Takada K,Ohyama Y,Okuda K

更新日期：1990-09-01 00:00:00

abstract：:SH3RF (SH3-domain-containing RING finger protein) family members, SH3RF1-3, are multidomain scaffold proteins involved in promoting cell survival and apoptosis. In this report, we show that SH3RF2 is an oncogene product that is overexpressed in human cancers and regulates p21-activated kinase 4 (PAK4) protein stabilit...

journal_title：Carcinogenesis

authors： Kim TW,Kang YK,Park ZY,Kim YH,Hong SW,Oh SJ,Sohn HA,Yang SJ,Jang YJ,Lee DC,Kim SY,Yoo HS,Kim E,Yeom YI,Park KC

更新日期：2014-03-01 00:00:00

abstract：:N-nitrosopiperidine (NPIP) is a potent esophageal carcinogen in rats whereas structurally similar N-nitrosopyrrolidine (NPYR) induces liver, but not esophageal tumors. NPIP is a possible causative agent for human esophageal cancer. Our goal is to explain mechanistically these differing carcinogenic activities in the e...

journal_title：Carcinogenesis

authors： Wong HL,Murphy SE,Wang M,Hecht SS

更新日期：2003-02-01 00:00:00

abstract：:Garcinol, a polyisoprenylated benzophenone, from the fruit rind of Garcinia spp., has been shown to have anti-inflammatory and anticarcinogenic activities. To study its mechanism of action, we analyzed the effects of garcinol and its derivatives, including cambogin, garcim-1 and garcim-2, on arachidonic acid metabolis...

journal_title：Carcinogenesis

authors： Hong J,Sang S,Park HJ,Kwon SJ,Suh N,Huang MT,Ho CT,Yang CS

更新日期：2006-02-01 00:00:00

abstract：:Whole-body autoradiography of [3H]aflatoxin B1 ([3H]AFB1) in lamb showed a localization of bound labelling, in addition to the liver, in the nasal olfactory and respiratory mucosa, in the mucosa of the nasopharynx, pharynx, oesophagus, larynx, trachea, bronchi and bronchioles and in the palpebral and bulbar conjunctiv...

journal_title：Carcinogenesis

authors： Larsson P,Busk L,Tjälve H

更新日期：1994-05-01 00:00:00

abstract：:The coordinate regulation of DNA synthesis and suppression of apoptosis was investigated in a rat hepatocyte cell culture system which supports high level induction of DNA synthesis by the peroxisome proliferator, methylclofenapate (MCP) (Plant, N.J. et al., 1998, Carcinogenesis, 19, 925-931). The peroxisome prolifera...

journal_title：Carcinogenesis

authors： Plant NJ,Horley NJ,Dickins M,Hasmall S,Elcombe CR,Bell DR

更新日期：1998-09-01 00:00:00

abstract：:Adducts produced by modification of DNA with benzo[a]pyrene diolepoxide (BPDE) are known to inhibit both DNA and RNA synthesis. This phenomenon has been used as a method for determining the distribution of carcinogen binding within defined DNA sequences. A critical comparison of different enzyme activities on adducted...

journal_title：Carcinogenesis

authors： Thrall BD,Mann DB,Smerdon MJ,Springer DL

更新日期：1992-09-01 00:00:00

abstract：:Cyclin E is reported to be an important cell cycle regulator, and its dysregulation is implicated in tumorigenesis including esophageal squamous cell carcinoma (ESCC). MicroRNAs (miRNAs) regulate gene expression at the posttranscriptional level and play important roles in tumor initiation and progression. However, the...

journal_title：Carcinogenesis

authors： Ding DP,Chen ZL,Zhao XH,Wang JW,Sun J,Wang Z,Tan FW,Tan XG,Li BZ,Zhou F,Shao K,Li N,Qiu B,He J

更新日期：2011-07-01 00:00:00

abstract：:To investigate the sensitivity of heterozygous p53-deficient CBA mice to carcinogens, 20 female mice [p53(+/-)] and 20 wild-type littermates [p53(+/+)] were given an intraperitoneal injection of 120 mg/kg body wt of N-ethyl-N-nitrosourea (ENU) and were maintained without any other treatment for a further 26 weeks. His...

journal_title：Carcinogenesis

authors： Mitsumori K,Onodera H,Shimo T,Yasuhara K,Takagi H,Koujitani T,Hirose M,Maruyama C,Wakana S

更新日期：2000-05-01 00:00:00

abstract：:3,4-Epoxy-1-butene (EB) is the major mutagenic metabolite of butadiene (BD), an important industrial chemical classified as a probable human carcinogen. Although the mechanism of carcinogenicity of EB is not known, its reactions with nucleophilic sites of DNA giving pro-mutagenic lesions are likely to constitute the e...

journal_title：Carcinogenesis

authors： Tretyakova N,Lin Y,Sangaiah R,Upton PB,Swenberg JA

更新日期：1997-01-01 00:00:00

abstract：:Transforming growth factor beta1 (TGFbeta1) expression is elevated by tumor promoters in the mouse skin, but its role in tumor promotion has not been well defined. To investigate this, we have compared TGFbeta1+/+ and +/- mice in a two-stage skin chemical carcinogenesis protocol. Surprisingly, TGFbeta1+/- mice had few...

journal_title：Carcinogenesis

authors： Pérez-Lorenzo R,Markell LM,Hogan KA,Yuspa SH,Glick AB

更新日期：2010-06-01 00:00:00

abstract：:To better understand drug and carcinogen metabolism pathways in head and neck squamous cell carcinoma we assayed the principal drug- and carcinogen-metabolizing enzyme systems in both tumors and their corresponding adjacent non-tumoral tissues. Cytochromes P450 (1A1/A2, 2B1/B2, 2C8-10, 2E1, 3A4), epoxide hydrolase and...

journal_title：Carcinogenesis

authors： Janot F,Massaad L,Ribrag V,de Waziers I,Beaune PH,Luboinski B,Parise O Jr,Gouyette A,Chabot GG

更新日期：1993-07-01 00:00:00

abstract：:The pulmonary adenoma susceptibility 1 (Pas1) gene affects susceptibility to the development of lung adenomas in mice with a subset of the adenomas progressing to adenocarcinoma (ADC). In this study, genotype distributions for 10 polymorphisms in the human counterparts for three mouse candidate Pas1 genes, KRAS, CASC1...

journal_title：Carcinogenesis

authors： Kohno T,Kunitoh H,Suzuki K,Yamamoto S,Kuchiba A,Matsuno Y,Yanagitani N,Yokota J

更新日期：2008-05-01 00:00:00

abstract：:The syn- and anti-isomers of 1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydro-6-methylchrysene (6-MeC-1,2-diol-3,4-epoxide) were synthesized and their mutagenic activities in Salmonella typhimurium were compared with those of the syn- and anti-isomers of 1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydro-5-methylchrysene (5-MeC-1,2...

journal_title：Carcinogenesis

authors： Amin S,Huie K,Hecht SS,Harvey RG

更新日期：1986-12-01 00:00:00

abstract：:Oreochromis mossambicus, commonly known as tilapia, is a freshwater teleost with a wide tolerance to environmental conditions. Multiple focal lesions in the liver were observed 2 months after cessation of a one-month long treatment with 100 p.p.m. diethylnitrosamine. Cells were small and compact and arranged in sheets...

journal_title：Carcinogenesis

authors： Ding JL,Hee PL,Lam TJ

更新日期：1989-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of short non-coding, single-stranded RNAs, which perform posttranscriptional regulatory functions as tumor suppressors or oncogenes. Single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) genes are currently being identified for contributing to cancer risk, prognosis and survival. ...

journal_title：Carcinogenesis

authors： Du M,Lu D,Wang Q,Chu H,Tong N,Pan X,Qin C,Yin C,Wang M,Zhang Z

更新日期：2014-07-01 00:00:00

abstract：:Comparative X-ray crystallographic structure analyses have been carried out on seven cyclopenta[a]phenanthrenes, namely 15,16-dihydocyclopenta[a]phenanthren-17-one and its 2-, 6- and 12-methyl homologues (non-carcinogens) and the 7-and 11-methyl and 1,11-methano derivatives (carcinogens). All-valence-electron molecula...

journal_title：Carcinogenesis

authors： Clayton AF,Coombs MM,Henrick K,McPartlin M,Trotter J

更新日期：1983-12-01 00:00:00

abstract：:Poly(ADP-ribose) polymerase, which catalyzes the formation of poly(ADP-ribose) polymers, is an enzyme involved in cell proliferation, differentiation and transformation as well as in recovery from DNA damage. Poly(ADP-ribose) polymers are rapidly synthesized from the ADP-ribose moieties from intracellular NAD+, which,...

journal_title：Carcinogenesis

authors： Stierum RH,van Herwijnen MH,Hageman GJ,Kleinjans JC

更新日期：1994-04-01 00:00:00

abstract：:Bacterial formation of carcinogenic N-nitroso compounds may play a role in the etiology of human cancer. Biochemical and immunological studies in denitrifying bacteria (Pseudomonas aeruginosa) strongly support the identification of cytochrome cd(1)-nitrite reductase as the enzyme responsible for the catalysis of nitro...

journal_title：Carcinogenesis

authors： Calmels S,Ohshima H,Henry Y,Bartsch H

更新日期：1996-03-01 00:00:00

abstract：:Histone deacetylase (HDAC) inhibitors have the potential to derepress epigenetically silenced genes in cancer cells, leading to cell cycle arrest and apoptosis. In the present study, we screened several garlic-derived small organosulfur compounds for their ability to inhibit HDAC activity in vitro. Among the organosul...

journal_title：Carcinogenesis

authors： Nian H,Delage B,Pinto JT,Dashwood RH

更新日期：2008-09-01 00:00:00

abstract：:Most cancer cells show resistance to ionizing radiation (IR)-induced cell death. Recently, Ki-Ras was reported to be responsible for the increased radioresistance. We report here that inhibition of IR-induced activaton of nuclear transcription factor kappa B (NF-kappaB) but not of either Akt or MAPK kinase (MEK), incr...

journal_title：Carcinogenesis

authors： Kim BY,Kim KA,Kwon O,Kim SO,Kim MS,Kim BS,Oh WK,Kim GD,Jung M,Ahn JS

更新日期：2005-08-01 00:00:00

abstract：:We have investigated the activity of insoluble and soluble lead compounds in inducing mutagenesis, cell transformation and sister chromatid exchange in mammalian cells. Insoluble lead sulfide, readily phagocytized, was more than four times as toxic to V79 cells on a microM basis, than two moderately soluble lead compo...

journal_title：Carcinogenesis

authors： Zelikoff JT,Li JH,Hartwig A,Wang XW,Costa M,Rossman TG

更新日期：1988-10-01 00:00:00

abstract：:Expression of the human placental form of glutathione S-transferase (GST-pi), an enzyme proposed as a marker for human and experimental neoplasia, was immunohistochemically evaluated in 51 samples of 'normal' and diseased adult human uterine cervix. Five fetal uteri were also studied. GST-pi positivity was detected in...

journal_title：Carcinogenesis

authors： de Camargo JL,Tsuda H,Tatematsu M,Rodrigues MA,Yamada M,Tzuji K,Ito N

更新日期：1989-12-01 00:00:00

abstract：:Thymidine kinase (TK), the enzyme in the pyrimidine salvage pathway, and its isozymes were examined in 15 specimens of normal mucosa, 14 polyps and 14 carcinomas in human colon. The average TK activities in colon polyps and carcinomas were about 1.6 and 2.9 times that in normal colon mucosa, respectively. The colon TK...

journal_title：Carcinogenesis

authors： Sakamoto S,Sagara T,Iwama T,Kawasaki T,Okamoto R

更新日期：1985-06-01 00:00:00

abstract：:A series of experiments was conducted to determine the efficacy of 15 synthetic retinoic acid amides (retinamides) as inhibitors of chemical carcinogenesis of the urinary bladder in C57BL/6 x DBA/2F1 mice. Eight of the retinamides tested had significant protective activity when administered at nontoxic levels in the d...

journal_title：Carcinogenesis

authors： Moon RC,McCormick DL,Becci PJ,Shealy YF,Frickel F,Paust J,Sporn MB

更新日期：1982-01-01 00:00:00

abstract：:Cultures of isolated human hepatocytes from three different human liver specimens were exposed for 24 h to media containing [3H]benzo[a]pyrene (BP) (0.1, 1.0, 10, 100 microM). The cells and media were harvested and extracted. Subsequent incubations of the aqueous phase with beta-glucuronidase and aryl sulfatase, follo...

journal_title：Carcinogenesis

authors： Monteith DK,Novotny A,Michalopoulos G,Strom SC

更新日期：1987-07-01 00:00:00

abstract：:The aim of this work was to optimize the ionic strength (tau) in the liver microsomal assay (LMA) in performing short-term genotoxicity tests. tau optimization would increase the sensitivity (i.e. decrease false negatives) and at the same time increase the specificity (decrease false positives). Such optimization depe...

journal_title：Carcinogenesis

authors： Paolini M,Mesirca R,Pozzetti L,Silingardi P,Grilli S,Cantelli-Forti G

更新日期：1992-08-01 00:00:00

abstract：:2-methoxyestradiol (2-MeOE(2)) is an endogenous metabolite of 17beta-estradiol and a proposed inhibitor of tumor growth and angiogenesis. However, 2-MeOE(2) is also an inhibitor of microtubule assembly and other microtubule inhibitors, e.g. colcemid and diethylstilbestrol, induce aneuploidy and cell transformation in ...

journal_title：Carcinogenesis

authors： Tsutsui T,Tamura Y,Hagiwara M,Miyachi T,Hikiba H,Kubo C,Barrett JC

更新日期：2000-04-01 00:00:00

abstract：:P-glycoprotein (P-gp) mediates the active transport of various substrates including xenobiotics, and it thus has a protective function in various cell types and tissues/organs including the intestinal epithelium. However, whether or not P-gp plays a positive role in the intestinal tumorigenesis is unclear. We have int...

journal_title：Carcinogenesis

authors： Mochida Y,Taguchi K,Taniguchi S,Tsuneyoshi M,Kuwano H,Tsuzuki T,Kuwano M,Wada M

更新日期：2003-07-01 00:00:00