Abstract:
:Vinyl chloride (VC) is a carcinogen associated with human and animal cancers. The ultimate carcinogenic form of VC, 2-chloroacetaldehyde (CAA), has been suspected to be mutagenic and we confirmed the mutagenicity of CAA using a modified shuttle vector plasmid. Base sequence analyses of 109 mutant plasmids with mutations in the supF gene, which were treated with CAA and propagated in the cultured human cells, revealed that more than half of the single base substitutions were G:C to A:T transitions with eight hotspots. The majority of the mutations involving G:C base pairs were in 5'-AAGG-3' or 5'-CCTT-3' sequences suggesting that these sequences are the main targets of mutagenesis caused by CAA.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Matsuda T,Yagi T,Kawanishi M,Matsui S,Takebe Hdoi
10.1093/carcin/16.10.2389subject
Has Abstractpub_date
1995-10-01 00:00:00pages
2389-94issue
10eissn
0143-3334issn
1460-2180journal_volume
16pub_type
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