Lycopene inhibits IGF-I signal transduction and growth in normal prostate epithelial cells by decreasing DHT-modulated IGF-I production in co-cultured reactive stromal cells.

abstract：:In the present study the role of two families of cytochrome P-450 proteins and the contribution of the cytosolic fraction in the activation of N-nitrosopiperidine to mutagens in the Ames test were investigated. The bioactivation of this nitrosamine was preferentially catalysed by the phenobarbitone-induced cytochromes...

journal_title：Carcinogenesis

authors： Ayrton AD,Smith JN,Ioannides C

更新日期：1987-11-01 00:00:00

abstract：:Salvia miltiorrhiza (SM) has been used clinically in Asian countries to improve the microcirculation in the human body. Salvianolic acid B (Sal B), a pure compound extracted from SM, has been reported to be effective against fibrosis and ischemia-reperfusion injury, possibly through its anti-lipid peroxidation action....

journal_title：Carcinogenesis

authors： Zhou ZT,Yang Y,Ge JP

更新日期：2006-04-01 00:00:00

abstract：:SH3RF (SH3-domain-containing RING finger protein) family members, SH3RF1-3, are multidomain scaffold proteins involved in promoting cell survival and apoptosis. In this report, we show that SH3RF2 is an oncogene product that is overexpressed in human cancers and regulates p21-activated kinase 4 (PAK4) protein stabilit...

journal_title：Carcinogenesis

authors： Kim TW,Kang YK,Park ZY,Kim YH,Hong SW,Oh SJ,Sohn HA,Yang SJ,Jang YJ,Lee DC,Kim SY,Yoo HS,Kim E,Yeom YI,Park KC

更新日期：2014-03-01 00:00:00

abstract：:Compounds of nickel(II) and cadmium(II) are carcinogenic to humans and to experimental animals. One frequently discussed mechanism involved in tumor formation is an increase in reactive oxygen species by both metals with the subsequent generation of oxidative DNA damage. In the present study we used human HeLa cells t...

journal_title：Carcinogenesis

authors： Dally H,Hartwig A

更新日期：1997-05-01 00:00:00

abstract：:Recent studies have demonstrated that K-ras mutations in lung epithelial cells elicit inflammation that promotes carcinogenesis in mice (intrinsic inflammation). The finding that patients with chronic obstructive pulmonary disease (COPD), an inflammatory disease of the lung, have an increased risk of lung cancer after...

journal_title：Carcinogenesis

authors： Moghaddam SJ,Barta P,Mirabolfathinejad SG,Ammar-Aouchiche Z,Garza NT,Vo TT,Newman RA,Aggarwal BB,Evans CM,Tuvim MJ,Lotan R,Dickey BF

更新日期：2009-11-01 00:00:00

abstract：:B-cell precursor acute lymphoblastic leukemia (BCP ALL) is the most common childhood leukemia, with a cure rate of 80%. Nevertheless, disease relapse is the most important prognostic factor for the disease outcome. We aimed to elucidate the role of Wnt secretion-regulating protein, Wntless (Wls)/GPR177, on disease out...

journal_title：Carcinogenesis

authors： Chiou SS,Wang LT,Huang SB,Chai CY,Wang SN,Liao YM,Lin PC,Liu KY,Hsu SH

更新日期：2014-10-01 00:00:00

abstract：:The purpose of this study was to determine whether the level of 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-hydroxy-2'-deoxyguanosine) (8-oxo-dG), a major mutagenic DNA oxidation product, is enhanced in newborn rat liver DNA as a consequence of oxidative stress incurred during the early postnatal period. 32P-postlabeling s...

journal_title：Carcinogenesis

authors： Randerath K,Zhou GD,Monk SA,Randerath E

更新日期：1997-07-01 00:00:00

abstract：:Complementary DNA of marmoset CYP1A2 was isolated by means of screening the cDNA library and reverse-transcriptase polymerase chain reaction. The deduced amino acid sequence of marmoset CYP1A2 consisted of 516 residues and showed 88.2 and 90.0% identities to corresponding forms in human and cynomolgus monkey, respecti...

journal_title：Carcinogenesis

authors： Sakuma T,Igarashi T,Hieda M,Ohgiya S,Isogai M,Ninomiya S,Nagata R,Nemoto N,Kamataki T

更新日期：1997-10-01 00:00:00

abstract：:Many chemoradiation therapies cause DNA damage through oxidative stress. An important cellular mechanism that protects cells against oxidative stress involves DNA repair. One of the primary DNA repair mechanisms for oxidative DNA damage is base excision repair (BER). BER involves the tightly coordinated function of fo...

journal_title：Carcinogenesis

authors： Zhang H,Mizumachi T,Carcel-Trullols J,Li L,Naito A,Spencer HJ,Spring PM,Smoller BR,Watson AJ,Margison GP,Higuchi M,Fan CY

更新日期：2007-08-01 00:00:00

abstract：:The potential carcinogenic activity of 5,6-dimethoxysterigmatocystin (DMSC) was examined by oral administration in rats. In Experiment I, all of eight effective ACI/N rats given DMSC in the diet at a concentration of 50 p.p.m. developed neoplastic nodules of the liver. Five rats developed hepatocellular carcinomas and...

journal_title：Carcinogenesis

authors： Mori H,Sugie S,Yoshimi N,Kuniyasu T,Iwata H,Kawai K,Hamasaki T

更新日期：1988-06-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a type of head and neck cancer with significantly high prevalence in Southern China. Unlike other head and neck cancers, mutations or deletions of tumor suppressor genes in NPC are not common. Recently, downregulation of tumor suppressor genes expression by microRNA (miRNA) is increas...

journal_title：Carcinogenesis

authors： Zhang LY,Ho-Fun Lee V,Wong AM,Kwong DL,Zhu YH,Dong SS,Kong KL,Chen J,Tsao SW,Guan XY,Fu L

更新日期：2013-02-01 00:00:00

abstract：:We have previously reported the disposition of benzo[a]pyrene (B[a]P) and its metabolites in male Sprague-Dawley rats following intratracheal instillation of [3H]B[a]P [Weyand, E.H. and Bevan, D.R. (1986) Cancer Res., 46, 5655-5661]. In some experiments, cannulas were implanted in the bile duct of the animals prior to...

journal_title：Carcinogenesis

authors： Bevan DR,Weyand EH

更新日期：1988-11-01 00:00:00

abstract：:Arsenic is an established human carcinogen. Deficiencies in available animal models have inhibited a detailed analysis of the mechanism of arsenic induced cancer. This study sought to determine the role of a methyl-deficient diet in combination with sodium arsenite on the genomic methylation status and Ha-ras methylat...

journal_title：Carcinogenesis

authors： Okoji RS,Yu RC,Maronpot RR,Froines JR

更新日期：2002-05-01 00:00:00

abstract：:The ability to repair damaged DNA was determined in different cell populations of rabbit lung cells isolated by centrifugal elutriation. DNA excision repair, measured as unscheduled DNA synthesis, was examined in in vitro confluent primary cultures. A dose dependent level of DNA excision repair was observed in alveola...

journal_title：Carcinogenesis

authors： Deilhaug T,Myrnes B,Aune T,Krokan H,Haugen A

更新日期：1985-04-01 00:00:00

abstract：:The variation in colorectal cancer (CRC) incidence worldwide strongly suggests a role for dietary influences. Based on epidemiological data, protective effects of vegetables and fruit intake on CRC are widely claimed, while other data indicate a possible increased CRC risk from (higher) dietary fat intake. Therefore, ...

journal_title：Carcinogenesis

authors： van Kranen HJ,van Iersel PW,Rijnkels JM,Beems DB,Alink GM,van Kreijl CF

更新日期：1998-09-01 00:00:00

abstract：:The O6-alkylguanine-DNA alkyltransferase (ATase) is known to overcome the effects of promutagenic, precarcinogenic O6-alkylguanine induced in DNA by exposure to environmental, chemotherapeutic and dietary alkylating agents. Within an organ, the cell type-specific responses to these agents may be attributed, in part, t...

journal_title：Carcinogenesis

authors： Wani G,Wani AA,D'Ambrosio SM

更新日期：1993-04-01 00:00:00

abstract：:Apigenin is a plant flavonoid which has been shown to significantly inhibit UV-induced mouse skin tumorigenesis when applied topically, and may represent an alternative sunscreen agent in humans. We have investigated the molecular mechanism(s) by which apigenin inhibits skin tumorigenesis. Initial studies examined the...

journal_title：Carcinogenesis

authors： Lepley DM,Li B,Birt DF,Pelling JC

更新日期：1996-11-01 00:00:00

abstract：:Acrylamide is an alkylating agent which reacts very slowly in direct reactions with DNA and is negative in the Ames test, but is carcinogenic in mice and rats. In order to explain the cancer-initiating properties of acrylamide we have studied DNA adduct formation in vitro with a metabolizing system and in vivo in mice...

journal_title：Carcinogenesis

authors： Segerbäck D,Calleman CJ,Schroeder JL,Costa LG,Faustman EM

更新日期：1995-05-01 00:00:00

abstract：:DNA double-strand break (DSB) repair is an important mechanism underlying chemotherapy resistance in human cancers. Dicer participates in DSB repair by facilitating homologous recombination. However, whether Dicer is involved in non-homologous end joining (NHEJ) remains unknown. Here, we addressed whether Dicer regula...

journal_title：Carcinogenesis

authors： Chen X,Li WF,Wu X,Zhang HC,Chen L,Zhang PY,Liu LY,Ma D,Chen T,Zhou L,Xu Y,Zhou MT,Tang KF

更新日期：2017-09-01 00:00:00

abstract：:Resveratrol has elicited many provocative anticancer effects in laboratory animals and cultured cells, including reduced levels of oxidative DNA damage, inhibition of tumor initiation and progression and induction of apoptosis in tumor cells. Use of resveratrol as a cancer-preventive agent in humans will require that ...

journal_title：Carcinogenesis

authors： Denissova NG,Nasello CM,Yeung PL,Tischfield JA,Brenneman MA

更新日期：2012-01-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1 (HIF-1) are important regulators of angiogenesis. HIF-1 is composed of HIF-1alpha and HIF-1beta subunits, and regulates VEGF expression at transcriptional level. In this study, we demonstrated that insulin induced H2O2 production and p70S6K1 acti...

journal_title：Carcinogenesis

authors： Zhou Q,Liu LZ,Fu B,Hu X,Shi X,Fang J,Jiang BH

更新日期：2007-01-01 00:00:00

abstract：:DNA strand breage in response to damage produced by UV (254 nm) radiation was characterized after permeabilization of diploid normal and xeroderma pigmentosum variant fibroblasts. The breakage reaction required ATP, Mg2+ and sucrose for maximal activity and was inhibited by 150 mM Na+ or K+ and 1 mM N-ethylmaleimide. ...

journal_title：Carcinogenesis

authors： Kaufmann WK,Briley LP

更新日期：1990-01-01 00:00:00

abstract：:Chloroethylnitrosoureas (CNU) are antitumor agents which produce DNA interstrand crosslinks. We have proposed that crosslinks are produced in DNA via monoadduct formation at the guanine-O6 position, followed by a delayed reaction with the opposite DNA strand. Human cells are known to differ in their capacity to repair...

journal_title：Carcinogenesis

authors： Zlotogorski C,Erickson LC

更新日期：1983-01-01 00:00:00

abstract：:Precursor T-cell lymphoblastic neoplasms are aggressive malignancies in need for more effective and specific therapeutic treatments. A significant fraction of these neoplasms harbor deletions on the locus 9p21, targeting the tumor suppressor CDKN2A but also deleting the aconitase 1 (ACO1) gene, a neighboring housekeep...

journal_title：Carcinogenesis

authors： Gonzalez-Sanchez L,Cobos-Fernandez MA,Lopez-Nieva P,Villa-Morales M,Stamatakis K,Cuezva JM,Marin-Rubio JL,Vazquez-Dominguez I,Gonzalez-Vasconcellos I,Salido E,Llamas P,Lopez-Lorenzo JL,Santos J,Fernandez-Piqueras J

更新日期：2020-08-12 00:00:00

abstract：:The caspase proteins are essential for the regulation of normal B cell development and regulation of apoptosis. We investigated five single nucleotide polymorphisms in four key caspase genes, CASP3 [Ex8-280C>A (rs6948) and Ex8+567T>C (rs1049216)], CASP8 Ex14-271A>T (rs13113), CASP9 Ex5+32G>A (rs1052576) and CASP10 Ex3...

journal_title：Carcinogenesis

authors： Lan Q,Zheng T,Chanock S,Zhang Y,Shen M,Wang SS,Berndt SI,Zahm SH,Holford TR,Leaderer B,Yeager M,Welch R,Hosgood D,Boyle P,Rothman N

更新日期：2007-04-01 00:00:00

abstract：:5,9-Dimethyldibenzo[c,g]carbazole (DMDBC), a potent mouse hepatocarcinogen, has been shown to induce a non-linear increase in mutant frequency in the liver of the transgenic MutaMouse. To gain insight into the mechanisms underlying the mutagenicity of DMDBC in vivo, DNA damage formation and removal were monitored in m...

journal_title：Carcinogenesis

authors： Renault D,Brault D,Lossouarn Y,Périn-Roussel O,Taras-Valéro D,Périn F,Thybaud V

更新日期：2000-02-01 00:00:00

abstract：:Reported habits of red meat consumption, particularly red meat that has been cooked to the degree termed 'well-done', is a positive risk factor for colorectal cancer. Under high, pyrolytic temperatures, heterocyclic amines (HCA) and benzo[a]pyrene (BP) molecules can form inside and on the surface of red meat, respecti...

journal_title：Carcinogenesis

authors： Gunter MJ,Probst-Hensch NM,Cortessis VK,Kulldorff M,Haile RW,Sinha R

更新日期：2005-03-01 00:00:00

abstract：:The enzyme O6-methylguanine-DNA methyltransferase repairs alkylation-induced DNA damage, O6-methylguanine and O4-methylthymine, the former being formed more frequently. Previously, by means of gene targeting, we generated mice in which alleles for methyltransferase were disrupted. We now use these mouse lines, which a...

journal_title：Carcinogenesis

authors： Iwakuma T,Sakumi K,Nakatsuru Y,Kawate H,Igarashi H,Shiraishi A,Tsuzuki T,Ishikawa T,Sekiguchi M

更新日期：1997-08-01 00:00:00

abstract：:Diethylstilbestrol (DES), a synthetic stilbene estrogen, is a potent development toxin and carcinogen in humans and rodents. A number of 32P-postlabeling studies suggest that genotoxic effects of DES substantially contribute to these biological effects. The mechanisms involved in DES-mediated genotoxicity are not comp...

journal_title：Carcinogenesis

authors： Moorthy B,Liehr J,Randerath E,Randerath K

更新日期：1995-11-01 00:00:00

abstract：:Transgenic mice containing one copy of hepatitis B virus (HBV) genome without the core gene and expressing hepatitis B surface antigen (HBsAg) were crossed with C3H/He mice. The F1 hybrids (approximately 50% HBV positive and approximately 50% HBV negative) were treated with a single dose of diethylnitrosamine (NDEA) o...

journal_title：Carcinogenesis

authors： Dragani TA,Manenti G,Farza H,Della Porta G,Tiollais P,Pourcel C

更新日期：1990-06-01 00:00:00