Bioactivation of N-nitrosopiperidine to mutagens: role of hepatic cytochrome P-450 proteins and contribution of cytosolic fraction.

abstract：:To explore the potential role for estrogen in lung cancer susceptibility, candidate single-nucleotide polymorphism (SNPs) in tobacco and estrogen metabolism genes were evaluated. Population-based cases (n = 504) included women aged 18-74, diagnosed with NSCLC in metropolitan Detroit between November 2001 and October 2...

journal_title：Carcinogenesis

authors： Cote ML,Yoo W,Wenzlaff AS,Prysak GM,Santer SK,Claeys GB,Van Dyke AL,Land SJ,Schwartz AG

更新日期：2009-04-01 00:00:00

abstract：:Testosterone, testosterone propionate, 17 beta-trenbolone and progesterone, which represent the main endogenous and synthetic androgens and a progestin, were evaluated for possible cell transformation and genetic effects in Syrian hamster embryo (SHE) cells. Cell growth was reduced by treatment with the steroids at 10...

journal_title：Carcinogenesis

authors： Tsutsui T,Komine A,Huff J,Barrett JC

更新日期：1995-06-01 00:00:00

abstract：:Apigenin, a flavonoid abundant in various vegetables and fruits, including parsley and onions, has been reported to possess anticarcinogenic effects. However, the direct molecular target of apigenin and its chemopreventive effect on ultraviolet (UV)-induced skin inflammation are not understood fully. Herein, we examin...

journal_title：Carcinogenesis

authors： Byun S,Park J,Lee E,Lim S,Yu JG,Lee SJ,Chen H,Dong Z,Lee KW,Lee HJ

更新日期：2013-02-01 00:00:00

abstract：:Conversion of the 2'-deoxyguanosine (dG) residues in calf thymus DNA to 8-hydroxy-2'-deoxyguanosine (8-OH-dG) was achieved at physiological pH by treating the DNA with hydrogen peroxide (H2O2) in the presence of nickel(II) chloride (NiCl2). The effectiveness of this reaction was enhanced by L-histidine (His) which for...

journal_title：Carcinogenesis

authors： Dutta AK,Misra M,North SL,Kasprzak KS

更新日期：1992-02-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is an important process implicated in tumor invasion and metastasis. Twist1 is a transcription factor that induces EMT, including E-cadherin suppression and cancer cell migration and invasion; hence it promotes cancer metastasis. Twist1 directly or indirectly regulates the expre...

journal_title：Carcinogenesis

authors： Nam EH,Lee Y,Moon B,Lee JW,Kim S

更新日期：2015-03-01 00:00:00

abstract：:A pilot study was conducted to determine whether any relationship exists between micronucleated cell rates of female uterine cervical epithelium and current smoking status. Cervical uterine cells obtained from 118 pre-menopausal females, seen between September 1994 and June 1995 at the Occupational Medecine Interprofe...

journal_title：Carcinogenesis

authors： Lehucher-Michel MP,Favre-Eloff G,Devictor B,Duffaud F,Botta A

更新日期：1997-04-01 00:00:00

abstract：:In the present study, we have evaluated the induction of ornithine decarboxylase (ODC) activity in rat liver after acute in vivo administration of different hepatocarcinogens, and correlated the ODC activity peaks with the accumulation of the three ODC-related mRNA species in rat liver at different times after the int...

journal_title：Carcinogenesis

authors： Lorenzini EC,Buccellato FR,Scalabrino G

更新日期：1996-06-01 00:00:00

abstract：:Garcinol, a polyisoprenylated benzophenone, from the fruit rind of Garcinia spp., has been shown to have anti-inflammatory and anticarcinogenic activities. To study its mechanism of action, we analyzed the effects of garcinol and its derivatives, including cambogin, garcim-1 and garcim-2, on arachidonic acid metabolis...

journal_title：Carcinogenesis

authors： Hong J,Sang S,Park HJ,Kwon SJ,Suh N,Huang MT,Ho CT,Yang CS

更新日期：2006-02-01 00:00:00

abstract：:1,3-Dimethyl-3-phenyl-1-nitrosourea (DMPNU) shows no spontaneous decomposition in aqueous buffered solution (pH 7.0) at 37 degrees C over a measuring period of 10 days, but it is directly genotoxic in all assays applied. This compound induces base substitutions in Salmonella typhimurium (especially in the plasmid harb...

journal_title：Carcinogenesis

authors： Thust R,Mendel J,Kaina B,Braun R

更新日期：1983-01-01 00:00:00

abstract：:The metabolism of [1,3-14C]benzo[f]quinoline (BfQ) by liver microsomes from control, 3-methylcholanthrene (3-MC)-pretreated and phenobarbital (PB)-pretreated rats has been investigated in order to gain insights into the effect of mixed function oxidase inducers on the types and levels of specific metabolites as formed...

journal_title：Carcinogenesis

authors： Kandaswami C,Kumar S,Dubey SK,Sikka HC

更新日期：1987-12-01 00:00:00

abstract：:Genetic risk factors for sporadic neuroendocrine tumors (NET) are poorly understood. We tested risk associations in patients with sporadic NET and non-cancer controls, using a custom array containing 1536 single-nucleotide polymorphisms (SNPs) in 355 candidate genes. We identified 18 SNPs associated with NET risk at a...

journal_title：Carcinogenesis

authors： Ter-Minassian M,Wang Z,Asomaning K,Wu MC,Liu CY,Paulus JK,Liu G,Bradbury PA,Zhai R,Su L,Frauenhoffer CS,Hooshmand SM,De Vivo I,Lin X,Christiani DC,Kulke MH

更新日期：2011-08-01 00:00:00

abstract：:Inbred male Leeds rats were administered either the liver carcinogen N-nitrosopiperidine or the non-carcinogen 2,2',6,6'-tetramethyl-N-nitrosopiperidine in their drinking water at a concentration of 0.02%. Treatment was continued until the animals were killed, at 12 or 28 days, when their hepatic tissues were removed ...

journal_title：Carcinogenesis

authors： Flaks B,Challis BC

更新日期：1981-01-01 00:00:00

abstract：:CXCR4 is a chemokine receptor probably involved in the homing of metastatic breast cancer, and its expression is modulated by tumor environmental stimuli such as hepatocyte growth factor (HGF) and hypoxia. Here, we demonstrate that, depending on the stimulus, different transcription factors can cooperate in enhancing ...

journal_title：Carcinogenesis

authors： Maroni P,Bendinelli P,Matteucci E,Desiderio MA

更新日期：2007-02-01 00:00:00

abstract：:Cigarette smoke (CS) contains hundreds of carcinogens and is a potent inducer of oxidative and bulky DNA damage, which when insufficiently repaired leads to activation of DNA damage response and possibly mutations. The DNA repair protein xeroderma pigmentosum group C (XPC) is primed to play an important role in CS-ind...

journal_title：Carcinogenesis

authors： Zhou H,Saliba J,Sandusky GE,Sears CR

更新日期：2019-05-14 00:00:00

abstract：:Telomerase activity is observed in approximately 90% of human cancer including esophageal squamous cell cancer. Normal somatic cells do not display telomerase activity on a regular basis. The major mechanism to regulate telomerase activity in human cells is the transcriptional control of the catalytic subunit, the hum...

journal_title：Carcinogenesis

authors： Quante M,Heeg S,von Werder A,Goessel G,Fulda C,Doebele M,Nakagawa H,Beijersbergen R,Blum HE,Opitz OG

更新日期：2005-11-01 00:00:00

abstract：:Since the results of an earlier study indicating no effect of dietary fat on dimethylhydrazine (DMH)-induced colon cancer in rats differed from those of other investigators, the present study was initiated to determine if the modulating effect of fat intake on colon tumorigenesis was dependent on the route of DMH admi...

journal_title：Carcinogenesis

authors： Locniskar M,Nauss KM,Kaufmann P,Newberne PM

更新日期：1985-03-01 00:00:00

abstract：:A series of cells representing normal, non-tumorigenic cell lines, as well as differentiating neoplastic and undifferentiated neoplastic rat tracheal epithelial cell populations were evaluated for their ability to establish homologous and/or heterologous cell-cell gap junction communication in culture. Gap junction co...

journal_title：Carcinogenesis

authors： Terzaghi-Howe M,Chang GW,Popp D

更新日期：1997-11-01 00:00:00

abstract：:2-Nitrofluorene (NF) is a potent genotoxic substance found in environments where incomplete combustion takes place. NF is a mutagen and a carcinogen in animal models. NF or 7,12-dimethylbenz[a]anthracene (DMBA) was administered once topically to female SENCAR mice followed by promotion by 12-O-tetradecanoylphorbol-13-...

journal_title：Carcinogenesis

authors： Möller L,Zeisig M,Toftgård R

更新日期：1993-08-01 00:00:00

abstract：:Oreochromis mossambicus, commonly known as tilapia, is a freshwater teleost with a wide tolerance to environmental conditions. Multiple focal lesions in the liver were observed 2 months after cessation of a one-month long treatment with 100 p.p.m. diethylnitrosamine. Cells were small and compact and arranged in sheets...

journal_title：Carcinogenesis

authors： Ding JL,Hee PL,Lam TJ

更新日期：1989-03-01 00:00:00

abstract：:To better understand the mechanisms of mutagenesis by the carcinogen, methylene chloride (DCM), we have determined the nature and distribution of forward mutations induced by DCM in the N-terminal region of the lacI gene of Escherichia coli. A total of 116 lacI-d mutations (50 from Uvr+, 66 from UvrB- strain) were cha...

journal_title：Carcinogenesis

authors： Zielenska M,Ahmed A,Pienkowska M,Anderson M,Glickman BW

更新日期：1993-05-01 00:00:00

abstract：:Glycyrrhizin (GL) is widely used in Japan as a therapeutic agent for chronic active liver diseases. However, its action on hepatocarcinogenesis remains to be elucidated. To clarify its effect, mice treated with diethylnitrosamine (NDEA) with or without GL were analyzed. Five-week-old male BALB/c mice were divided into...

journal_title：Carcinogenesis

authors： Shiota G,Harada K,Ishida M,Tomie Y,Okubo M,Katayama S,Ito H,Kawasaki H

更新日期：1999-01-01 00:00:00

abstract：:It has been proposed that extremely low frequency magnetic fields may enhance tumorigenesis through a co-promotional mechanism. This hypothesis has been further tested using the two-stage model of mouse skin carcinogenesis, i.e. 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced promotion of skin carcinogenesis in mic...

journal_title：Carcinogenesis

authors： DiGiovanni J,Johnston DA,Rupp T,Sasser LB,Anderson LE,Morris JE,Miller DL,Kavet R,Walborg EF Jr

更新日期：1999-04-01 00:00:00

abstract：:Previous studies have shown that 1- and 3-nitrobenzo[a]pyrene (NBaP) were mutagenic in the Salmonella reversion assay without exogenous activation and that 1-, 3- and 6-NBaP were mutagenic in the presence of hepatocytes or liver homogenate (S9). In the present study, 1-, 3- and 6-NBaP were tested for mutagenicity in C...

journal_title：Carcinogenesis

authors： Hass BS,Heflich RH,Schol HM,Chou MW,Fu PP,Casciano DA

更新日期：1986-04-01 00:00:00

abstract：:Woodchuck (Marmota monax) hepatic cells, which were immortalized by the simian virus 40 large T antigen (SV40 Tag) produced nitric oxide (NO; measured as nitrite) in vitro from L-arginine (L-Arg) after lipopolysaccharide (LPS) treatment. NO synthesis was related to L-Arg and LPS concentration and plateaued at 1.0 mM L...

journal_title：Carcinogenesis

authors： Liu RH,Jacob JR,Hotchkiss JH,Tennant BC

更新日期：1993-08-01 00:00:00

abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is formed in cooked meats and may be linked to dietary-associated colorectal, prostate and mammary cancers. Genotoxic N-oxidized metabolites of PhIP react with the Cys34 of albumin (Alb) to form a sulfinamide adduct, a biomarker of the biologically effective dose....

journal_title：Carcinogenesis

authors： Bellamri M,Wang Y,Yonemori K,White KK,Wilkens LR,Le Marchand L,Turesky RJ

更新日期：2018-12-31 00:00:00

abstract：:To better understand drug and carcinogen metabolism pathways in head and neck squamous cell carcinoma we assayed the principal drug- and carcinogen-metabolizing enzyme systems in both tumors and their corresponding adjacent non-tumoral tissues. Cytochromes P450 (1A1/A2, 2B1/B2, 2C8-10, 2E1, 3A4), epoxide hydrolase and...

journal_title：Carcinogenesis

authors： Janot F,Massaad L,Ribrag V,de Waziers I,Beaune PH,Luboinski B,Parise O Jr,Gouyette A,Chabot GG

更新日期：1993-07-01 00:00:00

abstract：:Well-differentiated squamous cell carcinomas were induced in hamster buccal pouch epithelium by twice weekly topical applications of N-methyl-N-benzylnitrosamine (MBN) or 7,12-dimethylbenz[a]anthracene (DMBA) over a period of 15 weeks. Each of the 22 tumors induced (14 MBN and eight DMBA) were evaluated by single-stra...

journal_title：Carcinogenesis

authors： Chang KW,Lin SC,Koos S,Pather K,Solt D

更新日期：1996-03-01 00:00:00

abstract：:DNA double-strand break (DSB) repair is an important mechanism underlying chemotherapy resistance in human cancers. Dicer participates in DSB repair by facilitating homologous recombination. However, whether Dicer is involved in non-homologous end joining (NHEJ) remains unknown. Here, we addressed whether Dicer regula...

journal_title：Carcinogenesis

authors： Chen X,Li WF,Wu X,Zhang HC,Chen L,Zhang PY,Liu LY,Ma D,Chen T,Zhou L,Xu Y,Zhou MT,Tang KF

更新日期：2017-09-01 00:00:00

abstract：:We previously reported a rapid production model for pancreatic carcinoma development in Syrian hamsters incorporating the principle of selection by resistance to cytotoxicity. In the present experiment, the efficacy of repeated augmentation pressure with regard to generation of pancreatic lesions in hamsters initiated...

journal_title：Carcinogenesis

authors： Mizumoto K,Kitazawa S,Ito S,Takashima Y,Tsutsumi M,Denda A,Konishi Y

更新日期：1989-08-01 00:00:00

abstract：:Resveratrol is a naturally occurring trihydroxyl-diphenylethylene compound that has been shown experimentally to have beneficial effects in the treatment of cancer and cardiovascular disease. Resveratrol induces programmed cell death (apoptosis) in these cells and activates important signal transducing proteins includ...

journal_title：Carcinogenesis

authors： Lin C,Crawford DR,Lin S,Hwang J,Sebuyira A,Meng R,Westfall JE,Tang HY,Lin S,Yu PY,Davis PJ,Lin HY

更新日期：2011-01-01 00:00:00