Abstract:
:B-cell precursor acute lymphoblastic leukemia (BCP ALL) is the most common childhood leukemia, with a cure rate of 80%. Nevertheless, disease relapse is the most important prognostic factor for the disease outcome. We aimed to elucidate the role of Wnt secretion-regulating protein, Wntless (Wls)/GPR177, on disease outcome in pediatric patients with BCP ALL, and assess its pathogenetic role in the regulation of the disease. Wls expression was characterized and correlated with Wnt pathway signaling in the bone marrow leukemia cells isolated from 44 pediatric patients with BCP ALL. The overexpression of Wls was detected in leukemia cells and was significantly correlated with the disease relapse and poor survival in the patients. The high expression of Wls also correlated with the Wnt expression and consequent downstream signaling activation, which was shown to provide essential proliferation, transformation and anti-apoptotic activity during leukemogenesis. These results indicated that Wls played an essential role in disease relapse and poor survival in patients with BCP ALL. Therefore, Wls may provide a potential future therapeutic target, particularly for patients who do not respond to existing therapies and suffer relapse.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Chiou SS,Wang LT,Huang SB,Chai CY,Wang SN,Liao YM,Lin PC,Liu KY,Hsu SHdoi
10.1093/carcin/bgu166subject
Has Abstractpub_date
2014-10-01 00:00:00pages
2357-64issue
10eissn
0143-3334issn
1460-2180pii
bgu166journal_volume
35pub_type
杂志文章相关文献
CARCINOGENESIS文献大全abstract::raf oncogenes have been implicated in hepatic carcinogenesis. We studied the effects of the v-raf of murine retrovirus 3611-MSV on the growth and differentiation of a simian virus 40 (SV40)-immortalized rat liver cell line (ALB-8) which maintained many of characteristics of differentiated hepatocytes. Cells were co-tr...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/14.4.669
更新日期:1993-04-01 00:00:00
abstract::The inability of cells in culture to grow in medium where methionine is replaced by its metabolic precursor, homocysteine, has been linked to neoplastic transformation and termed 'methionine dependence' or 'methionine auxotrophy'. The present investigation was undertaken to establish the influence of intracellular glu...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.2.241
更新日期:1991-02-01 00:00:00
abstract::Glycidyl ethers are reactive epoxides used as components of a variety of epoxy materials. These compounds are known to cause allergic reactions, but since they are generally also genotoxic it would be of interest to evaluate the risk for induction of such effects. Reaction products of allyl glycidyl ether with nucleic...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/17.7.1465
更新日期:1996-07-01 00:00:00
abstract::The major mammalian apurinic/apyrimidinic (AP) endonuclease (APE1) plays a central role in the DNA base excision repair pathway (BER) in two distinct ways. As an AP endonuclease, it initiates repair of AP sites in DNA produced either spontaneously or after removal of uracil and alkylated bases in DNA by monofunctional...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:
更新日期:2000-07-01 00:00:00
abstract::We have recently shown that a variety of human tumor cell lines are capable of preventing chloroethylnitrosourea (CNU)-induced DNA crosslinks, presumably by removing guanine O6-chloroethyl DNA monoadducts before crosslinks can form. Those cells capable of preventing crosslinking were of the Mer+ (Methylation repair) p...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/5.1.83
更新日期:1984-01-01 00:00:00
abstract::Prostate cancer (PCa) is the second cause of cancer deaths in men in the USA. When the cancer recurs, early stages can be controlled with hormone ablation therapy to delay the rate of cancer progression but, over time, the cancer overcomes its hormone dependence, becomes highly aggressive and metastasizes. Clinical tr...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgu145
更新日期:2014-10-01 00:00:00
abstract::Common genetic variation may play an important role in altering lung cancer risk. We conducted a pathway-based candidate gene evaluation to identify genetic variations that may be associated with lung cancer in a population-based case-control study in Xuan Wei, China (122 cases and 111 controls). A total of 1260 singl...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn178
更新日期:2008-10-01 00:00:00
abstract::S-Adenosyl-L-methionine (SAM) is a strong chemopreventive agent of rat liver carcinogenesis. Examination was made to determine whether inhibition by SAM of the development of preneoplastic liver lesions persists to SAM withdrawal in diethylnitrosamine-initiated F344 rats promoted with thiobenzamide (TB). The rats were...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/17.7.1533
更新日期:1996-07-01 00:00:00
abstract:UNLABELLED:Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2) is recognized as oncogenic and simulative role on tumorigenesis by virtue of abnormal expression in cancer including nasopharyngeal carcinoma (NPC). We hypothesized that the copy number variation (CNV)-30450, which duplicates the MAPKAPK2...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt314
更新日期:2014-01-01 00:00:00
abstract::Treatment of SV40-infected CV-1 cells with the ultimate carcinogen anti-benzo[a]pyrene diol epoxide (BPDE) at 1 X 10(-4) mg/ml or higher reduced the rate of viral DNA synthesis to an extent dependent on the BPDE concentration; similar reductions in cellular DNA synthesis were produced in infected and uninfected cells....
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.2.125
更新日期:1983-01-01 00:00:00
abstract::Childhood cancer is the leading cause of disease-related death in children aged 1-14 years in Canada and the USA and it has been hypothesized that transplacental exposure to environmental carcinogens such as benzene may contribute to the etiology of these cancers. Our objectives were to determine if transplacental ben...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq074
更新日期:2010-06-01 00:00:00
abstract::Base excision repair (BER) and nucleotide excision repair (NER) pathways repair damaged DNA, and polymorphisms in these genes might affect breast cancer susceptibility. We evaluated associations between seven single-nucleotide polymorphisms in four DNA repair genes (ERCC4 rs1799801, XPC rs2227998, rs2228001, rs2228000...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr096
更新日期:2011-08-01 00:00:00
abstract::Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants with high carcinogenic potencies that have been linked to the etiology of human cancers through their presence in cigarette smoke and environmental mixtures. They are metabolically activated in cells by cytochrome P450 enzymes and/or perox...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/20.10.1885
更新日期:1999-10-01 00:00:00
abstract::3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, pravastatin (Pr) and simvastatin (Si), suppressed 1,2-dimethylhydrazine (DMH)-induced colon cancer development in female ICR mice. All mice received an i.p. injection of 10 mg DMH/kg body wt once weekly for 15 weeks. Pr was administered at 0.01, 0.0...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/15.9.2045
更新日期:1994-09-01 00:00:00
abstract::Serum-free cultures of normal human buccal epithelial cells were transfected with a plasmid containing the SV40 T-antigen (SV40T) gene. Two major lines developed that showed extended lifespans (between 30 and 40 weeks) as compared with the controls (approximately 6 weeks). Continued growth through one or two crises ge...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/16.10.2515
更新日期:1995-10-01 00:00:00
abstract::Male Sprague-Dawley rats were fed a cube diet containing 2.51 mmol/kg 3'-hydroxymethyl-N,N-dimethyl-4-aminoazobenzene (3'-CH2OH-DAB) for a period of 1 or 3 months. (This is the molar equivalent of 0.06% 3'-Me-DAB in the diet). The oral administration of 3'-CH2OH-DAB for 3 months resulted in a high incidence of liver t...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/1.6.533
更新日期:1980-06-01 00:00:00
abstract::A 32P-postlabeling assay was employed for detection and quantitation of DNA adducts formed with carcinogenic 1-phenylazo-2-hydroxynaphthalene (Sudan I, Solvent Yellow 14) activated by a peroxidase system. Enrichment of adducts by digestion with nuclease P1 or by extraction into n-butanol prior to 32P-labeling was used...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/13.7.1221
更新日期:1992-07-01 00:00:00
abstract::We conducted a cross-sectional molecular epidemiological study of coke oven workers exposed to the established carcinogen polycyclic aromatic hydrocarbons (PAHs) to evaluate the relationships between both traditional 'exposure markers' and a series of biomarkers, including urinary 1-hydroxypyrene as a marker of intern...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/19.11.1963
更新日期:1998-11-01 00:00:00
abstract::The cyclin-dependent kinase (Cdk) inhibitor p27(Kip1) (p27) is a marker of prognosis in many cancers, including breast cancer. Low p27 expression correlates with poor prognosis, especially in hormone receptor positive breast tumors. This association suggests a role for p27 in hormone-dependent cancer. We used the Wnt-...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgp089
更新日期:2009-06-01 00:00:00
abstract::Transforming growth factor-alpha (TGF-alpha) is a potent mitogenic factor which acts by binding to the epidermal growth factor (EGF). c-erbB-2 is a member of the EGF receptor family and is known to be associated with cellular growth and differentiation. The roles played by these factors in benign prostatic hyperplasia...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/16.4.729
更新日期:1995-04-01 00:00:00
abstract::Reduced retinyl ester synthesis has been associated with several forms of cancer; we therefore proposed studying melanoma development from the perspective of this biochemical pathway. Cultures of human melanoma cells with fibroblastoid morphology showed negligible retinyl ester synthesis; in sharp contrast, those with...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/23.11.1821
更新日期:2002-11-01 00:00:00
abstract::Heterocyclic aromatic amines (HAAs), formed during the cooking of foods, are known to induce tumours in rodent bioassays and may thus contribute to human cancer risk. We tested six HAAs in a morphological transformation assay and in three in vitro genotoxicity assays. The morphological transforming abilities of HAAs w...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/20.4.545
更新日期:1999-04-01 00:00:00
abstract::Previous studies had indicated that complete skin tumor promoters of the phorbol ester class induce epidermal transglutaminase and cornification in a subpopulation of cultured mouse epidermal basal cells in proportion to their promoting properties. This report describes the effect of promoting agents other than phorbo...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.11.1413
更新日期:1983-11-01 00:00:00
abstract:BACKGROUND:The hepatitis B virus x gene (HBx) is a promiscuous transactivator implicated in the development of hepatocellular carcinoma (HCC). The present study was designed to investigate the molecular events regulated by HBx. METHODS:Genomic and proteomic expression profiling was performed in Huh7 HCC cells transfec...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn111
更新日期:2008-06-01 00:00:00
abstract::In order to study the mechanism of cancer production by aflatoxin B1 (AFB1) in extrahepatic tissues which have relatively low cytochrome P450 monooxygenase (P450) activity, we have examined prostaglandin H synthase (PHS)-mediated AFB1 activation [( 3H]AFB1-DNA binding). [3H]AFB1 was activated by both purified PHS and ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.11.1915
更新日期:1990-11-01 00:00:00
abstract::Since the results of an earlier study indicating no effect of dietary fat on dimethylhydrazine (DMH)-induced colon cancer in rats differed from those of other investigators, the present study was initiated to determine if the modulating effect of fat intake on colon tumorigenesis was dependent on the route of DMH admi...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/6.3.349
更新日期:1985-03-01 00:00:00
abstract::Human fibroblasts were embedded in microscopic-sized agarose beads and lysed in situ to produce chromosome-sized DNA trapped inside the beads. Conventional alkaline agarose gel electrophoresis of trapped DNA from cells damaged by X-rays before embedding gave mol. wts similar to those obtained with alkaline sucrose gra...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.9.1691
更新日期:1989-09-01 00:00:00
abstract::Although microRNAs (miRNA) have extensively been investigated in cancer research, less attention has been paid to their regulation by carcinogens and/or protective factors in early stages of the carcinogenesis process. The present study was designed to evaluate the modulation of mRNA expression as related to exposure ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq037
更新日期:2010-05-01 00:00:00
abstract::4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is the most abundant and carcinogenic tobacco-specific nitrosamine in tobacco and tobacco smoke. The major metabolic pathway for NNK is carbonyl reduction to form the (R) and (S) enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) which, like NNK, is...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy065
更新日期:2018-07-30 00:00:00
abstract::The breast cancer gene BRCA1 has previously been cloned from both human and mouse. We cloned a fragment of the rat Brca1 homologue in order to map it and explore its biological function. Partial cDNA fragments of the rat Brca1 homologue were isolated by RT-PCR. Sequence analysis revealed that the RING-finger domain is...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/17.8.1561
更新日期:1996-08-01 00:00:00