A study of multiple biomarkers in coke oven workers--a cross-sectional study in China.

abstract：:Hepatocellular carcinoma (HCC) is one of the leading causes for cancer related mortality worldwide. Poor prognosis of HCC patients is mainly due to frequent metastasis and recurrence. Deregulation of metastasis suppressors in malignant cells plays critical roles during cancer metastasis. Thus, novel metastasis suppres...

journal_title：Carcinogenesis

authors： Luo Q,Wang C,Jin G,Gu D,Wang N,Song J,Jin H,Hu F,Zhang Y,Ge T,Huo X,Chu W,Shu H,Fang J,Yao M,Gu J,Cong W,Qin W

更新日期：2015-10-01 00:00:00

abstract：:Modulation of microsome mediated benzo[a]pyrene (BP) metabolism by oleic and linoleic acids was studied. Oleic and linoleic acids did not influence the apparent activity of aryl hydrocarbon hydroxylase or the relative ratios of BP-7,8-dihydrodiol to phenol metabolites on high performance liquid chromatography. The tot...

journal_title：Carcinogenesis

authors： Nemoto N,Takayama S

更新日期：1983-10-01 00:00:00

abstract：:A line of C3H mouse fibroblasts designated CVP3SC6 (CVP) was found to be nonresponsive to the induction of morphological transformation by the polycyclic aromatic hydrocarbon benzo[a]pyrene (BaP) and its BaP-7,8-diol and BaP-diol-epoxide derivates. This cell line was, however, susceptible to BaP-induced mutation to ou...

journal_title：Carcinogenesis

authors： Gehly EB,Heidelberger C

更新日期：1982-01-01 00:00:00

abstract：:The modifying effects of 4,4'-diaminodiphenylmethane (DDPM) (0.1% in diet) administration on liver carcinogenesis induced by 2-acetylaminofluorene (2-AAF) (0.02% in diet), 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB) ( 0.06% in diet), diethylnitrosamine (DEN) (0.001% in drinking water) and N-ethyl-N-hydroxyethylnit...

journal_title：Carcinogenesis

authors： Tsuda H,Ogiso T,Hasegawa R,Imaida K,Masui T,Ito N

更新日期：1987-05-01 00:00:00

abstract：:Base excision repair (BER) corrects DNA damage caused by oxidative stress and chronic inflammation, putative risk factors for cancer. To understand the relationship between genetic variation in BER genes and risk of biliary tract cancer and biliary stones, we examined non-synonymous polymorphisms in three key BER gene...

journal_title：Carcinogenesis

authors： Huang WY,Gao YT,Rashid A,Sakoda LC,Deng J,Shen MC,Wang BS,Han TQ,Zhang BH,Chen BE,Rosenberg PS,Chanock SJ,Hsing AW

更新日期：2008-01-01 00:00:00

abstract：:Gene-environment interactions play an important role in folate metabolism, with a potential impact on human health. Deficiencies in the uptake of key micronutrients and variant genotypes can affect the folic acid cycle, modulating methyl group transfer in key processes and leading to increased cancer risk and Down syn...

journal_title：Carcinogenesis

authors： Zijno A,Andreoli C,Leopardi P,Marcon F,Rossi S,Caiola S,Verdina A,Galati R,Cafolla A,Crebelli R

更新日期：2003-06-01 00:00:00

abstract：:There is increasing concern that compounds formed during the chemical or biological transformation of pollutants in the environment may be more detrimental to human and environmental health than the original pollutant. In this study, two bacterial transformation products of polycyclic aromatic hydrocarbons (PAHs), pyr...

journal_title：Carcinogenesis

authors： Zielinska-Park J,Nakamura J,Swenberg JA,Aitken MD

更新日期：2004-09-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNA molecules that are often located in genomic breakpoint regions and can act as oncogenes or tumor suppressor genes in human cancer. Our previous study showed that microRNA-423 (miR-423), which localized to the frequently amplified region of chromosome 17q11, was upregulated i...

journal_title：Carcinogenesis

authors： Lin J,Huang S,Wu S,Ding J,Zhao Y,Liang L,Tian Q,Zha R,Zhan R,He X

更新日期：2011-11-01 00:00:00

abstract：:Colorectal tumors are continuously exposed to an inflammatory environment, which together with mitogenic signals sustain several cancer hallmarks. Nuclear factor-kappa B (NFκB) is a major regulator of inflammation and variation in NFκB-associated genes could potentially be used as biomarkers to identify patients with ...

journal_title：Carcinogenesis

authors： Ungerbäck J,Belenki D,Jawad ul-Hassan A,Fredrikson M,Fransén K,Elander N,Verma D,Söderkvist P

更新日期：2012-11-01 00:00:00

abstract：:Metastasis-supporting physiological alterations are regulated by cell signaling molecules, which target signal transduction pathways and gene expression. Osteopontin (OPN) overexpression may represent a key molecular event in cancer metastasis. In this study, using metastatic 4T1 and non-metastatic 4T07 murine mammary...

journal_title：Carcinogenesis

authors： Mi Z,Guo H,Wai PY,Gao C,Kuo PC

更新日期：2006-06-01 00:00:00

abstract：:Earlier studies have shown that the profile of mutations induced by (+)-7R,8S-dihydroxy-9S,10R-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (+)-BPDE at the hypoxanthine (guanine) phosphoribosyltransferase (hprt) gene of Chinese hamster V79 cells was dependent on the concentration of (+)-BPDE. In the present study, we exami...

journal_title：Carcinogenesis

authors： Schiltz M,Cui XX,Lu YP,Yagi H,Jerina DM,Zdzienicka MZ,Chang RL,Conney AH,Wei SJ

更新日期：1999-12-01 00:00:00

abstract：:Modification of 3,2'-dimethyl-4-aminobiphenyl (DMAB) multi-organ carcinogenesis by simultaneous treatment with butylated hydroxyanisole (BHA) or butylated hydroxytoluene (BHT) was studied using young and old male F344 rats. Animals, 4 or 54 weeks old, were given DMAB (s.c. injection of 50 mg/kg body wt once a week for...

journal_title：Carcinogenesis

authors： Shirai T,Fukushima S,Kawabe M,Shibata M,Iwasaki S,Tada M,Ito N

更新日期：1991-07-01 00:00:00

abstract：:Crude plasma membranes were prepared from the liver of control rats or of rats submitted to an initiation by diethyl-nitrosamine and selection with 2-acetylaminofluorene and carbon tetrachloride (group IS) or of rats submitted to an initiation-selection protocol followed by a promotion with phenobarbital (group IS PB)...

journal_title：Carcinogenesis

authors： Marino A,Ravelingien N,De Cannière D,Préat V,Dehaye JP,Pector JC

更新日期：1991-04-01 00:00:00

abstract：:Preparations of dietary fibre have an ability to bind potentially toxic compounds in vitro, but it is unclear how the measured binding properties are a reflection of either the relative affinity of such compounds for fibre or the saturation binding capacity of the fibre. Cooking and processing of foods and fermentatio...

journal_title：Carcinogenesis

authors： Ryden P,Robertson JA

更新日期：1995-02-01 00:00:00

abstract：:Plant chlorophylls and carotenoids are highly colored, conjugated polyenes that play central roles in photosynthesis. Other porphyrins (tetrapyrroles), such as cytochromes, which are structurally related to chlorophyll, participate in redox reactions in many living systems. An unexpected new property of tetrapyrroles,...

journal_title：Carcinogenesis

authors： Fahey JW,Stephenson KK,Dinkova-Kostova AT,Egner PA,Kensler TW,Talalay P

更新日期：2005-07-01 00:00:00

abstract：:Previous studies have demonstrated that O6-methylguanine-DNA methyltransferase (MGMT) is a major contributor to tumor cellular resistance toward chloroethylnitrosoureas. To further clarify the effect of MGMT gene expression on cellular chemosensitivity to 1-(4-amino-2-methyl-5-pyrimidinyl)-3-(2-chloroethyl)-3-nitrosou...

journal_title：Carcinogenesis

authors： Yang J,Chen JM,Zhang YP

更新日期：1995-09-01 00:00:00

abstract：:Phosphoinositide-specific phospholipase Cgamma (PLCgamma) is a key regulatory enzyme that binds to the phosphoryl-tyrosine residues in the cytoplasmic domain of certain activated receptors and catalyses the hydrolysis of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] forming IP3 and diacylglycerol (DAG) in resp...

journal_title：Carcinogenesis

authors： Smith MR,Court DW,Kim HK,Park JB,Rhee SG,Rhim JS,Kung HF

更新日期：1998-01-01 00:00:00

abstract：:In this study, our goal was to identify genes whose expression in liver is altered in female F-344 rats during mitosuppression induced by 42 days of ethinyl estradiol (EE) treatment (Yager et al., Carcinogenesis, 15, 2117-2123, 1994). Northern analysis demonstrated that the mRNA levels for transforming growth factor-b...

journal_title：Carcinogenesis

authors： Chen J,Schwartz DA,Young TA,Norris JS,Yager JD

更新日期：1996-12-01 00:00:00

abstract：:The identification of primary molecular targets of cancer-preventive phytochemicals is essential for a comprehensive understanding of their mechanism of action. In the present study, we investigated the chemopreventive effects and molecular targets of acacetin, a flavonoid found in Robinia p seudoacacia, also known as...

journal_title：Carcinogenesis

authors： Jung SK,Kim JE,Lee SY,Lee MH,Byun S,Kim YA,Lim TG,Reddy K,Huang Z,Bode AM,Lee HJ,Lee KW,Dong Z

更新日期：2014-01-01 00:00:00

abstract：:Benzidine diimine (BZDI), a reactive intermediate in the metabolic peroxidation of the carcinogen benzidine, has been reported to bind covalently to cellular proteins and nucleic acids. We have examined the nature of this interaction with DNA and have identified a major carcinogen-nucleoside adduct. BZDI (20-50 microM...

journal_title：Carcinogenesis

authors： Yamazoe Y,Roth RW,Kadlubar FF

更新日期：1986-01-01 00:00:00

abstract：:In Thailand, smoking of commercial cigarettes and of handmade cigarettes has drastically increased in recent decades. Cancer of the lung and of the upper aero-digestive tract have also increased in Thailand as they have in many other countries. It is our working hypothesis that the increase of primary cancer of the li...

journal_title：Carcinogenesis

authors： Mitacek EJ,Brunnemann KD,Hoffmann D,Limsila T,Suttajit M,Martin N,Caplan LS

更新日期：1999-01-01 00:00:00

abstract：:The ability of three benzodiazepine tranquilizers, diazepam, oxazepam and chlordiazepoxide chlorhydrate to block metabolic cooperation between human hepatoma cells was analysed using autoradiographical monitoring. Independent tests were performed with compound concentrations varying from 1 to 50 micrograms/ml. The res...

journal_title：Carcinogenesis

authors： Rolin-Limbosch S,Moens W,Szpirer C

更新日期：1987-07-01 00:00:00

abstract：:We demonstrated previously that growth factor receptor-bound protein 2 (Grb2) associates with the transforming growth factor-beta (TGF-beta) type II receptor [TbetaR-II] upon its phosphorylation on Tyr284 by Src. Although this phosphotransferase reaction is critical in mediating TGF-beta stimulation of epithelial-mese...

journal_title：Carcinogenesis

authors： Galliher-Beckley AJ,Schiemann WP

更新日期：2008-02-01 00:00:00

abstract：:Autophagy is an evolutionarily conserved mechanism to protect the cells from unfavorable environmental conditions. Inhibition of autophagy has been contemplated as a novel strategy to enhance anticancer efficacy of existing chemotherapeutic agents. We previously reported that pulsatilla saponin D (PSD) was a potent au...

journal_title：Carcinogenesis

authors： Wang K,Tu Y,Wan JB,Chen M,He C

更新日期：2020-07-10 00:00:00

abstract：:DNA polymerase beta (polbeta) is a major contributor to mammalian DNA damage repair through its gap-filling DNA synthesis and 5'-deoxyribose phosphate lyase activities. In this way, polbeta plays pivotal roles in the repair of oxidative DNA damage, replication, embryonic survival, neuronal development, meiosis, apopto...

journal_title：Carcinogenesis

authors： Wang L,Bhattacharyya N,Rabi T,Wang L,Banerjee S

更新日期：2007-06-01 00:00:00

abstract：:The influence of various dietary constituents--phenethylisothiocyanate (PEITC), oleic acid (OA), triolein (TO), and vitamin A (ROL)--on the genotoxic activity of nitrosamines (NDMA, NDELA, NPYR) was investigated. For this purpose differential DNA repair assays with Escherichia coli K-12 strains were performed in vitro...

journal_title：Carcinogenesis

authors： Knasmüller S,Huber WW,Kienzl H,Schulte-Hermann R

更新日期：1992-09-01 00:00:00

abstract：:The effect of retinoids on the induction of both epithelial and mesenchymal tumors of the rat kidney by a single dose of 40 mg/kg dimethylnitrosamine was tested using 13-cis-retinoic acid and the trimethylmethoxy phenyl analog of retinoic acid ethylamide. 13-cis-retinoic acid was administered for 3 weeks, 10 weeks, or...

journal_title：Carcinogenesis

authors： Hard GC,Ogiu T

更新日期：1984-05-01 00:00:00

abstract：:O6-Alkylguanine-DNA alkyltransferase (AGAT) activity was determined in macroscopically normal peripheral lung tissues from 122 patients undergoing lung surgery. AGAT activity of smokers was 1.4-fold higher than that of lifetime non-smokers (P = 0.030). Less than one year of abstinence from smoking did not cause a sign...

journal_title：Carcinogenesis

authors： Drin I,Schoket B,Kostic S,Vincze I

更新日期：1994-08-01 00:00:00

abstract：:Oral squamous cell carcinoma (SCC) is among the most prevalent cancers in the world and is characterized by high morbidity and few therapeutic options. Like most cancers, oral SCC arises from a multistep process involving alterations of genes responsible for balancing proliferation and differentiation. Among these, Kr...

journal_title：Carcinogenesis

authors： Abrigo M,Alvarez R,Paparella ML,Calb DE,Bal de Kier Joffe E,Gutkind JS,Raimondi AR

更新日期：2014-03-01 00:00:00

abstract：:Measurement of carcinogen DNA adducts in blood has been used as a surrogate for the target lung tissue. We aimed to examine whether genetic polymorphisms in several metabolic pathway genes modify the relation between DNA adducts in target lung and blood. One hundred and thirty-five early-stage lung cancer patients fro...

journal_title：Carcinogenesis

authors： Lee MS,Su L,Mark EJ,Wain JC,Christiani DC

更新日期：2010-12-01 00:00:00