Abstract:
:3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, pravastatin (Pr) and simvastatin (Si), suppressed 1,2-dimethylhydrazine (DMH)-induced colon cancer development in female ICR mice. All mice received an i.p. injection of 10 mg DMH/kg body wt once weekly for 15 weeks. Pr was administered at 0.01, 0.005 and 0.001% levels in drinking water, and Si at 0.01 and 0.002% levels in the diet. All animals had access to Pr or Si throughout the experiments which were terminated at weeks 25 or 30. Histologically most of the tumors were well-differentiated adenocarcinomas. The incidence of colon tumors examined at weeks 25 or 30 was reduced by 67% in the 0.01% Pr group, by 30% in the 0.005% Pr and 0.01% Si groups, and by 24% in the 0.001% Pr and 0.002% Si groups, compared with their respective controls. However, the differences did not reach statistical significance. The number of tumors per mouse was significantly reduced in all groups administered Pr and Si except the 0.001% Pr group as compared to their respective controls. The results from those three independent experiments seem to suggest that HMG-CoA reductase inhibitors may prevent colon tumorigenesis in laboratory animal model.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Narisawa T,Fukaura Y,Terada K,Umezawa A,Tanida N,Yazawa K,Ishikawa Cdoi
10.1093/carcin/15.9.2045subject
Has Abstractpub_date
1994-09-01 00:00:00pages
2045-8issue
9eissn
0143-3334issn
1460-2180journal_volume
15pub_type
杂志文章相关文献
CARCINOGENESIS文献大全abstract::Female inbred C3H/St mice infected with the Bittner Milk Particle, develop mammary adenocarcinoma with 27% incidence if maintained on a Torula Yeast diet supplemented with 1 ppm of selenium (organically bound, in yeast). Animals switched from the 1 ppm Se diet to a diet containing only 0.15 ppm Se after reaching the a...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/1.2.199
更新日期:1980-02-01 00:00:00
abstract::The nucleotide excision repair (NER) pathway is central in response to damage induced by environmental carcinogens. Efficiency of this pathway, probably genetically determined, may modulate individual risk of developing squamous cell carcinoma of the head and neck (SCCHN) as well as second primary malignancy (SPM) aft...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgp096
更新日期:2009-06-01 00:00:00
abstract::Spontaneous and hepatocarcinogen (2-nitropropane, 2-NP)-induced levels of 8-hydroxy-2'-deoxyguanosine (oh8dG) in the nuclear DNA of regenerating liver [24, 48, 72 h and 7 days after partial hepatectomy (PH)] of male Sprague-Dawley rats were analysed for the verification of a hypothesis that the high susceptibility of ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/15.3.539
更新日期:1994-03-01 00:00:00
abstract::Male Sprague-Dawley rats were fed a cube diet containing 2.51 mmol/kg 3'-hydroxymethyl-N,N-dimethyl-4-aminoazobenzene (3'-CH2OH-DAB) for a period of 1 or 3 months. (This is the molar equivalent of 0.06% 3'-Me-DAB in the diet). The oral administration of 3'-CH2OH-DAB for 3 months resulted in a high incidence of liver t...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/1.6.533
更新日期:1980-06-01 00:00:00
abstract::The nitrogen heterocycle dibenz[c,h]acridine (DB[c,h]ACR) and the enantiomers of the diastereomeric pair of bay-region 3,4-diol 1, 2-epoxides as well as other bay-region epoxides and dihydrodiol derivatives of this hydrocarbon have been evaluated for tumorigenicity on mouse skin and in the newborn mouse. On mouse skin...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/21.11.1997
更新日期:2000-11-01 00:00:00
abstract::The Raji human lymphoma line is able to remove O6-methylguanine (O6MeG) lesions introduced by treatment of cells with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The reaction has a rapid phase in which approximately 40% of the O6MeG is removed in the first 10 min. The capacity of cells for rapid O6MeG removal is limi...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/2.12.1293
更新日期:1981-01-01 00:00:00
abstract::Arsenic is a human carcinogen whose mechanism of action is unknown. Previously, this laboratory demonstrated that arsenite acts as a comutagen by interfering with DNA repair, although a specific DNA repair enzyme sensitive to arsenite has not been identified. A number of stable arsenite-sensitive and arsenite-resistan...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/20.2.311
更新日期:1999-02-01 00:00:00
abstract::We have shown previously that apoptosis induction by diallyl trisulfide (DATS), a constituent of processed garlic, in PC-3 and DU145 human prostate cancer cells is associated with c-Jun N-terminal kinase and extracellular signal-regulated kinase-mediated phosphorylation of Bcl-2. However, pharmacological inhibition of...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgi228
更新日期:2006-03-01 00:00:00
abstract::Transforming growth factor beta1 (TGFbeta1) expression is elevated by tumor promoters in the mouse skin, but its role in tumor promotion has not been well defined. To investigate this, we have compared TGFbeta1+/+ and +/- mice in a two-stage skin chemical carcinogenesis protocol. Surprisingly, TGFbeta1+/- mice had few...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq041
更新日期:2010-06-01 00:00:00
abstract::The H2-receptor antagonist, ranitidine, is among the most widely used pharmaceuticals to treat gastroesophageal reflux disease and peptic ulcers. While previous studies have demonstrated that amines can form N-nitrosamines when exposed to nitrite at stomach-relevant pH, N-nitrosamine formation from ranitidine, an amin...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgw034
更新日期:2016-06-01 00:00:00
abstract::The effect of phenobarbital (PB), p,p'-dichlorodiphenyltrichloroethane (DDT) or carbon tetrachloride (CCl4) on dimethylnitrosamine (DMN)-induced hepatocarcinogenesis in Syrian golden hamsters was examined. Hamsters were given a single injection of DMN (6 mg/kg body wt) followed by either PB or DDT in the diet or repea...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.9.1171
更新日期:1987-09-01 00:00:00
abstract::Despite advances in detection and treatment for breast cancer (BC), recurrence and death rates remain unacceptably high. Therefore, more convenient diagnostic and prognostic methods still required to optimize treatments among the patients. Here, we report the clinical significance of the serum cathepsin E (CatE) activ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt373
更新日期:2014-03-01 00:00:00
abstract::Mutant RAS (RAS(V12)) is known to transform most immortal cells but to induce premature senescence in primary cells. RAS(V12)-induced senescence in murine cells depends on the induction of the ARF/p53 and the retinoblastoma (Rb) family tumor suppressor pathways. We and others have shown previously that oncogene-induce...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgp296
更新日期:2010-02-01 00:00:00
abstract::We have compared liver, kidney and colon DNA damage, as single strand breaks, in mice with different strain-dependent susceptibility to the colon-specific carcinogen 1,2-dimethylhydrazine (DMH). The mouse strains studied were: AKR/J, DBA2 totally resistant; CD1, C57BL/6N moderately susceptible; SWR/J very susceptible ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.8.1347
更新日期:1988-08-01 00:00:00
abstract::Gap junctions are composed of protein subunits, called connexins, and provide a pathway for the exchange of ions and small molecules between contacting cells. This transfer of molecules is thought to be an important pathway for direct cell communication, and is involved in tissue homeostasis, growth control and embryo...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/23.5.697
更新日期:2002-05-01 00:00:00
abstract::Colorectal cancer (CRC) displays a predilection for metastasis to liver. Although stromal cell-derived factor-1 (SDF-1)/CXCR4 plays an important role in the liver metastasis, the molecular mechanism still remains obscure. We previously reported that integrin αvβ6 was implicated in the progression of CRC. However, no d...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt331
更新日期:2014-02-01 00:00:00
abstract::The liver-derived human cell line, Hep G2, has high benzo[a]pyrene-metabolizing activity and converts benzo[a]pyrene to intermediates that are mutagenic and that bind to DNA. This cell line will be useful for studying metabolic activation of polycyclic aromatic hydrocarbons and other xenobiotics by human tissue and as...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/1.10.871
更新日期:1980-01-01 00:00:00
abstract::Matrix metalloproteinases (MMP) are enzymes responsible for extracellular matrix degradation which play a role in cancer progression and metastatic spreading. We investigated the effects of the MMP inhibitor, batimastat, in vitro on the proliferation and invasiveness of the rat colon cancer cell line DHD/K12, and in v...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/20.8.1445
更新日期:1999-08-01 00:00:00
abstract::We previously characterized a clone of CHO cells, clone B, that displayed tolerance to the cytotoxic effects of N-methylnitrosourea (MNU) and 6-thioguanine (6-TG). To determine whether this phenotype affected the mutagenic response of the cells, MNU-induced mutation to 8-azaadenine resistance (8-AAr) was measured in t...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/14.10.2097
更新日期:1993-10-01 00:00:00
abstract::Ultraconserved elements (UCEs) are segments of >200 bp length showing absolute sequence identity between orthologous regions of human, rat and mouse genomes. The selection factors acting on these UCEs are still unknown. Recent studies have shown that UCEs function as long-range enhancers of flanking genes or are invol...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm290
更新日期:2008-02-01 00:00:00
abstract::Four inbred strains of mice (C3H/HeJ, C57BL/6J, AKR/J, and DBA/2J) were injected s.c. with 150 micrograms of dibenz[a,h]anthracene and followed for 9 months. Strains C3H/HeJ and C57BL/6J were most susceptible to dibenz[a,h]anthracene-induced carcinogenesis with 80% and 53% incidence of tumors, respectively. Strains AK...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.5.513
更新日期:1983-01-01 00:00:00
abstract::Lung cancer is the leading cause of cancer-related death, with non-small cell lung cancer (NSCLC) being the predominant form of the disease. Most lung cancer is caused by the accumulation of genomic alterations due to tobacco exposure. To uncover its mutational landscape, we performed whole-exome sequencing in 31 NSCL...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs148
更新日期:2012-07-01 00:00:00
abstract::The chemopreventive effects of phenethyl isothiocyanate (PEITC) were investigated in N-nitrosobis(2-oxopropyl)-amine (BOP)-treated hamsters. Female 5-week-old Syrian golden hamsters were divided into six groups. Animals in groups 1-3, each consisting of 30 hamsters, were given BOP by two subcutaneous injections 7 days...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/17.6.1381
更新日期:1996-06-01 00:00:00
abstract::Cytochrome P4501A1 (CYP1A1) has been implicated in the conversion of numerous polycyclic aromatic hydrocarbons into electrophilic species capable of binding covalently to DNA and has therefore been postulated to be involved in the initiation of carcinogenesis. The expression of CYP1A1 protein appears not to be constit...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/19.8.1361
更新日期:1998-08-01 00:00:00
abstract::Individuals carrying germline mutations in one allele of the BRCA1 or BRCA2 genes are at significantly increased risk of developing cancer. Although the increased risk of breast cancer is often highlighted, cancer at several other sites is also considerably more common in these individuals. Here, we discuss existing k...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgi136
更新日期:2005-10-01 00:00:00
abstract::Evidence from live cell bioassays shows that the flat mucosa from patients with colon cancer exhibits resistance to bile salt-induced apoptosis. Three independent cell lines derived from the colonic epithelial cell line HCT-116 were selected for resistance to bile salt-induced apoptosis. These cell lines were develope...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/23.12.2063
更新日期:2002-12-01 00:00:00
abstract::Adipocytokines are a group of adipocyte-secreted proteins that have significant effects on the metabolism of lipids and carbohydrates, as well as numerous other processes. A number of recent studies have indicated that some adipocytokines may significantly influence the proliferation of malignant cells in vitro, where...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn080
更新日期:2008-05-01 00:00:00
abstract::The mutational specificity of the monofunctional alkylating agent N-propyl-N'-nitro-N-nitrosoguanidine (PNNG) has been determined through the DNA sequence characterization of 109 LacI- mutations of Escherichia coli. The predominant mutation induced was the G:C----A:T transition (73%), presumably the result of O6-propy...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.5.949
更新日期:1989-05-01 00:00:00
abstract::SENCAR mice are unusually sensitive to induction of papillomas and squamous cell carcinomas by initiation with 7,12-dimethylbenzanthracene (DMBA) and promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA). Tumors induced by this protocol were tested for the presence of papillomavirus by immunohistochemistry, Southern...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.2.341
更新日期:1990-02-01 00:00:00
abstract::Apoptosis is a morphologically and biochemically distinct form of cell death which determines specific patterns of tissue size and shape and balances cell proliferation. In the present study, the sequence of cellular proliferative alterations in urinary bladder epithelium associated with uracil-induced reversible urin...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/18.8.1485
更新日期:1997-08-01 00:00:00