Diallyl trisulfide, a constituent of processed garlic, inactivates Akt to trigger mitochondrial translocation of BAD and caspase-mediated apoptosis in human prostate cancer cells.

abstract：:The rat liver 9000 g supernatant mediated metabolism of the carcinogenic aristolochic acid, which consists of aristolochic acid I (AAI) and aristolochic acid II (AAII), was investigated. Under anaerobic conditions the major metabolites were the corresponding aristolactams for both AAI and AAII. In contrast under aerob...

journal_title：Carcinogenesis

authors： Schmeiser HH,Pool BL,Wiessler M

更新日期：1986-01-01 00:00:00

abstract：:Thapsigargin (Tg), applied twice weekly to the backs of CD-1 mice initiated with 7,12-dimethylbenz[a]anthracene, promoted papillomas on the skin of approximately 50% of the mice. Tg alone induced papillomas in 10% of the mice. Although Tg and 12-O-tetradecanoylphorbol-13-acetate (TPA) are synergistic in a keratinocyte...

journal_title：Carcinogenesis

authors： Lowry DT,Li L,Hennings H

更新日期：1996-04-01 00:00:00

abstract：:The aims of this study were to examine the anti-proliferative effects of different concentrations of a commercial preparation of conjugated linoleic acids (CLA) mixture of isomers [cis-9, trans-11 CLA (c9,t11 CLA): trans-10, cis-12 CLA (50:50)] and their constituent isomers on PC-3, a human prostatic carcinoma cell li...

journal_title：Carcinogenesis

authors： Ochoa JJ,Farquharson AJ,Grant I,Moffat LE,Heys SD,Wahle KW

更新日期：2004-07-01 00:00:00

abstract：:Specific methylated derivatives of anthracene are mutagenic in S. typhimurium and have tumor-initiating activity on mouse skin. In this study, the mutagenic activities of 1-, 2-, and 9-methylanthracene, 2,9- and 9,10-dimethylanthracene, 2,9,-10-trimethylanthracene, 2,3,9,10-tetramethylanthracene, and the photo-oxide o...

journal_title：Carcinogenesis

authors： La Voie EJ,Coleman DT,Rice JE,Geddie NG,Hoffmann D

更新日期：1985-10-01 00:00:00

abstract：:Aphidicolin is a specific inhibitor of DNA polymerase alpha. Its influence of DNA repair has been studied in both normal and excision deficient xeroderma pigmentosum cells exposed to u.v. irradiation at 254 nm. Single strand DNA breaks accumulated in u.v. irradiated normal cells when the inhibitor was present. Such br...

journal_title：Carcinogenesis

authors： Waters R

更新日期：1981-01-01 00:00:00

abstract：:It has recently been reported that the XPD (ERCC2) gene is an integral component of the basal transcription factor TFIIH. We have studied the direct role of this repair gene on the fine structure of DNA repair in hamster cells. The gene and strand specific DNA repair of UV induced pyrimidine dimers was determined in w...

journal_title：Carcinogenesis

authors： Cullinane C,Weber CA,Dianov G,Bohr VA

更新日期：1997-04-01 00:00:00

abstract：:Apurinic/apyrimidinic endonuclease/redox effector factor-1 (APE/Ref-1) is a multifunctional protein involved both in DNA base excision repair and redox regulation. Studies have suggested that abnormal Ref-1 levels and/or activities are associated with tumor progression and sensitivities to treatment, but no direct evi...

journal_title：Carcinogenesis

authors： Yang S,Misner BJ,Chiu RJ,Meyskens FL Jr

更新日期：2007-11-01 00:00:00

abstract：:Observational studies suggest that fish consumption is associated with a decreased colorectal cancer (CRC) risk. A possible mechanism by which fish could reduce CRC risk is by decreasing colonic genotoxicity. However, concerns have also been raised over the levels of toxic compounds found in mainly oil-rich fish, whic...

journal_title：Carcinogenesis

authors： Pot GK,Habermann N,Majsak-Newman G,Harvey LJ,Geelen A,Przybylska-Philips K,Nagengast FM,Witteman BJ,van de Meeberg PC,Hart AR,Schaafsma G,Hooiveld G,Glei M,Lund EK,Pool-Zobel BL,Kampman E

更新日期：2010-06-01 00:00:00

abstract：:The carcinogen N-acetoxy-N-2-acetylaminofluorene reacts with dG and dG-containing nucleotides to give good yields of the C-8 adducts, but the analogous 4-aminobiphenyl derivative does not. Replacement of the N-acetoxy group by 2,6-dichlorobenzoyloxy circumvents this difficulty. This reaction is shown to be generally a...

journal_title：Carcinogenesis

authors： Underwood GR,Price MF,Shapiro R

更新日期：1988-10-01 00:00:00

abstract：:Sulforaphane (SFN), an isothiocyanate first isolated from broccoli, exhibits chemopreventive properties in prostate cancer cells through mechanisms that are poorly understood. We recently reported on a novel mechanism of chemoprotection by SFN in human colon cancer cells, namely the inhibition of histone deacetylase (...

journal_title：Carcinogenesis

authors： Myzak MC,Hardin K,Wang R,Dashwood RH,Ho E

更新日期：2006-04-01 00:00:00

abstract：:The carcinogenicities of 1-nitropyrene (1-NP), 4-nitropyrene (4-NP), 1,3-dinitropyrene (1,3-DNP), 1,6-dinitropyrene (1,6-DNP), 1,8-dinitropyrene (1,8-DNP), 3-hydroxy-1-nitropyrene (3-OH-1-NP) and a mixture of 6- and 8-hydroxy-1-nitropyrene (6/8-OH-1-NP) were investigated in newborn female rats. Newborn female CD rats ...

journal_title：Carcinogenesis

authors： Imaida K,Lee MS,Land SJ,Wang CY,King CM

更新日期：1995-12-01 00:00:00

abstract：:The effects of D-limonene and citrus fruit oils, i.e. orange oil and lemon oil, on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced neoplasia of the lungs and forestomach of female A/J mice were investigated. D-Limonene and the citrus fruit oils given p.o. 1 h prior to NNK, also administered p.o., inhibite...

journal_title：Carcinogenesis

authors： Wattenberg LW,Coccia JB

更新日期：1991-01-01 00:00:00

abstract：:Genetic variants in multiple cellular pathways have been associated with an altered risk of oesophageal cancer. In this study, eight genes previously associated with an altered risk of oesophageal squamous cell carcinoma (OSCC) in European or Asian populations were investigated in two South African populations. We gen...

journal_title：Carcinogenesis

authors： Bye H,Prescott NJ,Matejcic M,Rose E,Lewis CM,Parker MI,Mathew CG

更新日期：2011-12-01 00:00:00

abstract：:In order to study the relationship between altered gap junctional intercellular communication (GJIC) and induction of cell transformation by oncogenes, we transfected six viral oncogenes into BALB/c3T3 A31-1-1 cells. BALB/c3T3 cells with v-src, v-ras or polyoma middle T (PyMT) genes grew in soft agar and formed distin...

journal_title：Carcinogenesis

authors： Katoh F,Klein JL,Bignami M,Yamasaki H

更新日期：1993-03-01 00:00:00

abstract：:Weanling male F344 rats were fed either a semi-purified diet low in methionine and lacking in choline and folic acid (folate/methyl deficient) or a supplemented control diet for periods of 2, 5, 7 days, 3 weeks, and 9 weeks. Two days after initiating the folate/methyl deficient diet in weanling F344 rats, the incidenc...

journal_title：Carcinogenesis

authors： James SJ,Miller BJ,Basnakian AG,Pogribny IP,Pogribna M,Muskhelishvili L

更新日期：1997-02-01 00:00:00

abstract：:Specific repair endonucleases were used to quantify oxidative modifications in mitochondrial DNA (mtDNA) from rat liver and from porcine liver and kidney by means of a relaxation assay. In rat liver mitochondria the number of modifications sensitive to formamidopyrimidine--DNA glycosylase (FPG protein), which include ...

journal_title：Carcinogenesis

authors： Hegler J,Bittner D,Boiteux S,Epe B

更新日期：1993-11-01 00:00:00

abstract：:Childhood cancer is the leading cause of disease-related death in children aged 1-14 years in Canada and the USA and it has been hypothesized that transplacental exposure to environmental carcinogens such as benzene may contribute to the etiology of these cancers. Our objectives were to determine if transplacental ben...

journal_title：Carcinogenesis

authors： Badham HJ,LeBrun DP,Rutter A,Winn LM

更新日期：2010-06-01 00:00:00

abstract：:Recent genome-wide association studies have identified 15 single nucleotide polymorphisms (SNPs) associated with non-Hodgkin lymphoma (NHL) and its subtypes. Because the incidence and subtype portion of NHL between the Chinese population and Caucasian populations are substantially different, we assessed the associatio...

journal_title：Carcinogenesis

authors： Qiao Y,Zhou Y,Wu C,Zhai K,Han X,Chen J,Tian X,Chang J,Lu Z,Zhang B,Yu D,Yao J,Shi Y,Tan W,Lin D

更新日期：2013-07-01 00:00:00

abstract：:Studies with experimental animals indicate that acetaldehyde, the first metabolite of ethanol that is microbially formed in the colonic lumen, may play a role in ethanol-associated colorectal co-carcinogenesis. Although intracoIonic acetaldehyde concentrations are highest during the metabolism of exogenous ethanol, so...

journal_title：Carcinogenesis

authors： Koivisto T,Salaspuro M

更新日期：1998-11-01 00:00:00

abstract：:Insulin-like growth factor 1 receptor (IGF-1R) activation is required for prostate cell proliferation. Prostate cancer is one of the most commonly diagnosed malignant tumors in Western countries. Overexpression of IGF-1R in prostate cancer is associated with tumor growth. These suggest that IGF-1R inhibitory agents ma...

journal_title：Carcinogenesis

authors： Fang J,Zhou Q,Shi XL,Jiang BH

更新日期：2007-03-01 00:00:00

abstract：:Resveratrol is a phytochemical that has been under consideration for use as a prostate cancer chemopreventive agent. However, the efficacy, as well as the mechanisms of action of resveratrol on prostate cancer prevention, remains largely unknown. This study seeks to address these questions and examine the cancer preve...

journal_title：Carcinogenesis

authors： Wang TT,Hudson TS,Wang TC,Remsberg CM,Davies NM,Takahashi Y,Kim YS,Seifried H,Vinyard BT,Perkins SN,Hursting SD

更新日期：2008-10-01 00:00:00

abstract：:Amarogentin, a secoiridoid glycoside, is an active component of the medicinal plant Swertia chirata. In this study, chemopreventive and chemotherapeutic actions of amarogentin were evaluated in a carbon tetrachloride (CCl(4))/N-nitrosodiethylamine (NDEA)-induced liver carcinogenesis mouse model system during continuou...

journal_title：Carcinogenesis

authors： Pal D,Sur S,Mandal S,Das A,Roy A,Das S,Panda CK

更新日期：2012-12-01 00:00:00

abstract：:The activity of nuclear transcription factors is often regulated by specific kinase-signaling pathways. We have previously shown that the organochlorine pesticide dichlorodiphenyltrichloroethane (DDT) stimulates activator protein-1 activity through the p38 mitogen-activated protein kinase (MAPK). Here, we show that DD...

journal_title：Carcinogenesis

authors： Bratton MR,Frigo DE,Vigh-Conrad KA,Fan D,Wadsworth S,McLachlan JA,Burow ME

更新日期：2009-01-01 00:00:00

abstract：:Receptor tyrosine kinase EphB3 is expressed in cells in the bottom of intestinal crypts near stem cell niches. Loss of Ephb3 has recently been reported to produce invasive colorectal carcinoma in Apc(Min/+) mice and EphB-mediated compartmentalization was demonstrated to be a mechanism suppressing colorectal cancer pro...

journal_title：Carcinogenesis

authors： Chiu ST,Chang KJ,Ting CH,Shen HC,Li H,Hsieh FJ

更新日期：2009-09-01 00:00:00

abstract：:Transforming growth factor beta1 (TGFbeta1) expression is elevated by tumor promoters in the mouse skin, but its role in tumor promotion has not been well defined. To investigate this, we have compared TGFbeta1+/+ and +/- mice in a two-stage skin chemical carcinogenesis protocol. Surprisingly, TGFbeta1+/- mice had few...

journal_title：Carcinogenesis

authors： Pérez-Lorenzo R,Markell LM,Hogan KA,Yuspa SH,Glick AB

更新日期：2010-06-01 00:00:00

abstract：:A large series of assays of the hepatocarcinogenic potential of 112 different compounds were carried out using a rapid bioassay system developed in this laboratory based on the two-step concept of hepatocarcinogenesis. Rats were initially given a single dose (200 mg/kg) of diethylnitrosamine (DEN) i.p. and starting 2 ...

journal_title：Carcinogenesis

authors： Ito N,Tsuda H,Tatematsu M,Inoue T,Tagawa Y,Aoki T,Uwagawa S,Kagawa M,Ogiso T,Masui T

更新日期：1988-03-01 00:00:00

abstract：:DNA repair after gamma radiation was studied in purified T lymphocytes from young and aged subjects. Two different assays were employed. In the first, T lymphocytes were stimulated with phytohemagglutinin (PHA) for 72 h and then treated with hydroxyurea, irradiated with 30 K rads and pulsed with [3H]thymidine (TdR) fo...

journal_title：Carcinogenesis

authors： Licastro F,Franceschi C,Chiricolo M,Battelli MG,Tabacchi P,Cenci M,Barboni F,Pallenzona D

更新日期：1982-01-01 00:00:00

abstract：:In order to address the hypothesis that 6-aminochrysene (6-AC) is converted to genotoxic products by cytochrome P450 enzymes via two activation pathways (N-hydroxylation and epoxidation), the activation of 6-AC and trans-1,2-dihydro-1,2-dihydroxy-6-aminochrysene (6-AC-diol) to genotoxic metabolites was examined in rat...

journal_title：Carcinogenesis

authors： Yamazaki H,Mimura M,Oda Y,Gonzalez FJ,el-Bayoumy K,Chae YH,Guengerich FP,Shimada T

更新日期：1994-03-01 00:00:00

abstract：:Mice with non-phosphorylated serine 389 in p53 are susceptible for bladder tumors induced by 2-acetylaminofluorene (2-AAF). Since p53 is a transcription factor, this might well be preceded by differences in the regulation of gene expression. Microarray analysis was used to determine early transcriptional changes that ...

journal_title：Carcinogenesis

authors： Bruins W,Jonker MJ,Bruning O,Pennings JL,Schaap MM,Hoogervorst EM,van Steeg H,Breit TM,de Vries A

更新日期：2007-08-01 00:00:00

abstract：:The Manchester (England) Children's Tumour Registry is population-based with a high level of ascertainment. Pathologic review ensured diagnostic accuracy. Routine monitoring of annual incidence revealed a significant increase in germ cell tumours from approximately 1 per million person years to approximately 4. Analys...

journal_title：Carcinogenesis

authors： Birch JM,Marsden HB,Swindell R

更新日期：1982-01-01 00:00:00