Abstract:
:Observational studies suggest that fish consumption is associated with a decreased colorectal cancer (CRC) risk. A possible mechanism by which fish could reduce CRC risk is by decreasing colonic genotoxicity. However, concerns have also been raised over the levels of toxic compounds found in mainly oil-rich fish, which could increase genotoxicity. Therefore, the objective was to investigate the effects of fish on genotoxicity markers in the colon in a randomized controlled parallel intervention study. For a period of 6 months, subjects were randomly allocated to receive two extra weekly portions of (i) oil-rich fish (salmon), (ii) lean fish (cod) or (iii) just dietary advice (DA). The Comet Assay was used to measure the DNA damage-inducing potential of fecal water (n = 89) and DNA damage in colonocytes (n = 70) collected pre- and post-intervention as markers of genotoxicity. Genotoxicity of fecal water was not markedly changed after fish consumption: 1.0% increase in tail intensity (TI) [95% confidence interval (CI) -5.1; 7.0] in the salmon group and 0.4% increase in TI (95% CI -5.3; 6.1) in the cod group compared with the DA group. DNA damage in colonocytes was also not significantly changed after fish consumption, in either the salmon group (-0.5% TI, 95% CI -6.9; 6.0) or cod group (-3.3% TI, 95% CI -10.8; 4.3) compared with the DA group. Measurements of genotoxicity of fecal water and DNA damage in colonocytes did not correlate (r = 0.06, n = 34). In conclusion, increasing consumption of either oil-rich or lean fish did not affect genotoxicity markers in the colon.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Pot GK,Habermann N,Majsak-Newman G,Harvey LJ,Geelen A,Przybylska-Philips K,Nagengast FM,Witteman BJ,van de Meeberg PC,Hart AR,Schaafsma G,Hooiveld G,Glei M,Lund EK,Pool-Zobel BL,Kampman Edoi
10.1093/carcin/bgp255subject
Has Abstractpub_date
2010-06-01 00:00:00pages
1087-91issue
6eissn
0143-3334issn
1460-2180pii
bgp255journal_volume
31pub_type
杂志文章,多中心研究,随机对照试验相关文献
CARCINOGENESIS文献大全abstract::Lung cancer is the leading cause of cancer-related death, with non-small cell lung cancer (NSCLC) being the predominant form of the disease. Most lung cancer is caused by the accumulation of genomic alterations due to tobacco exposure. To uncover its mutational landscape, we performed whole-exome sequencing in 31 NSCL...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs148
更新日期:2012-07-01 00:00:00
abstract::Transforming growth factors alpha and beta (TGF-alpha and TGF-beta) isolated from normal mouse kidney induced gross morphological changes in rat urothelial cells maintained in organ culture. These morphological effects are similar to those observed after long-term treatment of rat bladder organ cultures with the carci...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/6.4.595
更新日期:1985-04-01 00:00:00
abstract::Groups of rats, either dosed with N-nitrosodiethylamine (NDEA) for 10 weeks (from the age of 7 to 17 weeks) or untreated, were fed diets containing either 2% (low fat, LF) or 30% polyunsaturated fat (high fat, HF) on an equicaloric basis from 5 weeks until rats were 43 weeks old. Biochemical parameters were measured d...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.4.591
更新日期:1991-04-01 00:00:00
abstract::Sixty-three male cigarette smokers were entered into a cross-sectional study to determine whether inverse associations existed between polycyclic aromatic hydrocarbon (PAH)-DNA adduct levels and intake/serum levels of vitamin A, vitamin C and vitamin E. Associations between PAH-DNA adducts and intakes of carotene, as ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/15.11.2449
更新日期:1994-11-01 00:00:00
abstract::Phenobarbital and clofibrate, two non-genotoxic carcinogens, have been investigated regarding the relationship between reactive oxygen species, antioxidant enzyme expression and apoptosis in primary cultures of rat hepatocytes. Low toxicity concentrations, 200 and 100 microg/ml for phenobarbital and clofibrate respect...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/19.10.1715
更新日期:1998-10-01 00:00:00
abstract::The experiments reported in this study were designed to examine the question of whether a mammary epithelial cell's independence from hormonal requirements is established at the time of carcinogenic initiation, or whether the emergence of hormone independence is associated with the process of tumor progression. A newl...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/19.3.383
更新日期:1998-03-01 00:00:00
abstract::The heterocyclic aromatic amines, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (4,8-DiMeIQx) are formed during frying of meat. PhIP and 4,8-DiMeIQx have, after metabolic activation, been shown to form adducts with DNA at the C8 of guanine both in vitro and...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/18.8.1555
更新日期:1997-08-01 00:00:00
abstract::When exogenous [(3)H]retinol (vitamin A) was added to culture medium, normal human epithelial cells from the oral cavity, skin, lung and breast took up and esterified essentially all of the [(3)H]retinol within a few hours. As shown by [(3)H]retinol pulse-chase experiments, normal epithelial cells then slowly hydrolyz...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/21.11.1925
更新日期:2000-11-01 00:00:00
abstract::Alterations of epigenetic modifications are promising targets for cancer therapy, and several epigenetic drugs are now being clinically utilized. At the same time, individual epigenetic modifications have physiological functions in normal cells, and cancer cell specificity is considered difficult to achieve using a dr...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgu238
更新日期:2015-02-01 00:00:00
abstract::The dysplastic nevus syndrome (DNS) is a preneoplastic melanocyte abnormality which occurs in families affected by hereditary cutaneous malignant melanoma (HCMM). A putative role of host-environmental interactions in the etiology of hereditary melanoma has been strengthened by the recent finding that fibroblasts deriv...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.7.911
更新日期:1983-01-01 00:00:00
abstract::Cytochrome P450 1B1 (CYP1B1) is an enzyme that has a unique tumor-specific pattern of expression and is capable of bioactivating a wide range of carcinogenic compounds. We have reported previously that coordinated upregulation of CYP1B1 by inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and the aryl hy...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgu190
更新日期:2014-11-01 00:00:00
abstract::Hepatic microsomes of female F344 rats were capable of N,O-acyltransfer of N-hydroxy-N-acetyl-2-aminofluorene (N-OH-AAF) and N-hydroxy-N-formyl-2-aminofluorene (N-OH-FAF), N-deacetylation of N-OH-AAF and N-acetyl-2-aminofluorene (2-AAF), and O-deacetylation of 4-nitrophenyl acetate (NPA). The activity for N,O-acyltran...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/13.11.2017
更新日期:1992-11-01 00:00:00
abstract::Prostate cancer (PCa) is the second cause of cancer deaths in men in the USA. When the cancer recurs, early stages can be controlled with hormone ablation therapy to delay the rate of cancer progression but, over time, the cancer overcomes its hormone dependence, becomes highly aggressive and metastasizes. Clinical tr...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgu145
更新日期:2014-10-01 00:00:00
abstract::Telomerase contributes to the infinite replicative potential of cancer cells by conferring proliferation and survival through the regulation of growth factors and apoptotic proteins. Although it is generally known that the phytoestrogen, genistein, has telomerase-repressing and anti-proliferative effects on various ca...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm148
更新日期:2007-11-01 00:00:00
abstract::The carcinogenic heterocyclic amine 2-amino-3,8-dimethyl-imidazo[4,5-f]quinoxaline (MeIQx) is widely distributed in cooked foods. The nuclease P1 method increased the sensitivity of the standard 32P-postlabeling analysis about 1000-fold for detection of MeIQx-DNA adducts. The recovery of MeIQx-DNA adducts by the nucle...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/14.10.2165
更新日期:1993-10-01 00:00:00
abstract::Despite significant research, our understanding of the molecular mechanisms of Human Papilloma Virus (HPV) induced cancers remains incomplete. Majority of invasive cervical cancers are caused by high-risk HPV 16 and 18. Two potent HPV oncoproteins, E6 and E7, promote human malignancies by disrupting the activities of ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgu104
更新日期:2014-08-01 00:00:00
abstract::Nutritional deficiencies or imbalances are suspected contributory factors to several types of human cancers, and perhaps other human diseases related to long-term metabolic derangements. In order to study these more effectively in laboratory animals, it is suggested that the laboratory diets more closely mimic the nut...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.7.871
更新日期:1987-07-01 00:00:00
abstract::Alcohol is a major risk factor for oesophageal squamous cell carcinoma (OSCC), the most prevalent histological subtype of oesophageal cancer (OC) worldwide. The metabolism of alcohol is regulated by specific enzymes whose activity and expression is influenced by genetic polymorphisms. We conducted a systematic review ...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/bgx067
更新日期:2017-09-01 00:00:00
abstract::It is now widely accepted that cancer is attributed to the accumulation of genetic alterations in cells. Thus, to understand the molecular mechanisms of cancer metastasis, it is indispensable to identify the genes whose alterations accumulate during cancer progression as well as the genes whose expression is responsib...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/21.3.497
更新日期:2000-03-01 00:00:00
abstract::17beta-estradiol (E2), estrone and diethylstilbestrol (DES) had no effect on nuclear and nucleolar RNA synthesis in vitro. However, after reacting with dimethyldioxirane (DMDO), a versatile epoxide-forming oxidant, these estrogens were able to inhibit and in a dose-dependent manner nuclear and nucleolar RNA synthesis ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/17.9.1957
更新日期:1996-09-01 00:00:00
abstract::Autoradiography has been used to study the effect of 12-O-tetradecanoylphorbol-13-acetate (TPA), 4-O-methyl TPA, and phorbol on metabolic cooperation between human diploid fibroblasts. When the donors, hypoxanthine-guanine phosphoribosyl transferase+ (HGPRT+) cells, and recipients, HGPRT- cells, were plated together i...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.10.1207
更新日期:1982-01-01 00:00:00
abstract::People are constantly being exposed to toxic and carcinogenic aldehydes. However, little is actually known about the mechanisms underlying the toxic and carcinogenic effects of these aldehydes on human cells. The DNA alkylating activities of two of the more toxic and environmentally prominent alpha,beta-unsaturated al...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.8.1483
更新日期:1991-08-01 00:00:00
abstract::Spontaneous and hepatocarcinogen (2-nitropropane, 2-NP)-induced levels of 8-hydroxy-2'-deoxyguanosine (oh8dG) in the nuclear DNA of regenerating liver [24, 48, 72 h and 7 days after partial hepatectomy (PH)] of male Sprague-Dawley rats were analysed for the verification of a hypothesis that the high susceptibility of ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/15.3.539
更新日期:1994-03-01 00:00:00
abstract::The p53 gene was examined for point mutations in archived, alpha-radiation-associated lung and liver cancers. Lung tumors of 50 uranium miners in Germany were screened by restriction fragment length analysis for the putative hotspot mutation at codon 249 (Arg-->Met) previously detected in a significant fraction of min...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/18.3.511
更新日期:1997-03-01 00:00:00
abstract::Genetically based differences in metabolism, related to MspI restriction site and Ile-Val polymorphisms of the cytochrome P450 (CYP) 1A1 gene and the null genotype of glutathione transferase class mu (GSTM1), have been reported to be associated with lung cancer susceptibility. The present study was set up to establish...
journal_title:Carcinogenesis
pub_type: 杂志文章,多中心研究
doi:10.1093/carcin/15.9.1785
更新日期:1994-09-01 00:00:00
abstract::Retinoids have been shown to exert an anticarcinogenic effect through suppression of the cell cycle, induction of apoptosis and/or differentiation. In rat liver, in particular, retinoic acid has been shown to inhibit regeneration after partial hepatectomy, most probably through repression of the expression of c-fos an...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh221
更新日期:2004-11-01 00:00:00
abstract::Losses of heterozygosity (LOH) of the short arm of chromosome 19 are frequent in lung cancer, suggesting that one or more tumor suppressor genes are present in this region. The LKB1 gene, also called STK11, is somatically inactivated through point mutations and large deletions in lung tumors, demonstrating that LKB1 i...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/bgp035
更新日期:2009-04-01 00:00:00
abstract::Lack of functional telomeres can cause chromosomal aberrations. This type of genetic instability may promote tumorigenesis. We have investigated the association between mean telomere length in buccal cells (assessed with quantitative real-time PCR) and bladder cancer risk in a case-control study. Patients with bladder...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgi063
更新日期:2005-07-01 00:00:00
abstract::The present study was designed to evaluate whether etodolac, a cyclooxgenase-2 (COX-2)-specific inhibitor, could prevent chemically induced biliary carcinogenesis in bilioenterostomized hamsters. Syrian golden hamsters were subjected to choledochojejunostomy and then received subcutaneous injections of N-nitrosobis(2-...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh311
更新日期:2005-02-01 00:00:00
abstract::Skin is a major target of carcinogenic trivalent arsenic (arsenite, As3+). It has been thought that cell proliferation is one of the central events involved in the carcinogenic effect of arsenite. Cyclin D1, a nuclear protein playing a pivotal role in cell proliferation and cell cycle transition from G1 to S phases, h...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgi321
更新日期:2006-04-01 00:00:00