Luteolin inhibits insulin-like growth factor 1 receptor signaling in prostate cancer cells.

abstract：:Low selenium (Se) status correlates with increased risk of colorectal cancer (CRC). Since Se exerts its biological roles through the selenoproteins, genetic variations in selenoprotein genes may influence susceptibility to CRC. This study analysed 12 single-nucleotide polymorphisms (SNPs) in selenoprotein genes [gluta...

journal_title：Carcinogenesis

authors： Méplan C,Hughes DJ,Pardini B,Naccarati A,Soucek P,Vodickova L,Hlavatá I,Vrána D,Vodicka P,Hesketh JE

更新日期：2010-06-01 00:00:00

abstract：:Trabectedin is a marine-derived antineoplastic drug. Besides targeting the cancer cells, trabectedin has a peculiar activity on the tumor microenvironment with marked effects on the vasculature and the immune response. Because a favorable microenvironment is a key factor in the progression of cutaneous melanoma, we hy...

journal_title：Carcinogenesis

authors： Carminati L,Pinessi D,Borsotti P,Minoli L,Giavazzi R,D'Incalci M,Belotti D,Taraboletti G

更新日期：2019-04-29 00:00:00

abstract：:The influence of various dietary constituents--phenethylisothiocyanate (PEITC), oleic acid (OA), triolein (TO), and vitamin A (ROL)--on the genotoxic activity of nitrosamines (NDMA, NDELA, NPYR) was investigated. For this purpose differential DNA repair assays with Escherichia coli K-12 strains were performed in vitro...

journal_title：Carcinogenesis

authors： Knasmüller S,Huber WW,Kienzl H,Schulte-Hermann R

更新日期：1992-09-01 00:00:00

abstract：:Cyproterone acetate (CPA) is a synthetic steroid which is used in oral contraceptive and anti-androgen formulations. It has previously been classified as a tumor promoter in rat liver. Recent studies have shown that CPA induces DNA repair synthesis in isolated hepatocytes, and this implies that CPA is genotoxic. We st...

journal_title：Carcinogenesis

authors： Deml E,Schwarz LR,Oesterle D

更新日期：1993-06-01 00:00:00

abstract：:The effects of exposure to benzo[a]pyrene (BAP) and formaldehyde (HCHO), alone and combined, on the induction of carcinogenesis in rat tracheal implants was determined as the number of growth-altered cell populations (tumor-initiation sites, TIS) per trachea. While exposure twice-weekly for 4.5 months to 0.2% HCHO sol...

journal_title：Carcinogenesis

authors： Cosma GN,Marchok AC

更新日期：1987-12-01 00:00:00

abstract：:Telomerase activity in cancer cells is dependent on the transcriptional regulation of the human telomerase reverse transcriptase (hTERT) gene, encoding the catalytic subunit of human telomerase. We have shown previously that HTLV-1 basic leucine zipper (HBZ), a viral regulatory protein encoded by the human retrovirus,...

journal_title：Carcinogenesis

authors： Borowiak M,Kuhlmann AS,Girard S,Gazzolo L,Mesnard JM,Jalinot P,Dodon MD

更新日期：2013-11-01 00:00:00

abstract：:Debrisoquine hydroxylase activity has been attributed to CYP2D6 and poor metabolizers of debrisoquine have a reduced relative risk of developing aggressive bladder cancer. Production of a proximate carcinogen could occur in liver or bladder mucosa. However, it is not known if CYP2D6 is expressed in human bladder mucos...

journal_title：Carcinogenesis

authors： Romkes-Sparks M,Mnuskin A,Chern HD,Persad R,Fleming C,Sibley GN,Smith P,Wilkinson GR,Branch RA

更新日期：1994-09-01 00:00:00

abstract：:The effect of whole body ionising radiation from a linear accelerator on rat tissue O6-methylguanine (O6-meG) methyltransferase (MT) activity has been assessed using an assay which measures the transfer of 3H-radioactivity from 3H-methylated substrate DNA to protein. The maximal effect occurred 2 days after a 1 krad d...

journal_title：Carcinogenesis

authors： Margison GP,Butler J,Hoey B

更新日期：1985-12-01 00:00:00

abstract：:To elucidate the function of the Ras-homologous GTPase Rac1 in hepatocarcinogenesis induced by diethylnitrosamine (DEN), mice lacking hepatic Rac1 expression were treated with DEN and compared to the wild-type (WT). Rac1 knock-out (KO) mice were found to have a lower tumor yield as compared to Rac1 proficient mice. Th...

journal_title：Carcinogenesis

authors： Bopp A,Wartlick F,Henninger C,Schwarz M,Kaina B,Fritz G

更新日期：2015-03-01 00:00:00

abstract：:Gangliosides from liver parenchymal and non-parenchymal cells were isolated from Fischer 344 rats that had been fed normal diet or a diet supplemented with 0.03% N-2-acetylaminofluorene (AAF) for 4 weeks. Gangliosides from liver cell fractions were characterized by an induction of both II3NeuAcIV3 alpha GalIV2FucGg4 a...

journal_title：Carcinogenesis

authors： Holmes EH

更新日期：1990-01-01 00:00:00

abstract：:Genetically based differences in metabolism, related to MspI restriction site and Ile-Val polymorphisms of the cytochrome P450 (CYP) 1A1 gene and the null genotype of glutathione transferase class mu (GSTM1), have been reported to be associated with lung cancer susceptibility. The present study was set up to establish...

journal_title：Carcinogenesis

authors： Alexandrie AK,Sundberg MI,Seidegård J,Tornling G,Rannug A

更新日期：1994-09-01 00:00:00

abstract：:Oltipraz (OPZ) is a potent chemopreventive agent against chemically-induced carcinogenesis in several animal models. It affects the expression and/or activity of xenobiotic-metabolizing enzymes and its effects are altered in the course of inflammation in liver. The present study was undertaken to analyse the effect of...

journal_title：Carcinogenesis

authors： Le Ferrec E,Ilyin G,Mahéo K,Bardiau C,Courtois A,Guillouzo A,Morel F

更新日期：2001-01-01 00:00:00

abstract：:Proliferation, apoptosis and angiogenesis are critical biologic processes altered during carcinogenesis. Surrogate biomarkers of these processes represent potential intermediate endpoints for short-term intervention studies with preventive and therapeutic agents. We examined the interrelationships among these processe...

journal_title：Carcinogenesis

authors： Liao Z,Boileau TW,Erdman JW Jr,Clinton SK

更新日期：2002-10-01 00:00:00

abstract：:The potential importance of prostaglandin H synthase (PGHS) in the genotoxicity of fecapentaene-12 (fec-12) has been indicated by the finding that non-steroidal anti-inflammatory agents (NSAIDs) block the induction of oxidative DNA base damage by fec-12 in HeLa cells. To further investigate the role of PGHS in the met...

journal_title：Carcinogenesis

authors： Plummer SM,Hall M,Faux SP

更新日期：1995-05-01 00:00:00

abstract：:Despite decreases in the cancer death rates in high-resource countries, such as the USA, the number of cancer cases and deaths is projected to more than double worldwide over the next 20-40 years. Cancer is now the third leading cause of death, with >12 million new cases and 7.6 million cancer deaths estimated to have...

journal_title：Carcinogenesis

authors： Thun MJ,DeLancey JO,Center MM,Jemal A,Ward EM

更新日期：2010-01-01 00:00:00

abstract：:The ability of cytosolic 3-methylcholanthrene binding proteins from rat liver to interact with DNA was studied using DNA-cellulose chromatography. Two DNA binding fractions, eluting in 0.15 M KCl (peak 1) and 0.33 M KCl (peak 2), were observed on salt elution from a denatured DNA-cellulose column which had been incuba...

journal_title：Carcinogenesis

authors： Weaver D,Amos A,Tierney B,Bresnick E

更新日期：1980-06-01 00:00:00

abstract：:Both trans-4-acetylaminostilbene (AAS) and 2-acetylaminofluorene (AAF) exert tumor-initiating activity in rat liver when administered in the initiation phase of an initiation-promotion experiment. The effects are more than additive when the compounds are sequentially combined in the initiation phase of such an experim...

journal_title：Carcinogenesis

authors： Ruthsatz M,Neumann HG

更新日期：1988-02-01 00:00:00

abstract：:We examined the effects of the aliphatic amides isopropyl-valeramide (IVA) and allylisopropylacetamide (AIA) on oncogenic transformation and sister chromatid exchanges (SCE) induced by cyclopenta[cd]pyrene (CPP) and benzo[a]pyrene (B[a]P) in C3H/10T1/2 cells and on B[a]Pdiol-epoxide (BPDE)-induced mutation at the HGPR...

journal_title：Carcinogenesis

authors： Krolewski B,Nagasawa H,Little JB

更新日期：1986-10-01 00:00:00

abstract：:Acrylamide is an alkylating agent which reacts very slowly in direct reactions with DNA and is negative in the Ames test, but is carcinogenic in mice and rats. In order to explain the cancer-initiating properties of acrylamide we have studied DNA adduct formation in vitro with a metabolizing system and in vivo in mice...

journal_title：Carcinogenesis

authors： Segerbäck D,Calleman CJ,Schroeder JL,Costa LG,Faustman EM

更新日期：1995-05-01 00:00:00

abstract：:The 80%-ethanol extract of lemon grass (Cymbopogon citratus Stapf), a medicinal plant in Thailand, has been reported to be antimutagenic against various known mutagens in the Salmonella mutation assay. To investigate chemoprevention in an animal carcinogenesis model, we examined inhibitory effects of the lemon grass e...

journal_title：Carcinogenesis

authors： Suaeyun R,Kinouchi T,Arimochi H,Vinitketkumnuen U,Ohnishi Y

更新日期：1997-05-01 00:00:00

abstract：:We examined allelic loss in colon tumors induced by 1,2-dimethylhydrazine (DMH) in F1 hybrid mice, using sequence-tagged microsatellite site (STMS) primers derived from the chromosomal region closely linked to the p53 locus. Polymerase chain reaction--single-strand conformation polymorphism (PCR-SSCP) analysis of 155 ...

journal_title：Carcinogenesis

authors： Okamoto M,Ohtsu H,Miyaki M,Yonekawa H

更新日期：1993-07-01 00:00:00

abstract：:The DNA damaging and mutagenic activities of procarbazine, a methylating drug employed in cancer chemotherapy and suspected of causing therapy-related leukaemia, were investigated in the liver and bone marrow of lambda lacZ transgenic mice (MutaMouse). The drug was administered using two different protocols, a 'high-d...

journal_title：Carcinogenesis

authors： Pletsa V,Valavanis C,van Delft JH,Steenwinkel MJ,Kyrtopoulos SA

更新日期：1997-11-01 00:00:00

abstract：:Incubation of 3-[3H]fluoranthene with a rat liver microsomal activation system in the presence of calf thymus DNA resulted in radioactivity bound to the DNA. The fluoranthene-modified DNA was enzymatically digested and a DNA adduct elution profile developed using h.p.l.c. The fraction containing the major fluoranthene...

journal_title：Carcinogenesis

authors： Babson JR,Russo-Rodriguez SE,Rastetter WH,Wogan GN

更新日期：1986-06-01 00:00:00

abstract：:DL-N-acetyl-N'-nitrosotryptophan (I) and its methyl ester (II), readily formed under mild conditions by the reaction of nitrite with N-acetyltryptophan or its methyl ester, are model compounds for the study of the nitrosation of alpha-amino acid side chains, considered relevant to possible role of nitrosation of pepti...

journal_title：Carcinogenesis

authors： Venitt S,Crofton-Sleigh C,Ooi SL,Bonnett R

更新日期：1980-06-01 00:00:00

abstract：:The JB6 mouse epidermal cell system has been extensively used as an in vitro model for the study of tumor promotion. The present study aimed to assess the relevance of monolayer measurements to the process of transformation, which is induced more efficiently under anchorage-independent (AI) conditions. Although it wou...

journal_title：Carcinogenesis

authors： Dong Z,Cmarik JL,Wendel EJ,Colburn NH

更新日期：1994-05-01 00:00:00

abstract：:Currently there is no well-defined biological parameter or marker to help define agents, doses, and dose schedules for human cancer chemoprevention trials. Induction of ornithine decarboxylase, the rate limiting enzyme in the polyamine biosynthetic pathway, has been shown to be an essential aspect of mouse skin tumor ...

journal_title：Carcinogenesis

authors： Loprinzi CL,Verma AK

更新日期：1985-11-01 00:00:00

abstract：:We employed cDNA microarray analysis to identify, in mammary adenocarcinomas induced by 7,12-dimethylbenz[a] anthracene (DMBA) in the rat, target genes as potential biomarkers for cancer chemoprevention by 1,4-phenylenebis(methylene)selenocyanate (p-XSC). Confirmation of selected genes was conducted by reverse transcr...

journal_title：Carcinogenesis

authors： El-Bayoumy K,Narayanan BA,Desai DH,Narayanan NK,Pittman B,Amin SG,Schwartz J,Nixon DW

更新日期：2003-09-01 00:00:00

abstract：:Receptor tyrosine kinase EphB3 is expressed in cells in the bottom of intestinal crypts near stem cell niches. Loss of Ephb3 has recently been reported to produce invasive colorectal carcinoma in Apc(Min/+) mice and EphB-mediated compartmentalization was demonstrated to be a mechanism suppressing colorectal cancer pro...

journal_title：Carcinogenesis

authors： Chiu ST,Chang KJ,Ting CH,Shen HC,Li H,Hsieh FJ

更新日期：2009-09-01 00:00:00

abstract：:Colorectal cancer (CRC) is the fourth leading cause of cancer mortality worldwide. Genome-wide association studies (GWAS) identified more than 50 CRC loci. However, most of the previous studies were conducted in European population, and host genetic factors among Japanese population are largely remained to be identifi...

journal_title：Carcinogenesis

authors： Tanikawa C,Kamatani Y,Takahashi A,Momozawa Y,Leveque K,Nagayama S,Mimori K,Mori M,Ishii H,Inazawa J,Yasuda J,Tsuboi A,Shimizu A,Sasaki M,Yamaji T,Sawada N,Iwasaki M,Tsugane S,Naito M,Wakai K,Koyama T,Takezaki T

更新日期：2018-05-03 00:00:00

abstract：:This study was conducted to investigate the modifying effect of glutathione S-transferase (GST) M1 and T1 polymorphisms on aflatoxin-induced hepatocarcinogenesis among chronic hepatitis B virus surface antigen (HBsAg) carriers. A total of 79 HBsAg-positive cases of hepatocellular carcinoma (HCC) diagnosed between 1991...

journal_title：Carcinogenesis

authors： Sun CA,Wang LY,Chen CJ,Lu SN,You SL,Wang LW,Wang Q,Wu DM,Santella RM

更新日期：2001-08-01 00:00:00