Abstract:
:Cyproterone acetate (CPA) is a synthetic steroid which is used in oral contraceptive and anti-androgen formulations. It has previously been classified as a tumor promoter in rat liver. Recent studies have shown that CPA induces DNA repair synthesis in isolated hepatocytes, and this implies that CPA is genotoxic. We studied the initiating activity of CPA in vivo by means of a rat liver foci bioassay, using weanling female Sprague-Dawley rats. The results show that CPA induces adenosine-triphosphatase-deficient and gamma-glutamyltranspeptidase-positive putative preneoplastic foci in a dose-dependent manner. This indicates that CPA has not only promoting but also initiating activity and may therefore act as a complete carcinogen in rat liver.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Deml E,Schwarz LR,Oesterle Ddoi
10.1093/carcin/14.6.1229subject
Has Abstractpub_date
1993-06-01 00:00:00pages
1229-31issue
6eissn
0143-3334issn
1460-2180journal_volume
14pub_type
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