No allelic loss at the p53 locus in 1,2-dimethylhydrazine-induced mouse colon tumours: PCR-SSCP analysis with sequence-tagged microsatellite site primers.

abstract：:DNA-methyltransferase-3B (DNMT3B) plays an important role in the generation of aberrant methylation in carcinogenesis. Polymorphisms and haplotypes of the DNMT3B gene may influence DNMT3B activity on DNA methylation, thereby modulating the susceptibility to lung cancer. To test this hypothesis, we investigated the ass...

journal_title：Carcinogenesis

authors： Lee SJ,Jeon HS,Jang JS,Park SH,Lee GY,Lee BH,Kim CH,Kang YM,Lee WK,Kam S,Park RW,Kim IS,Cho YL,Jung TH,Park JY

更新日期：2005-02-01 00:00:00

abstract：:Observational studies have been largely consistent in showing an inverse association between vitamin D and an individual's risk of developing colorectal cancer. Vitamin D protection is further supported by a range of preclinical colon cancer models, including carcinogen, genetic and dietary models. A large number of m...

journal_title：Carcinogenesis

authors： Giardina C,Madigan JP,Tierney CA,Brenner BM,Rosenberg DW

更新日期：2012-03-01 00:00:00

abstract：:The genes that are involved in estrogen biosynthesis, cellular binding and metabolism may contribute to breast cancer susceptibility. We examined the effect of the CYP17 promoter T --> C polymorphism and its interactions with the reproductive history, exogenous hormone use and selected lifestyle risk factors on breast...

journal_title：Carcinogenesis

authors： Chen Y,Gammon MD,Teitelbaum SL,Britton JA,Terry MB,Shantakumar S,Eng SM,Wang Q,Gurvich I,Neugut AI,Santella RM,Ahsan H

更新日期：2008-04-01 00:00:00

abstract：:The effect of the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was studied using an immortalized human bronchial epithelial cell line, BEAS-2B, both in vivo and in vitro. The in vivo model consisted of tracheas reconstituted with an epithelium of BEAS-2B cells xenotransplanted into athymic nude mice. Int...

journal_title：Carcinogenesis

authors： Bonfil RD,Momiki S,Fridman R,Reich R,Reddel R,Harris CC,Klein-Szanto A

更新日期：1989-12-01 00:00:00

abstract：:A family of 2-amino-N-methylimidazoazaarene (AIA) mutagens are produced in meats by cooking, and are of concern as potential carcinogens in the human diet. These are potent genotoxins in bacterial mutation assays, but are present only in trace quantities in cooked foods. Conventional analytical chemistry methods have ...

journal_title：Carcinogenesis

authors： Vanderlaan M,Watkins BE,Hwang M,Knize MG,Felton JS

更新日期：1988-01-01 00:00:00

abstract：:2-Hexenal is an alpha,beta-unsaturated carbonyl compound which is mutagenic, genotoxic and forms cyclic 1,N2-propanodeoxyguanosine adducts like similar propenals for which carcinogenicity was shown, e.g. acrolein or crotonaldehyde. Since humans have a permanent intake of 2-hexenal via vegetarian food this genotoxic co...

journal_title：Carcinogenesis

authors： Schuler D,Eder E

更新日期：1999-07-01 00:00:00

abstract：:Extracts of human urine were shown to contain substances that strongly inhibited the liver S9-mediated mutagenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in Salmonella typhimurium TA98 strain in a liquid incubation assay. The inhibitory effect was unrelated to cytotoxicity and was similar with urin...

journal_title：Carcinogenesis

authors： Malaveille C,Hautefeuille A,Brun G,Vineis P,Bartsch H

更新日期：1992-12-01 00:00:00

abstract：:N-nitrosopiperidine (NPIP) is a potent esophageal carcinogen in rats whereas structurally similar N-nitrosopyrrolidine (NPYR) induces liver, but not esophageal tumors. NPIP is a possible causative agent for human esophageal cancer. Our goal is to explain mechanistically these differing carcinogenic activities in the e...

journal_title：Carcinogenesis

authors： Wong HL,Murphy SE,Wang M,Hecht SS

更新日期：2003-02-01 00:00:00

abstract：:The modulating effects of dietary feeding of two xanthophylls, astaxanthin (AX) and canthaxanthin (CX) during the postinitiation phase on colon carcinogenesis initiated with azoxymethane (AOM) were investigated in male F344 rats. Animals were initiated with AOM by weekly s.c. injections of 15 mg/kg body wt for 3 weeks...

journal_title：Carcinogenesis

authors： Tanaka T,Kawamori T,Ohnishi M,Makita H,Mori H,Satoh K,Hara A

更新日期：1995-12-01 00:00:00

abstract：:Adipocytokines are a group of adipocyte-secreted proteins that have significant effects on the metabolism of lipids and carbohydrates, as well as numerous other processes. A number of recent studies have indicated that some adipocytokines may significantly influence the proliferation of malignant cells in vitro, where...

journal_title：Carcinogenesis

authors： Miyamoto S,Yasui Y,Tanaka T,Ohigashi H,Murakami A

更新日期：2008-05-01 00:00:00

abstract：:Acutely transforming retrovirus AKT8 in rodent T cell lymphoma (Akt) phosphorylates and regulates the function of many cellular proteins involved in processes such as metabolism, apoptosis and proliferation. However, the precise mechanisms by which Akt promotes cell survival and inhibits apoptosis have been characteri...

journal_title：Carcinogenesis

authors： Chen HZ,Zhao BX,Zhao WX,Li L,Zhang B,Wu Q

更新日期：2008-11-01 00:00:00

abstract：:The modifying effects of oltipraz on induction of glandular stomach carcinogenesis by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) were investigated in a total of 120 male 6-week-old Wistar rats, divided into six groups. Groups 1-3 (30 animals each) were given 100 p.p.m. MNNG in their drinking water for 10 weeks as an ...

journal_title：Carcinogenesis

authors： Nishikawa A,Tanakamura Z,Furukawa F,Lee IS,Kasahara K,Ikezaki S,Takahashi M

更新日期：1998-02-01 00:00:00

abstract：:3-Methylcholanthrene (3-MC) pretreatment induces the liver microsomal 2-acetylaminofluorene (2-AAF) N-hydroxylase activity of C57BL6 responsive mice. The same pretreatment modifies this enzyme by significantly increasing its apparent Km value which, moreover, becomes protein concentration dependent. After 3-MC inducti...

journal_title：Carcinogenesis

authors： Razzouk C,Batardy-Grégoire M,Roberfroid M

更新日期：1982-01-01 00:00:00

abstract：:Apoptosis is a morphologically and biochemically distinct form of cell death which determines specific patterns of tissue size and shape and balances cell proliferation. In the present study, the sequence of cellular proliferative alterations in urinary bladder epithelium associated with uracil-induced reversible urin...

journal_title：Carcinogenesis

authors： Otori K,Yano Y,Takada N,Lee CC,Hayashi S,Otani S,Fukushima S

更新日期：1997-08-01 00:00:00

abstract：:N-Acetoxyarylamines are reactive metabolites that lead to arylamine adduct formation with biological macromolecules. A series of 7-substituted-N-hydroxy-2-acetylaminofluorenes were converted to reactive N-acetoxyarylamines by enzymatic N,O-acyltransfer in the presence of DNA. The N-arylhydroxamic acid substrates that ...

journal_title：Carcinogenesis

authors： Boteju LW,Hanna PE

更新日期：1993-08-01 00:00:00

abstract：:The carcinogenicity of two commonly used brown and black varieties of masheri, a pyrolysed tobacco product, was studied by feeding the masheri through the diet at a 10% level to three different animal species of both sexes. In Sprague-Dawley rats, only brown masheri was used, while in Swiss mice and Syrian golden hams...

journal_title：Carcinogenesis

authors： Kulkarni JR,Lalitha VS,Bhide SV

更新日期：1988-11-01 00:00:00

abstract：:The steroid hormone 1,25-dihydroxyvitamin D(3), [1,25(OH)(2)D(3), calcitriol], the active metabolite of vitamin D, exerts pleiotropic antitumor effects against several malignancies. However, the clinical use of this hormone is limited by hypercalcemia. 25-Hydroxyvitamin D(3), the prohormone of 1,25(OH)(2)D(3), is hydr...

journal_title：Carcinogenesis

authors： Schwartz GG,Eads D,Rao A,Cramer SD,Willingham MC,Chen TC,Jamieson DP,Wang L,Burnstein KL,Holick MF,Koumenis C

更新日期：2004-06-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer-related death, with non-small cell lung cancer (NSCLC) being the predominant form of the disease. Most lung cancer is caused by the accumulation of genomic alterations due to tobacco exposure. To uncover its mutational landscape, we performed whole-exome sequencing in 31 NSCL...

journal_title：Carcinogenesis

authors： Liu P,Morrison C,Wang L,Xiong D,Vedell P,Cui P,Hua X,Ding F,Lu Y,James M,Ebben JD,Xu H,Adjei AA,Head K,Andrae JW,Tschannen MR,Jacob H,Pan J,Zhang Q,Van den Bergh F,Xiao H,Lo KC,Patel J,Richmond T,Watt MA,

更新日期：2012-07-01 00:00:00

abstract：:O6-Methylguanine-DNA methyltransferase (MT)-proficient Chinese hamster ovary cells were grown in the presence of low, gradually increasing levels of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) with the aim of selecting MNNG-resistant cell lines. Six resistant clones with two levels of resistance were isolated. A 3-fol...

journal_title：Carcinogenesis

authors： Aquilina G,Frosina G,Zijno A,Di Muccio A,Dogliotti E,Abbondandolo A,Bignami M

更新日期：1988-07-01 00:00:00

abstract：:Dose-response relationships in the induction of urinary bladder cancer in male C57BL/6 x DBA/2-F1 (BDF) mice by intragastric instillation of N-butyl-N-(4-hydroxybutyl)nitrosamine (OH-BBN) were studied. Administration of a total dose of 0 to 80 mg OH-BBN in 10 weekly fractions to groups of 25 mice resulted in a linear ...

journal_title：Carcinogenesis

authors： McCormick DL,Ronan SS,Becci PJ,Moon RC

更新日期：1981-01-01 00:00:00

abstract：:Although Epstein-Barr virus (EBV) infection is widely distributed, certain EBV-driven malignancies are geographically restricted. EBV-associated Burkitt's lymphoma (eBL) is endemic in children living in sub-Saharan Africa. This population is heavily exposed to food contaminated with the mycotoxin aflatoxin B1 (AFB1). ...

journal_title：Carcinogenesis

authors： Accardi R,Gruffat H,Sirand C,Fusil F,Gheit T,Hernandez-Vargas H,Le Calvez-Kelm F,Traverse-Glehen A,Cosset FL,Manet E,Wild CP,Tommasino M

更新日期：2015-11-01 00:00:00

abstract：:Formaldehyde (FA) is a widely produced industrial chemical. Sufficient evidence exists to consider FA as an animal carcinogen. In humans the evidence is not conclusive. DNA-protein crosslinks (DPC) may be one of the early lesions in the carcinogenesis process in cells following exposures to carcinogens. It has been sh...

journal_title：Carcinogenesis

authors： Shaham J,Bomstein Y,Meltzer A,Kaufman Z,Palma E,Ribak J

更新日期：1996-01-01 00:00:00

abstract：:Aromatic DNA adducts in total white blood cells, cytochrome P450 (CYP) class 1A1 and glutathione transferase (GST1) class mu genotypes and micronuclei in T- and B-lymphocytes were studied in 69 full-time chimney sweeps and 35 controls, all male subjects. The sweeps had a higher (22%) but statistically non-significant ...

journal_title：Carcinogenesis

authors： Ichiba M,Hagmar L,Rannug A,Högstedt B,Alexandrie AK,Carstensen U,Hemminki K

更新日期：1994-07-01 00:00:00

abstract：:Several studies have indicated a correlation between the presence of inflammation and the development of cancer. The aim of our study was to determine if pulmonary neutrophils could transform the proximate respiratory carcinogen (+-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene (B[a]P-7,8-diol), to an ultimate carcin...

journal_title：Carcinogenesis

authors： Petruska JM,Mosebrook DR,Jakab GJ,Trush MA

更新日期：1992-07-01 00:00:00

abstract：:Okadaic acid is both a potent inhibitor of protein serine/threonine phosphatases and a tumor promoter in the mouse skin model. We have previously shown that at non-toxic nanomolar concentrations okadaic acid reversibly inhibits induction (promotion) by PDGF of transformed cells by the 'complete' and 'two-stage' protoc...

journal_title：Carcinogenesis

authors： Dean NM,Mordan LJ,Tse K,Mooberry SL,Boynton AL

更新日期：1991-04-01 00:00:00

abstract：:Groups of male and female IF strain mice were fed a diet containing either 0.5% or 1.0% paracetamol for up to 18 months. Among male mice fed the higher dose, the total liver cell tumour incidence was 87%, 21.7% developing hepatocellular carcinomas: both yields were statistically significant. The corresponding incidenc...

journal_title：Carcinogenesis

authors： Flaks A,Flaks B

更新日期：1983-01-01 00:00:00

abstract：:The mapping near Kras2 of pulmonary adenoma susceptibility 1 (Pas1), a major locus affecting inherited predisposition to lung cancer in mice prompted us to test the homologous human region (12p12) for association with lung adenocarcinoma, by a population-based study. We genotyped 213 lung adenocarcinoma patients and 2...

journal_title：Carcinogenesis

authors： Manenti G,De Gregorio L,Pilotti S,Falvella FS,Incarbone M,Ravagnani F,Pierotti MA,Dragani TA

更新日期：1997-10-01 00:00:00

abstract：:Base excision repair (BER) corrects DNA damage caused by oxidative stress and chronic inflammation, putative risk factors for cancer. To understand the relationship between genetic variation in BER genes and risk of biliary tract cancer and biliary stones, we examined non-synonymous polymorphisms in three key BER gene...

journal_title：Carcinogenesis

authors： Huang WY,Gao YT,Rashid A,Sakoda LC,Deng J,Shen MC,Wang BS,Han TQ,Zhang BH,Chen BE,Rosenberg PS,Chanock SJ,Hsing AW

更新日期：2008-01-01 00:00:00

abstract：:Apigenin, a flavonoid abundant in various vegetables and fruits, including parsley and onions, has been reported to possess anticarcinogenic effects. However, the direct molecular target of apigenin and its chemopreventive effect on ultraviolet (UV)-induced skin inflammation are not understood fully. Herein, we examin...

journal_title：Carcinogenesis

authors： Byun S,Park J,Lee E,Lim S,Yu JG,Lee SJ,Chen H,Dong Z,Lee KW,Lee HJ

更新日期：2013-02-01 00:00:00

abstract：:Resveratrol (RSVL) is a well-established chemopreventive agent in human breast cancer models. The molecular basis of its action is far less characterized. We investigated the effects of RSVL on activity of adenylate- and guanylate-cyclase (AC, GC) enzymes; two known cytostatic cascades in MCF-7 breast cancer cells. RS...

journal_title：Carcinogenesis

authors： El-Mowafy AM,Alkhalaf M

更新日期：2003-05-01 00:00:00