Effect of aliphatic amides on oncogenic transformation, sister chromatid exchanges, and mutations induced by cyclopenta[cd]-pyrene and benzo[a]pyrene.

abstract：:The reaction of chloroacetaldehyde, a reactive metabolic of the carcinogen vinyl chloride, with DNA produces in addition to the hitherto known adducts, 1,N6-ethenoadenine and 3,N4-ethenocytosine, an ethenoguanine adduct, namely N2,3-ethenoguanine. This adduct is formed in the reaction of chloroacetaldehyde with the fr...

journal_title：Carcinogenesis

authors： Oesch F,Doerjer G

更新日期：1982-01-01 00:00:00

abstract：:Pharmacological inhibitors of the transforming growth factor β (TGFβ) type I receptor (ALK5) have shown promise in blocking growth of xenotransplanted cancer cell lines but the effect on a multistage cancer model is not known. To test this, we treated mouse skin with SB431542 (SB), a well-characterized ALK5 inhibitor,...

journal_title：Carcinogenesis

authors： Mordasky Markell L,Pérez-Lorenzo R,Masiuk KE,Kennett MJ,Glick AB

更新日期：2010-12-01 00:00:00

abstract：:Exposure of rats to diesel emissions results in the development of lung tumors. The objective of this study was to determine whether the polycyclic aromatic hydrocarbons (PAHs), nitro-PAHs or other polycyclic organic matter adsorbed to diesel particles induces the formation of DNA adducts in the lung when compared to ...

journal_title：Carcinogenesis

authors： Gallagher J,Heinrich U,George M,Hendee L,Phillips DH,Lewtas J

更新日期：1994-07-01 00:00:00

abstract：:Wildtype 10T1/2 cells and 42 clonally derived morphologically transformed 10T1/2 cell lines were evaluated for expression of p53 mRNA and protein. Wildtype 10T1/2 cells expressed detectable levels of p53 mRNA and multiple immunologically distinct forms of the p53 protein, including both PAb240- and PAb246-reactive con...

journal_title：Carcinogenesis

authors： Coleman WB,Grisham JW,Smith GJ

更新日期：1994-02-01 00:00:00

abstract：:A method was devised to quantitate N-acetoxy-N-acetyl-2-aminofluorene (N-AcO-AAF) induced crosslinking of the ionic complex between [methyl-3H]thymidine labeled pBR322 DNA and lysozyme. This involved chromatography of the modified complex on Sephadex CM 25 with a high salt buffer that dissociated the non-covalently bo...

journal_title：Carcinogenesis

authors： Rayshell M,Ross J,Werbin H

更新日期：1983-01-01 00:00:00

abstract：:To better understand the mechanisms of mutagenesis by the carcinogen, methylene chloride (DCM), we have determined the nature and distribution of forward mutations induced by DCM in the N-terminal region of the lacI gene of Escherichia coli. A total of 116 lacI-d mutations (50 from Uvr+, 66 from UvrB- strain) were cha...

journal_title：Carcinogenesis

authors： Zielenska M,Ahmed A,Pienkowska M,Anderson M,Glickman BW

更新日期：1993-05-01 00:00:00

abstract：:The polysubstituted benzamide derivative metoclopramide (MCA) has previously been shown to enhance the effect of cisplatin and ionizing radiation treatment of xenografted human squamous cell carcinomas from the head and neck region. In the present work we show that MCA decreases the nucleoid sedimentation rate, indica...

journal_title：Carcinogenesis

authors： Lybak S,Pero RW

更新日期：1991-09-01 00:00:00

abstract：:This commentary celebrates the 40th year of Carcinogenesis, spanning 1980-2020 with a focus on lung cancer. For lung cancer, these 40 years come toward the end of a century of scientific inquiry that began with descriptions of this highly fatal malignancy and that closes with emphasis on molecular processes and genomi...

journal_title：Carcinogenesis

authors： Samet JM

更新日期：2020-10-15 00:00:00

abstract：:A diet that is deficient in methionine, choline, folic acid and vitamin B12 has been found to induce alterations rapidly in liver tRNA methylation in male Fischer rats. In vitro assays indicated that activity of N2-guanine tRNA methyltransferase II (NMG2) was increased to 150% of controls levels in 1 week and 300% of ...

journal_title：Carcinogenesis

authors： Wainfan E,Dizik M,Hluboky M,Balis ME

更新日期：1986-03-01 00:00:00

abstract：:Cell motility is partially dependent on interactions between the integrins and the extracellular matrix. Our previous studies have identified synthetic D-amino acid cell adhesion peptides using a combinatorial screening approach. In this study, we demonstrate that HYD1 (kikmviswkg) completely blocks random haptotactic...

journal_title：Carcinogenesis

authors： Sroka TC,Pennington ME,Cress AE

更新日期：2006-09-01 00:00:00

abstract：:Telomere dynamics are a critical component of both aging and cancer. Telomeres progressively shorten in almost all dividing cells and most human cells do not express or maintain sufficient telomerase activity to fully maintain telomeres. There is accumulating evidence that when only a few telomeres are short, they for...

journal_title：Carcinogenesis

authors： Shay JW,Wright WE

更新日期：2005-05-01 00:00:00

abstract：:2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a mutagenic and carcinogenic heterocyclic amine formed during ordinary cooking. PhIP is metabolically activated to the ultimate mutagenic metabolite by CYP P450-mediated N-hydroxylation followed by phase II esterification. Incubation of N-hydroxy-PhIP (N-OH-PhI...

journal_title：Carcinogenesis

authors： Frandsen H,Alexander J

更新日期：2000-06-01 00:00:00

abstract：:3-Methylcholanthrene (3-MC) pretreatment induces the liver microsomal 2-acetylaminofluorene (2-AAF) N-hydroxylase activity of C57BL6 responsive mice. The same pretreatment modifies this enzyme by significantly increasing its apparent Km value which, moreover, becomes protein concentration dependent. After 3-MC inducti...

journal_title：Carcinogenesis

authors： Razzouk C,Batardy-Grégoire M,Roberfroid M

更新日期：1982-01-01 00:00:00

abstract：:Epidemiological studies have suggested that frequent olive oil consumption may be a protective factor against lung cancer formation. Squalene, a characteristic compound in olive oil, is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and has been proposed to inhibit the farnesylation of ras on...

journal_title：Carcinogenesis

authors： Smith TJ,Yang GY,Seril DN,Liao J,Kim S

更新日期：1998-04-01 00:00:00

abstract：:Possible relationships between structure and metabolism of nitrosamines have been investigated in the rat small intestine. Isolated segments of jejunum and ileum were perfused from the luminal side for 2 h with a Tyrode solution containing one of four symmetrical dialkylnitrosamines with 2-5 carbon atoms per side chai...

journal_title：Carcinogenesis

authors： Richter E,Richter-Cooberg U,Feng X,Schulze J,Wiessler M

更新日期：1986-07-01 00:00:00

abstract：:Human fibroblasts repair DNA damaged by bleomycin through both short-patch and long-patch pathways, mediated by an aphidicolin-resistant (beta) and aphidicolin-sensitive (delta) DNA polymerase respectively (DiGiuseppe, J.A. and Dresler, S.L. (1989) Biochemistry, 28, 9515-9520). Despite certain similarities, aphidicoli...

journal_title：Carcinogenesis

authors： DiGiuseppe JA,Hunting DJ,Dresler SL

更新日期：1990-06-01 00:00:00

abstract：:The oxidative metabolites of estrogen have been proposed to play an important role in the development of some human cancers. The two major pathways of estrogen metabolism, to the carcinogenic 4-hydroxyestradiol (4-OHE2) and to the non-carcinogenic 2-hydroxyestradiol (2-OHE2), are mediated by cytochromes P450 CYP1B1 an...

journal_title：Carcinogenesis

authors： Husbeck B,Powis G

更新日期：2002-10-01 00:00:00

abstract：:Cytochrome P4501A1 (CYP1A1) has been implicated in the conversion of numerous polycyclic aromatic hydrocarbons into electrophilic species capable of binding covalently to DNA and has therefore been postulated to be involved in the initiation of carcinogenesis. The expression of CYP1A1 protein appears not to be constit...

journal_title：Carcinogenesis

authors： Drahushuk AT,McGarrigle BP,Larsen KE,Stegeman JJ,Olson JR

更新日期：1998-08-01 00:00:00

abstract：:The anti-cancer efficacy of grape seed extract (GSE) against prostate cancer (PCA) via its anti-proliferative, pro-apoptotic and anti-angiogenic activities in both cell culture and animal models have recently been described by us. GSE is a complex mixture containing gallic acid (GA), catechin (C), epicatechin (EC) and...

journal_title：Carcinogenesis

authors： Veluri R,Singh RP,Liu Z,Thompson JA,Agarwal R,Agarwal C

更新日期：2006-07-01 00:00:00

abstract：:The hedgehog pathway plays a critical role in the development of the foregut. Recent studies indicate that the hedgehog pathway activation occurs in the stomach and other gastrointestinal cancers. However, the association of hedgehog pathway activation with tumor stage, differentiation and tumor subtype is not well do...

journal_title：Carcinogenesis

authors： Ma X,Chen K,Huang S,Zhang X,Adegboyega PA,Evers BM,Zhang H,Xie J

更新日期：2005-10-01 00:00:00

abstract：:The karyopherin β proteins are involved in nuclear-cytoplasmic trafficking and are crucial for protein and RNA subcellular localization. We previously showed that Kpnβ1, a nuclear importin protein, is overexpressed in cervical cancer and is critical for cervical cancer cell survival and proliferation, whereas non-canc...

journal_title：Carcinogenesis

authors： Angus L,van der Watt PJ,Leaner VD

更新日期：2014-05-01 00:00:00

abstract：:The nasal passages are a common portal of entry and are a prime site for toxicant-induced pathology. Sustained increases in regenerative cell proliferation can be a significant driving force in chemical carcinogenesis. The atmosphere in Mexico City contains a complex mixture of air pollutants and its residents are exp...

journal_title：Carcinogenesis

authors： Calderón-Garcidueñas L,Rodriguez-Alcaraz A,Garcia R,Barragan G,Villarreal-Calderón A,Madden MC

更新日期：1999-03-01 00:00:00

abstract：:The aim of this work was to optimize the ionic strength (tau) in the liver microsomal assay (LMA) in performing short-term genotoxicity tests. tau optimization would increase the sensitivity (i.e. decrease false negatives) and at the same time increase the specificity (decrease false positives). Such optimization depe...

journal_title：Carcinogenesis

authors： Paolini M,Mesirca R,Pozzetti L,Silingardi P,Grilli S,Cantelli-Forti G

更新日期：1992-08-01 00:00:00

abstract：:The metabolism of 7,12-dimethylbenz[a]anthracene (DMBA), benzo[a]pyrene (BP) and benz[a]anthracene (BA) by epithelial cell aggregates and fibroblasts in culture has been investigated using mammary tissue obtained from female Wistar rats. The results show that: (a) both types of mammary cells metabolise all three hydro...

journal_title：Carcinogenesis

authors： Cooper CS,Pal K,Hewer A,Grover PL,Sims P

更新日期：1982-01-01 00:00:00

abstract：:Previous studies have shown that 1- and 3-nitrobenzo[a]pyrene (NBaP) were mutagenic in the Salmonella reversion assay without exogenous activation and that 1-, 3- and 6-NBaP were mutagenic in the presence of hepatocytes or liver homogenate (S9). In the present study, 1-, 3- and 6-NBaP were tested for mutagenicity in C...

journal_title：Carcinogenesis

authors： Hass BS,Heflich RH,Schol HM,Chou MW,Fu PP,Casciano DA

更新日期：1986-04-01 00:00:00

abstract：:An earlier study indicated that ozone (O3), a major pollutant in our atmosphere, acts as a carcinogen as well as a synergistic co-carcinogen with radiation in cultured hamster embryo cells and in mouse C3H10T1/2 cells. In this investigation we further characterize the oncogenic action of ozone, alone or in combination...

journal_title：Carcinogenesis

authors： Borek C,Ong A,Zaider M

更新日期：1989-08-01 00:00:00

abstract：:We have investigated the activity of insoluble and soluble lead compounds in inducing mutagenesis, cell transformation and sister chromatid exchange in mammalian cells. Insoluble lead sulfide, readily phagocytized, was more than four times as toxic to V79 cells on a microM basis, than two moderately soluble lead compo...

journal_title：Carcinogenesis

authors： Zelikoff JT,Li JH,Hartwig A,Wang XW,Costa M,Rossman TG

更新日期：1988-10-01 00:00:00

abstract：:E mu-pim-1 transgenic mice, which overexpress the pim-1 oncogene in lymphoid tissues, have shown increased susceptibility to induction of T cell lymphomas by N-ethyl-N-nitrosourea, a direct-acting chemical carcinogen (Nature, 340, 61-63, 1989). We sought to further evaluate E mu-pim-1 transgenic mice as a potential te...

journal_title：Carcinogenesis

authors： Storer RD,Cartwright ME,Cook WO,Soper KA,Nichols WW

更新日期：1995-02-01 00:00:00

abstract：:To study the relationship between epidermal DNA synthesis and carcinogenesis, hairless mice of both sexes were given a single topical application of 1 mg N-methyl-N-nitrosourea (MNU) in acetone. A control group received only MNU, whereas other groups were injected i.p. with 5 mg hydroxyurea (HU), 1 h, 45 min and 15 mi...

journal_title：Carcinogenesis

authors： Iversen OH

更新日期：1982-01-01 00:00:00

abstract：:The purpose of this work was to study the relative activities and stabilities of phase-I and phase-II drug metabolizing enzymes in incubation mixtures used in vitro genotoxicity testing in order to optimize the conditions of the assay, increase sensitivity and eliminate false negative results. Cytochrome P-450, NADPH-...

journal_title：Carcinogenesis

authors： Paolini M,Tonelli F,Bauer C,Corsi C,Bronzetti G

更新日期：1987-09-01 00:00:00