The metabolism and activation of polycyclic aromatic hydrocarbons in epithelial cell aggregates and fibroblasts prepared from rat mammary tissue.

abstract：:The experiments reported in this study were designed to examine the question of whether a mammary epithelial cell's independence from hormonal requirements is established at the time of carcinogenic initiation, or whether the emergence of hormone independence is associated with the process of tumor progression. A newl...

journal_title：Carcinogenesis

authors： Thompson HJ,McGinley J,Rothhammer K,Singh M

更新日期：1998-03-01 00:00:00

abstract：:The cyclin-dependent kinase (Cdk) inhibitor p27(Kip1) (p27) is a marker of prognosis in many cancers, including breast cancer. Low p27 expression correlates with poor prognosis, especially in hormone receptor positive breast tumors. This association suggests a role for p27 in hormone-dependent cancer. We used the Wnt-...

journal_title：Carcinogenesis

authors： Glover CE,Gurley KE,Kim KH,Storer B,Fero ML,Kemp CJ

更新日期：2009-06-01 00:00:00

abstract：:The hypolipidaemic drug nafenopin (NAF) has been shown to enhance the hepatocarcinogenic effect of N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine in rats. We have investigated whether the NAF-induced peroxisome proliferation in hepatocytes interferes with NDMA's metabolism and interaction with DNA. Adult male...

journal_title：Carcinogenesis

authors： Wiestler OD,Schmerold I,Fringes B,Volk B,Kleihues P

更新日期：1985-09-01 00:00:00

abstract：:Reactive oxygen species (ROS) have been implicated in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance of many cancers. We evaluated the role of peroxiredoxin (Prx) I in TRAIL resistance governed by coupling of nicotinamide adenosine dinucleotide phosphate oxidase (Nox)-derived ROS signaling ...

journal_title：Carcinogenesis

authors： Song IS,Kim SU,Oh NS,Kim J,Yu DY,Huang SM,Kim JM,Lee DS,Kim NS

更新日期：2009-07-01 00:00:00

abstract：:The effect of changing the format of administration as well as the total dose of the promoting agent phenobarbital (PB) on the development of altered hepatic foci (AHF) was determined in an initiation-promotion protocol with female rats fed the purified AIN-76 diet. Effects on the total number of AHF and the volume pe...

journal_title：Carcinogenesis

authors： Xu YD,Dragan YP,Young T,Pitot HC

更新日期：1991-06-01 00:00:00

abstract：:We previously reported that quinacrine (QC) has anticancer activity against breast cancer cells. Here, we examine the mechanism of action of QC and its ability to inhibit Wnt-TCF signaling in two independent breast cancer cell lines. QC altered Wnt-TCF signaling components by increasing the levels of adenomatous polyp...

journal_title：Carcinogenesis

authors： Preet R,Mohapatra P,Das D,Satapathy SR,Choudhuri T,Wyatt MD,Kundu CN

更新日期：2013-02-01 00:00:00

abstract：:The nitrogen heterocycle dibenz[c,h]acridine (DB[c,h]ACR) and the enantiomers of the diastereomeric pair of bay-region 3,4-diol 1, 2-epoxides as well as other bay-region epoxides and dihydrodiol derivatives of this hydrocarbon have been evaluated for tumorigenicity on mouse skin and in the newborn mouse. On mouse skin...

journal_title：Carcinogenesis

authors： Chang RL,Wood AW,Kumar S,Lehr RE,Shirai N,Jerina DM,Conney AH

更新日期：2000-11-01 00:00:00

abstract：:Base excision repair (BER) and nucleotide excision repair (NER) pathways repair damaged DNA, and polymorphisms in these genes might affect breast cancer susceptibility. We evaluated associations between seven single-nucleotide polymorphisms in four DNA repair genes (ERCC4 rs1799801, XPC rs2227998, rs2228001, rs2228000...

journal_title：Carcinogenesis

authors： Roberts MR,Shields PG,Ambrosone CB,Nie J,Marian C,Krishnan SS,Goerlitz DS,Modali R,Seddon M,Lehman T,Amend KL,Trevisan M,Edge SB,Freudenheim JL

更新日期：2011-08-01 00:00:00

abstract：:Formation of O6-ethylguanine (O6EG) in trachea DNA was measured 12 h after acute i.p. administration of 50, 100 and 200 mg diethylnitrosamine (DEN)/kg body wt to Syrian golden hamsters. Purine bases were fractionated by h.p.l.c., and ethylated guanines were quantified optically by fluorescence spectrophotometry. Signi...

journal_title：Carcinogenesis

authors： Fong AT,Rasmussen RE

更新日期：1986-09-01 00:00:00

abstract：:The Manchester (England) Children's Tumour Registry is population-based with a high level of ascertainment. Pathologic review ensured diagnostic accuracy. Routine monitoring of annual incidence revealed a significant increase in germ cell tumours from approximately 1 per million person years to approximately 4. Analys...

journal_title：Carcinogenesis

authors： Birch JM,Marsden HB,Swindell R

更新日期：1982-01-01 00:00:00

abstract：:Soy-based products consumed in Asian countries are minimally processed whereas in the USA many of the soy foods and soy ingredients are highly processed. Soy foods contain complex mixtures of bioactive compounds, which may interact with one another. The objective of this study was to evaluate the ability of various so...

journal_title：Carcinogenesis

authors： Allred CD,Allred KF,Ju YH,Goeppinger TS,Doerge DR,Helferich WG

更新日期：2004-09-01 00:00:00

abstract：:To better understand the mechanisms of mutagenesis by the carcinogen, methylene chloride (DCM), we have determined the nature and distribution of forward mutations induced by DCM in the N-terminal region of the lacI gene of Escherichia coli. A total of 116 lacI-d mutations (50 from Uvr+, 66 from UvrB- strain) were cha...

journal_title：Carcinogenesis

authors： Zielenska M,Ahmed A,Pienkowska M,Anderson M,Glickman BW

更新日期：1993-05-01 00:00:00

abstract：:The possibility that alpha-tocopherol (vitamin E) inhibits the formation of nitrosomorpholine (NMOR) in vivo was investigated in mice orally pretreated with alpha-tocopherol (2.5-100 mg/kg body wt) once daily for 6 days. Twenty-four hours later, the animals were injected i.p. with 2 mg of morpholine (MOR) per animal f...

journal_title：Carcinogenesis

authors： Norkus EP,Kuenzig WA,Chau J,Mergens WJ,Conney AH

更新日期：1986-03-01 00:00:00

abstract：:Base excision repair pathway may play an important role in repairing DNA damage related to Helicobacter pylori-induced inflammatory process. To evaluate the association between genetic polymorphisms of X-ray repair cross-complementing group 1 (XRCC1, Arg194Trp and Arg399Gln), adenosine diphosphate ribosyl transferase ...

journal_title：Carcinogenesis

authors： Li WQ,Zhang L,Ma JL,Zhang Y,Li JY,Pan KF,You WC

更新日期：2009-03-01 00:00:00

abstract：:Previous studies had indicated that complete skin tumor promoters of the phorbol ester class induce epidermal transglutaminase and cornification in a subpopulation of cultured mouse epidermal basal cells in proportion to their promoting properties. This report describes the effect of promoting agents other than phorbo...

journal_title：Carcinogenesis

authors： Yuspa SH,Ben T,Hennings H

更新日期：1983-11-01 00:00:00

abstract：:The role of rat O6-alkylguanine-DNA alkyltransferase (AGT) in modulating mutagenesis by O6-substituted guanines in the rat H-ras gene was examined. Rat4 cells were transfected with vectors carrying O6-methyl-, O6-ethyl- or O6-benzylguanine residues in place of the normal guanines at either the first, second, or both t...

journal_title：Carcinogenesis

authors： Bishop RE,Dunn LL,Pauly GT,Dolan ME,Moschel RC

更新日期：1993-04-01 00:00:00

abstract：:The role of aflatoxin B1 (AFB1) in the induction of rearrangements affecting minisatellite sequences was studied in an in vitro yeast model. The Saccharomyces cerevisiae strain used expresses human cytochrome P450 1A2 and NADPH-cytochrome P450 oxidoreductase and has previously been used to study genetic recombination ...

journal_title：Carcinogenesis

authors： Kaplanski C,Wild CP,Sengstag C

更新日期：1998-09-01 00:00:00

abstract：:The carcinogen N-acetoxy-N-2-acetylaminofluorene reacts with dG and dG-containing nucleotides to give good yields of the C-8 adducts, but the analogous 4-aminobiphenyl derivative does not. Replacement of the N-acetoxy group by 2,6-dichlorobenzoyloxy circumvents this difficulty. This reaction is shown to be generally a...

journal_title：Carcinogenesis

authors： Underwood GR,Price MF,Shapiro R

更新日期：1988-10-01 00:00:00

abstract：:Cigarette smoking is a major cause of human cancer at a variety of sites, although its carcinogenic mechanisms remains unestablished. Cigarette smoke can be divided into two phases, gas phase and particulate matter (tar). Both phases contain high concentrations of oxidants and free radicals, especially nitric oxide (N...

journal_title：Carcinogenesis

authors： Yoshie Y,Ohshima H

更新日期：1997-07-01 00:00:00

abstract：:Sodium arsenite and sodium arsenate were observed to induce morphological transformation of Syrian hamster embryo cells in a dose-dependent manner. A linear dose-dependence with a slope of approximately 1 was observed with both compounds when the data were plotted on a log-log graph. The trivalent sodium arsenite was ...

journal_title：Carcinogenesis

authors： Lee TC,Oshimura M,Barrett JC

更新日期：1985-10-01 00:00:00

abstract：:Several purified polychlorinated biphenyl (PCB) congeners with differing toxicity/tumor promotional activities in rat liver in vivo were tested for their effects on gap-junctional intercellular communication (GJIC) in cell strains and lines derived from human liver and skin. This in vitro assay is being developed to d...

journal_title：Carcinogenesis

authors： Swierenga SH,Yamasaki H,Piccoli C,Robertson L,Bourgon L,Marceau N,Fitzgerald DJ

更新日期：1990-06-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1 (HIF-1) are important regulators of angiogenesis. HIF-1 is composed of HIF-1alpha and HIF-1beta subunits, and regulates VEGF expression at transcriptional level. In this study, we demonstrated that insulin induced H2O2 production and p70S6K1 acti...

journal_title：Carcinogenesis

authors： Zhou Q,Liu LZ,Fu B,Hu X,Shi X,Fang J,Jiang BH

更新日期：2007-01-01 00:00:00

abstract：:The incidence and mortality statistics for oral squamous cell carcinoma (OSCC) were 10th and 12th, respectively, in human cancers diagnosed worldwide in 2008. In this study, to identify novel tumor-suppressive microRNAs (TS-miRNAs) and their direct targets in OSCC, we performed methylation-based screening for 43 miRNA...

journal_title：Carcinogenesis

authors： Endo H,Muramatsu T,Furuta M,Uzawa N,Pimkhaokham A,Amagasa T,Inazawa J,Kozaki K

更新日期：2013-03-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a significant risk factor for lung cancer. One potential mechanism through which COPD contributes to lung cancer development could be through generation of an immunosuppressive microenvironment that allows tumor formation and progression. In this study, we compared the s...

journal_title：Carcinogenesis

authors： Narayanapillai SC,Han YH,Song JM,Kebede ME,Upadhyaya P,Kassie F

更新日期：2020-11-13 00:00:00

abstract：:3-Methyladenine is one of the major products formed by reaction of a large number of environmental methylating agents with DNA in vivo and in vitro. In spite of the rapid spontaneous depurination of this base an enzyme, 3-methyladenine DNA glycosylase, has been shown to catalyse its excision. The relevance of this enz...

journal_title：Carcinogenesis

authors： Craddock VM,Henderson AR

更新日期：1982-01-01 00:00:00

abstract：:Trabectedin is a marine-derived antineoplastic drug. Besides targeting the cancer cells, trabectedin has a peculiar activity on the tumor microenvironment with marked effects on the vasculature and the immune response. Because a favorable microenvironment is a key factor in the progression of cutaneous melanoma, we hy...

journal_title：Carcinogenesis

authors： Carminati L,Pinessi D,Borsotti P,Minoli L,Giavazzi R,D'Incalci M,Belotti D,Taraboletti G

更新日期：2019-04-29 00:00:00

abstract：:We measured the mutation frequency and spectrum induced by exposure of the mutation reporter plasmid pSP189 in vivo to phorbol myristate acetate (PMA)-activated human polymorphonuclear leukocytes (PMNs). The mutation frequency induced in the supF tRNA gene of pSP189 transfected into human Ad293 cells by a 30 min expos...

journal_title：Carcinogenesis

authors： Akman SA,Sander F,Garbutt K

更新日期：1996-10-01 00:00:00

abstract：:A new sensitive 32P-postlabeling assay for DNA adducts has been developed in which DNA is hydrolyzed initially by nuclease P1 and prostatic acid phosphatase instead of micrococcal nuclease and spleen phosphodiesterase as employed in previous postlabeling procedures. When DNA containing bulky adducts, X1, X2, .....Xn, ...

journal_title：Carcinogenesis

authors： Randerath K,Randerath E,Danna TF,van Golen L,Putman KL

更新日期：1989-07-01 00:00:00

abstract：:In vitro exposures of isolated DNA to one of the two carcinogenic and mutagenic chemicals, diethylsulfate or dimethylsulfate, induces several kinds of physicochemical and morphological alterations. These changes are detectable by a variety of independent techniques. A fraction of DNA treated briefly with either of the...

journal_title：Carcinogenesis

authors： Kubinski H,Kubinski ZO,Fiandt M,Konopa G

更新日期：1981-01-01 00:00:00

abstract：:To investigate the mechanistic basis for the biological properties of anthocyanins, two aglycone anthocyanins [delphinidin (DY) and cyanidin (CY)] were used to examine their effects on cell cycle progression and on induction of apoptosis in human cancer cells (uterine carcinoma and colon adenocarcinoma cells) and in n...

journal_title：Carcinogenesis

authors： Lazzè MC,Savio M,Pizzala R,Cazzalini O,Perucca P,Scovassi AI,Stivala LA,Bianchi L

更新日期：2004-08-01 00:00:00