Abstract:
:3-Methyladenine is one of the major products formed by reaction of a large number of environmental methylating agents with DNA in vivo and in vitro. In spite of the rapid spontaneous depurination of this base an enzyme, 3-methyladenine DNA glycosylase, has been shown to catalyse its excision. The relevance of this enzyme in carcinogenesis induced by alkylating agents was studied. Acute or chronic treatment of rats with diethylnitrosamine or with N-acetylaminofluorene caused a slight increase in glycosylase activity in liver. Experiments with liver regenerating after partial hepatectomy showed a similar increase to occur at the time of DNA replication. It could be that the increase found after treatment with carcinogens was related to the accompanying increase in cell replication, rather than being the result of a specific induction by the carcinogen. Glycosylase activity was found to be higher in the liver of the rabbit and cat than in rat or hamster liver. Organ differences (liver, kidney and brain of the rabbit) were smaller than the species differences found for enzyme activity in liver.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Craddock VM,Henderson ARdoi
10.1093/carcin/3.7.747subject
Has Abstractpub_date
1982-01-01 00:00:00pages
747-50issue
7eissn
0143-3334issn
1460-2180journal_volume
3pub_type
杂志文章相关文献
CARCINOGENESIS文献大全abstract::The carcinogenicity of two commonly used brown and black varieties of masheri, a pyrolysed tobacco product, was studied by feeding the masheri through the diet at a 10% level to three different animal species of both sexes. In Sprague-Dawley rats, only brown masheri was used, while in Swiss mice and Syrian golden hams...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.11.2137
更新日期:1988-11-01 00:00:00
abstract::p53-upregulated modulator of apoptosis (PUMA) plays an essential role in p53-dependent apoptosis following DNA damage. PUMA also mediates apoptosis independent of p53. In this study, we investigated the role and mechanism of PUMA induction in response to serum starvation in p53-deficient cancer cells. Following serum ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn150
更新日期:2008-10-01 00:00:00
abstract::BALB/c 3T3 A31-1-13 cells are highly susceptible to chemical-induced cell transformation and their gap-junctional intercellular communication (GJIC) is decreased when these cells become confluent. On the other hand, A31-1-1 cells do not show such a change in GJIC and are more resistant to chemical induction of transfo...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.10.1923
更新日期:1991-10-01 00:00:00
abstract::Apoptosis, a form of programmed cell death, plays a fundamental role in the maintenance of tissues and organ systems by providing a controlled cell deletion to balanced cell proliferation. The last decade has witnessed an exponential increase in the number of studies investigating how different components of the diet ...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/bgl243
更新日期:2007-02-01 00:00:00
abstract::The effects of hyperoxia on lung tumor development were examined in mice and rats. In mice, exposure to 70% O2 prevented the development of urethan- or 3-methylcholanthrene-induced lung tumors. Dietary antioxidants [butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA)] were unable to prevent the inhibitio...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/7.9.1581
更新日期:1986-09-01 00:00:00
abstract::Apurinic/apyrimidinic endonuclease/redox effector factor-1 (APE/Ref-1) is a multifunctional protein involved both in DNA base excision repair and redox regulation. Studies have suggested that abnormal Ref-1 levels and/or activities are associated with tumor progression and sensitivities to treatment, but no direct evi...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm128
更新日期:2007-11-01 00:00:00
abstract::The DNA damaging and mutagenic activities of procarbazine, a methylating drug employed in cancer chemotherapy and suspected of causing therapy-related leukaemia, were investigated in the liver and bone marrow of lambda lacZ transgenic mice (MutaMouse). The drug was administered using two different protocols, a 'high-d...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/18.11.2191
更新日期:1997-11-01 00:00:00
abstract::Occupational nitrosamine exposures from a rubber vehicle seal (VS) curing operation were compared with the peripheral blood lymphocyte concentrations of two nitrosamine-related DNA adducts, N(7)-methylguanine (N(7)mdG) and O(6)-methylguanine (O(6)mdG), and with the activity of the enzyme that repairs O(6)mdG adducts, ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/21.1.29
更新日期:2000-01-01 00:00:00
abstract::Following intraperitoneal administration of [3H] aflatoxin B1 (AFB1) to young adult male rats, there is rapid uptake of the carcinogen by the liver, the target organ for carcinogenesis, leading to DNA covalent binding. Acid hydrolysis of this DNA shows that after 2h, the major DNA adduct is trans 8,9-dihydro-8-(7-guan...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/1.9.787
更新日期:1980-09-01 00:00:00
abstract::SH3RF (SH3-domain-containing RING finger protein) family members, SH3RF1-3, are multidomain scaffold proteins involved in promoting cell survival and apoptosis. In this report, we show that SH3RF2 is an oncogene product that is overexpressed in human cancers and regulates p21-activated kinase 4 (PAK4) protein stabilit...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt338
更新日期:2014-03-01 00:00:00
abstract::The regulation of growth hormone 1 (GH1) and insulin-like-growth factor-1 (IGF-1) release is under the influence of three pituitary hormones [growth hormone releasing hormone (GHRH), ghrelin (GHRL) and somatostatin (SST)], which act in an autocrine/paracrine fashion in the breast. By binding to their respective recept...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgl036
更新日期:2006-09-01 00:00:00
abstract::Incubation of 3-[3H]fluoranthene with a rat liver microsomal activation system in the presence of calf thymus DNA resulted in radioactivity bound to the DNA. The fluoranthene-modified DNA was enzymatically digested and a DNA adduct elution profile developed using h.p.l.c. The fraction containing the major fluoranthene...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/7.6.859
更新日期:1986-06-01 00:00:00
abstract::p53 is a tumor suppressor that responds to a variety of stresses such as oncogenes and DNA damage by activating its transcriptional targets to allow repair or elimination of damaged cells. In the absence of stress signals, p53 needs to be kept in check and this is achieved by the E3 ligase MDM2. For tumors that retain...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs092
更新日期:2012-04-01 00:00:00
abstract::Male F344 rats were administered phenobarbital, polychlorinated biphenyl (PCB), retinol acetate, indomethacin, 6-amino-caproic acid, dexamethasone (DEX) or diethylmaleate (DEM) for one week and then were treated with these chemicals plus butylated hydroxyanisole (BHA) for a further four weeks. Histopathologically, the...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.10.1555
更新日期:1987-10-01 00:00:00
abstract::DL-N-acetyl-N'-nitrosotryptophan (I) and its methyl ester (II), readily formed under mild conditions by the reaction of nitrite with N-acetyltryptophan or its methyl ester, are model compounds for the study of the nitrosation of alpha-amino acid side chains, considered relevant to possible role of nitrosation of pepti...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/1.6.523
更新日期:1980-06-01 00:00:00
abstract::Overexpression of the helix-loop-helix protein Id-1 has been reported in over 20 types of cancer. While a number of factors have been demonstrated to regulate Id-1 gene transcription, little is known about the mechanisms responsible for its degradation. In this study, we have demonstrated that Id-1 protein stability w...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgi217
更新日期:2006-02-01 00:00:00
abstract::Conversion of the 2'-deoxyguanosine (dG) residues in calf thymus DNA to 8-hydroxy-2'-deoxyguanosine (8-OH-dG) was achieved at physiological pH by treating the DNA with hydrogen peroxide (H2O2) in the presence of nickel(II) chloride (NiCl2). The effectiveness of this reaction was enhanced by L-histidine (His) which for...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/13.2.283
更新日期:1992-02-01 00:00:00
abstract::Sphingadienes (SDs) derived from soy and other natural sphingolipids are cytotoxic to colon cancer cells via an Akt-dependent mechanism and reduce adenoma formation in Apc(Min/+) mice. Wnt signaling is fundamental to colon carcinogenesis and is the basis for spontaneous tumorigenesis in Apc(Min/+) mice and patients wi...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs174
更新日期:2012-09-01 00:00:00
abstract::The natural flavonoid quercetin has been suggested by epidemiological studies to have preventive activity against lung cancer; however, the mechanism of which has not been well elucidated. In this report, we demonstrate that quercetin significantly enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAI...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm133
更新日期:2007-10-01 00:00:00
abstract::Abnormalities in the expression of DMBT1 (deleted in malignant brain tumors 1) have been implicated in the development of esophageal, gastric and colorectal cancers of the alimentary tract, but the underlying mechanism remains unclear. In the present study, using the gastric cell line AGS, we identified two intracellu...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgi045
更新日期:2005-06-01 00:00:00
abstract::Effect of nicotine on PDGF AA and PDGF BB interaction with cervical cancer SiHa cells was tested. [125I]PDGF AA was internalized by cells and accumulated in the cytoplasm and nucleus (chromatin). In the absence of nicotine, maximal accumulation of [125I]PDGF AA inside the cells occurred after 1 day of incubation, whic...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/17.9.1813
更新日期:1996-09-01 00:00:00
abstract::To investigate the mechanistic basis for the biological properties of anthocyanins, two aglycone anthocyanins [delphinidin (DY) and cyanidin (CY)] were used to examine their effects on cell cycle progression and on induction of apoptosis in human cancer cells (uterine carcinoma and colon adenocarcinoma cells) and in n...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh138
更新日期:2004-08-01 00:00:00
abstract::Cyclin D1 is one of the major enhancers of cell cycle progression and its expression is regulated in several growth stimulatory signaling pathways. ARA54 is an androgen receptor (AR) co-activator that enhances AR-dependent transcriptional activation. Although expression of ARA54 mRNA is observed in a variety of human ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm120
更新日期:2007-08-01 00:00:00
abstract::The G protein-coupled formylpeptide receptor (FPR), known to mediate phagocytic leucocyte chemotaxis in response to bacterial- and host-derived agonists, was expressed by tumor cells in specimens of surgically removed more highly malignant human gliomas. In human glioblastoma cell lines, FPR activation increased cell ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn266
更新日期:2009-02-01 00:00:00
abstract::Two new mouse epidermal cell lines have been isolated and characterized as target cells for three chemical carcinogens. The ability to grow these cells at low density (approximately 5 clonogenic cells/cm2) has permitted more precise quantitation of chemical carcinogen-induced changes in epidermal differentiation. The ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/6.9.1245
更新日期:1985-09-01 00:00:00
abstract::To better understand drug and carcinogen metabolism pathways in head and neck squamous cell carcinoma we assayed the principal drug- and carcinogen-metabolizing enzyme systems in both tumors and their corresponding adjacent non-tumoral tissues. Cytochromes P450 (1A1/A2, 2B1/B2, 2C8-10, 2E1, 3A4), epoxide hydrolase and...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/14.7.1279
更新日期:1993-07-01 00:00:00
abstract::Reflux of gastroduodenal contents and consequent inflammatory responses are associated with the development of Barrett's oesophagus (BO) and the promotion of oesophageal adenocarcinoma (OAC). Deregulation of inflammatory processes is a hallmark of oesophageal cancer. In this study, we aimed to investigate (i) the tran...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq036
更新日期:2010-05-01 00:00:00
abstract::Both dehydroepiandrosterone (DHEA) and the synthetic steroid 16 alpha-Br-epiandrosterone (Br-Epi), a more potent inhibitor of glucose-6-phosphate dehydrogenase (G6PDH) than DHEA, inhibit the 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation of superoxide anion (O2-) formation by human neutrophils. DHEA has previo...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/6.3.333
更新日期:1985-03-01 00:00:00
abstract::Estrogens are major risk factors for the development of breast cancer; they can be metabolized to catechols, which are further oxidized to DNA-reactive quinones and semiquinones (SQs). These metabolites are mutagenic and may contribute to the carcinogenic activity of estrogens. Redox cycling of the SQs and subsequent ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr109
更新日期:2011-08-01 00:00:00
abstract::Multicellular tumor spheroids (MCTSs) constitute a three-dimensional culture system that recapitulates the in vivo tumor microenvironment. Tumor cells cultured as MCTSs present antineoplastic resistance due to the effect of microenvironmental signals acting upon them. In this work, we evaluated the biological function...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgaa078
更新日期:2020-11-13 00:00:00