The role of O6-alkylguanine-DNA alkyltransferase in protecting Rat4 cells against the mutagenic effects of O6-substituted guanine residues incorporated in codon 12 of the H-ras gene.

abstract：:Preparations of dietary fibre have an ability to bind potentially toxic compounds in vitro, but it is unclear how the measured binding properties are a reflection of either the relative affinity of such compounds for fibre or the saturation binding capacity of the fibre. Cooking and processing of foods and fermentatio...

journal_title：Carcinogenesis

authors： Ryden P,Robertson JA

更新日期：1995-02-01 00:00:00

abstract：:The dorsal skins of 6-8 week old female SENCAR mice were initiated with a single application of 10 nmol of 7,12-dimethylbenz[a]anthracene (DMBA) and subsequently promoted twice/week with topical applications of vitamin E (dl-alpha-tocopherol, 80 mumol/treatment). Vitamin E from two separate commercial suppliers was te...

journal_title：Carcinogenesis

authors： Mitchel RE,McCann R

更新日期：1993-04-01 00:00:00

abstract：:Crude plasma membranes were prepared from the liver of control rats or of rats submitted to an initiation by diethyl-nitrosamine and selection with 2-acetylaminofluorene and carbon tetrachloride (group IS) or of rats submitted to an initiation-selection protocol followed by a promotion with phenobarbital (group IS PB)...

journal_title：Carcinogenesis

authors： Marino A,Ravelingien N,De Cannière D,Préat V,Dehaye JP,Pector JC

更新日期：1991-04-01 00:00:00

abstract：:7-Hydroxymethylbenz[a]anthracene (7-HBA) showed potent mutagenicity towards Salmonella typhimurium TA 98 in the presence of untreated rat liver cytosol fortified with the PAPS-generating system, sodium sulphate and ATP. No mutagenic activity was observed either when the cytosol was boiled or when sodium sulphate or AT...

journal_title：Carcinogenesis

authors： Watabe T,Hakamata Y,Hiratsuka A,Ogura K

更新日期：1986-02-01 00:00:00

abstract：:The Bowman-Birk protease inhibitor (BBI) is a legume-derived inhibitor of chymotrypsin and trypsin that has been shown to suppress cellular transformation and tumorigenesis. In the present investigation the effects of various BBI administration schedules were evaluated for suppression of 3-methylcholanthrene (3-MCA)-i...

journal_title：Carcinogenesis

authors： St Clair WH

更新日期：1991-05-01 00:00:00

abstract：:A growing number of studies indicate a link between oxidative stress and cancer. We previously developed a rat model of renal cell carcinoma (RCC) induced by ferric nitrilotriacetate (Fe-NTA). Here, we performed a genome-wide analysis to study characteristics of genomic alteration and identify putative genes involved ...

journal_title：Carcinogenesis

authors： Zhong Y,Onuki J,Yamasaki T,Ogawa O,Akatsuka S,Toyokuni S

更新日期：2009-01-01 00:00:00

abstract：:The incidence of esophageal adenocarcinoma (EA) has been increasing rapidly, particularly among white males, over the past few decades in the USA. However, the etiology of EA and the striking male predominance is not fully explained by known risk factors. To identify susceptible genes for EA risk, we conducted a pathw...

journal_title：Carcinogenesis

authors： Liu CY,Wu MC,Chen F,Ter-Minassian M,Asomaning K,Zhai R,Wang Z,Su L,Heist RS,Kulke MH,Lin X,Liu G,Christiani DC

更新日期：2010-07-01 00:00:00

abstract：:Herbacetin is a flavonol compound that is found in plants such as flaxseed and ramose scouring rush herb, it possesses a strong antioxidant capacity, and exerts anticancer effects on colon and breast cancer. However, the effect of herbacetin on skin cancer has not been investigated. Herein, we identified herbacetin as...

journal_title：Carcinogenesis

authors： Kim DJ,Lee MH,Liu K,Lim DY,Roh E,Chen H,Kim SH,Shim JH,Kim MO,Li W,Ma F,Fredimoses M,Bode AM,Dong Z

更新日期：2017-10-26 00:00:00

abstract：:Constituents in food and fluids, tobacco chemicals and many drugs are candidates for oral absorption and oxidative metabolism. On this basis, the expression of cytochrome P450 isozymes (CYPs) and the conversion of CYP substrates were analysed in reference to buccal mucosa. A RT-PCR based analysis of human buccal tissu...

journal_title：Carcinogenesis

authors： Vondracek M,Xi Z,Larsson P,Baker V,Mace K,Pfeifer A,Tjälve H,Donato MT,Gomez-Lechon MJ,Grafström RC

更新日期：2001-03-01 00:00:00

abstract：:To explore the potential role for estrogen in lung cancer susceptibility, candidate single-nucleotide polymorphism (SNPs) in tobacco and estrogen metabolism genes were evaluated. Population-based cases (n = 504) included women aged 18-74, diagnosed with NSCLC in metropolitan Detroit between November 2001 and October 2...

journal_title：Carcinogenesis

authors： Cote ML,Yoo W,Wenzlaff AS,Prysak GM,Santer SK,Claeys GB,Van Dyke AL,Land SJ,Schwartz AG

更新日期：2009-04-01 00:00:00

abstract：:The methylation status of the rat gamma-glutamyl transpeptidase (GGT) gene was investigated during liver development and hepatocarcinogenesis. The analysis with the restriction enzymes MspI/HpaII revealed that, during ontogeny, there is a progressive methylation of the GGT gene that coincides with a progressive decrea...

journal_title：Carcinogenesis

authors： Baik JH,Griffiths S,Giuili G,Manson M,Siegrist S,Guellaen G

更新日期：1991-06-01 00:00:00

abstract：:For a group of nine hydrocarbon and halogenated hydrocarbon epoxides, there is shown to be a good correlation between their abilities to inhibit epoxide hydrase and the quantity Vmin /Es, where Vmin is the most negative value of the molecule's electrostatic potential in the neighborhood of the epoxide oxygen and Es is...

journal_title：Carcinogenesis

authors： Politzer P,Laurence PR

更新日期：1984-06-01 00:00:00

abstract：:Women who carry the BRCA mutation are at high lifetime risk of breast cancer, but there is no consensus regarding an effective and safe chemoprevention strategy. A large body of evidence suggests that 3,3-diindolylmethane (DIM), a dimer of indole-3-carbinol found in cruciferous vegetables, can potentially prevent carc...

journal_title：Carcinogenesis

authors： Yerushalmi R,Bargil S,Ber Y,Ozlavo R,Sivan T,Rapson Y,Pomerantz A,Tsoref D,Sharon E,Caspi O,Grubsrein A,Margel D

更新日期：2020-10-15 00:00:00

abstract：:Abnormalities in the expression of DMBT1 (deleted in malignant brain tumors 1) have been implicated in the development of esophageal, gastric and colorectal cancers of the alimentary tract, but the underlying mechanism remains unclear. In the present study, using the gastric cell line AGS, we identified two intracellu...

journal_title：Carcinogenesis

authors： Kang W,Nielsen O,Fenger C,Leslie G,Holmskov U,Reid KB

更新日期：2005-06-01 00:00:00

abstract：:The addition of supplementary cytosolic fraction greatly enhances the activation of 2-acetylaminofluorene (AAF) by uninduced 9,000 x g supernatant fractions (S9) in the Ames test. Uninduced S9 is poor at activating AAF in the Ames test (although it is effective in the liquid based fluctuation test) probably because cy...

journal_title：Carcinogenesis

authors： Forster R,Green MH,Priestley A

更新日期：1981-01-01 00:00:00

abstract：:Mouse ovarian surface epithelial cells (MOSEC) were obtained from virgin, mature mice by mild trypsinization and were repeatedly passaged in vitro. Early passage cells (<20 passages) exhibited a cobblestone morphology and contact inhibition of growth. After approximately 20 passages in vitro, cobblestone morphology an...

journal_title：Carcinogenesis

authors： Roby KF,Taylor CC,Sweetwood JP,Cheng Y,Pace JL,Tawfik O,Persons DL,Smith PG,Terranova PF

更新日期：2000-04-01 00:00:00

abstract：:Polyphenols have shown promising bioactivity in experimental in vitro and in vivo models for cancer chemoprevention. However, consumed orally, they are often transformed by gut microbes into new active principles with so far incompletely deciphered molecular mechanisms. Here, enterolacton, S-equol and urolithin A as r...

journal_title：Carcinogenesis

authors： Norden E,Heiss EH

更新日期：2019-03-12 00:00:00

abstract：:Oxidized DNA base lesions, such as thymine glycol (Tg) and 8-hydroxyguanine, are often toxic and mutagenic and have been implicated in carcinogenesis. To clarify whether NEIL1 protein, which exhibits excision repair activity towards such base lesions, is involved in gastric carcinogenesis, we examined 71 primary gastr...

journal_title：Carcinogenesis

authors： Shinmura K,Tao H,Goto M,Igarashi H,Taniguchi T,Maekawa M,Takezaki T,Sugimura H

更新日期：2004-12-01 00:00:00

abstract：:The genotoxic effects of intragastrically administered benzo[a]pyrene (BaP) were studied in isolated rat liver and intestinal cells. We found that BaP was unable to induce unscheduled DNA synthesis in rat parenchymal liver cells in vivo. In contrast, alkaline elution showed that at 5 h after administration of BaP a co...

journal_title：Carcinogenesis

authors： Mullaart E,Buytenhek M,Brouwer A,Lohman PH,Vijg J

更新日期：1989-02-01 00:00:00

abstract：:Inflammatory tumor microenvironments play pivotal roles in the development of cancer. Inflammatory cytokines such as CXCL1/GROα exert cancer-promoting activities by increasing tumor angiogenesis. However, whether CXCL1/GROα also plays a role in the progression of prostate cancer, particularly in highly invasive castra...

journal_title：Carcinogenesis

authors： Kuo PL,Shen KH,Hung SH,Hsu YL

更新日期：2012-12-01 00:00:00

abstract：:Hepatocyte growth factor (HGF)-stimulated Met signaling influences tumor survival, growth and progression, all processes involving the transcription factor NF-kappaB. NF-kappaB plays a complex role in the control of survival due to the influence of cellular factors acting downstream. We undertook a comparative investi...

journal_title：Carcinogenesis

authors： Tacchini L,De Ponti C,Matteucci E,Follis R,Desiderio MA

更新日期：2004-11-01 00:00:00

abstract：:Comparative in vitro metabolic experiments with 7,8-benzoflavone using microsomes prepared from the livers of control Sprague-Dawley rats or from rats of the same strain treated with phenobarbitone, 3-methylcholanthrene, or Aroclor 1254 (known inducers of hepatic cytochrome P450 mixed function oxidases) disclose varia...

journal_title：Carcinogenesis

authors： Coombs MM

更新日期：1982-01-01 00:00:00

abstract：:The O6-alkylguanine-DNA alkyltransferase (ATase) is known to overcome the effects of promutagenic, precarcinogenic O6-alkylguanine induced in DNA by exposure to environmental, chemotherapeutic and dietary alkylating agents. Within an organ, the cell type-specific responses to these agents may be attributed, in part, t...

journal_title：Carcinogenesis

authors： Wani G,Wani AA,D'Ambrosio SM

更新日期：1993-04-01 00:00:00

abstract：:Human Papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma (HPV+OPSCC) is increasing in prevalence in the United States, as are cases of patients with multiple HPV+OPSCCs (mHPV+OPSCC). mHPV+OPSCCs present a unique opportunity to examine HPV+OPSCC mutation acquisition and evolution. We performed sequenci...

journal_title：Carcinogenesis

authors： Faden DL,Langenbucher A,Kuhs K,Lewis JS,Mirabello L,Yeager M,Boland JF,Bass S,Steinberg M,Cullen M,Lawrence MS,Ferris RL

更新日期：2020-10-19 00:00:00

abstract：:We examined the genotypes of two polymorphic genes involved in the detoxification of several mutagenic and carcinogenic compounds in relation to tobacco smoking-associated urinary mutagenicity. The genes studied were the glutathione S-transferase-encoding GSTM1 gene and acetyltransferase-encoding NAT2 gene. Smokers wi...

journal_title：Carcinogenesis

authors： Hirvonen A,Nylund L,Kociba P,Husgafvel-Pursiainen K,Vainio H

更新日期：1994-05-01 00:00:00

abstract：:The effects of five non-mutagenic carcinogens--Aroclor 1260, benzoyl peroxide (BP), phenobarbital (PB), 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and 1,1'-(2,2,2-trichloroethylidene)bis[4-chlorobenzene] (DDT)--on gap junctional intercellular communication (GJIC) were tested in a cell line consisting of initiated cel...

journal_title：Carcinogenesis

authors： Jansen LA,Jongen WM

更新日期：1996-02-01 00:00:00

abstract：:People are constantly being exposed to toxic and carcinogenic aldehydes. However, little is actually known about the mechanisms underlying the toxic and carcinogenic effects of these aldehydes on human cells. The DNA alkylating activities of two of the more toxic and environmentally prominent alpha,beta-unsaturated al...

journal_title：Carcinogenesis

authors： Wilson VL,Foiles PG,Chung FL,Povey AC,Frank AA,Harris CC

更新日期：1991-08-01 00:00:00

abstract：:Hypoxia-inducible factors (HIFs), in particular HIF-1alpha, have been implicated in tumor biology. However, HIF target genes in the esophageal tumor microenvironment remain elusive. Gene expression profiling was performed upon hypoxia-exposed non-transformed immortalized human esophageal epithelial cells, EPC2-hTERT, ...

journal_title：Carcinogenesis

authors： Lee JJ,Natsuizaka M,Ohashi S,Wong GS,Takaoka M,Michaylira CZ,Budo D,Tobias JW,Kanai M,Shirakawa Y,Naomoto Y,Klein-Szanto AJ,Haase VH,Nakagawa H

更新日期：2010-03-01 00:00:00

abstract：:Patients with inflammatory bowel diseases are at increased risk for colorectal cancer. Pharmacological inhibition of cyclooxygenase (COX) function exacerbates symptoms in colitis patients. Animal models of colitis using Cox-2-knockout mice and COX inhibitors also indicate that COX-2 has a protective role against colon...

journal_title：Carcinogenesis

authors： Ishikawa TO,Oshima M,Herschman HR

更新日期：2011-03-01 00:00:00

abstract：:Oral squamous cell carcinoma (SCC) is among the most prevalent cancers in the world and is characterized by high morbidity and few therapeutic options. Like most cancers, oral SCC arises from a multistep process involving alterations of genes responsible for balancing proliferation and differentiation. Among these, Kr...

journal_title：Carcinogenesis

authors： Abrigo M,Alvarez R,Paparella ML,Calb DE,Bal de Kier Joffe E,Gutkind JS,Raimondi AR

更新日期：2014-03-01 00:00:00