Induction of DMBT1 expression by reduced ERK activity during a gastric mucosa differentiation-like process and its association with human gastric cancer.

abstract：:Alterations in the Rb pathway have been described in many different tumors. In order to study this cell cycle regulatory mechanism in murine T cell lymphomas, we have analyzed the RNA and protein expression of the cyclin D1, cdk4 and retinoblastoma genes in primary tumor samples. We have detected overexpression of the...

journal_title：Carcinogenesis

authors： Pérez de Castro IP,Malumbres M,Santos J,Pellicer A,Fernández-Piqueras J

更新日期：1999-09-01 00:00:00

abstract：:Genotoxic carcinogens, including 2-acetylaminofluorene (2-AAF), in addition to exerting their genotoxic effects, often cause a variety of non-genotoxic alterations in cells. It is believed that these non-genotoxic effects may be indispensable events in tumorigenesis; however, there is insufficient knowledge to clarify...

journal_title：Carcinogenesis

authors： Bagnyukova TV,Tryndyak VP,Montgomery B,Churchwell MI,Karpf AR,James SR,Muskhelishvili L,Beland FA,Pogribny IP

更新日期：2008-03-01 00:00:00

abstract：:A mismatch between metabolic demand and oxygen delivery leads to microenvironmental changes in solid tumors. The resulting tumor hypoxia is associated with malignant progression, therapy resistance and poor prognosis. However, the molecular mechanisms underlying therapy resistance in hypoxic tumors are not fully under...

journal_title：Carcinogenesis

authors： Wirthner R,Wrann S,Balamurugan K,Wenger RH,Stiehl DP

更新日期：2008-12-01 00:00:00

abstract：:N-Acetoxyarylamines are reactive metabolites that lead to arylamine adduct formation with biological macromolecules. A series of 7-substituted-N-hydroxy-2-acetylaminofluorenes were converted to reactive N-acetoxyarylamines by enzymatic N,O-acyltransfer in the presence of DNA. The N-arylhydroxamic acid substrates that ...

journal_title：Carcinogenesis

authors： Boteju LW,Hanna PE

更新日期：1993-08-01 00:00:00

abstract：:Tumor suppression by insulin-like growth factor-binding protein-3 (IGFBP-3) has been demonstrated to occur via insulin-like growth factor-dependent and -independent mechanisms in vitro and in vivo. We have recently described IGFBP-3-induced mitochondrial translocation of the nuclear receptors RXRalpha/Nur77 in the ind...

journal_title：Carcinogenesis

authors： Lee KW,Cobb LJ,Paharkova-Vatchkova V,Liu B,Milbrandt J,Cohen P

更新日期：2007-08-01 00:00:00

abstract：:In this case-control study with 387 White esophageal patients and 462 White controls matched to cases by age and sex, we evaluated the associations between 13 potential functional polymorphisms in eight major nucleotide excision repair (NER) genes and esophageal cancer risk. In individual single nucleotide polymorphis...

journal_title：Carcinogenesis

authors： Pan J,Lin J,Izzo JG,Liu Y,Xing J,Huang M,Ajani JA,Wu X

更新日期：2009-05-01 00:00:00

abstract：:Our previous report demonstrated that RSK2 plays an important role in cell proliferation and transformation induced by tumor promoters such as epidermal growth factor mediated through the N-terminal kinase domain of RSK2 in JB6 Cl41 mouse skin epidermal cells in vitro. However, no direct evidence has been reported reg...

journal_title：Carcinogenesis

authors： Cho YY,Lee MH,Lee CJ,Yao K,Lee HS,Bode AM,Dong Z

更新日期：2012-12-01 00:00:00

abstract：:Colorectal cancer (CRC) is the fourth leading cause of cancer mortality worldwide. Genome-wide association studies (GWAS) identified more than 50 CRC loci. However, most of the previous studies were conducted in European population, and host genetic factors among Japanese population are largely remained to be identifi...

journal_title：Carcinogenesis

authors： Tanikawa C,Kamatani Y,Takahashi A,Momozawa Y,Leveque K,Nagayama S,Mimori K,Mori M,Ishii H,Inazawa J,Yasuda J,Tsuboi A,Shimizu A,Sasaki M,Yamaji T,Sawada N,Iwasaki M,Tsugane S,Naito M,Wakai K,Koyama T,Takezaki T

更新日期：2018-05-03 00:00:00

abstract：:The influence of the enzymatic inducer beta-naphthoflavone (BNF) and of the inhibitors alpha-naphthoflavone (ANF) and 2-diethylaminoethyl-2,2-diphenylvalerate HCl (SKF 525-A) on the frequency of sister chromatid exchanges (SCE) induced by cyclophosphamide (CPA) was studied in vivo in C57BL/6J male mice. Neither induce...

journal_title：Carcinogenesis

authors： Dragani TA,Sozzi G,Della Porta G

更新日期：1983-01-01 00:00:00

abstract：:2-methoxyestradiol (2-MeOE(2)) is an endogenous metabolite of 17beta-estradiol and a proposed inhibitor of tumor growth and angiogenesis. However, 2-MeOE(2) is also an inhibitor of microtubule assembly and other microtubule inhibitors, e.g. colcemid and diethylstilbestrol, induce aneuploidy and cell transformation in ...

journal_title：Carcinogenesis

authors： Tsutsui T,Tamura Y,Hagiwara M,Miyachi T,Hikiba H,Kubo C,Barrett JC

更新日期：2000-04-01 00:00:00

abstract：:Liver DNA, obtained at various time intervals from rats chronically fed a choline-devoid diet, was analysed for the presence of aromatic or alkyl adducts by the 32P-postlabeling assay. Alkyl adducts were not detected. Aromatic DNA adduct lesions were revealed, but only at levels (1 adduct per 0.5-3 X 10(9) nucleotides...

journal_title：Carcinogenesis

authors： Gupta RC,Earley K,Locker J,Lombardi B

更新日期：1987-01-01 00:00:00

abstract：:Primary hepatocyte cultures from six human donors were established and their abilities to metabolize the polycyclic aromatic hydrocarbon carcinogen benzo[a]pyrene (B[a]P) were examined. Cells from each donor were plated at similar densities (1 X 10(7) cells/100 mm dish). All cultures metabolized B[a]P to a significant...

journal_title：Carcinogenesis

authors： Moore CJ,Gould MN

更新日期：1984-12-01 00:00:00

abstract：:Mouse ovarian surface epithelial cells (MOSEC) were obtained from virgin, mature mice by mild trypsinization and were repeatedly passaged in vitro. Early passage cells (<20 passages) exhibited a cobblestone morphology and contact inhibition of growth. After approximately 20 passages in vitro, cobblestone morphology an...

journal_title：Carcinogenesis

authors： Roby KF,Taylor CC,Sweetwood JP,Cheng Y,Pace JL,Tawfik O,Persons DL,Smith PG,Terranova PF

更新日期：2000-04-01 00:00:00

abstract：:In light of clinical and biological evidence that bile constituents exert preventive effects against colorectal cancer, we evaluated the influence of oral bilirubin and sodium taurocholate (NaTC) on intestinal tumor formation in APC(Min/+) mice. Mice received bilirubin and/or bovine serum albumin (BSA) and NaTC in the...

journal_title：Carcinogenesis

authors： Smith DL,Keshavan P,Avissar U,Ahmed K,Zucker SD

更新日期：2010-06-01 00:00:00

abstract：:Results of previous serologic studies on the association of human papillomavirus (HPV) with esophageal squamous cell carcinoma (ESCC) have been inconsistent. From 2007 to 2010, the authors collected blood samples and relevant demographic data from 1435 patients with ESCC and 2071 age- and sex-matched normal controls f...

journal_title：Carcinogenesis

authors： He Z,Xu Z,Hang D,Guo F,Abliz A,Weiss NS,Xi L,Liu F,Ning T,Pan Y,Guo C,Liang Y,Lu C,Zhang L,Cai H,Ke Y

更新日期：2014-04-01 00:00:00

abstract：:The metabolic activation of the heterocyclic food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) by two human cytochrome P450 monoxygenases (P4501A1 and P4501A2) and two human N-acetyltransferases (NAT1 and NAT2) was investigated. Various combinations of these enzymes were functionally expressed in COS-1 cell...

journal_title：Carcinogenesis

authors： Probst MR,Blum M,Fasshauer I,D'Orazio D,Meyer UA,Wild D

更新日期：1992-10-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is an important process implicated in tumor invasion and metastasis. Twist1 is a transcription factor that induces EMT, including E-cadherin suppression and cancer cell migration and invasion; hence it promotes cancer metastasis. Twist1 directly or indirectly regulates the expre...

journal_title：Carcinogenesis

authors： Nam EH,Lee Y,Moon B,Lee JW,Kim S

更新日期：2015-03-01 00:00:00

abstract：:We have investigated the activity of insoluble and soluble lead compounds in inducing mutagenesis, cell transformation and sister chromatid exchange in mammalian cells. Insoluble lead sulfide, readily phagocytized, was more than four times as toxic to V79 cells on a microM basis, than two moderately soluble lead compo...

journal_title：Carcinogenesis

authors： Zelikoff JT,Li JH,Hartwig A,Wang XW,Costa M,Rossman TG

更新日期：1988-10-01 00:00:00

abstract：:Low-carbohydrate diets have become a popular approach for weight loss in recent years. However, whether low-carbohydrate diets are associated with the risk of pancreatic cancer remains to be elucidated. Hence, we examined the association of low-carbohydrate diets with the risk of pancreatic cancer in a US population. ...

journal_title：Carcinogenesis

authors： Zhong GC,Li QJ,Yang PF,Wang YB,Hao FB,Wang K,Hu JJ,Wu JJ

更新日期：2021-01-22 00:00:00

abstract：:It is estimated that one-third of Americans use dietary herbal supplements on a regular basis. Diets rich in bioactive phytochemicals are associated with reduced risk of certain cancers, notably, colon cancer. Herbal supplements have not been directly tested as sources of bioactive cancer preventives. Hence, this stud...

journal_title：Carcinogenesis

authors： Volate SR,Davenport DM,Muga SJ,Wargovich MJ

更新日期：2005-08-01 00:00:00

abstract：:In Thailand, smoking of commercial cigarettes and of handmade cigarettes has drastically increased in recent decades. Cancer of the lung and of the upper aero-digestive tract have also increased in Thailand as they have in many other countries. It is our working hypothesis that the increase of primary cancer of the li...

journal_title：Carcinogenesis

authors： Mitacek EJ,Brunnemann KD,Hoffmann D,Limsila T,Suttajit M,Martin N,Caplan LS

更新日期：1999-01-01 00:00:00

abstract：:The syn- and anti-isomers of 1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydro-6-methylchrysene (6-MeC-1,2-diol-3,4-epoxide) were synthesized and their mutagenic activities in Salmonella typhimurium were compared with those of the syn- and anti-isomers of 1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydro-5-methylchrysene (5-MeC-1,2...

journal_title：Carcinogenesis

authors： Amin S,Huie K,Hecht SS,Harvey RG

更新日期：1986-12-01 00:00:00

abstract：:Previous results in a number of laboratories have demonstrated that epidermal papillomas and carcinomas induced by the two-stage protocol of initiation and promotion contain a point mutation in the 61st codon of the c-Ha-ras oncogene when the initiating agent used is 7,12-dimethylbenz[a]anthracene (DMBA). In the prese...

journal_title：Carcinogenesis

authors： Pelling JC,Neades R,Strawhecker J

更新日期：1988-04-01 00:00:00

abstract：:Animal studies demonstrated that females are more susceptible than males to benzo[a]pyrene (BaP)-induced toxicities, including lung carcinogenesis. Elevation of cyclooxygenase-2 (COX-2) expression has been shown to increase the risk of cancer development. BaP induces COX-2 expression, and an interaction between BaP an...

journal_title：Carcinogenesis

authors： Chang LW,Chang YC,Ho CC,Tsai MH,Lin P

更新日期：2007-07-01 00:00:00

abstract：:The O6-alkylguanine-DNA alkyltransferase (ATase) is known to overcome the effects of promutagenic, precarcinogenic O6-alkylguanine induced in DNA by exposure to environmental, chemotherapeutic and dietary alkylating agents. Within an organ, the cell type-specific responses to these agents may be attributed, in part, t...

journal_title：Carcinogenesis

authors： Wani G,Wani AA,D'Ambrosio SM

更新日期：1993-04-01 00:00:00

abstract：:The objectives of this study were to isolate several rat liver epithelial cell clones containing the human bcl-2 and myc/bcl-2 genes in order to study their potential cooperative effect on neoplastic transformation and gap junction-mediated intercellular communication (GJIC) and to test the hypothesis that the loss of...

journal_title：Carcinogenesis

authors： DeoCampo ND,Wilson MR,Trosko JE

更新日期：2000-08-01 00:00:00

abstract：:Prior work has demonstrated that food restriction of mice markedly suppresses 12-O-tetradecanoylphorbol-13-acetate (TPA) promotion of skin papillomas and adrenalectomy prior to initiating food restriction completely reverses the tumor inhibitory effect of underfeeding. In the present experiment the effect of food rest...

journal_title：Carcinogenesis

authors： Pashko LL,Schwartz AG

更新日期：1996-02-01 00:00:00

abstract：:Genomic alterations affecting components of the mechanistic target of rapamycin (mTOR) pathway are found rather frequently in cancers, suggesting that aberrant pathway activity is implicated in oncogenesis of different tumor types. mTOR functions as the core catalytic kinase of two distinct complexes, mTOR complex 1 (...

journal_title：Carcinogenesis

authors： Gkountakos A,Pilotto S,Mafficini A,Vicentini C,Simbolo M,Milella M,Tortora G,Scarpa A,Bria E,Corbo V

更新日期：2018-07-30 00:00:00

abstract：:Elevated Bcl-xL expression in cancer cells contributes to doxorubicin (DOX) resistance, leading to failure in chemotherapy. In addition, the clinical use of high-dose doxorubicin (DOX) in cancer therapy has been limited by issues with cardiotoxicity and hepatotoxicity. Here, we show that co-treatment with pyrrolidine ...

journal_title：Carcinogenesis

authors： Park SS,Lee DM,Lim JH,Lee D,Park SJ,Kim HM,Sohn S,Yoon G,Eom YW,Jeong SY,Choi EK,Choi KS

更新日期：2018-03-08 00:00:00

abstract：:Tea polyphenolic constituents induce apoptosis in cancer cells but not in normal cells. To study the mechanism of this selective effect, we used the ornithine decarboxylase (ODC)/Ras double transgenic mouse model that develops spontaneous skin tumors due to over-expression of ODC and a v-Ha-ras transgene. Administrati...

journal_title：Carcinogenesis

authors： Paul B,Hayes CS,Kim A,Athar M,Gilmour SK

更新日期：2005-01-01 00:00:00