Epidermal papillomas and carcinomas induced in uninitiated mouse skin by tumor promoters alone contain a point mutation in the 61st codon of the Ha-ras oncogene.

abstract：:2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a mutagenic and carcinogenic heterocyclic amine formed during ordinary cooking. PhIP is metabolically activated to the ultimate mutagenic metabolite by CYP P450-mediated N-hydroxylation followed by phase II esterification. Incubation of N-hydroxy-PhIP (N-OH-PhI...

journal_title：Carcinogenesis

authors： Frandsen H,Alexander J

更新日期：2000-06-01 00:00:00

abstract：:Prepubertal exposure to soy or its biologically active component genistein reduces later breast cancer risk in both animal models and human populations. We investigated whether that might be due to reported estrogenic properties of genistein. Our study indicated that daily prepubertal exposures between postnatal days ...

journal_title：Carcinogenesis

authors： Cabanes A,Wang M,Olivo S,DeAssis S,Gustafsson JA,Khan G,Hilakivi-Clarke L

更新日期：2004-05-01 00:00:00

abstract：:Sweet potato (Ipomoea batatas) leaves or greens, extensively consumed as a vegetable in Africa and Asia, are an excellent source of dietary polyphenols such as anthocyanins and phenolic acids. Here, we show that sweet potato greens extract (SPGE) has the maximum polyphenol content compared with several commercial vege...

journal_title：Carcinogenesis

authors： Karna P,Gundala SR,Gupta MV,Shamsi SA,Pace RD,Yates C,Narayan S,Aneja R

更新日期：2011-12-01 00:00:00

abstract：:Retinoids have been shown to exert an anticarcinogenic effect through suppression of the cell cycle, induction of apoptosis and/or differentiation. In rat liver, in particular, retinoic acid has been shown to inhibit regeneration after partial hepatectomy, most probably through repression of the expression of c-fos an...

journal_title：Carcinogenesis

authors： Ledda-Columbano GM,Pibiri M,Molotzu F,Cossu C,Sanna L,Simbula G,Perra A,Columbano A

更新日期：2004-11-01 00:00:00

abstract：:It is widely believed that abnormal production of polypeptide growth factors, together with other molecular alterations, play an important role in neoplastic development. Transforming growth factor alpha (TGFalpha), hepatocyte growth factor (HGF) and acidic fibroblast growth factor (aFGF) are the three major growth fa...

journal_title：Carcinogenesis

authors： Hu Z,Evarts RP,Fujio K,Omori N,Omori M,Marsden ER,Thorgeirsson SS

更新日期：1996-05-01 00:00:00

abstract：:Aminoacyl-transfer ribonucleic acid (tRNA) synthetases-interacting multifunctional protein (AIMP) 2 is a factor associated with the macromolecular protein synthesis machinery consisting of nine different aminoacyl-tRNA synthetases and three non-enzymatic factors. However, it was shown to work as a multifaceted regulat...

journal_title：Carcinogenesis

authors： Choi JW,Um JY,Kundu JK,Surh YJ,Kim S

更新日期：2009-09-01 00:00:00

abstract：:Genetic risk factors for sporadic neuroendocrine tumors (NET) are poorly understood. We tested risk associations in patients with sporadic NET and non-cancer controls, using a custom array containing 1536 single-nucleotide polymorphisms (SNPs) in 355 candidate genes. We identified 18 SNPs associated with NET risk at a...

journal_title：Carcinogenesis

authors： Ter-Minassian M,Wang Z,Asomaning K,Wu MC,Liu CY,Paulus JK,Liu G,Bradbury PA,Zhai R,Su L,Frauenhoffer CS,Hooshmand SM,De Vivo I,Lin X,Christiani DC,Kulke MH

更新日期：2011-08-01 00:00:00

abstract：:Although Epstein-Barr virus (EBV) infection is widely distributed, certain EBV-driven malignancies are geographically restricted. EBV-associated Burkitt's lymphoma (eBL) is endemic in children living in sub-Saharan Africa. This population is heavily exposed to food contaminated with the mycotoxin aflatoxin B1 (AFB1). ...

journal_title：Carcinogenesis

authors： Accardi R,Gruffat H,Sirand C,Fusil F,Gheit T,Hernandez-Vargas H,Le Calvez-Kelm F,Traverse-Glehen A,Cosset FL,Manet E,Wild CP,Tommasino M

更新日期：2015-11-01 00:00:00

abstract：:4-Oxo-4-(3-pyridyl)butanal (OPB) is an aldehyde formed during the activation of the tobacco-specific N-nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Using the DNA alkaline elution technique, the properties of DNA alkali-labile sites induced in the isolated rat hepatocytes by NNK and OPB were compar...

journal_title：Carcinogenesis

authors： Demkowicz-Dobrzanski K,Castonguay A

更新日期：1991-11-01 00:00:00

abstract：:Tea polyphenolic constituents induce apoptosis in cancer cells but not in normal cells. To study the mechanism of this selective effect, we used the ornithine decarboxylase (ODC)/Ras double transgenic mouse model that develops spontaneous skin tumors due to over-expression of ODC and a v-Ha-ras transgene. Administrati...

journal_title：Carcinogenesis

authors： Paul B,Hayes CS,Kim A,Athar M,Gilmour SK

更新日期：2005-01-01 00:00:00

abstract：:Well-differentiated squamous cell carcinomas were induced in hamster buccal pouch epithelium by twice weekly topical applications of N-methyl-N-benzylnitrosamine (MBN) or 7,12-dimethylbenz[a]anthracene (DMBA) over a period of 15 weeks. Each of the 22 tumors induced (14 MBN and eight DMBA) were evaluated by single-stra...

journal_title：Carcinogenesis

authors： Chang KW,Lin SC,Koos S,Pather K,Solt D

更新日期：1996-03-01 00:00:00

abstract：:Oxidative DNA modifications such as 7,8-dihydro-8-oxoguanine (8-oxoG) are generated endogenously in apparently all living cells. The defect of the repair of 8-oxoG in Csb(m/m)Ogg1⁻(/)⁻ mice results in elevated basal levels of these lesions and increased frequencies of spontaneous mutations, which initiate tumorigenesi...

journal_title：Carcinogenesis

authors： Fusser M,Nesse GJ,Khobta A,Xia N,Li H,Klungland A,Epe B

更新日期：2011-01-01 00:00:00

abstract：:Amarogentin, a secoiridoid glycoside, is an active component of the medicinal plant Swertia chirata. In this study, chemopreventive and chemotherapeutic actions of amarogentin were evaluated in a carbon tetrachloride (CCl(4))/N-nitrosodiethylamine (NDEA)-induced liver carcinogenesis mouse model system during continuou...

journal_title：Carcinogenesis

authors： Pal D,Sur S,Mandal S,Das A,Roy A,Das S,Panda CK

更新日期：2012-12-01 00:00:00

abstract：:Recent studies have revealed that 1,2,3,4,6-penta-O-galloyl-beta-d-glucose (PGG) has anti-tumorigenic activity in vitro. In the present work, we evaluated the in vitro and in vivo antiangiogenic and antitumor activities of PGG and examined its molecular mechanisms. PGG significantly inhibited the proliferation and tub...

journal_title：Carcinogenesis

authors： Huh JE,Lee EO,Kim MS,Kang KS,Kim CH,Cha BC,Surh YJ,Kim SH

更新日期：2005-08-01 00:00:00

abstract：:[3H]Benzo[a]pyrene (B[a]P) was administered to male Sprague-Dawley rats via intratracheal instillation, and bile was collected over a period of 6 h. Conjugated metabolites of B[a]P in bile were separated by paper chromatography or reversed-phase ion-pair HPLC and quantified by liquid scintillation spectrometry. In pap...

journal_title：Carcinogenesis

authors： Bevan DR,Sadler VM

更新日期：1992-03-01 00:00:00

abstract：:Chemopreventive activities of all-trans retinoic acid (AtRA), 9-cis retinoic acid (9cRA), retinol (ROL) and beta-carotene (betaC) were evaluated during hepatocarcinogenesis. Rats received 1 mg/100 g body wt AtRA (AtRA group), 9cRA (9cRA group), ROL (ROL group), 7 mg/100 g body wt betaC (betaC group) or corn oil (CO gr...

journal_title：Carcinogenesis

authors： de Almeida Vasconcelos Fonseca EM,Chagas CE,Mazzantini RP,Heidor R,Ong TP,Moreno FS

更新日期：2005-11-01 00:00:00

abstract：:Conjugated linoleic acid (CLA) is a class of commercially available fatty acids that have been associated with anticancer properties in rodent models of chemical carcinogenesis. We conducted a pilot study to examine the antitumor effect of dietary CLA in a polyoma virus-middle T antigen (PyMT) mouse model of invasive ...

journal_title：Carcinogenesis

authors： Flowers M,Schroeder JA,Borowsky AD,Besselsen DG,Thomson CA,Pandey R,Thompson PA

更新日期：2010-09-01 00:00:00

abstract：:Administration of methylglyoxal at doses of 300-600 mg/kg body weight by gastric tube to male F344 rats induced 100-fold increase in ornithine decarboxylase activity (formation of 682 pmol CO2/30 min/mg protein) within 7 h, 26-fold increase in DNA synthesis (incorporation of 17 800 d.p.m. of [3H]thymidine/microgram DN...

journal_title：Carcinogenesis

authors： Furihata C,Sato Y,Matsushima T,Tatematsu M

更新日期：1985-01-01 00:00:00

abstract：:Super elongation complex (SEC) controls gene transcription by releasing Pol II from pausing. Previous studies have shown that dysfunction of SEC was associated with multiple human cancers, such as leukemia and breast cancer. However, the role of SEC in head and neck squamous cell carcinoma (HNSCC) development remains ...

journal_title：Carcinogenesis

authors： Deng P,Wang J,Zhang X,Wu X,Ji N,Li J,Zhou M,Jiang L,Zeng X,Chen Q

更新日期：2018-07-03 00:00:00

abstract：:In this report we describe results showing that both arachidonic acid (20:4) release and prostaglandin (PG) synthesis in herpes simplex virus type 2 (HSV-2)-transformed tumor-derived rat fibrosarcoma (RFS) cells are inhibited by indomethacin (cyclooxygenase inhibitor). These data suggest that cyclooxygenase (prostagla...

journal_title：Carcinogenesis

authors： Heitman CR,Waite M,Kucera LS

更新日期：1989-11-01 00:00:00

abstract：:Two new mouse epidermal cell lines have been isolated and characterized as target cells for three chemical carcinogens. The ability to grow these cells at low density (approximately 5 clonogenic cells/cm2) has permitted more precise quantitation of chemical carcinogen-induced changes in epidermal differentiation. The ...

journal_title：Carcinogenesis

authors： Kulesz-Martin M,Yoshida MA,Prestine L,Yuspa SH,Bertram JS

更新日期：1985-09-01 00:00:00

abstract：:Alkylation of DNA and hemoglobin was compared in male F344 rats given a single s.c. injection of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), or its major metabolite formed by carbonyl reduction, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL). In hepatic DNA, levels of 7...

journal_title：Carcinogenesis

authors： Hecht SS,Trushin N

更新日期：1988-09-01 00:00:00

abstract：:3-Amino-1,2,4-triazole, a thyroid carcinogen and goitrogen, is negative in a wide variety of short-term mutagenicity assays. However, amitrole induces gene mutations and morphological transformation in Syrian hamster embryo fibroblasts, cells known to carry out the prostaglandin H synthase (PHS)-mediated peroxidative ...

journal_title：Carcinogenesis

authors： Krauss RS,Eling TE

更新日期：1987-05-01 00:00:00

abstract：:5-Aminolevulinic acid (ALA), a heme precursor accumulated in chemical and inborn porphyrias, may behave as an endogenous pro-oxidant. In chronically treated rats (40 mg ALA/kg body wt every 2 days for 15 days) the steady-state level of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in liver DNA (94.5 +/- 23.3 residues/10(6) dG)...

journal_title：Carcinogenesis

authors： Fraga CG,Onuki J,Lucesoli F,Bechara EJ,Di Mascio P

更新日期：1994-10-01 00:00:00

abstract：:Mutations of the tumor suppressor gene p53 have been found in hepatocellular carcinomas (HCCs) from many countries where HCC is common, but p53 mutations detected by direct sequencing in HCCs from the United States (where HCC is uncommon) have been reported only rarely. p53 Exons 1 to 11 were analyzed by polymerase ch...

journal_title：Carcinogenesis

authors： Kazachkov Y,Khaoustov V,Yoffe B,Solomon H,Klintmalm GB,Tabor E

更新日期：1996-10-01 00:00:00

abstract：:Epidemiological evidence suggests that the presence of human papillomaviruses (HPV), when combined with smoking behaviors, considerably enhances the risk of developing oral, cervical, vulvar, and/or anal carcinomas. It is well established that the cytochrome P450 (CYP), microsomal epoxide hydrolase (mEH), and other bi...

journal_title：Carcinogenesis

authors： Farin FM,Bigler LG,Oda D,McDougall JK,Omiecinski CJ

更新日期：1995-06-01 00:00:00

abstract：:3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, pravastatin (Pr) and simvastatin (Si), suppressed 1,2-dimethylhydrazine (DMH)-induced colon cancer development in female ICR mice. All mice received an i.p. injection of 10 mg DMH/kg body wt once weekly for 15 weeks. Pr was administered at 0.01, 0.0...

journal_title：Carcinogenesis

authors： Narisawa T,Fukaura Y,Terada K,Umezawa A,Tanida N,Yazawa K,Ishikawa C

更新日期：1994-09-01 00:00:00

abstract：:There is indirect evidence to suggest that the excision-repair mechanism responsible for the removal of UV-induced thymine dimers may also play a role in the repair of cis-diamminedichloroplatinum(II) (cis-DDP)-induced DNA adducts in both bacteria and mammalian cells. It was hypothesized that UV dimers and cis-DDP add...

journal_title：Carcinogenesis

authors： Swinnen LJ,Fisher SG,Erickson LC

更新日期：1989-08-01 00:00:00

abstract：:O6-Methylguanine-DNA methyltransferase (MT)-proficient Chinese hamster ovary cells were grown in the presence of low, gradually increasing levels of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) with the aim of selecting MNNG-resistant cell lines. Six resistant clones with two levels of resistance were isolated. A 3-fol...

journal_title：Carcinogenesis

authors： Aquilina G,Frosina G,Zijno A,Di Muccio A,Dogliotti E,Abbondandolo A,Bignami M

更新日期：1988-07-01 00:00:00

abstract：:The bioactivation of cyclopenta[cd]pyrene (CPP) was investigated to determine the major DNA adduct-forming metabolite(s) of this widespread environmental contaminant and suspect carcinogen. DNA adducts were analyzed by 32P-postlabeling. Four major and at least seven minor adducts formed when CPP was incubated with cal...

journal_title：Carcinogenesis

authors： Beach AC,Gupta RC

更新日期：1994-05-01 00:00:00