Abstract:
:There is indirect evidence to suggest that the excision-repair mechanism responsible for the removal of UV-induced thymine dimers may also play a role in the repair of cis-diamminedichloroplatinum(II) (cis-DDP)-induced DNA adducts in both bacteria and mammalian cells. It was hypothesized that UV dimers and cis-DDP adducts, when present simultaneously, might compete for a common repair system. Colony survival assays were performed in HT-29 human colon carcinoma cells exposed either to cis-DDP alone or to cis-DDP immediately followed by UV exposure. Progressively greater cytotoxic synergy with both increasing UV dose and cis-DDP dose was observed, to a point of saturation beyond which further toxicity was purely additive. Alkaline elution analyses for DNA interstrand crosslinking were performed 6 h after exposure. An approximate doubling in crosslink frequency, relative to cis-DDP alone, was found in cells exposed to cis-DDP plus UV (P = 0.002). Since cis-DDP produces both inter- and intrastrand DNA crosslinks similar studies were performed with trans-DDP, which is incapable of producing intrastrand crosslinks, but does produce interstrand crosslinks. Cytotoxic synergy and increased interstrand crosslinking again resulted from the addition of UV exposure, but not to the same extent as seen with cis-DDP. These data support the hypothesis that cis-DDP induced DNA adducts are, at least in part, removed by an excision-repair mechanism. The similar but quantitatively smaller effects with trans-DDP suggest that intrastrand crosslink removal may also occur by this mechanism.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Swinnen LJ,Fisher SG,Erickson LCdoi
10.1093/carcin/10.8.1465subject
Has Abstractpub_date
1989-08-01 00:00:00pages
1465-70issue
8eissn
0143-3334issn
1460-2180journal_volume
10pub_type
杂志文章相关文献
CARCINOGENESIS文献大全abstract::Non-classical class Ib (class Ib) genes are found in all jawed vertebrates, including the amphibian Xenopus, which possesses at least 20 distinct Xenopus non-classical class Ib genes (XNCs). As an immune evasion strategy, tumors often downregulate surface expression of classical major histocompatibility complex class ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgu100
更新日期:2014-08-01 00:00:00
abstract::Observational studies and animal evidence suggest an association between coffee consumption and the risk of prostate cancer. However, the results are inconsistent. We evaluated the association by conducting a meta-analysis of prospective cohort studies. PubMed and Embase were searched through June 2013 to identify stu...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/bgt482
更新日期:2014-02-01 00:00:00
abstract::The three-dimensional structure of the product of the reaction of a diol epoxide of the carcinogen 5-methylchrysene with methanol has been determined by an X-ray diffraction analysis. The diol epoxide used to obtain this compound contains a stereochemically hindered bay region because of the location of the 5-methyl g...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/17.11.2507
更新日期:1996-11-01 00:00:00
abstract::In this communication, we investigate the preventive effect of a flavonoid antioxidant, silymarin, on free radical-generating skin tumor promoting agent benzoyl peroxide (BPO)-induced tumor promotion, oxidative stress and inflammatory responses in SENCAR mouse skin. Topical application of silymarin at a dose of 6 mg p...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/21.4.811
更新日期:2000-04-01 00:00:00
abstract::58 MCA Cl 16 is an oncogenic methylcholanthrene-transformed variant of the non-transformed mouse embryo fibroblast cell line, C3H/10T1/2 Cl 8. Using two different protocols, we have isolated six temperature-sensitive mutants from N-methyl-N'-nitro-N-nitrosoguanidine treated cultures of 58 MCA Cl 16. C3H/10T1/2 Cl 8, 5...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/1.12.1059
更新日期:1980-01-01 00:00:00
abstract::3-Methyladenine DNA glycosylases initiate base excision repair by flipping the nucleotide bearing the target base out of double-stranded DNA into an active site pocket for glycosylic bond cleavage and base release. Substrate bases for the murine 3-methyladenine DNA glycosylase (other than 3-methyladenine) include hypo...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/21.5.901
更新日期:2000-05-01 00:00:00
abstract::2-methoxyestradiol (2-MeOE(2)) is an endogenous metabolite of 17beta-estradiol and a proposed inhibitor of tumor growth and angiogenesis. However, 2-MeOE(2) is also an inhibitor of microtubule assembly and other microtubule inhibitors, e.g. colcemid and diethylstilbestrol, induce aneuploidy and cell transformation in ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/21.4.735
更新日期:2000-04-01 00:00:00
abstract::DNA repair after gamma radiation was studied in purified T lymphocytes from young and aged subjects. Two different assays were employed. In the first, T lymphocytes were stimulated with phytohemagglutinin (PHA) for 72 h and then treated with hydroxyurea, irradiated with 30 K rads and pulsed with [3H]thymidine (TdR) fo...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.1.45
更新日期:1982-01-01 00:00:00
abstract::Effects of estrogens on the cytoplasmic microtubule network were examined by the indirect immunofluorescence method using anti-beta-tubulin antibody. Estradiol, a naturally occurring estrogen, decreased the amount of cytoplasmic microtubule fibers during interphase in the human breast cancer cell lines MCF-7 and MDA-M...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/15.9.1875
更新日期:1994-09-01 00:00:00
abstract::Integrins control the cell attachment to the extracellular matrix and play an important role in mediating cell proliferation, migration and survival. A number of important cancer-associated integrin genes can be regulated by microRNAs (miRNAs) that bind to their target sites in the 3' untranslated regions. We examined...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn126
更新日期:2008-07-01 00:00:00
abstract::Male Ah-responsive C57BL/10ScSn mice received a single dose of iron-dextran (600 mg Fe/kg) and were fed a diet containing 0.01% of the PCBs mixture Aroclor 1254 for up to 12 months. Iron caused a marked synergistic increase in liver size from 2 months with greatly elevated mitotic rates, numbers of basophilic foci and...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.3.437
更新日期:1990-03-01 00:00:00
abstract::Orotic acid, a precursor of pyrimidine nucleotide biosynthesis and a promoter for liver carcinogenesis, when fed at 1% level in a diet for 5 weeks resulted in liver DNA damage. The damage can be monitored as alkali-labile lesions using alkaline sucrose gradients as well as alkaline elution technique. Furthermore, the ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/6.5.765
更新日期:1985-05-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1 (HIF-1) are important regulators of angiogenesis. HIF-1 is composed of HIF-1alpha and HIF-1beta subunits, and regulates VEGF expression at transcriptional level. In this study, we demonstrated that insulin induced H2O2 production and p70S6K1 acti...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgl085
更新日期:2007-01-01 00:00:00
abstract::Adult rat hepatocytes in primary culture were used to study the effect of tryptophan pyrolysis products on the transcriptional process. Hepatocytes were treated with 1, 5 and 10 micrograms/ml of 3-amino-1,4-dimethyl-5H-pyrido-[4,3-b]-indole (Trp-P-1) or 3-amino-1-methyl-5H-pyrido-[4,3-b]-indole (Trp-P-2) for 2 and 4 h...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.4.481
更新日期:1983-01-01 00:00:00
abstract::As we have shown previously [Tardieu,D., Jaeg,J.P., Cadet,J., Embvani,E., Corpet,D.E. and Petit,C. (1998) Cancer Lett, 134, 1-5], a 48-h treatment of 6% dextran sodium sulphate (DSS) in drinking water led to a reproducible 2-fold increase of the mutagenic oxidative lesion 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/21.5.973
更新日期:2000-05-01 00:00:00
abstract::A number of drug-metabolizing systems were measured in hyperplastic noduli from the livers of rats receiving 2-acetyl-aminofluorene in their diet and compared with corresponding activities in control liver. The level of microsomal cytochrome P-450 is reduced 54% in the nodular tissue, while 5 activities catalyzed by t...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.5.577
更新日期:1983-01-01 00:00:00
abstract::The metabolism of [1,3-14C]benzo[f]quinoline (BfQ) by liver microsomes from control, 3-methylcholanthrene (3-MC)-pretreated and phenobarbital (PB)-pretreated rats has been investigated in order to gain insights into the effect of mixed function oxidase inducers on the types and levels of specific metabolites as formed...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.12.1861
更新日期:1987-12-01 00:00:00
abstract::Dose-related differences in the binding of DNA reactive intermediates for three environmentally important complex mixture particulate extracts and a well-studied carcinogen, benzo[a]pyrene (BaP), were examined in female C-57 mice following multiple topical treatments ranging from 1 to 120 mg/mouse. Particulate extract...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.1.63
更新日期:1990-01-01 00:00:00
abstract::Cytochrome P450 1B1 (CYP1B1) is an enzyme that has a unique tumor-specific pattern of expression and is capable of bioactivating a wide range of carcinogenic compounds. We have reported previously that coordinated upregulation of CYP1B1 by inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and the aryl hy...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgu190
更新日期:2014-11-01 00:00:00
abstract::Incubation of 3-[3H]fluoranthene with a rat liver microsomal activation system in the presence of calf thymus DNA resulted in radioactivity bound to the DNA. The fluoranthene-modified DNA was enzymatically digested and a DNA adduct elution profile developed using h.p.l.c. The fraction containing the major fluoranthene...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/7.6.859
更新日期:1986-06-01 00:00:00
abstract::We compared the frequencies of mutation and morphological transformation in relation to the repair of potentially lethal damage (PLD) and sublethal damage (SLD) in X-irradiated golden hamster embryo (GHE) cells. The repair of PLD induced in GHE cells by X-rays was shown to be an error-free process which reduced the fr...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/5.10.1293
更新日期:1984-10-01 00:00:00
abstract::The hepatitis B virus X protein (HBx) has pleiotropic biological effects, which underlies its potential role in cell transformation. However, its involvement in hepatic fibrosis remains unclear. In this study, we wanted to clarify, in vivo, the role of HBx protein in the development of liver fibrosis. Mice transgenic ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgz109
更新日期:2020-05-14 00:00:00
abstract::We reported the inhibitory effects of genistein, an inhibitor of tyrosine protein kinase (TPK), on ultraviolet B (UVB)-induced expression of c-fos and c-jun in SENCAR mouse skin. UVB irradiation substantially increased transcript levels of c-fos and c-jun mRNA in mouse skin. Topical application of genistein 60 min bef...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/19.4.649
更新日期:1998-04-01 00:00:00
abstract::O6-Alkylguanine-DNA alkyltransferase (AGAT) activity was determined in macroscopically normal peripheral lung tissues from 122 patients undergoing lung surgery. AGAT activity of smokers was 1.4-fold higher than that of lifetime non-smokers (P = 0.030). Less than one year of abstinence from smoking did not cause a sign...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/15.8.1535
更新日期:1994-08-01 00:00:00
abstract::Hepatocarcinogenesis was initiated in rats with a single dose of either of two chemical mutagens--benzo[a]pyrene diolepoxide I and methyl(acetoxymethyl)nitrosamine--administered 15 h after partial hepatectomy. The development of hepatocellular foci and neoplasms was then promoted with dietary phenobarbital given for 4...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/13.8.1481
更新日期:1992-08-01 00:00:00
abstract::To evaluate the significance of C-C chemokine receptor type 5 (CCR5) in lung tumor development, we compared carcinogen-induced tumor growth in CCR5 knockout (CCR5(-/-)) mice and wild-type (CCR5(+/+)) mice. CCR5(-/-) mice showed reduced urethane (1g/kg)-induced tumor incidence when compared with those of CCR5(+/+) mice...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs265
更新日期:2012-12-01 00:00:00
abstract::Several converging lines of evidence suggest that keratinocyte stem cells including those clonogenic in vitro, are the target cells in skin carcinogenesis. However, the mechanism of their involvement in carcinogenesis continues to be unknown. Recently, we have demonstrated that the number of keratinocyte clonogenic st...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/24.3.417
更新日期:2003-03-01 00:00:00
abstract::Basic in vitro systems can be used to model and assess complex diseases, such as cancer. Recent advances in this field include the incorporation of multiple cell types and extracellular matrix proteins into three-dimensional (3D) models to recapitulate the structure, organization and functionality of live tissue in si...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/bgu108
更新日期:2014-08-01 00:00:00
abstract::The metabolism of the carcinogenic pentacyclic azaaromatic compound, dibenz[a,j]acridine, has been examined in liver microsomal incubations using preparations from 3-methylcholanthrene-pretreated Wistar rats. Using authentic synthetic standards, u.v. spectroscopy and mass spectrometry, the following were proved to be ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/7.8.1371
更新日期:1986-08-01 00:00:00
abstract::In the era of precision oncology, bladder cancer (BlCa) is characterized by generic patient management and lack of personalized prognosis and surveillance. Herein, we have studied the clinical significance of urothelial cancer associated 1 (UCA1) lncRNA in improving patients' risk stratification and prognosis. A scree...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgz045
更新日期:2019-08-22 00:00:00