Isolation of mutants temperature-sensitive for expression of the transformed state from chemically transformed C3H/10T1/2 cells.

abstract：:The fluorescent 12-O-tetradecanoylphorbol-13-acetate (TPA) analogue dansyl-TPA allowed the distribution of fluorescent molecules to be visualized in living mouse fibroblasts. The entry of dansyl-TPA into cells occurred within millisecond time scale and was found largely energy independent. Dansyl-TPA was shown to stai...

journal_title：Carcinogenesis

authors： Tran PL,Deugnier MA

更新日期：1985-03-01 00:00:00

abstract：:The ability of cytosolic 3-methylcholanthrene binding proteins from rat liver to interact with DNA was studied using DNA-cellulose chromatography. Two DNA binding fractions, eluting in 0.15 M KCl (peak 1) and 0.33 M KCl (peak 2), were observed on salt elution from a denatured DNA-cellulose column which had been incuba...

journal_title：Carcinogenesis

authors： Weaver D,Amos A,Tierney B,Bresnick E

更新日期：1980-06-01 00:00:00

abstract：:The genetic factors that mediate the pathogenesis of multiple primary cutaneous basal cell carcinomas (BCC) are largely unclear. Thus, some patients suffer many BCC (>30) and/or rapid accrual (number of tumours/year from first presentation) of further lesions. We have studied, in 827 English Caucasians, the influence ...

journal_title：Carcinogenesis

authors： Lear JT,Heagerty AH,Smith A,Bowers B,Payne CR,Smith CA,Jones PW,Gilford J,Yengi L,Alldersea J,Fryer AA,Strange RC

更新日期：1996-09-01 00:00:00

abstract：:Breast cancer incidence is increased in women with both high and low birth weight. The latter is also associated with hyperglycaemia, insulin resistance and type-2 diabetes, each of which independently increases breast cancer risk. We showed previously in our model of poor early-growth that pregnancy estradiol levels ...

journal_title：Carcinogenesis

authors： Fernandez-Twinn DS,Ekizoglou S,Gusterson BA,Luan J,Ozanne SE

更新日期：2007-03-01 00:00:00

abstract：:Forty-two compounds belonging to various chemical groups have been tested for their ability to suppress formation of aflatoxin B1--DNA adduct mediated by microsome in vitro. While many of these compounds have either marginal or no modulating effect, some have been identified as effective inhibitors. The strong inhibit...

journal_title：Carcinogenesis

authors： Bhattacharya RK,Firozi PF,Aboobaker VS

更新日期：1984-10-01 00:00:00

abstract：:The arylamine carcinogen 3,2'-dimethyl-4-aminobiphenyl (DMABP) has been proposed to be metabolically activated to DNA-binding derivatives through the formation of an N-hydroxy intermediate. In this study, the subsequent activation of N-hydroxy-DMABP through acid catalysis or enzymatic esterification was examined. [Rin...

journal_title：Carcinogenesis

authors： Flammang TJ,Westra JG,Kadlubar FF,Beland FA

更新日期：1985-02-01 00:00:00

abstract：:Polyphenols have shown promising bioactivity in experimental in vitro and in vivo models for cancer chemoprevention. However, consumed orally, they are often transformed by gut microbes into new active principles with so far incompletely deciphered molecular mechanisms. Here, enterolacton, S-equol and urolithin A as r...

journal_title：Carcinogenesis

authors： Norden E,Heiss EH

更新日期：2019-03-12 00:00:00

abstract：:Angiogenesis, the formation of new blood vessels, is critical to tumor growth and metastasis. Vascular endothelial growth factor (VEGF), an important angiogenic activator, is essential for angiogenesis. Our laboratory has used a rodent model of human esophageal squamous cell carcinoma (ESCC) to identify putative chemo...

journal_title：Carcinogenesis

authors： Chen T,Rose ME,Hwang H,Nines RG,Stoner GD

更新日期：2006-11-01 00:00:00

abstract：:Recent evidence demonstrates the existence of diversified microbiota in the lung. However, the effect of lung carcinogenesis on the flora in lung microenvironment has yet not been well investigated. In this study, we surveyed the microbial composition and diversity in lung tumor and paired adjacent normal tissues obta...

journal_title：Carcinogenesis

authors： Mao Q,Ma W,Wang Z,Liang Y,Zhang T,Yang Y,Xia W,Jiang F,Hu J,Xu L

更新日期：2020-08-12 00:00:00

abstract：:Maternal nutrition during pregnancy influences the development and metabolism of the fetus. Recent studies suggest that the cancer risk of offspring later in life is associated with maternal diet, but little is known about the effect of a maternal diet high in methyl nutrients on breast cancer risk. Lipotropes are met...

journal_title：Carcinogenesis

authors： Cho K,Mabasa L,Bae S,Walters MW,Park CS

更新日期：2012-05-01 00:00:00

abstract：:Both Snell dwarf mice (dw/dw) and their phenotypically normal heterozygotes (dw/+) were dosed with methylclofenapate (MCP) at daily intervals by gavage (25 mg/kg). Animals were killed at 12, 24, 36 and 72 h after the initial dose and the parameters of ploidy, nuclearity and DNA synthesis were measured in hepatocytes i...

journal_title：Carcinogenesis

authors： Styles JA,Kelly MD,Pritchard NR,Foster JR

更新日期：1990-03-01 00:00:00

abstract：:Hydrazine sulfate is a genotoxic hepatocarcinogen for the hamster. A study was conducted to follow changes in DNA maintenance methylation in selected genes in liver DNA during the 21-month induction of liver adenomas and hepatocellular carcinomas by demonstrating changes in restriction fragment length polymorphism. Ma...

journal_title：Carcinogenesis

authors： Zheng H,Shank RC

更新日期：1996-12-01 00:00:00

abstract：:Serum selenium (Se) levels were measured before, during and after high-dose induction chemotherapy in 70 patients with acute non-lymphocytic leukemia (ANLL). Pre-treatment serum Se levels were lower in patients than in controls (0.082 +/- 0.033 micrograms/ml versus 0.097 +/- 0.035 micrograms/ml, P less than 0.01). Pre...

journal_title：Carcinogenesis

authors： Beguin Y,Bours V,Delbrouck JM,Robaye G,Roelandts I,Bury J,Fillet G,Weber G

更新日期：1989-11-01 00:00:00

abstract：:Multiple myeloma (MM) cells accumulate in the bone marrow (BM) where their interactions impede disease therapy. We have shown that microvesicles (MVs) derived from BM mesenchymal stem cells (MSCs) of MM patients promote the malignant traits via modulation of translation initiation (TI), whereas MVs from normal donors ...

journal_title：Carcinogenesis

authors： Dabbah M,Jarchowsky-Dolberg O,Attar-Schneider O,Tartakover Matalon S,Pasmanik-Chor M,Drucker L,Lishner M

更新日期：2020-03-13 00:00:00

abstract：:p53-upregulated modulator of apoptosis (PUMA) plays an essential role in p53-dependent apoptosis following DNA damage. PUMA also mediates apoptosis independent of p53. In this study, we investigated the role and mechanism of PUMA induction in response to serum starvation in p53-deficient cancer cells. Following serum ...

journal_title：Carcinogenesis

authors： Ming L,Sakaida T,Yue W,Jha A,Zhang L,Yu J

更新日期：2008-10-01 00:00:00

abstract：:Catechol (1,2-dihydroxybenzene) is a major phenolic compound present in the co-carcinogenic fraction of cigarette tar. It has been shown to be a potent co-carcinogen with benzo[a]pyrene (BaP) in mouse skin. In this study we have examined the co-carcinogenic and co-initiating activities of catechol with racemic and ena...

journal_title：Carcinogenesis

authors： Melikian AA,Jordan KG,Braley J,Rigotty J,Meschter CL,Hecht SS,Hoffmann D

更新日期：1989-10-01 00:00:00

abstract：:Resveratrol has elicited many provocative anticancer effects in laboratory animals and cultured cells, including reduced levels of oxidative DNA damage, inhibition of tumor initiation and progression and induction of apoptosis in tumor cells. Use of resveratrol as a cancer-preventive agent in humans will require that ...

journal_title：Carcinogenesis

authors： Denissova NG,Nasello CM,Yeung PL,Tischfield JA,Brenneman MA

更新日期：2012-01-01 00:00:00

abstract：:To evaluate the significance of C-C chemokine receptor type 5 (CCR5) in lung tumor development, we compared carcinogen-induced tumor growth in CCR5 knockout (CCR5(-/-)) mice and wild-type (CCR5(+/+)) mice. CCR5(-/-) mice showed reduced urethane (1g/kg)-induced tumor incidence when compared with those of CCR5(+/+) mice...

journal_title：Carcinogenesis

authors： Lee NJ,Choi DY,Song JK,Jung YY,Kim DH,Kim TM,Kim DJ,Kwon SM,Kim KB,Choi KE,Moon DC,Kim Y,Han SB,Hong JT

更新日期：2012-12-01 00:00:00

abstract：:The P53 tumor suppressor pathway plays an important role in cancer development. The auto-regulatory feedback mechanism of the P53 and MDM2 expression is critical in keeping proper tumor suppressor function of this pathway. This study examined the effect of P53 Arg72Pro variants on transactivation of polymorphic MDM2 p...

journal_title：Carcinogenesis

authors： Yang M,Guo Y,Zhang X,Miao X,Tan W,Sun T,Zhao D,Yu D,Liu J,Lin D

更新日期：2007-09-01 00:00:00

abstract：:Recent studies have examined and demonstrated the potential cancer chemopreventive activity of freeze-dried berries including strawberries and black raspberries. Although ellagic acid, an abundant component in these berries, has been shown to inhibit carcinogenesis both in vivo and in vitro, several studies have repor...

journal_title：Carcinogenesis

authors： Xue H,Aziz RM,Sun N,Cassady JM,Kamendulis LM,Xu Y,Stoner GD,Klaunig JE

更新日期：2001-02-01 00:00:00

abstract：:Alcohol is a major risk factor for oesophageal squamous cell carcinoma (OSCC), the most prevalent histological subtype of oesophageal cancer (OC) worldwide. The metabolism of alcohol is regulated by specific enzymes whose activity and expression is influenced by genetic polymorphisms. We conducted a systematic review ...

journal_title：Carcinogenesis

authors： Matejcic M,Gunter MJ,Ferrari P

更新日期：2017-09-01 00:00:00

abstract：:Tobacco-specific nitrosamines are a group of carcinogens that are present in tobacco and tobacco smoke. They are formed from nicotine and related tobacco alkaloids. Two of the nicotine-derived nitrosamines, NNK and NNN, are strong carcinogens in laboratory animals. They can induce tumors both locally and systemically....

journal_title：Carcinogenesis

authors： Hecht SS,Hoffmann D

更新日期：1988-06-01 00:00:00

abstract：:We reported the inhibitory effects of genistein, an inhibitor of tyrosine protein kinase (TPK), on ultraviolet B (UVB)-induced expression of c-fos and c-jun in SENCAR mouse skin. UVB irradiation substantially increased transcript levels of c-fos and c-jun mRNA in mouse skin. Topical application of genistein 60 min bef...

journal_title：Carcinogenesis

authors： Wang Y,Zhang X,Lebwohl M,DeLeo V,Wei H

更新日期：1998-04-01 00:00:00

abstract：:Peroxisome proliferator activated receptor(alpha) (PPARalpha) mediates the liver's responses to peroxisome proliferator compounds. These responses include induction of specific hepatic enzymes, peroxisome proliferation and hepatocyte proliferation. PPARalpha null mice, which lack receptor in all cells of the body, do ...

journal_title：Carcinogenesis

authors： Weglarz TC,Sandgren EP

更新日期：2004-01-01 00:00:00

abstract：:Nitrosododecamethyleneimine (NDMI) was given to NZR/Gd rats by gavage in olive oil solution, confirming its hepatocarcinogenic activity. Twenty male and 20 female rats received 2.5 mg NDMI twice a week for 52 weeks; a further 10 male rats received 25.0 mg twice a week for 12 weeks. Two-thirds of the animals survived m...

journal_title：Carcinogenesis

authors： Goodall CM,Lijinsky W

更新日期：1984-04-01 00:00:00

abstract：:Tamoxifen is a non-steroidal anti-estrogen used for the treatment of breast cancer and, more recently, as a chemopreventive agent in healthy women at high risk of developing breast cancer. On the other hand, tamoxifen is a potent hepatocarcinogen in rats, with both tumor-initiating and tumor-promoting properties. Ther...

journal_title：Carcinogenesis

authors： Tryndyak VP,Muskhelishvili L,Kovalchuk O,Rodriguez-Juarez R,Montgomery B,Churchwell MI,Ross SA,Beland FA,Pogribny IP

更新日期：2006-08-01 00:00:00

abstract：:TP63, a member of the TP53 gene family, encodes two groups of three isoforms (alpha, beta and gamma). The TAp63 isoforms act as transcription factors. The DeltaNp63 isoforms lack the main transcription activation domain and act as dominant-negative inhibitors of transactivation (TA) isoforms. To clarify the role of th...

journal_title：Carcinogenesis

authors： Petitjean A,Ruptier C,Tribollet V,Hautefeuille A,Chardon F,Cavard C,Puisieux A,Hainaut P,Caron de Fromentel C

更新日期：2008-02-01 00:00:00

abstract：:DNA mismatch repair defects in certain cell types confer resistance to the cytotoxic effects of alkylating agents, suggesting that a normally functioning DNA mismatch repair pathway can actually mediate alkylation-induced cell death. In eukaryotic cells this phenomenon is only observed in cells lacking adequate DNA me...

journal_title：Carcinogenesis

authors： Rasmussen LJ,Samson L

更新日期：1996-09-01 00:00:00

abstract：:N-nitrosopiperidine (NPIP) is a potent esophageal carcinogen in rats whereas structurally similar N-nitrosopyrrolidine (NPYR) induces liver, but not esophageal tumors. NPIP is a possible causative agent for human esophageal cancer. Our goal is to explain mechanistically these differing carcinogenic activities in the e...

journal_title：Carcinogenesis

authors： Wong HL,Murphy SE,Wang M,Hecht SS

更新日期：2003-02-01 00:00:00

abstract：:A diet that is deficient in methionine, choline, folic acid and vitamin B12 has been found to induce alterations rapidly in liver tRNA methylation in male Fischer rats. In vitro assays indicated that activity of N2-guanine tRNA methyltransferase II (NMG2) was increased to 150% of controls levels in 1 week and 300% of ...

journal_title：Carcinogenesis

authors： Wainfan E,Dizik M,Hluboky M,Balis ME

更新日期：1986-03-01 00:00:00