Inhibition of cellular transformation by berry extracts.

abstract：:Genomic alterations affecting components of the mechanistic target of rapamycin (mTOR) pathway are found rather frequently in cancers, suggesting that aberrant pathway activity is implicated in oncogenesis of different tumor types. mTOR functions as the core catalytic kinase of two distinct complexes, mTOR complex 1 (...

journal_title：Carcinogenesis

authors： Gkountakos A,Pilotto S,Mafficini A,Vicentini C,Simbolo M,Milella M,Tortora G,Scarpa A,Bria E,Corbo V

更新日期：2018-07-30 00:00:00

abstract：:The present study was designed to evaluate the tolerance and cancer chemopreventive activity of triphenylselenonium chloride in female Sprague-Dawley rats. No information is available in the literature on the anticarcinogenic efficacy of a lipophilic cationic selenium compound as exemplified by the triphenylselenonium...

journal_title：Carcinogenesis

authors： Ip C,Thompson H,Ganther H

更新日期：1994-12-01 00:00:00

abstract：:The addition of supplementary cytosolic fraction greatly enhances the activation of 2-acetylaminofluorene (AAF) by uninduced 9,000 x g supernatant fractions (S9) in the Ames test. Uninduced S9 is poor at activating AAF in the Ames test (although it is effective in the liquid based fluctuation test) probably because cy...

journal_title：Carcinogenesis

authors： Forster R,Green MH,Priestley A

更新日期：1981-01-01 00:00:00

abstract：:In the present study the modulating effects of dietary fish oil (MaxEPA) on unsaturated fat-promoted pancreatic carcinogenesis in azaserine-treated rats were investigated. Three groups of 20 rats (each group comprised five saline-treated and 15 azaserine-treated animals) were fed an AIN76-based purified diet containin...

journal_title：Carcinogenesis

authors： Appel MJ,Woutersen RA

更新日期：1994-10-01 00:00:00

abstract：:The G protein-coupled formylpeptide receptor (FPR), known to mediate phagocytic leucocyte chemotaxis in response to bacterial- and host-derived agonists, was expressed by tumor cells in specimens of surgically removed more highly malignant human gliomas. In human glioblastoma cell lines, FPR activation increased cell ...

journal_title：Carcinogenesis

authors： Huang J,Chen K,Huang J,Gong W,Dunlop NM,Howard OM,Bian X,Gao Y,Wang JM

更新日期：2009-02-01 00:00:00

abstract：:Proliferation, apoptosis and angiogenesis are critical biologic processes altered during carcinogenesis. Surrogate biomarkers of these processes represent potential intermediate endpoints for short-term intervention studies with preventive and therapeutic agents. We examined the interrelationships among these processe...

journal_title：Carcinogenesis

authors： Liao Z,Boileau TW,Erdman JW Jr,Clinton SK

更新日期：2002-10-01 00:00:00

abstract：:Several purified polychlorinated biphenyl (PCB) congeners with differing toxicity/tumor promotional activities in rat liver in vivo were tested for their effects on gap-junctional intercellular communication (GJIC) in cell strains and lines derived from human liver and skin. This in vitro assay is being developed to d...

journal_title：Carcinogenesis

authors： Swierenga SH,Yamasaki H,Piccoli C,Robertson L,Bourgon L,Marceau N,Fitzgerald DJ

更新日期：1990-06-01 00:00:00

abstract：:Both trans-4-acetylaminostilbene (AAS) and 2-acetylaminofluorene (AAF) exert tumor-initiating activity in rat liver when administered in the initiation phase of an initiation-promotion experiment. The effects are more than additive when the compounds are sequentially combined in the initiation phase of such an experim...

journal_title：Carcinogenesis

authors： Ruthsatz M,Neumann HG

更新日期：1988-02-01 00:00:00

abstract：:The use of naturally occurring botanicals with substantial antioxidant activity to afford protection to human skin against UV damage is receiving increasing attention. The green tea constituent (-)-epigallocatechin-3-gallate (EGCG) is a potent antioxidant and has shown remarkable preventive effects against photocarcin...

journal_title：Carcinogenesis

authors： Katiyar SK,Afaq F,Perez A,Mukhtar H

更新日期：2001-02-01 00:00:00

abstract：:The activation of 2-nitrofluorene (2-NF) to reactive intermediates that bind covalently to DNA, RNA and protein has been investigated both in vitro and in the rat in vivo. In vitro, such binding was catalyzed by the hepatic microsomal fraction, was NADPH dependent and could be inhibited by SKF 525A, an inhibitor of cy...

journal_title：Carcinogenesis

authors： Wierckx FC,Wedzinga R,Meerman JH,Mulder GJ

更新日期：1990-01-01 00:00:00

abstract：:ROS1-fusion genes, resulting from chromosomal rearrangement, have been reported in 1-2% of human non-small cell lung cancer cases. More than 10 distinct ROS1-fusion genes, including break-point variants, have been identified to date. In this study, to investigate the in vivo oncogenic activities of one of the most fre...

journal_title：Carcinogenesis

authors： Inoue M,Toki H,Matsui J,Togashi Y,Dobashi A,Fukumura R,Gondo Y,Minowa O,Tanaka N,Mori S,Takeuchi K,Noda T

更新日期：2016-05-01 00:00:00

abstract：:We investigated whether the addition of d-limonene to the diets of rats would modify the process of mammary tumor induction by 7,12-dimethylbenz[a]anthracene (DMBA). When diets containing 1000 or 10 000 p.p.m. d-limonene were fed to rats from one week before DMBA administration to the end of the experiment (27 weeks p...

journal_title：Carcinogenesis

authors： Elegbede JA,Elson CE,Qureshi A,Tanner MA,Gould MN

更新日期：1984-05-01 00:00:00

abstract：:The naturally occurring anticarcinogens flavone and alpha-angelicalactone incorporated separately and simultaneously in the diet at 0.5, 0.1, 0.05 and 0.01% w/w, were studied with respect to their effects on oesophageal, gastric, intestinal, colonic and hepatic (i) glutathione S-transferase (GST) enzyme activity, (ii)...

journal_title：Carcinogenesis

authors： Nijhoff WA,Bosboom MA,Smidt MH,Peters WH

更新日期：1995-03-01 00:00:00

abstract：:Human cancers are often associated with numerical and structural chromosomal instability. Structural chromosomal aberrations (CAs) in peripheral blood lymphocytes (PBL) arise as consequences of direct DNA damage or due to replication on a damaged DNA template. In both cases, DNA repair is critical and inter-individual...

journal_title：Carcinogenesis

authors： Vodicka P,Musak L,Frank C,Kazimirova A,Vymetalkova V,Barancokova M,Smolkova B,Dzupinkova Z,Jiraskova K,Vodenkova S,Kroupa M,Osina O,Naccarati A,Palitti F,Försti A,Dusinska M,Vodickova L,Hemminki K

更新日期：2015-11-01 00:00:00

abstract：:Copenhagen (Cop) rats are completely resistant to the chemical induction of mammary adenocarcinomas, but their susceptibility to hepatocarcinogenesis is virtually unknown. Rat liver is a well-characterized and easily manipulated tissue in which to study carcinogenesis. Therefore, if Cop rats are resistant to hepatocar...

journal_title：Carcinogenesis

authors： Wood GA,Korkola JE,Lee VM,Sarma DS,Archer MC

更新日期：1997-09-01 00:00:00

abstract：:The spectrum of mutations induced by N-acetoxy-N-acetyl-2-aminofluorene (N-AcO-AAF) was examined by the pZipHprtNeo shuttle vector in mammalian cells. The vector carries a cDNA of the human hypoxanthine phosphoribosyl transferase (hprt) gene, which is stably integrated into chromosomal DNA of a mouse cell line, VH12. ...

journal_title：Carcinogenesis

authors： Ogawa HI,Kimura H,Koya M,Higuchi H,Kato T

更新日期：1993-11-01 00:00:00

abstract：:In the era of precision oncology, bladder cancer (BlCa) is characterized by generic patient management and lack of personalized prognosis and surveillance. Herein, we have studied the clinical significance of urothelial cancer associated 1 (UCA1) lncRNA in improving patients' risk stratification and prognosis. A scree...

journal_title：Carcinogenesis

authors： Avgeris M,Tsilimantou A,Levis PK,Rampias T,Papadimitriou MA,Panoutsopoulou K,Stravodimos K,Scorilas A

更新日期：2019-08-22 00:00:00

abstract：:Xanthorrhizol is an active component isolated from Curcuma xanthorrhiza Roxb. (Zingiberaceae) that is traditionally used in Indonesia for medicinal purposes. In the present study, we found that the topical application of xanthorrhizol before 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment significantly inhibits T...

journal_title：Carcinogenesis

authors： Chung WY,Park JH,Kim MJ,Kim HO,Hwang JK,Lee SK,Park KK

更新日期：2007-06-01 00:00:00

abstract：:Ovarian cancer is developed from a single layer of thin epithelial cells covering the surface of ovary, named human ovarian surface epithelial cells. Like all primary human cells, human ovarian surface epithelial cells have a finite life span and will go into senescence and eventually die when cultured in vitro. Immor...

journal_title：Carcinogenesis

authors： Yang G,Rosen DG,Mercado-Uribe I,Colacino JA,Mills GB,Bast RC Jr,Zhou C,Liu J

更新日期：2007-01-01 00:00:00

abstract：:Fish or vegetable oils were fed during the promotion stage of a mouse skin carcinogenesis model in order to investigate the effects of dietary fat on tumor development. Two weeks after initiation with 10 nmol dimethylbenz[a]anthracene, SENCAR mice were divided into five groups and maintained on one of the following se...

journal_title：Carcinogenesis

authors： Locniskar M,Belury MA,Cumberland AG,Patrick KE,Fischer SM

更新日期：1991-06-01 00:00:00

abstract：:The inability of cells in culture to grow in medium where methionine is replaced by its metabolic precursor, homocysteine, has been linked to neoplastic transformation and termed 'methionine dependence' or 'methionine auxotrophy'. The present investigation was undertaken to establish the influence of intracellular glu...

journal_title：Carcinogenesis

authors： Djurhuus R,Svardal AM,Mansoor MA,Ueland PM

更新日期：1991-02-01 00:00:00

abstract：:Previous studies have shown that platinum-DNA adduct level in leukocyte DNA (measured by antibody methodology) is directly related to disease response in ovarian cancer and testicular cancer. To determine if this principle could be more broadly applied, platinum-DNA damage was studied in a blinded fashion in leukocyte...

journal_title：Carcinogenesis

authors： Parker RJ,Gill I,Tarone R,Vionnet JA,Grunberg S,Muggia FM,Reed E

更新日期：1991-07-01 00:00:00

abstract：:Long-Evans Cinnamon (LEC) rats, a model for human Wilson's disease, develop chronic hepatitis and liver tumors owing to accumulation of copper and induced oxidative stress. Lipid peroxidation (LPO)-induced etheno-DNA adducts in nuclear- and mitochondrial-DNA along with apoptosis was measured in LEC rat liver. Levels o...

journal_title：Carcinogenesis

authors： Nair J,Strand S,Frank N,Knauft J,Wesch H,Galle PR,Bartsch H

更新日期：2005-07-01 00:00:00

abstract：:Preparations of dietary fibre have an ability to bind potentially toxic compounds in vitro, but it is unclear how the measured binding properties are a reflection of either the relative affinity of such compounds for fibre or the saturation binding capacity of the fibre. Cooking and processing of foods and fermentatio...

journal_title：Carcinogenesis

authors： Ryden P,Robertson JA

更新日期：1995-02-01 00:00:00

abstract：:Constituents in food and fluids, tobacco chemicals and many drugs are candidates for oral absorption and oxidative metabolism. On this basis, the expression of cytochrome P450 isozymes (CYPs) and the conversion of CYP substrates were analysed in reference to buccal mucosa. A RT-PCR based analysis of human buccal tissu...

journal_title：Carcinogenesis

authors： Vondracek M,Xi Z,Larsson P,Baker V,Mace K,Pfeifer A,Tjälve H,Donato MT,Gomez-Lechon MJ,Grafström RC

更新日期：2001-03-01 00:00:00

abstract：:The expression of cytochrome (CYP) P450 enzymes in human oesophageal mucosa was investigated in a total of 25 histologically non-neoplastic surgical tissue specimens by using specific antibodies in immunoblots and by RT-PCR mRNA analysis. The presence of CYP1A, 2E1, 3A and 4A enzymes was demonstrated by both technique...

journal_title：Carcinogenesis

authors： Lechevrel M,Casson AG,Wolf CR,Hardie LJ,Flinterman MB,Montesano R,Wild CP

更新日期：1999-02-01 00:00:00

abstract：:Dysbiosis of oral microbiome may dictate the progression of oral squamous cell carcinoma (OSCC). Yet, the composition of oral microbiome fluctuates by saliva and distinct sites of oral cavity and is affected by risky behaviors (smoking, drinking, and betel quid chewing) and individuals' oral health condition. To chara...

journal_title：Carcinogenesis

authors： Su SC,Chang LC,Huang HD,Peng CY,Chuang CY,Chen YT,Lu MY,Chiu YW,Chen PY,Yang SF

更新日期：2020-07-04 00:00:00

abstract：:Resveratrol is a phytochemical that has been under consideration for use as a prostate cancer chemopreventive agent. However, the efficacy, as well as the mechanisms of action of resveratrol on prostate cancer prevention, remains largely unknown. This study seeks to address these questions and examine the cancer preve...

journal_title：Carcinogenesis

authors： Wang TT,Hudson TS,Wang TC,Remsberg CM,Davies NM,Takahashi Y,Kim YS,Seifried H,Vinyard BT,Perkins SN,Hursting SD

更新日期：2008-10-01 00:00:00

abstract：:The present study was designed to compare the skin tumor promoting and epidermal ornithine decarboxylase (ODC) inducing activities of various structural analogs of anthralin (1,8-dihydroxy-9-anthrone) and chrysarobin (1,8-dihydroxy-3-methyl-9-anthrone). Groups of 30 SENCAR mice each were initiated with 7,12-dimethylbe...

journal_title：Carcinogenesis

authors： DiGiovanni J,Kruszewski FH,Coombs MM,Bhatt TS,Pezeshk A

更新日期：1988-08-01 00:00:00

abstract：:Previous studies have shown that 1- and 3-nitrobenzo[a]pyrene (NBaP) were mutagenic in the Salmonella reversion assay without exogenous activation and that 1-, 3- and 6-NBaP were mutagenic in the presence of hepatocytes or liver homogenate (S9). In the present study, 1-, 3- and 6-NBaP were tested for mutagenicity in C...

journal_title：Carcinogenesis

authors： Hass BS,Heflich RH,Schol HM,Chou MW,Fu PP,Casciano DA

更新日期：1986-04-01 00:00:00