Abstract:
:In the present study the modulating effects of dietary fish oil (MaxEPA) on unsaturated fat-promoted pancreatic carcinogenesis in azaserine-treated rats were investigated. Three groups of 20 rats (each group comprised five saline-treated and 15 azaserine-treated animals) were fed an AIN76-based purified diet containing (i) 5 wt% fat, (ii) 25 wt% fat including 5 wt% linoleic acid or (iii) 25 wt% fat including 5 wt% linoleic acid and 9.4 wt% (20 cal%) MaxEPA for 6 months. The number and size of pancreatic atypical acinar cell foci was significantly higher (P < 0.01) in azaserine-treated animals maintained on a high fat diet than in those fed a low fat diet. MaxEPA did not influence the promoting effect of the high fat diet. The labeling index of atypical acinar cell foci in animals maintained on both a low fat or a high fat/MaxEPA diet was significantly (P < 0.01) lower than that in rats fed a high fat diet without MaxEPA. The linoleic acid concentration was higher, whereas the arachidonic acid concentration was lower, in blood plasma and to a lesser extent also in the pancreas of animals given MaxEPA in comparison with the other groups. Furthermore, animals fed MaxEPA showed lower 6-keto-prostaglandin F1 alpha, prostaglandin F2 alpha and thromboxane B2 levels, but not prostaglandin E2 levels in pancreatic tissue in comparison with the other groups. It is concluded that a high fat diet containing 5 wt% linoleic acid has a strong promoting effect on pancreatic carcinogenesis in azaserine-treated rats. Dietary MaxEPA did not influence the promoting effect of unsaturated fat on pancreatic carcinogenesis, although it caused a decrease in both cell proliferation in atypical acinar cell foci and prostaglandin levels in the pancreas.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Appel MJ,Woutersen RAdoi
10.1093/carcin/15.10.2107subject
Has Abstractpub_date
1994-10-01 00:00:00pages
2107-12issue
10eissn
0143-3334issn
1460-2180journal_volume
15pub_type
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