Abstract:
:Dysbiosis of oral microbiome may dictate the progression of oral squamous cell carcinoma (OSCC). Yet, the composition of oral microbiome fluctuates by saliva and distinct sites of oral cavity and is affected by risky behaviors (smoking, drinking, and betel quid chewing) and individuals' oral health condition. To characterize the disturbances in the oral microbial population mainly due to oral tumorigenicity, we profiled the bacteria within the surface of OSCC lesion and its contralateral normal tissue from discovery (n=74) and validation (n=42) cohorts of male patients with cancers of the buccal mucosa. Significant alterations in the bacterial diversity and relative abundance of specific oral microbiota (most profoundly, an enrichment for genus Fusobacterium and the loss of genus Streptococcus in the tumor sites) were identified. Functional prediction of oral microbiome shown that microbial genes related to the metabolism of terpenoids and polyketides were differentially enriched between the control and tumor group, indicating a functional role of oral microbiome in formulating a tumor microenvironment via attenuated biosynthesis of secondary metabolites with anti-cancer effects. Furthermore, the vast majority of microbial signatures detected in the discovery cohort was generalized well to the independent validation cohort, and the clinical validity of these OSCC-associated microbes was observed and successfully replicated. Overall, our analyses reveal signatures (a profusion of Fusobacterium nucleatum CTI-2 and a decrease in Streptococcus pneumoniae) and functions (decreased production of tumor-suppressive metabolites) of oral microbiota related to oral cancer.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Su SC,Chang LC,Huang HD,Peng CY,Chuang CY,Chen YT,Lu MY,Chiu YW,Chen PY,Yang SFdoi
10.1093/carcin/bgaa062subject
Has Abstractpub_date
2020-07-04 00:00:00eissn
0143-3334issn
1460-2180pii
5867492pub_type
杂志文章相关文献
CARCINOGENESIS文献大全abstract::Dietary resistant starch (RS), as a high amylose maize starch (HAMS), prevents dietary protein-induced colonocyte genetic damage in rats, possibly through the short-chain fatty acid (SCFA) butyrate produced by large bowel bacterial RS fermentation. Increasing butyrate availability may improve colonic health and dietar...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn173
更新日期:2008-11-01 00:00:00
abstract::We have previously demonstrated that betel quid containing safrole induced DNA adducts are highly associated with the development of oral squamous cell carcinoma (OSCC) in Taiwan. Sulfotransferase (SULT) is essential for the formation of these adducts. To elucidate the effects of SULT1A1 haplotypes on OSCC susceptibil...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn283
更新日期:2009-02-01 00:00:00
abstract::We have previously reported the disposition of benzo[a]pyrene (B[a]P) and its metabolites in male Sprague-Dawley rats following intratracheal instillation of [3H]B[a]P [Weyand, E.H. and Bevan, D.R. (1986) Cancer Res., 46, 5655-5661]. In some experiments, cannulas were implanted in the bile duct of the animals prior to...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.11.2027
更新日期:1988-11-01 00:00:00
abstract::Apurinic/apyrimidinic endonuclease/redox effector factor-1 (APE/Ref-1) is a multifunctional protein involved both in DNA base excision repair and redox regulation. Studies have suggested that abnormal Ref-1 levels and/or activities are associated with tumor progression and sensitivities to treatment, but no direct evi...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm128
更新日期:2007-11-01 00:00:00
abstract::We previously reported a rapid production model for pancreatic carcinoma development in Syrian hamsters incorporating the principle of selection by resistance to cytotoxicity. In the present experiment, the efficacy of repeated augmentation pressure with regard to generation of pancreatic lesions in hamsters initiated...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.8.1457
更新日期:1989-08-01 00:00:00
abstract::It has been demonstrated that nuclear factor-kappa B (NF-κB), which is overactivated in hepatocellular carcinoma (HCC), plays important roles in the development of HCC. Recently, a group of dysregulated micro RNAs were reported to be involved in HCC progression. Further understanding of micro RNA-mediated regulation o...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt206
更新日期:2013-11-01 00:00:00
abstract::Previous studies have shown that decorin expression is significantly reduced in colorectal cancer tissues and cancer cells, and genetic deletion of the decorin gene is sufficient to cause intestinal tumor formation in mice, resulting from a downregulation of p21, p27(kip1) and E-cadherin and an upregulation of β-caten...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr293
更新日期:2012-02-01 00:00:00
abstract::To indicate how readily nitrosamines (NAms) diffuse into the esophagus, we measured diffusion rate (flux) through rat esophagus of dialkyl-NAms using side-by-side diffusion apparatuses. Mucosal and serosal flux at 37 degrees C of two NAms, each at 50 microM, was followed for 90 min by gas chromatography-thermal energy...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/20.5.825
更新日期:1999-05-01 00:00:00
abstract::Alterations in the pattern of epidermal cell differentiation and proliferation in mouse skin and benign skin tumors were studied by two-color immunofluorescence using monospecific antibodies. Replicating cells were identified by 5-bromo-deoxyuridine (BrdU) pulse-labeling and differentiating cells by keratins K1 and K1...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.11.2063
更新日期:1991-11-01 00:00:00
abstract::Common genetic variation may play an important role in altering lung cancer risk. We conducted a pathway-based candidate gene evaluation to identify genetic variations that may be associated with lung cancer in a population-based case-control study in Xuan Wei, China (122 cases and 111 controls). A total of 1260 singl...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn178
更新日期:2008-10-01 00:00:00
abstract::In light of clinical and biological evidence that bile constituents exert preventive effects against colorectal cancer, we evaluated the influence of oral bilirubin and sodium taurocholate (NaTC) on intestinal tumor formation in APC(Min/+) mice. Mice received bilirubin and/or bovine serum albumin (BSA) and NaTC in the...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq050
更新日期:2010-06-01 00:00:00
abstract::We previously reported that quinacrine (QC) has anticancer activity against breast cancer cells. Here, we examine the mechanism of action of QC and its ability to inhibit Wnt-TCF signaling in two independent breast cancer cell lines. QC altered Wnt-TCF signaling components by increasing the levels of adenomatous polyp...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs351
更新日期:2013-02-01 00:00:00
abstract::Okadaic acid is both a potent inhibitor of protein serine/threonine phosphatases and a tumor promoter in the mouse skin model. We have previously shown that at non-toxic nanomolar concentrations okadaic acid reversibly inhibits induction (promotion) by PDGF of transformed cells by the 'complete' and 'two-stage' protoc...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.4.665
更新日期:1991-04-01 00:00:00
abstract::Wildtype 10T1/2 cells and 42 clonally derived morphologically transformed 10T1/2 cell lines were evaluated for expression of p53 mRNA and protein. Wildtype 10T1/2 cells expressed detectable levels of p53 mRNA and multiple immunologically distinct forms of the p53 protein, including both PAb240- and PAb246-reactive con...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/15.2.145
更新日期:1994-02-01 00:00:00
abstract::Quantum and molecular mechanical calculations were employed to examine the effect on binding energies and structure of methylation and ethylation at O6-guanine in double-stranded DNA. Ab initio quantum chemical calculations (STO-3G, 3-21G) were initially used to pseudo-optimize the structure of the 9-methyl derivative...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.9.1553
更新日期:1988-09-01 00:00:00
abstract::The purpose of this study was to determine if decreasing dietary protein from 24% (high protein) to 5% casein (low protein), substituting sucrose and cornstarch isocalorifically for casein, would modify the activity of protein kinase C (PKC) alpha and beta isoenzymes, as well as the expression of PKC alpha, beta, delt...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/16.5.1233
更新日期:1995-05-01 00:00:00
abstract::Cryptic deletions at chromosome 6q are common cytogenetic abnormalities in T-cell lymphoblastic leukemia/lymphoma (T-LBL), but the target genes have not been formally identified. Our results build on detection of specific chromosomal losses in a mouse model of γ-radiation-induced T-LBLs and provide interesting clues f...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr271
更新日期:2012-02-01 00:00:00
abstract::DNA-methyltransferase-3B (DNMT3B) plays an important role in the generation of aberrant methylation in carcinogenesis. Polymorphisms and haplotypes of the DNMT3B gene may influence DNMT3B activity on DNA methylation, thereby modulating the susceptibility to lung cancer. To test this hypothesis, we investigated the ass...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh307
更新日期:2005-02-01 00:00:00
abstract::The oxidative stress induced in vivo by benzoyl peroxide (BzPo) or 12-O-tetradecanoylphorbol-13-acetate (TPA) was evaluated in terms of chemiluminescence (CL) emitted by SENCAR mouse skin, a non-invasive method that allows an estimation of overall oxidative stress. The ability of a biomimetic superoxide dismutase, cop...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.11.2047
更新日期:1991-11-01 00:00:00
abstract::Poly(ADP-ribose) (polymer) is enzymatically synthesized on nuclear proteins in response to DNA strand breaks. NAD+ is the substrate for this reaction, which is catalyzed by poly(ADP-ribose)polymerase. This post-translational modification occurs in response to DNA strand breaks and is thought to play an important role ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/14.12.2513
更新日期:1993-12-01 00:00:00
abstract::The present study was designed to evaluate whether etodolac, a cyclooxgenase-2 (COX-2)-specific inhibitor, could prevent chemically induced biliary carcinogenesis in bilioenterostomized hamsters. Syrian golden hamsters were subjected to choledochojejunostomy and then received subcutaneous injections of N-nitrosobis(2-...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh311
更新日期:2005-02-01 00:00:00
abstract::In this communication, we investigate the preventive effect of a flavonoid antioxidant, silymarin, on free radical-generating skin tumor promoting agent benzoyl peroxide (BPO)-induced tumor promotion, oxidative stress and inflammatory responses in SENCAR mouse skin. Topical application of silymarin at a dose of 6 mg p...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/21.4.811
更新日期:2000-04-01 00:00:00
abstract::The dysplastic nevus syndrome (DNS) is a preneoplastic melanocyte abnormality which occurs in families affected by hereditary cutaneous malignant melanoma (HCMM). A putative role of host-environmental interactions in the etiology of hereditary melanoma has been strengthened by the recent finding that fibroblasts deriv...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.7.911
更新日期:1983-01-01 00:00:00
abstract::Male F344 rats were administered phenobarbital, polychlorinated biphenyl (PCB), retinol acetate, indomethacin, 6-amino-caproic acid, dexamethasone (DEX) or diethylmaleate (DEM) for one week and then were treated with these chemicals plus butylated hydroxyanisole (BHA) for a further four weeks. Histopathologically, the...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.10.1555
更新日期:1987-10-01 00:00:00
abstract::Base excision repair (BER) and nucleotide excision repair (NER) pathways repair damaged DNA, and polymorphisms in these genes might affect breast cancer susceptibility. We evaluated associations between seven single-nucleotide polymorphisms in four DNA repair genes (ERCC4 rs1799801, XPC rs2227998, rs2228001, rs2228000...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr096
更新日期:2011-08-01 00:00:00
abstract::The suppression of apoptosis may contribute to the carcinogenicity of the peroxisome proliferators (PPs), a class of non-genotoxic rodent hepatocarcinogens. Our previous work demonstrated that the PP nafenopin suppressed both spontaneous and transforming growth factor beta1 (TGFbeta1)-induced hepatocyte apoptosis both...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/19.2.299
更新日期:1998-02-01 00:00:00
abstract::The nucleotide excision repair (NER) pathway is central in response to damage induced by environmental carcinogens. Efficiency of this pathway, probably genetically determined, may modulate individual risk of developing squamous cell carcinoma of the head and neck (SCCHN) as well as second primary malignancy (SPM) aft...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgp096
更新日期:2009-06-01 00:00:00
abstract::p53 is a tumor suppressor that responds to a variety of stresses such as oncogenes and DNA damage by activating its transcriptional targets to allow repair or elimination of damaged cells. In the absence of stress signals, p53 needs to be kept in check and this is achieved by the E3 ligase MDM2. For tumors that retain...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs092
更新日期:2012-04-01 00:00:00
abstract::Reduced retinyl ester synthesis has been associated with several forms of cancer; we therefore proposed studying melanoma development from the perspective of this biochemical pathway. Cultures of human melanoma cells with fibroblastoid morphology showed negligible retinyl ester synthesis; in sharp contrast, those with...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/23.11.1821
更新日期:2002-11-01 00:00:00
abstract::Checkpoint kinase (CHEK) 2, a tumor suppressor gene, plays an essential role in the DNA damage checkpoint response cascade. We first investigated two polymorphisms in the proximal promoter of the CHEK2 gene and evaluated their associations with the risk of lung cancer in a case-control study using 500 incident lung ca...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq089
更新日期:2010-07-01 00:00:00