Okadaic acid inhibits PDGF-induced proliferation and decreases PDGF receptor number in C3H/10T1/2 mouse fibroblasts.

abstract：:Metabolomic analysis of feces may provide insights on colorectal cancer (CRC) if assay performance is satisfactory. In lyophilized feces from 48 CRC cases, 102 matched controls, and 48 masked quality control specimens, 1043 small molecules were detected with a commercial platform. Assay reproducibility was good for 52...

journal_title：Carcinogenesis

authors： Goedert JJ,Sampson JN,Moore SC,Xiao Q,Xiong X,Hayes RB,Ahn J,Shi J,Sinha R

更新日期：2014-09-01 00:00:00

abstract：:Reprogrammed metabolism has been identified as an emerging hallmark in cancer cells. It has been demonstrated that fructose-1, 6-bisphosphatase 1 (FBP1) as a rate-limiting enzyme in gluconeogenesis plays critical roles in tumor initiation and progression in several cancer types. However, function of FBP1 in hepatocell...

journal_title：Carcinogenesis

authors： Yang J,Wang C,Zhao F,Luo X,Qin M,Arunachalam E,Ge Z,Wang N,Deng X,Jin G,Cong W,Qin W

更新日期：2017-02-01 00:00:00

abstract：:Cisplatin alone or in combination with 5FU (5-fluorouracil) and docetaxel (TPF) are common regimen chemotherapeutics for treatment of advanced oral squamous cell carcinoma (OSCC). Despite the initial positive response, several patients experience relapse due to chemoresistance. The potential role of Bcl-2 antiapoptoti...

journal_title：Carcinogenesis

authors： Maji S,Shriwas O,Samal SK,Priyadarshini M,Rath R,Panda S,Das Majumdar SK,Muduly DK,Dash R

更新日期：2019-03-12 00:00:00

abstract：:Quantum and molecular mechanical calculations were employed to examine the effect on binding energies and structure of methylation and ethylation at O6-guanine in double-stranded DNA. Ab initio quantum chemical calculations (STO-3G, 3-21G) were initially used to pseudo-optimize the structure of the 9-methyl derivative...

journal_title：Carcinogenesis

authors： Pedersen LG,Darden TA,Deerfield DW 2nd,Anderson MW,Hoel DG

更新日期：1988-09-01 00:00:00

abstract：:Comparative X-ray crystallographic structure analyses have been carried out on seven cyclopenta[a]phenanthrenes, namely 15,16-dihydocyclopenta[a]phenanthren-17-one and its 2-, 6- and 12-methyl homologues (non-carcinogens) and the 7-and 11-methyl and 1,11-methano derivatives (carcinogens). All-valence-electron molecula...

journal_title：Carcinogenesis

authors： Clayton AF,Coombs MM,Henrick K,McPartlin M,Trotter J

更新日期：1983-12-01 00:00:00

abstract：:The expression of cyclooxygenase-2 (COX-2) has been reported as an indicator of poor prognosis in a wide variety of human tumors, including colon, breast and uveal melanoma (UM). COX-2 inhibitors have shown promise in controlling the malignancy of several types of tumors. Previous studies have demonstrated the efficac...

journal_title：Carcinogenesis

authors： Marshall JC,Fernandes BF,Di Cesare S,Maloney SC,Logan PT,Antecka E,Burnier MN Jr

更新日期：2007-09-01 00:00:00

abstract：:Oxidized DNA base lesions, such as thymine glycol (Tg) and 8-hydroxyguanine, are often toxic and mutagenic and have been implicated in carcinogenesis. To clarify whether NEIL1 protein, which exhibits excision repair activity towards such base lesions, is involved in gastric carcinogenesis, we examined 71 primary gastr...

journal_title：Carcinogenesis

authors： Shinmura K,Tao H,Goto M,Igarashi H,Taniguchi T,Maekawa M,Takezaki T,Sugimura H

更新日期：2004-12-01 00:00:00

abstract：:Chrysoidine dyes are used by fishermen to colour bait and recent epidemiological evidence has suggested that this may explain why they are at increased risk of urothelial cancer. In recent years Bismark brown dyes have been used as chrysoidine substitutes. Previous mutagenicity studies on these azo-dyes have examined ...

journal_title：Carcinogenesis

authors： Sole GM,Chipman JK

更新日期：1986-11-01 00:00:00

abstract：:The liver-derived human cell line, Hep G2, has high benzo[a]pyrene-metabolizing activity and converts benzo[a]pyrene to intermediates that are mutagenic and that bind to DNA. This cell line will be useful for studying metabolic activation of polycyclic aromatic hydrocarbons and other xenobiotics by human tissue and as...

journal_title：Carcinogenesis

authors： Diamond L,Kruszewski F,Aden DP,Knowles BB,Baird WM

更新日期：1980-01-01 00:00:00

abstract：:We have previously demonstrated that the active dihydrofolate reductase (DHFR) gene is efficiently repaired in Chinese hamster ovary (CHO) cells which remove only a small fraction of u.v.-induced pyrimidine dimers from the overall genome. Preferential DNA repair of essential genes may explain why the u.v. resistance o...

journal_title：Carcinogenesis

authors： Bohr VA,Hanawalt PC

更新日期：1987-09-01 00:00:00

abstract：:In order to develop more efficient in vitro systems for the study of pro-mutagenic or pro-carcinogenic chemicals, we have produced transgenic C3H/10T1/2 cell lines expressing human cytochrome P450 (CYP) 2A6. A retroviral vector containing the cDNA was packaged in psi-2 cells, and used to infect C3H/10T1/2 cells. From ...

journal_title：Carcinogenesis

authors： Tiano HF,Hosokawa M,Chulada PC,Smith PB,Wang RL,Gonzalez FJ,Crespi CL,Langenbach R

更新日期：1993-07-01 00:00:00

abstract：:Untreated and Aroclor 1254-pretreated male Wistar rats were given a single dose of 1.0 mg/kg body weight of randomly tritium-labelled 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (3H-PhIP) by oral intubation. Urine and faeces were collected at 24, 48 and 72 hours after dosing, and total radioactivity determined. A...

journal_title：Carcinogenesis

authors： Dragsted LO,Frandsen H,Reistad R,Alexander J,Larsen JC

更新日期：1995-11-01 00:00:00

abstract：:Monoclonal antibodies were produced that recognized alkali-stabilized modifications of DNA formed by the anticancer drug melphalan in order to permit measurement of melphalan-DNA adducts in individual cells by immunofluorescent staining. Antibody Amp4/42 did not bind to alkali-treated control DNA or to DNA that had be...

journal_title：Carcinogenesis

authors： Tilby MJ,McCartney H,Cordell J,Frank AJ,Dean CJ

更新日期：1995-08-01 00:00:00

abstract：:Pancreatic cancer has remained refractory to treatment. In large part, this results from the lack of an animal model that mimics pancreatic cancer in man. We describe a novel experimental model of pancreatic cancer that shares the genetic background, histologic features and natural history of human mixed acinar-ductal...

journal_title：Carcinogenesis

authors： Doiron B,DeFronzo RA

更新日期：2018-02-09 00:00:00

abstract：:The three-dimensional structure of the product of the reaction of a diol epoxide of the carcinogen 5-methylchrysene with methanol has been determined by an X-ray diffraction analysis. The diol epoxide used to obtain this compound contains a stereochemically hindered bay region because of the location of the 5-methyl g...

journal_title：Carcinogenesis

authors： Afshar CE,Carrell CJ,Carrell HL,Harvey RG,Kiselyov AS,Amin S,Glusker JP

更新日期：1996-11-01 00:00:00

abstract：:Formaldehyde (FA) is a widely produced industrial chemical. Sufficient evidence exists to consider FA as an animal carcinogen. In humans the evidence is not conclusive. DNA-protein crosslinks (DPC) may be one of the early lesions in the carcinogenesis process in cells following exposures to carcinogens. It has been sh...

journal_title：Carcinogenesis

authors： Shaham J,Bomstein Y,Meltzer A,Kaufman Z,Palma E,Ribak J

更新日期：1996-01-01 00:00:00

abstract：:The effects of alternating ad libitum feeding and 30% restriction of the dietary intake on the development of diethylnitrosamine (DEN)-induced hepatic neoplasia were investigated. Dietary restriction retarded the growth of glucose-6-phosphatase-deficient (G6Pd) preneoplastic foci and subsequently that of hepatocellula...

journal_title：Carcinogenesis

authors： Lagopoulos L,Sunahara GI,Würzner H,Dombrowsky I,Stalder R

更新日期：1991-02-01 00:00:00

abstract：:It has been proposed that extremely low frequency magnetic fields may enhance tumorigenesis through a co-promotional mechanism. This hypothesis has been further tested using the two-stage model of mouse skin carcinogenesis, i.e. 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced promotion of skin carcinogenesis in mic...

journal_title：Carcinogenesis

authors： DiGiovanni J,Johnston DA,Rupp T,Sasser LB,Anderson LE,Morris JE,Miller DL,Kavet R,Walborg EF Jr

更新日期：1999-04-01 00:00:00

abstract：:The present study was conducted to clarify the cooperative significance of epigenomic and genomic abnormalities during gastric carcinogenesis. Using 21 samples of normal control gastric mucosa (C), 109 samples of non-cancerous gastric mucosa (N) and 105 samples of cancerous tissue (T) from 109 patients with primary ga...

journal_title：Carcinogenesis

authors： Yang M,Arai E,Takahashi Y,Totsuka H,Chiku S,Taniguchi H,Katai H,Sakamoto H,Yoshida T,Kanai Y

更新日期：2020-11-13 00:00:00

abstract：:The epidermal growth factor receptor (EGFR) pathway has recently been appreciated as a central mediator of tumorigenesis and an important drug target; however, the influence of genetic variation in this pathway on bladder cancer is not understood. Pathway activation leads to cell proliferation, angiogenesis and is ant...

journal_title：Carcinogenesis

authors： Mason RA,Morlock EV,Karagas MR,Kelsey KT,Marsit CJ,Schned AR,Andrew AS

更新日期：2009-07-01 00:00:00

abstract：:Information suggests that the cyclooxygenase (COX) metabolites, the prostanoids, play a role in gall bladder physiology and disease. Non-steroidal anti-inflammatory drugs which inhibit COX enzymes have been shown in vivo and in vitro to alter the growth patterns of intestinal epithelial cells, and specific COX-2 inhib...

journal_title：Carcinogenesis

authors： Grossman EM,Longo WE,Panesar N,Mazuski JE,Kaminski DL

更新日期：2000-07-01 00:00:00

abstract：:Examination of p53 mutation spectra may provide clues to molecular mechanisms involved in different histologic types of gastric cancer. A total of 105 gastric cancer cases classified according to the Laurén's system were selected from a high-risk area around Florence, Italy. Exons 5-8 of the p53 gene were examined for...

journal_title：Carcinogenesis

authors： Shiao YH,Palli D,Buzard GS,Caporaso NE,Amorosi A,Saieva C,Fraumeni JF Jr,Anderson LM,Rice JM

更新日期：1998-12-01 00:00:00

abstract：:Apoptosis is a morphologically and biochemically distinct form of cell death which determines specific patterns of tissue size and shape and balances cell proliferation. In the present study, the sequence of cellular proliferative alterations in urinary bladder epithelium associated with uracil-induced reversible urin...

journal_title：Carcinogenesis

authors： Otori K,Yano Y,Takada N,Lee CC,Hayashi S,Otani S,Fukushima S

更新日期：1997-08-01 00:00:00

abstract：:Chemical carcinogenesis in mouse skin has been divided into the process of initiation, promotion and progression. Recently we have shown that ionizing radiation acts as an initiator in this model system. In this paper we describe a three-stage experiment using ionizing radiation in the third stage of mouse skin carcin...

journal_title：Carcinogenesis

authors： Jaffe DR,Williamson JF,Bowden GT

更新日期：1987-11-01 00:00:00

abstract：:Inactivation of the adenomatous polyposis coli (Apc) gene by loss of the wild-type Apc allele (LOH) is a prerequisite for the development of intestinal adenomas in Msh2 proficient Min (Apc+/-Msh2+/+) mice. In contrast, adenomas from Msh2 deficient Min (Apc+/-Msh2-/-) mice are not usually associated with LOH. Given the...

journal_title：Carcinogenesis

authors： Sohn KJ,Choi M,Song J,Chan S,Medline A,Gallinger S,Kim YI

更新日期：2003-02-01 00:00:00

abstract：:Overexpressed DNA methyltransferase 1 (DNMT1) strongly contributes to tumor suppressor gene silencing in colorectal cancer (CRC). However, the underlying mechanism of DNMT1 overexpression is still unclear. MicroRNAs (miRNA) have been implicated as gene regulators controlling diverse biological processes, including car...

journal_title：Carcinogenesis

authors： Wang H,Wu J,Meng X,Ying X,Zuo Y,Liu R,Pan Z,Kang T,Huang W

更新日期：2011-07-01 00:00:00

abstract：:Orotic acid, a precursor of pyrimidine nucleotide biosynthesis and a promoter for liver carcinogenesis, when fed at 1% level in a diet for 5 weeks resulted in liver DNA damage. The damage can be monitored as alkali-labile lesions using alkaline sucrose gradients as well as alkaline elution technique. Furthermore, the ...

journal_title：Carcinogenesis

authors： Rao PM,Rajalakshmi S,Alam A,Sarma DS,Pala M,Parodi S

更新日期：1985-05-01 00:00:00

abstract：:Low vitamin E and selenium (Ve/Se) nutritional status is known to be associated with increased risk of esophageal squamous cell carcinoma (ESCC). A previous human intervention trial demonstrated that Ve/Se supplementation decreased the occurrence of esophageal cancer death among younger participants but not among olde...

journal_title：Carcinogenesis

authors： Yang H,Fang J,Jia X,Han C,Chen X,Yang CS,Li N

更新日期：2011-03-01 00:00:00

abstract：:SENCAR mice are unusually sensitive to induction of papillomas and squamous cell carcinomas by initiation with 7,12-dimethylbenzanthracene (DMBA) and promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA). Tumors induced by this protocol were tested for the presence of papillomavirus by immunohistochemistry, Southern...

journal_title：Carcinogenesis

authors： Sundberg JP,Binder RL,Maurer JK,Newmann EA,Cunniff JJ

更新日期：1990-02-01 00:00:00

abstract：:Integrins control the cell attachment to the extracellular matrix and play an important role in mediating cell proliferation, migration and survival. A number of important cancer-associated integrin genes can be regulated by microRNAs (miRNAs) that bind to their target sites in the 3' untranslated regions. We examined...

journal_title：Carcinogenesis

authors： Brendle A,Lei H,Brandt A,Johansson R,Enquist K,Henriksson R,Hemminki K,Lenner P,Försti A

更新日期：2008-07-01 00:00:00