Unmasking the impact of Rictor in cancer: novel insights of mTORC2 complex.

abstract：:The DNA double-strand breaks (DSBs) repair pathway has been implicated in maintaining genomic integrity via suppression of chromosomal rearrangements. DNA-dependent protein kinase (DNA-PK) has an important role with DNA DSBs repair. In this study, 93 of untreated cancer patients and 41 of cancer-free healthy volunteer...

journal_title：Carcinogenesis

authors： Someya M,Sakata K,Matsumoto Y,Yamamoto H,Monobe M,Ikeda H,Ando K,Hosoi Y,Suzuki N,Hareyama M

更新日期：2006-01-01 00:00:00

abstract：:Previous studies have shown that TIPE1 inhibits tumor proliferation and metastasis in certain cancers; however, increased expression of TIPE1 is observed in cervical cancer cell lines and tissues, indicating it might exert a distinctive role in cervical cancer. Cell and xenograft tumorigenicity assays showed that TIPE...

journal_title：Carcinogenesis

authors： Zhao P,Pang X,Jiang J,Wang L,Zhu X,Yin Y,Zhai Q,Xiang X,Feng F,Xu W

更新日期：2019-06-10 00:00:00

abstract：:The androgen receptor (AR) is involved in the development and progression of prostate cancer. In order to find new compounds that may present novel mechanisms to attenuate the function of AR, we investigated the effect of a natural flavonoid chemical, quercetin, on androgen action in an androgen-responsive LNCaP prost...

journal_title：Carcinogenesis

authors： Xing N,Chen Y,Mitchell SH,Young CY

更新日期：2001-03-01 00:00:00

abstract：:The effects of in vivo exposure to DDT on hepatic gap junctional intercellular communication (GJIC) and connexin gene/protein expression in Sprague-Dawley rats were examined by in vivo/in vitro dye-transfer assay, immunohistochemical staining, and by Western and Northern blot analyses. In the dose-response study, thre...

journal_title：Carcinogenesis

authors： Tateno C,Ito S,Tanaka M,Oyamada M,Yoshitake A

更新日期：1994-03-01 00:00:00

abstract：:Practical methods for the routine solid-phase synthesis of oligodeoxynucleotides containing O6-alkylguanine are described. It is shown that if the 2-amino group of the alkylated base is protected with a phenylacetyl group, and a mixture of nitrobenzaldoximate ions and ammonia used to remove the protecting groups from ...

journal_title：Carcinogenesis

authors： Smith CA,Xu YZ,Swann PF

更新日期：1990-05-01 00:00:00

abstract：:Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disorder, and prophylactic colectomy has been shown to decrease the incidence of colorectal cancer (CRC). Duodenal cancer and desmoids are now the leading causes of death in FAP. We evaluate whether 3 months of oral supplementation with a patented...

journal_title：Carcinogenesis

authors： Calabrese C,Rizzello F,Gionchetti P,Calafiore A,Pagano N,De Fazio L,Valerii MC,Cavazza E,Strillacci A,Comelli MC,Poggioli G,Campieri M,Spisni E

更新日期：2016-06-01 00:00:00

abstract：:Many chemoradiation therapies cause DNA damage through oxidative stress. An important cellular mechanism that protects cells against oxidative stress involves DNA repair. One of the primary DNA repair mechanisms for oxidative DNA damage is base excision repair (BER). BER involves the tightly coordinated function of fo...

journal_title：Carcinogenesis

authors： Zhang H,Mizumachi T,Carcel-Trullols J,Li L,Naito A,Spencer HJ,Spring PM,Smoller BR,Watson AJ,Margison GP,Higuchi M,Fan CY

更新日期：2007-08-01 00:00:00

abstract：:The aim of this study was to investigate selected proteomic markers of the metabolic phenotype of breast carcinomas as prognostic markers of cancer progression. For this purpose, a series of 101 breast carcinomas and 13 uninvolved breast samples were examined for quantitative differences in protein expression of mitoc...

journal_title：Carcinogenesis

authors： Isidoro A,Casado E,Redondo A,Acebo P,Espinosa E,Alonso AM,Cejas P,Hardisson D,Fresno Vara JA,Belda-Iniesta C,González-Barón M,Cuezva JM

更新日期：2005-12-01 00:00:00

abstract：:ROS1-fusion genes, resulting from chromosomal rearrangement, have been reported in 1-2% of human non-small cell lung cancer cases. More than 10 distinct ROS1-fusion genes, including break-point variants, have been identified to date. In this study, to investigate the in vivo oncogenic activities of one of the most fre...

journal_title：Carcinogenesis

authors： Inoue M,Toki H,Matsui J,Togashi Y,Dobashi A,Fukumura R,Gondo Y,Minowa O,Tanaka N,Mori S,Takeuchi K,Noda T

更新日期：2016-05-01 00:00:00

abstract：:The inability of cells in culture to grow in medium where methionine is replaced by its metabolic precursor, homocysteine, has been linked to neoplastic transformation and termed 'methionine dependence' or 'methionine auxotrophy'. The present investigation was undertaken to establish the influence of intracellular glu...

journal_title：Carcinogenesis

authors： Djurhuus R,Svardal AM,Mansoor MA,Ueland PM

更新日期：1991-02-01 00:00:00

abstract：:Here we report that colorectal cancer patients show a markedly higher frequency (3-fold) of wild-type NAT2*4 allele homozygotes than the control population. However, a marked difference in NAT2*4/NAT2*4 genotype frequency associated with the patients gender was observed pointing to a male-specific effect of this genot...

journal_title：Carcinogenesis

authors： Gil JP,Lechner MC

更新日期：1998-01-01 00:00:00

abstract：:3,4-Epoxy-1-butene (EB) is the major mutagenic metabolite of butadiene (BD), an important industrial chemical classified as a probable human carcinogen. Although the mechanism of carcinogenicity of EB is not known, its reactions with nucleophilic sites of DNA giving pro-mutagenic lesions are likely to constitute the e...

journal_title：Carcinogenesis

authors： Tretyakova N,Lin Y,Sangaiah R,Upton PB,Swenberg JA

更新日期：1997-01-01 00:00:00

abstract：:A diet deficient in choline when fed to rats for as few as 3 days resulted in liver DNA damage. The damage could be monitored as alkali-labile lesions using alkaline-sucrose gradients as well as alkaline elution technique. The DNA damage disappeared when the choline-deficient diet was replaced by a choline-supplemente...

journal_title：Carcinogenesis

authors： Rushmore TH,Farber E,Ghoshal AK,Parodi S,Pala M,Taningher M

更新日期：1986-10-01 00:00:00

abstract：:Receptor tyrosine kinase EphB3 is expressed in cells in the bottom of intestinal crypts near stem cell niches. Loss of Ephb3 has recently been reported to produce invasive colorectal carcinoma in Apc(Min/+) mice and EphB-mediated compartmentalization was demonstrated to be a mechanism suppressing colorectal cancer pro...

journal_title：Carcinogenesis

authors： Chiu ST,Chang KJ,Ting CH,Shen HC,Li H,Hsieh FJ

更新日期：2009-09-01 00:00:00

abstract：:Epidemiological evidence suggests that the presence of human papillomaviruses (HPV), when combined with smoking behaviors, considerably enhances the risk of developing oral, cervical, vulvar, and/or anal carcinomas. It is well established that the cytochrome P450 (CYP), microsomal epoxide hydrolase (mEH), and other bi...

journal_title：Carcinogenesis

authors： Farin FM,Bigler LG,Oda D,McDougall JK,Omiecinski CJ

更新日期：1995-06-01 00:00:00

abstract：:AP-endonuclease (APE) plays a central role in the base excision repair process for oxidative and alkylation damage in DNA. The major human APE with 318 amino acid residues possesses transcriptional regulatory activities for which the N-terminal region was found to be essential. Systematic deletion studies of both amin...

journal_title：Carcinogenesis

authors： Izumi T,Mitra S

更新日期：1998-03-01 00:00:00

abstract：:Recent studies have demonstrated that K-ras mutations in lung epithelial cells elicit inflammation that promotes carcinogenesis in mice (intrinsic inflammation). The finding that patients with chronic obstructive pulmonary disease (COPD), an inflammatory disease of the lung, have an increased risk of lung cancer after...

journal_title：Carcinogenesis

authors： Moghaddam SJ,Barta P,Mirabolfathinejad SG,Ammar-Aouchiche Z,Garza NT,Vo TT,Newman RA,Aggarwal BB,Evans CM,Tuvim MJ,Lotan R,Dickey BF

更新日期：2009-11-01 00:00:00

abstract：:The conformation of N-(deoxyguanosin-8-yl)-2-acetylaminofluorene and N-(deoxyguanosin-8-yl)-2-aminofluorene was investigated by 1H n.m.r. spectroscopy. There was rotation about the glycosyl bond and preference for either the anti or syn conformation depended on whether or not the 8-arylamino nitrogen was acetylated. T...

journal_title：Carcinogenesis

authors： Evans FE,Miller DW,Beland FA

更新日期：1980-01-01 00:00:00

abstract：:DNA strand breage in response to damage produced by UV (254 nm) radiation was characterized after permeabilization of diploid normal and xeroderma pigmentosum variant fibroblasts. The breakage reaction required ATP, Mg2+ and sucrose for maximal activity and was inhibited by 150 mM Na+ or K+ and 1 mM N-ethylmaleimide. ...

journal_title：Carcinogenesis

authors： Kaufmann WK,Briley LP

更新日期：1990-01-01 00:00:00

abstract：:The nitrogen heterocycle dibenz[c,h]acridine (DB[c,h]ACR) and the enantiomers of the diastereomeric pair of bay-region 3,4-diol 1, 2-epoxides as well as other bay-region epoxides and dihydrodiol derivatives of this hydrocarbon have been evaluated for tumorigenicity on mouse skin and in the newborn mouse. On mouse skin...

journal_title：Carcinogenesis

authors： Chang RL,Wood AW,Kumar S,Lehr RE,Shirai N,Jerina DM,Conney AH

更新日期：2000-11-01 00:00:00

abstract：:Effect of nicotine on PDGF AA and PDGF BB interaction with cervical cancer SiHa cells was tested. [125I]PDGF AA was internalized by cells and accumulated in the cytoplasm and nucleus (chromatin). In the absence of nicotine, maximal accumulation of [125I]PDGF AA inside the cells occurred after 1 day of incubation, whic...

journal_title：Carcinogenesis

authors： Rakowicz-Szulczynska EM,McIntosh DG,Perry M,Smith ML

更新日期：1996-09-01 00:00:00

abstract：:Cancer testis antigens (CTAs) are promising targets for T cell-based immunotherapy and studies have shown that certain CT genes are epigenetically depressed in cancer cells through DNA demethylation. Melanoma-associated antigen A11 (MAGE-A11) is a CTA that is frequently expressed in esophageal cancer and is correlated...

journal_title：Carcinogenesis

authors： Wu Y,Sang M,Liu F,Zhang J,Li W,Li Z,Gu L,Zheng Y,Li J,Shan B

更新日期：2020-07-14 00:00:00

abstract：:The PEA3/E1AF/ETV4 gene encodes an Ets-related transcription factor that is expressed in the epithelial cells of the mammary gland. Previous reports have shown that PEA3 can up-regulate promoter activities of many genes associated with tumorigenesis. A significant fraction of those encode matrix metalloproteinases (MM...

journal_title：Carcinogenesis

authors： Bièche I,Tozlu S,Girault I,Onody P,Driouch K,Vidaud M,Lidereau R

更新日期：2004-03-01 00:00:00

abstract：:Vinyl chloride (VC) is a carcinogen associated with human and animal cancers. The ultimate carcinogenic form of VC, 2-chloroacetaldehyde (CAA), has been suspected to be mutagenic and we confirmed the mutagenicity of CAA using a modified shuttle vector plasmid. Base sequence analyses of 109 mutant plasmids with mutatio...

journal_title：Carcinogenesis

authors： Matsuda T,Yagi T,Kawanishi M,Matsui S,Takebe H

更新日期：1995-10-01 00:00:00

abstract：:In this study we have investigated the relationship between the dose of 1,2-dimethylhydrazine (DMH) and the yield (and location) of tumours in a mouse strain susceptible to colon tumour induction. Female SWR mice were injected with 6.8 mg/kg DMH i.p. once a week for 1, 5, 10 and 20 weeks and the animals were followed ...

journal_title：Carcinogenesis

authors： Jackson PE,Cooper DP,O'Connor PJ,Povey AC

更新日期：1999-03-01 00:00:00

abstract：:Two complementary genetic parameters were followed in liver parenchymal cells during the first steps of rat hepatocarcinogenesis: the expression of nucleolar genes estimated from their silver stainability and the nuclear DNA content determined after Feulgen staining. Putative preneoplastic lesions as foci and nodules ...

journal_title：Carcinogenesis

authors： Deleener A,Castelain P,Preat V,de Gerlache J,Alexandre H,Kirsch-Volders M

更新日期：1987-02-01 00:00:00

abstract：:The promoting action of hexachlorocyclohexane (HCH) was evaluated in female Wistar rats by counting the gamma-glutamyltranspeptidase-positive foci which appeared in the liver after diethylnitrosamine (DENA) initiation. Liver tumor promotion by HCH was further confirmed in a long-term tumorigenicity study after DENA pr...

journal_title：Carcinogenesis

authors： Munir KM,Rao KV,Bhide SV

更新日期：1984-04-01 00:00:00

abstract：:In this report we describe results showing that both arachidonic acid (20:4) release and prostaglandin (PG) synthesis in herpes simplex virus type 2 (HSV-2)-transformed tumor-derived rat fibrosarcoma (RFS) cells are inhibited by indomethacin (cyclooxygenase inhibitor). These data suggest that cyclooxygenase (prostagla...

journal_title：Carcinogenesis

authors： Heitman CR,Waite M,Kucera LS

更新日期：1989-11-01 00:00:00

abstract：:The ability of sodium bisulfite to induce morphological transformation and mutagenesis of cultured Syrian hamster embryo cells was examined. Treatment of the cells at neutral pH for 15 min with 5-20 mM sodium bisulfite resulted in a dose-dependent increase in cell transformation but no induction of gene mutations meas...

journal_title：Carcinogenesis

authors： Tsutsui T,Barrett JC

更新日期：1990-10-01 00:00:00

abstract：:An increased neuroendocrine (NE) cell population in prostate cancer is associated with more aggressive disease and recurrence after androgen-deprivation therapy, although the mechanism responsible is unknown. In this study, we report that the treatment of LNCaP cells with epidermal growth factor (EGF) in the presence ...

journal_title：Carcinogenesis

authors： Cortés MA,Cariaga-Martinez AE,Lobo MV,Martín Orozco RM,Motiño O,Rodríguez-Ubreva FJ,Angulo J,López-Ruiz P,Colás B

更新日期：2012-06-01 00:00:00