Abstract:
:Practical methods for the routine solid-phase synthesis of oligodeoxynucleotides containing O6-alkylguanine are described. It is shown that if the 2-amino group of the alkylated base is protected with a phenylacetyl group, and a mixture of nitrobenzaldoximate ions and ammonia used to remove the protecting groups from the oligomer at the end of the synthesis, there is negligible formation of 2,6-diaminopurine and that after chromatography pure oligomers are obtained.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Smith CA,Xu YZ,Swann PFdoi
10.1093/carcin/11.5.811subject
Has Abstractpub_date
1990-05-01 00:00:00pages
811-6issue
5eissn
0143-3334issn
1460-2180journal_volume
11pub_type
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