Activity of triphenylselenonium chloride in mammary cancer prevention.

abstract：:Aberrant crypt foci (ACF) are microscopic surface abnormalities that are putative precursors to colorectal cancer (CRC). ACF exhibit similar histological and molecular abnormalities to adenomas and CRC and potentially represent useful biomarkers of cancer risk. Microsatellite instability (MSI) is one molecular abnorma...

journal_title：Carcinogenesis

authors： Greenspan EJ,Cyr JL,Pleau DC,Levine J,Rajan TV,Rosenberg DW,Heinen CD

更新日期：2007-04-01 00:00:00

abstract：:The Bowman-Birk protease inhibitor (BBI) is a legume-derived inhibitor of chymotrypsin and trypsin that has been shown to suppress cellular transformation and tumorigenesis. In the present investigation the effects of various BBI administration schedules were evaluated for suppression of 3-methylcholanthrene (3-MCA)-i...

journal_title：Carcinogenesis

authors： St Clair WH

更新日期：1991-05-01 00:00:00

abstract：:A new sensitive 32P-postlabeling assay for DNA adducts has been developed in which DNA is hydrolyzed initially by nuclease P1 and prostatic acid phosphatase instead of micrococcal nuclease and spleen phosphodiesterase as employed in previous postlabeling procedures. When DNA containing bulky adducts, X1, X2, .....Xn, ...

journal_title：Carcinogenesis

authors： Randerath K,Randerath E,Danna TF,van Golen L,Putman KL

更新日期：1989-07-01 00:00:00

abstract：:Reduced DNA repair capacity of carcinogen-induced DNA damage is now thought to significantly influence inherent susceptibility to lung cancer. DNA-dependent protein kinase (DNA-PK) is a serine-threonine kinase activated by the presence of double-strand breaks in DNA that appears to play a major role in non-homologous ...

journal_title：Carcinogenesis

authors： Auckley DH,Crowell RE,Heaphy ER,Stidley CA,Lechner JF,Gilliland FD,Belinsky SA

更新日期：2001-05-01 00:00:00

abstract：:Reactive intermediates (ultimate mutagens/carcinogens) generated by alkylating agents are unstable and difficult to characterize by chemical means. We have used a genetic system to distinguish the in vivo interactions of eight carcinogenic methylating agents and five ethylating agents by the patterns of induced mutati...

journal_title：Carcinogenesis

authors： Elespuru RK,Stupar LL,Gordon JA

更新日期：1991-07-01 00:00:00

abstract：:Quantum and molecular mechanical calculations were employed to examine the effect on binding energies and structure of methylation and ethylation at O6-guanine in double-stranded DNA. Ab initio quantum chemical calculations (STO-3G, 3-21G) were initially used to pseudo-optimize the structure of the 9-methyl derivative...

journal_title：Carcinogenesis

authors： Pedersen LG,Darden TA,Deerfield DW 2nd,Anderson MW,Hoel DG

更新日期：1988-09-01 00:00:00

abstract：:A culture method to grow two morphologically distinguishable normal human breast epithelial cell types derived from reduction mammoplasty has been developed. Type I cells were characterized by a more variable cell shape, smooth cell colony boundaries, the expression of epithelial membrane antigen (EMA) and keratin 18 ...

journal_title：Carcinogenesis

authors： Kao CY,Nomata K,Oakley CS,Welsch CW,Chang CC

更新日期：1995-03-01 00:00:00

abstract：:Male ICR Swiss mice, weighing 16-20 g, were fed ad libitum either a fat-free diet or a diet containing 10% corn oil. After three weeks on these diets, the rates of benzo[a]pyrene (B[a]P) metabolite formation and metabolism to products which covalently bind with macromolecules were compared using hepatic nuclei and mic...

journal_title：Carcinogenesis

authors： Baker MT,Karr SW,Wade AE

更新日期：1983-01-01 00:00:00

abstract：:Dog urinary bladder is a target organ of carcinogenic arylamines. However, dog hepatic and urothelial cytosols lack acetylation enzymes that are capable of activating N-hydroxy metabolites of arylamines, suggesting that other enzymes may be involved. In the present study, we found that dog liver microsomes were capabl...

journal_title：Carcinogenesis

authors： Sone T,Zukowski K,Land SJ,King CM,Wang CY

更新日期：1991-10-01 00:00:00

abstract：:The purpose of this study was to compare the metabolism and DNA binding of aflatoxicol (AFL) with that of aflatoxin B1 (AFB1) in vivo and in isolated hepatocytes from Mt Shasta strain rainbow trout (Salmo gairdneri). Maximum total binding of [3H]AFL to liver DNA from trout exposed by intraperitoneal injection was 38-4...

journal_title：Carcinogenesis

authors： Loveland PM,Wilcox JS,Pawlowski NE,Bailey GS

更新日期：1987-08-01 00:00:00

abstract：:The human homolog of the Drosophila headcase (HECA) belongs to a new class of cell differentiation regulators. In Drosophila, the HECA protein regulates the proliferation and differentiation of cells during adult morphogenesis. There is growing evidence that HECA plays an important role in human carcinogenesis. In dif...

journal_title：Carcinogenesis

authors： Dowejko A,Bauer RJ,Müller-Richter UD,Reichert TE

更新日期：2009-10-01 00:00:00

abstract：:Benzo[a]pyrene diol epoxide (BPDE)-DNA adducts are involved in the induction of p53 mutations and probably in the causation of human lung cancer associated with cigarette smoking. The ratio between CYP1A1 and GST enzyme activities is a critical determinant of the target dose of carcinogenic BPDE and other DNA-reactive...

journal_title：Carcinogenesis

authors： Alexandrov K,Cascorbi I,Rojas M,Bouvier G,Kriek E,Bartsch H

更新日期：2002-12-01 00:00:00

abstract：:Alteration in microRNAs (miRNAs) expression is a frequent finding in human cancers. In particular, widespread miRNAs down-regulation is a hallmark of malignant transformation. In the present report, we showed that the miR-128-3p, which is up-regulated in lung cancer tissues, has Drosha and Dicer, two key enzymes of mi...

journal_title：Carcinogenesis

authors： Frixa T,Sacconi A,Cioce M,Roscilli G,Ferrara FF,Aurisicchio L,Pulito C,Telera S,Carosi M,Muti P,Strano S,Donzelli S,Blandino G

更新日期：2018-02-09 00:00:00

abstract：:Checkpoint kinase (CHEK) 2, a tumor suppressor gene, plays an essential role in the DNA damage checkpoint response cascade. We first investigated two polymorphisms in the proximal promoter of the CHEK2 gene and evaluated their associations with the risk of lung cancer in a case-control study using 500 incident lung ca...

journal_title：Carcinogenesis

authors： Zhang S,Lu J,Zhao X,Wu W,Wang H,Lu J,Wu Q,Chen X,Fan W,Chen H,Wang F,Hu Z,Jin L,Wei Q,Shen H,Huang W,Lu D

更新日期：2010-07-01 00:00:00

abstract：:In order to develop more efficient in vitro systems for the study of pro-mutagenic or pro-carcinogenic chemicals, we have produced transgenic C3H/10T1/2 cell lines expressing human cytochrome P450 (CYP) 2A6. A retroviral vector containing the cDNA was packaged in psi-2 cells, and used to infect C3H/10T1/2 cells. From ...

journal_title：Carcinogenesis

authors： Tiano HF,Hosokawa M,Chulada PC,Smith PB,Wang RL,Gonzalez FJ,Crespi CL,Langenbach R

更新日期：1993-07-01 00:00:00

abstract：:In vivo incorporation of [3H] thymidine into DNA was determined in rats at 28 h after partial hepatectomy. Administration of nickel carbonyl (Ni(CO)4) at 2 or 4 h before sacrifice inhibited [3H] thymidine uptake into liver and kidney DNA. For example, in rats killed 4 h after i.v. injection of Ni(CO)4 (2 mg Ni/100 g),...

journal_title：Carcinogenesis

authors： Hui G,Sunderman FW Jr

更新日期：1980-04-01 00:00:00

abstract：:In the era of precision oncology, bladder cancer (BlCa) is characterized by generic patient management and lack of personalized prognosis and surveillance. Herein, we have studied the clinical significance of urothelial cancer associated 1 (UCA1) lncRNA in improving patients' risk stratification and prognosis. A scree...

journal_title：Carcinogenesis

authors： Avgeris M,Tsilimantou A,Levis PK,Rampias T,Papadimitriou MA,Panoutsopoulou K,Stravodimos K,Scorilas A

更新日期：2019-08-22 00:00:00

abstract：:Spindle cell carcinomas were identified using polyacrylamide gel electrophoresis and immunoblotting of proteins extracted from paraffin-embedded tissue sections. Immunohistochemistry using rabbit monospecific antisera against the mouse 55 kd keratin polypeptide also identified these tumors. A group of 53 SENCAR mice i...

journal_title：Carcinogenesis

authors： Klein-Szanto AJ,Larcher F,Bonfil RD,Conti CJ

更新日期：1989-11-01 00:00:00

abstract：:58 MCA Cl 16 is an oncogenic methylcholanthrene-transformed variant of the non-transformed mouse embryo fibroblast cell line, C3H/10T1/2 Cl 8. Using two different protocols, we have isolated six temperature-sensitive mutants from N-methyl-N'-nitro-N-nitrosoguanidine treated cultures of 58 MCA Cl 16. C3H/10T1/2 Cl 8, 5...

journal_title：Carcinogenesis

authors： Boreiko C,Heidelberger C

更新日期：1980-01-01 00:00:00

abstract：:The hypolipidaemic drug nafenopin (NAF) has been shown to enhance the hepatocarcinogenic effect of N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine in rats. We have investigated whether the NAF-induced peroxisome proliferation in hepatocytes interferes with NDMA's metabolism and interaction with DNA. Adult male...

journal_title：Carcinogenesis

authors： Wiestler OD,Schmerold I,Fringes B,Volk B,Kleihues P

更新日期：1985-09-01 00:00:00

abstract：:Circulating microRNAs (miRNAs) are potential biomarkers for cancer diagnosis, screening and prognosis. This study aimed to identify serum miRNAs as predictors of survival in patients with advanced non-small cell lung cancer (NSCLC). We profiled serum miRNAs in a pilot set of four patients with good survival (>24 month...

journal_title：Carcinogenesis

authors： Zhang Y,Roth JA,Yu H,Ye Y,Xie K,Zhao H,Chang DW,Huang M,Li H,Qu J,Wu X

更新日期：2019-07-04 00:00:00

abstract：:A decreased incidence of squamous cell carcinoma of the head and neck (SCCHN) associated with fruit and vegetable intake may act through chemopreventive compounds, which may be more available to persons homozygous for the deletion genotypes of the glutathione S-transferase (GST). We evaluated interactions between frui...

journal_title：Carcinogenesis

authors： Gaudet MM,Olshan AF,Poole C,Weissler MC,Watson M,Bell DA

更新日期：2004-05-01 00:00:00

abstract：:The mutational specificity of the monofunctional alkylating agent N-propyl-N'-nitro-N-nitrosoguanidine (PNNG) has been determined through the DNA sequence characterization of 109 LacI- mutations of Escherichia coli. The predominant mutation induced was the G:C----A:T transition (73%), presumably the result of O6-propy...

journal_title：Carcinogenesis

authors： van der Vliet GM,Zielenska M,Anderson MW,Glickman BW

更新日期：1989-05-01 00:00:00

abstract：:The effect of oral vitamin C supplementation on intragastric ascorbate levels and gastric mucosal DNA damage as measured by the 32P-postlabelling assay was assessed in 43 patients. In patients with normal gastric mucosa, treatment with vitamin C resulted in elevation of intragastric ascorbate levels in all cases. In t...

journal_title：Carcinogenesis

authors： Dyke GW,Craven JL,Hall R,Garner RC

更新日期：1994-02-01 00:00:00

abstract：:Conjugated linoleic acid (CLA) is a class of commercially available fatty acids that have been associated with anticancer properties in rodent models of chemical carcinogenesis. We conducted a pilot study to examine the antitumor effect of dietary CLA in a polyoma virus-middle T antigen (PyMT) mouse model of invasive ...

journal_title：Carcinogenesis

authors： Flowers M,Schroeder JA,Borowsky AD,Besselsen DG,Thomson CA,Pandey R,Thompson PA

更新日期：2010-09-01 00:00:00

abstract：:Transcripts originating from the transcriptional read through of two adjacent, similarly oriented genes have been identified in normal and neoplastic tissues, but their functional role and the mechanisms that regulate their expression are mostly unknown. Here, we investigated whether the expression of read-through tra...

journal_title：Carcinogenesis

authors： Maspero D,Dassano A,Pintarelli G,Noci S,De Cecco L,Incarbone M,Tosi D,Santambrogio L,Dragani TA,Colombo F

更新日期：2020-07-14 00:00:00

abstract：:N-Nitrosodimethylamine (NDMA) is a potent mutagen and animal carcinogen to which many people are exposed through the consumption of contaminated food and the use of tobacco products. Although the mutational specificity of NDMA has been studied in bacteria, little is known about the specific types of mutations induced ...

journal_title：Carcinogenesis

authors： Dobo KL,Eastmond DA,Grosovsky AJ

更新日期：1998-05-01 00:00:00

abstract：:Mammalian DNA contains bulky endogenous DNA modifications (I-compounds), which increase with age in unexposed animals, as shown by 32P-postlabeling. We have examined the perinatal formation of a subclass (type II) of I-compounds in rat liver, kidney, skin and lung. These I-compounds represent bulky oxidative DNA lesio...

journal_title：Carcinogenesis

authors： Randerath E,Zhou GD,Randerath K

更新日期：1996-12-01 00:00:00

abstract：:The effects of consumption of glucosinolate-containing Brussels sprouts on plasma and urinary glutathione S-transferase (GST) class-alpha and -pi were investigated. Five male and five female non-smoking volunteers were randomly assigned to two groups in a crossover design. Five persons started on a glucosinolate-free ...

journal_title：Carcinogenesis

authors： Nijhoff WA,Mulder TP,Verhagen H,van Poppel G,Peters WH

更新日期：1995-04-01 00:00:00

abstract：:Serum-free cultures of normal human buccal epithelial cells were transfected with a plasmid containing the SV40 T-antigen (SV40T) gene. Two major lines developed that showed extended lifespans (between 30 and 40 weeks) as compared with the controls (approximately 6 weeks). Continued growth through one or two crises ge...

journal_title：Carcinogenesis

authors： Kulkarni PS,Sundqvist K,Betsholtz C,Höglund P,Wiman KG,Zhivotovsky B,Bertolero F,Liu Y,Grafström RC

更新日期：1995-10-01 00:00:00