Abstract:
:The effect of oral vitamin C supplementation on intragastric ascorbate levels and gastric mucosal DNA damage as measured by the 32P-postlabelling assay was assessed in 43 patients. In patients with normal gastric mucosa, treatment with vitamin C resulted in elevation of intragastric ascorbate levels in all cases. In the presence of chronic atrophic gastritis, however, the effect was variable. Gastric mucosal DNA damage was decreased in 28 of the 43 patients after vitamin C supplementation (P = 0.01; Wilcoxon sign rank test). This supports epidemiological evidence that suggests vitamin C may exert a protective effect against the development of gastric cancer.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Dyke GW,Craven JL,Hall R,Garner RCdoi
10.1093/carcin/15.2.291subject
Has Abstractpub_date
1994-02-01 00:00:00pages
291-5issue
2eissn
0143-3334issn
1460-2180journal_volume
15pub_type
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