Microsatellite instability in aberrant crypt foci from patients without concurrent colon cancer.

abstract：:Dysbiosis of oral microbiome may dictate the progression of oral squamous cell carcinoma (OSCC). Yet, the composition of oral microbiome fluctuates by saliva and distinct sites of oral cavity and is affected by risky behaviors (smoking, drinking, and betel quid chewing) and individuals' oral health condition. To chara...

journal_title：Carcinogenesis

authors： Su SC,Chang LC,Huang HD,Peng CY,Chuang CY,Chen YT,Lu MY,Chiu YW,Chen PY,Yang SF

更新日期：2020-07-04 00:00:00

abstract：:In 2000, Douglas Hanahan and Robert Weinberg published a review detailing the six hallmarks of cancer. These are six phenotypes that a tumour requires in order to become a fully fledged malignancy: persistent growth signals, evasion of apoptosis, insensitivity to anti-growth signals, unlimited replicative potential, a...

journal_title：Carcinogenesis

authors： Tennant DA,Durán RV,Boulahbel H,Gottlieb E

更新日期：2009-08-01 00:00:00

abstract：:Adult rat hepatocytes in primary culture were used to study the effect of tryptophan pyrolysis products on the transcriptional process. Hepatocytes were treated with 1, 5 and 10 micrograms/ml of 3-amino-1,4-dimethyl-5H-pyrido-[4,3-b]-indole (Trp-P-1) or 3-amino-1-methyl-5H-pyrido-[4,3-b]-indole (Trp-P-2) for 2 and 4 h...

journal_title：Carcinogenesis

authors： Thybaud-Lambay V,Decloitre F,Moulé Y,Florentin Y

更新日期：1983-01-01 00:00:00

abstract：:The role of bacteria in catalysing intragastric formation of N-nitrosothiazolidine-4-carboxylic acid and N-nitrosomorpholine was investigated in a rat model of omeprazole-induced achlorhydria. Omeprazole-treated rats gavaged with nitrosation-proficient bacteria were treated with nitrosamines and/or precursors and comp...

journal_title：Carcinogenesis

authors： Calmels S,Béréziat JC,Ohshima H,Bartsch H

更新日期：1991-03-01 00:00:00

abstract：:Garcinol, a polyisoprenylated benzophenone, from the fruit rind of Garcinia spp., has been shown to have anti-inflammatory and anticarcinogenic activities. To study its mechanism of action, we analyzed the effects of garcinol and its derivatives, including cambogin, garcim-1 and garcim-2, on arachidonic acid metabolis...

journal_title：Carcinogenesis

authors： Hong J,Sang S,Park HJ,Kwon SJ,Suh N,Huang MT,Ho CT,Yang CS

更新日期：2006-02-01 00:00:00

abstract：:DNA double-strand break (DSB) repair is an important mechanism underlying chemotherapy resistance in human cancers. Dicer participates in DSB repair by facilitating homologous recombination. However, whether Dicer is involved in non-homologous end joining (NHEJ) remains unknown. Here, we addressed whether Dicer regula...

journal_title：Carcinogenesis

authors： Chen X,Li WF,Wu X,Zhang HC,Chen L,Zhang PY,Liu LY,Ma D,Chen T,Zhou L,Xu Y,Zhou MT,Tang KF

更新日期：2017-09-01 00:00:00

abstract：:Celastrol is an anti-inflammatory natural triterpenoid, isolated from the herb Tripterygium wilfordii or thunder god vine. Here, we define mechanisms mediating anti-inflammatory activity of celastrol and demonstrate efficacy of a dietary celastrol supplement for chemoprevention of inflammation-driven carcinogenesis in...

journal_title：Carcinogenesis

authors： Barker EC,Kim BG,Yoon JH,Tochtrop GP,Letterio JJ,Choi SH

更新日期：2018-01-12 00:00:00

abstract：:We have examined both the initial nuclease sensitivity and subsequent nucleosome rearrangement of newly repaired regions of chromatin in human diploid fibroblasts treated with methyl methanesulfonate (MMS) and methylnitrosourea (MNU). We initially examined the effect of these two alkylating agents on DNA replicative s...

journal_title：Carcinogenesis

authors： Sidik K,Smerdon MJ

更新日期：1984-02-01 00:00:00

abstract：:Dog urinary bladder is a target organ of carcinogenic arylamines. However, dog hepatic and urothelial cytosols lack acetylation enzymes that are capable of activating N-hydroxy metabolites of arylamines, suggesting that other enzymes may be involved. In the present study, we found that dog liver microsomes were capabl...

journal_title：Carcinogenesis

authors： Sone T,Zukowski K,Land SJ,King CM,Wang CY

更新日期：1991-10-01 00:00:00

abstract：:A large series of assays of the hepatocarcinogenic potential of 112 different compounds were carried out using a rapid bioassay system developed in this laboratory based on the two-step concept of hepatocarcinogenesis. Rats were initially given a single dose (200 mg/kg) of diethylnitrosamine (DEN) i.p. and starting 2 ...

journal_title：Carcinogenesis

authors： Ito N,Tsuda H,Tatematsu M,Inoue T,Tagawa Y,Aoki T,Uwagawa S,Kagawa M,Ogiso T,Masui T

更新日期：1988-03-01 00:00:00

abstract：:The activation of 2-nitrofluorene (2-NF) to reactive intermediates that bind covalently to DNA, RNA and protein has been investigated both in vitro and in the rat in vivo. In vitro, such binding was catalyzed by the hepatic microsomal fraction, was NADPH dependent and could be inhibited by SKF 525A, an inhibitor of cy...

journal_title：Carcinogenesis

authors： Wierckx FC,Wedzinga R,Meerman JH,Mulder GJ

更新日期：1990-01-01 00:00:00

abstract：:Nitric oxide donating aspirin (NO-ASA), consisting of a traditional ASA to which a NO-releasing moiety is covalently attached, is a promising chemopreventive agent against colon cancer. Its mechanism of action is not fully delineated. Here we examined its effect on the expression of the nuclear receptor PPARdelta, who...

journal_title：Carcinogenesis

authors： Ouyang N,Williams JL,Rigas B

更新日期：2006-02-01 00:00:00

abstract：:4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is the most abundant and carcinogenic tobacco-specific nitrosamine in tobacco and tobacco smoke. The major metabolic pathway for NNK is carbonyl reduction to form the (R) and (S) enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) which, like NNK, is...

journal_title：Carcinogenesis

authors： Ashmore JH,Luo S,Watson CJW,Lazarus P

更新日期：2018-07-30 00:00:00

abstract：UNLABELLED:Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2) is recognized as oncogenic and simulative role on tumorigenesis by virtue of abnormal expression in cancer including nasopharyngeal carcinoma (NPC). We hypothesized that the copy number variation (CNV)-30450, which duplicates the MAPKAPK2...

journal_title：Carcinogenesis

authors： Yang L,Liu B,Qiu F,Huang B,Li Y,Huang D,Yang R,Yang X,Deng J,Jiang Q,Zhou Y,Lu J

更新日期：2014-01-01 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) tend to have tumor-promoting capacity, and can provide therapeutic targets. Even without cancer cells, CAF phenotypes are stably maintained, and DNA methylation and H3K27me3 changes have been shown to be involved. Here, we searched for a potential therapeutic target in primary CAFs...

journal_title：Carcinogenesis

authors： Yasukawa Y,Hattori N,Iida N,Takeshima H,Maeda M,Kiyono T,Sekine S,Seto Y,Ushijima T

更新日期：2020-12-07 00:00:00

abstract：:The aim of the present study was to investigate the effects of galacto-oligosaccharides (GOS, Elix'or) on the development of aberrant crypt foci (ACF) and colorectal tumours in rats treated with azoxymethane (AOM). Two groups of 102 male Fischer 344 rats were injected twice with AOM to induce colorectal tumours, and f...

journal_title：Carcinogenesis

authors： Wijnands MV,Schoterman HC,Bruijntjes JB,Hollanders VM,Woutersen RA

更新日期：2001-01-01 00:00:00

abstract：:The most potent carcinogen of the cyclopenta[a]phenanthrene series, 15, 16-dihydro-11-methylcyclopenta[a]phenanthren-17-one and its non-carcinogenic, unmethylated parent compound, were compared for their abilities to induce micronuclei in epidermal keratinocytes after application onto the dorsal skin of Skh/HR-1 hairl...

journal_title：Carcinogenesis

authors： Baker RS,Bonin AM,Arlauskas A,He S,Coombs MM

更新日期：1992-03-01 00:00:00

abstract：:Mammalian DNA contains bulky endogenous DNA modifications (I-compounds), which increase with age in unexposed animals, as shown by 32P-postlabeling. We have examined the perinatal formation of a subclass (type II) of I-compounds in rat liver, kidney, skin and lung. These I-compounds represent bulky oxidative DNA lesio...

journal_title：Carcinogenesis

authors： Randerath E,Zhou GD,Randerath K

更新日期：1996-12-01 00:00:00

abstract：:Examination of p53 mutation spectra may provide clues to molecular mechanisms involved in different histologic types of gastric cancer. A total of 105 gastric cancer cases classified according to the Laurén's system were selected from a high-risk area around Florence, Italy. Exons 5-8 of the p53 gene were examined for...

journal_title：Carcinogenesis

authors： Shiao YH,Palli D,Buzard GS,Caporaso NE,Amorosi A,Saieva C,Fraumeni JF Jr,Anderson LM,Rice JM

更新日期：1998-12-01 00:00:00

abstract：:The H2-receptor antagonist, ranitidine, is among the most widely used pharmaceuticals to treat gastroesophageal reflux disease and peptic ulcers. While previous studies have demonstrated that amines can form N-nitrosamines when exposed to nitrite at stomach-relevant pH, N-nitrosamine formation from ranitidine, an amin...

journal_title：Carcinogenesis

authors： Zeng T,Mitch WA

更新日期：2016-06-01 00:00:00

abstract：:Inbred male Leeds rats were administered either the liver carcinogen N-nitrosopiperidine or the non-carcinogen 2,2',6,6'-tetramethyl-N-nitrosopiperidine in their drinking water at a concentration of 0.02%. Treatment was continued until the animals were killed, at 12 or 28 days, when their hepatic tissues were removed ...

journal_title：Carcinogenesis

authors： Flaks B,Challis BC

更新日期：1981-01-01 00:00:00

abstract：:2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) is a heterocyclic amine mutagen found in cooked meats and is carcinogenic in mice and rats at high doses (mg/kg body wt). Humans, however, are exposed to low amounts (p.p.b.) in the diet, and the effects caused by exposure to human equivalent doses of MeIQx have be...

journal_title：Carcinogenesis

authors： Frantz CE,Bangerter C,Fultz E,Mayer KM,Vogel JS,Turteltaub KW

更新日期：1995-02-01 00:00:00

abstract：:Chondrosarcoma is a form of malignant skeletal tumor of cartilaginous origin. The non-malignant form of the disease is termed chondroma. Correctly distinguishing between the two forms is essential for making therapeutic decisions. However, due to their similar histological appearances and the lack of a reliable diagno...

journal_title：Carcinogenesis

authors： Kumari R,Li H,Haudenschild DR,Fierro F,Carlson CS,Overn P,Gupta L,Gupta K,Nolta J,Yik JH,Di Cesare PE

更新日期：2012-11-01 00:00:00

abstract：:Pleomorphic adenoma gene like-2 (PLAGL2), a member of the PLAG gene family, is a C2H2 zinc finger transcriptional factor that is involved in cellular transformation and apoptosis. In this report, we show that PLAGL2 is associated with the organization of stress fibers and with small guanosine triphosphatase (GTPase) a...

journal_title：Carcinogenesis

authors： Sekiya R,Maeda M,Yuan H,Asano E,Hyodo T,Hasegawa H,Ito S,Shibata K,Hamaguchi M,Kikkawa F,Kajiyama H,Senga T

更新日期：2014-09-01 00:00:00

abstract：:Autophagy is an evolutionarily conserved mechanism to protect the cells from unfavorable environmental conditions. Inhibition of autophagy has been contemplated as a novel strategy to enhance anticancer efficacy of existing chemotherapeutic agents. We previously reported that pulsatilla saponin D (PSD) was a potent au...

journal_title：Carcinogenesis

authors： Wang K,Tu Y,Wan JB,Chen M,He C

更新日期：2020-07-10 00:00:00

abstract：:Polyphenols have shown promising bioactivity in experimental in vitro and in vivo models for cancer chemoprevention. However, consumed orally, they are often transformed by gut microbes into new active principles with so far incompletely deciphered molecular mechanisms. Here, enterolacton, S-equol and urolithin A as r...

journal_title：Carcinogenesis

authors： Norden E,Heiss EH

更新日期：2019-03-12 00:00:00

abstract：:A 32P-postlabeling assay was employed for detection and quantitation of DNA adducts formed with carcinogenic 1-phenylazo-2-hydroxynaphthalene (Sudan I, Solvent Yellow 14) activated by a peroxidase system. Enrichment of adducts by digestion with nuclease P1 or by extraction into n-butanol prior to 32P-labeling was used...

journal_title：Carcinogenesis

authors： Stiborová M,Frei E,Schmeiser HH,Wiessler M

更新日期：1992-07-01 00:00:00

abstract：:Ovarian surface epithelium (OSE) is considered to give rise to epithelial ovarian carcinomas (EOCs). To elucidate early processes contributing to the development of EOCs from the OSE, two batches of primary human OSE cells were transduced with non-viral human genes (mutant Cdk4, cyclinD1 and hTERT) so as to efficientl...

journal_title：Carcinogenesis

authors： Sasaki R,Narisawa-Saito M,Yugawa T,Fujita M,Tashiro H,Katabuchi H,Kiyono T

更新日期：2009-03-01 00:00:00

abstract：:Mice with non-phosphorylated serine 389 in p53 are susceptible for bladder tumors induced by 2-acetylaminofluorene (2-AAF). Since p53 is a transcription factor, this might well be preceded by differences in the regulation of gene expression. Microarray analysis was used to determine early transcriptional changes that ...

journal_title：Carcinogenesis

authors： Bruins W,Jonker MJ,Bruning O,Pennings JL,Schaap MM,Hoogervorst EM,van Steeg H,Breit TM,de Vries A

更新日期：2007-08-01 00:00:00

abstract：:A monoclonal antibody specific for cyclobutane thymine dimers in DNA was used in immunofluorescence studies to detect these lesions in skin sections taken from hairless mice that had been irradiated with UV-B. The dimer-specific fluorescence in epidermal cell nuclei was quantified with fluorescence microscopy through ...

journal_title：Carcinogenesis

authors： Vink AA,Berg RJ,de Gruijl FR,Roza L,Baan RA

更新日期：1991-05-01 00:00:00