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Effects of consumption of brussels sprouts on plasma and urinary glutathione S-transferase class-alpha and -pi in humans.

Abstract：

:The effects of consumption of glucosinolate-containing Brussels sprouts on plasma and urinary glutathione S-transferase (GST) class-alpha and -pi were investigated. Five male and five female non-smoking volunteers were randomly assigned to two groups in a crossover design. Five persons started on a glucosinolate-free diet (control period), while the other five consumed 300 g of cooked Brussels sprouts per day, at the expense of 300 g of glucosinolate-free vegetables (sprouts period). Dietary regimes were reversed after 1 week. GST levels were measured by enzyme-linked immunoabsorbent assay. At the end of the sprouts period, a significant increase (1.5-fold) in plasma class-alpha GST levels was observed in males but not in females (control versus sprouts, paired t-test; P-values 0.031 and 0.317 respectively), while plasma GST class-pi levels as well as secretion of urinary GST class-alpha and -pi levels remained unchanged. We conclude that (i) increased plasma GST class-alpha levels in males originate probably solely from the liver and not from stomach, intestine or kidney; (ii) males are more susceptible for induction of hepatic GSTs than females; and (iii) urinary GST concentration seems less useful as a biomarker for hepatic GST induction.

journal_name

Carcinogenesis

journal_title

Carcinogenesis

authors

Nijhoff WA,Mulder TP,Verhagen H,van Poppel G,Peters WH

doi

10.1093/carcin/16.4.955

subject

Has Abstract

pub_date

1995-04-01 00:00:00

pages

955-7

issue

4

eissn

0143-3334

issn

1460-2180

journal_volume

16

pub_type

临床试验,杂志文章,随机对照试验

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