Cyclin D1 gene polymorphism and susceptibility to lung cancer in a Chinese population.


:The objective was to study the relationship between cyclin D1 gene (CCND1) polymorphism and lung cancer in the Chinese population. Blood samples of 182 cases and 185 controls were collected from a hospital based case-control study. PCR-SSCP was used to examine the G/A polymorphism in exon 4 of CCND1. The results showed that the frequencies of the CCND1 AA, GA and GG genotypes were 31.3, 46.7 and 22.0% respectively in cases, and 21.1, 53.0 and 25.9 respectively in controls. Adjusted by age (in years), sex and smoking status, multivariate logistic regression analysis showed that the AA genotype was associated with a significantly increased risk (OR = 1.87, 95% CI 1.01-3.45) for lung cancer. In the stratification analysis, the CCND1 AA variant genotype was associated with increased risk in individuals who were






Qiuling S,Yuxin Z,Suhua Z,Cheng X,Shuguang L,Fengsheng H





Has Abstract


2003-09-01 00:00:00














  • Pyruvate kinase isoenzyme shift from L-type to M2-type is a late event in hepatocarcinogenesis induced in rats by a choline-deficient/DL-ethionine-supplemented diet.

    abstract::Rats received a choline-deficient diet containing 0.1% (w/w) DL-ethionine (CDE) for 4, 10, 14 or 22 weeks. A separate group was treated for 4 weeks with CDE and then received a normal diet for 4 weeks. The L and M2 isoenzymes of pyruvate kinase were immunocytochemically demonstrated in liver sections. L-PK expression ...


    pub_type: 杂志文章


    authors: Hacker HJ,Steinberg P,Bannasch P

    更新日期:1998-01-01 00:00:00

  • Implications of p53 mutation spectrum for cancer etiology in gastric cancers of various histologic types from a high-risk area of central Italy.

    abstract::Examination of p53 mutation spectra may provide clues to molecular mechanisms involved in different histologic types of gastric cancer. A total of 105 gastric cancer cases classified according to the Laurén's system were selected from a high-risk area around Florence, Italy. Exons 5-8 of the p53 gene were examined for...


    pub_type: 杂志文章


    authors: Shiao YH,Palli D,Buzard GS,Caporaso NE,Amorosi A,Saieva C,Fraumeni JF Jr,Anderson LM,Rice JM

    更新日期:1998-12-01 00:00:00

  • Genetic associations with sporadic neuroendocrine tumor risk.

    abstract::Genetic risk factors for sporadic neuroendocrine tumors (NET) are poorly understood. We tested risk associations in patients with sporadic NET and non-cancer controls, using a custom array containing 1536 single-nucleotide polymorphisms (SNPs) in 355 candidate genes. We identified 18 SNPs associated with NET risk at a...


    pub_type: 杂志文章


    authors: Ter-Minassian M,Wang Z,Asomaning K,Wu MC,Liu CY,Paulus JK,Liu G,Bradbury PA,Zhai R,Su L,Frauenhoffer CS,Hooshmand SM,De Vivo I,Lin X,Christiani DC,Kulke MH

    更新日期:2011-08-01 00:00:00

  • Radical oxidation reactions of the purine moiety of 2'-deoxyribonucleosides and DNA by iron-containing minerals.

    abstract::The radical oxidation capability of several classes of iron minerals, including biotite, hematite, magnetite, minette, nemalite, pyrite, vivianite and two chrysotiles (asbestos), was investigated by using a double experimental approach. One involved the electron spin resonance spin-trapping measurement of organic radi...


    pub_type: 杂志文章


    authors: Berger M,de Hazen M,Nejjari A,Fournier J,Guignard J,Pezerat H,Cadet J

    更新日期:1993-01-01 00:00:00

  • Immunohistochemical localization of transforming growth factor-alpha, epidermal growth factor receptor and c-erbB-2 protein in hyperplastic human prostates.

    abstract::Transforming growth factor-alpha (TGF-alpha) is a potent mitogenic factor which acts by binding to the epidermal growth factor (EGF). c-erbB-2 is a member of the EGF receptor family and is known to be associated with cellular growth and differentiation. The roles played by these factors in benign prostatic hyperplasia...


    pub_type: 杂志文章


    authors: Giri DK,Pal R,Wadhwa SN,Talwar GP

    更新日期:1995-04-01 00:00:00

  • Suppressive oligodeoxynucleotides reduce lung cancer susceptibility in mice with silicosis.

    abstract::Silicosis is an inflammatory lung disease induced by the inhalation of silica-containing dust particles. There is conflicting data on whether patients with silicosis are more susceptible to lung cancer induced by cigarette smoke. To examine this issue experimentally, a model was developed in which one of the most abun...


    pub_type: 杂志文章


    authors: Bode C,Kinjo T,Alvord WG,Klinman DM

    更新日期:2014-05-01 00:00:00

  • Transplacental genotoxicity of diethylstilbestrol.

    abstract::Diethylstilbestrol (DES) is a transplacental carcinogen in humans and in rodents. As part of an attempt to examine the mechanism of transplacental carcinogenesis, the transplacental genotoxity of this stilbene estrogen has been investigated. Pregnant hamsters received single injections of 200 mg/kg DES on the 10th day...


    pub_type: 杂志文章


    authors: Gladek A,Liehr JG

    更新日期:1991-05-01 00:00:00

  • Potentiating effect of benzo[a]pyrene and caffeine on Friend viral leukemogenesis.

    abstract::The effect of exposing mice to both a chemical carcinogen and leukemia virus with and without an inhibitor of DNA repair were compared. The data indicated that benzo[a]pyrene (BP) could exert a potentiating effect of Friend viral leukemogenesis in mice, which was dependent on the relative times of administration of th...


    pub_type: 杂志文章


    authors: Raikow RB,Okunewick JP,Buffo MJ,Jones DL,Brozovich BJ,Seeman PR,Koval TM

    更新日期:1981-01-01 00:00:00

  • Correlation between the DNA damage in urinary bladder epithelium and the urinary 2-phenyl-1,4-benzoquinone levels from F344 rats fed sodium o-phenylphenate in the diet.

    abstract::The relationship between urinary metabolites and DNA damage in the urinary bladder epithelium of male and female rats was tested by alkaline elution assay after an intravesical injection of OPP or its urinary metabolites. 2-Phenyl-1,4-benzoquinone (PBQ) revealed a weak DNA-damaging activity in both sexes at 0.05-0.1%....


    pub_type: 杂志文章


    authors: Morimoto K,Sato M,Fukuoka M,Hasegawa R,Takahashi T,Tsuchiya T,Tanaka A,Takahashi A,Hayashi Y

    更新日期:1989-10-01 00:00:00

  • Selective in vivo inhibition of rat mammary 7,12-dimethylbenz[a]anthracene-DNA adduct formation by dietary butylated hydroxytoluene.

    abstract::The in vivo formation of specific 7,12-dimethylbenz[a]-anthracene (DMBA)-DNA adducts in the mammary gland of the female Sprague-Dawley rat was studied in response to dietary butylated hydroxytoluene (BHT). Dietary BHT concentrations of 0.4 and 0.8% significantly inhibited total DMBA-DNA binding by 41.5 and 35.6% respe...


    pub_type: 杂志文章


    authors: Singletary KW,Nelshoppen JM

    更新日期:1991-10-01 00:00:00

  • DNA damage and mutagenesis induced by procarbazine in lambda lacZ transgenic mice: evidence that bone marrow mutations do not arise primarily through miscoding by O6-methylguanine.

    abstract::The DNA damaging and mutagenic activities of procarbazine, a methylating drug employed in cancer chemotherapy and suspected of causing therapy-related leukaemia, were investigated in the liver and bone marrow of lambda lacZ transgenic mice (MutaMouse). The drug was administered using two different protocols, a 'high-d...


    pub_type: 杂志文章


    authors: Pletsa V,Valavanis C,van Delft JH,Steenwinkel MJ,Kyrtopoulos SA

    更新日期:1997-11-01 00:00:00

  • Expression of CYP1B1 but not CYP1A1 by primary cultured human mammary stromal fibroblasts constitutively and in response to dioxin exposure: role of the Ah receptor.

    abstract::The expression of CYP1B1 in human mammary fibroblasts (HMFs) was characterized as a potential modulator of their individual function as well as effects on adjacent mammary epithelia. We have used these characteristics to explore the diversity of fibroblast cells isolated from reduction mammoplasty patients and from di...


    pub_type: 杂志文章


    authors: Eltom SE,Larsen MC,Jefcoate CR

    更新日期:1998-08-01 00:00:00

  • Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes.

    abstract::Plant chlorophylls and carotenoids are highly colored, conjugated polyenes that play central roles in photosynthesis. Other porphyrins (tetrapyrroles), such as cytochromes, which are structurally related to chlorophyll, participate in redox reactions in many living systems. An unexpected new property of tetrapyrroles,...


    pub_type: 杂志文章


    authors: Fahey JW,Stephenson KK,Dinkova-Kostova AT,Egner PA,Kensler TW,Talalay P

    更新日期:2005-07-01 00:00:00

  • Maternal high-methyl diet suppresses mammary carcinogenesis in female rat offspring.

    abstract::Maternal nutrition during pregnancy influences the development and metabolism of the fetus. Recent studies suggest that the cancer risk of offspring later in life is associated with maternal diet, but little is known about the effect of a maternal diet high in methyl nutrients on breast cancer risk. Lipotropes are met...


    pub_type: 杂志文章


    authors: Cho K,Mabasa L,Bae S,Walters MW,Park CS

    更新日期:2012-05-01 00:00:00

  • Associations of dietary methyl donor intake with MLH1 promoter hypermethylation and related molecular phenotypes in sporadic colorectal cancer.

    abstract::Intake of dietary factors that serve as methyl group donors may influence promoter hypermethylation in colorectal carcinogenesis. We investigated whether dietary folate, vitamin B2 and vitamin B6, methionine and alcohol were associated with mutL homologue 1 (MLH1) hypermethylation and the related molecular phenotypes ...


    pub_type: 杂志文章


    authors: de Vogel S,Bongaerts BW,Wouters KA,Kester AD,Schouten LJ,de Goeij AF,de Bruïne AP,Goldbohm RA,van den Brandt PA,van Engeland M,Weijenberg MP

    更新日期:2008-09-01 00:00:00

  • DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis.

    abstract::Epidemiological studies indicate that N-nitroso compounds (NOC) are causally linked to colorectal cancer (CRC). NOC induce DNA alkylations, including O (6)-methylguanine (O (6)-MeG) and N-methylated purines, which are repaired by O (6)-MeG-DNA methyltransferase (MGMT) and N-alkyladenine-DNA glycosylase (AAG)-initiated...


    pub_type: 杂志文章


    authors: Fahrer J,Frisch J,Nagel G,Kraus A,Dörsam B,Thomas AD,Reißig S,Waisman A,Kaina B

    更新日期:2015-10-01 00:00:00

  • TIMP-2 suppresses tumor growth and metastasis in murine model of triple-negative breast cancer.

    abstract::Metastasis is the primary cause of treatment failures and mortality in most cancers. Triple-negative breast cancer (TNBC) is refractory to treatment and rapidly progresses to disseminated disease. We utilized an orthotopic mouse model that molecularly and phenotypically resembles human TNBC to study the effects of exo...


    pub_type: 杂志文章


    authors: Peeney D,Jensen SM,Castro NP,Kumar S,Noonan S,Handler C,Kuznetsov A,Shih J,Tran AD,Salomon DS,Stetler-Stevenson WG

    更新日期:2020-05-14 00:00:00

  • Diethylnitrosamine administration in vivo increases hepatic poly(ADP-ribose) levels in rats: results of a modified technique for poly(ADP-ribose) measurement.

    abstract::Poly(ADP-ribose) (polymer) is enzymatically synthesized on nuclear proteins in response to DNA strand breaks. NAD+ is the substrate for this reaction, which is catalyzed by poly(ADP-ribose)polymerase. This post-translational modification occurs in response to DNA strand breaks and is thought to play an important role ...


    pub_type: 杂志文章


    authors: Rawling JM,Driscoll ER,Poirier GG,Kirkland JB

    更新日期:1993-12-01 00:00:00

  • Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate.

    abstract::Epidemiological studies have linked consumption of broccoli to a reduced risk of colon cancer in individuals with the glutathione S-transferase M1 (GSTM1) null genotype. GSTs are involved in excretion and elimination of isothiocyanates (ITCs), which are major constituents of broccoli and other cruciferous vegetables a...


    pub_type: 杂志文章


    authors: Chung FL,Conaway CC,Rao CV,Reddy BS

    更新日期:2000-12-01 00:00:00

  • Three-dimensional cancer models mimic cell-matrix interactions in the tumour microenvironment.

    abstract::Basic in vitro systems can be used to model and assess complex diseases, such as cancer. Recent advances in this field include the incorporation of multiple cell types and extracellular matrix proteins into three-dimensional (3D) models to recapitulate the structure, organization and functionality of live tissue in si...


    pub_type: 杂志文章,评审


    authors: Herrmann D,Conway JR,Vennin C,Magenau A,Hughes WE,Morton JP,Timpson P

    更新日期:2014-08-01 00:00:00

  • Structure-activity relationships for epidermal ornithine decarboxylase induction and skin tumor promotion by anthrones.

    abstract::The present study was designed to compare the skin tumor promoting and epidermal ornithine decarboxylase (ODC) inducing activities of various structural analogs of anthralin (1,8-dihydroxy-9-anthrone) and chrysarobin (1,8-dihydroxy-3-methyl-9-anthrone). Groups of 30 SENCAR mice each were initiated with 7,12-dimethylbe...


    pub_type: 杂志文章


    authors: DiGiovanni J,Kruszewski FH,Coombs MM,Bhatt TS,Pezeshk A

    更新日期:1988-08-01 00:00:00

  • The nonmutagenicity of purified 4-amino-2-nitrophenol in Salmonella typhimurium.

    abstract::Two samples of 4-amino-2-nitrophenol were tested for mutagenicity in Salmonella typhimurium strains TA1535, TA1537, TA1538, TA98, and TA100. Significant mutagenic activity was detected with a sample of this compound obtained from Aldrich (technical grade (Aldrich), TGA) both in the presence and in the absence of a rat...


    pub_type: 杂志文章


    authors: Shahin MM,Bugaut A,Junino A,Kalopissis G

    更新日期:1982-01-01 00:00:00

  • Peroxisome proliferation and modulation of rat liver carcinogenesis by 2,4-dichlorophenoxyacetic acid, 2,4,5-trichlorophenoxyacetic acid, perfluorooctanoic acid and nafenopin.

    abstract::Using an initiation--selection--promotion protocol for induction of liver tumors in Wistar rats, the modulating action of various peroxisome proliferators on neoplasia as well as on selected biochemical parameters was studied. After treatment with diethylnitrosamine (DEN), the animals were subsequently subjected to a ...


    pub_type: 杂志文章


    authors: Abdellatif AG,Préat V,Vamecq J,Nilsson R,Roberfroid M

    更新日期:1990-11-01 00:00:00

  • All-trans and 9-cis retinoic acids, retinol and beta-carotene chemopreventive activities during the initial phases of hepatocarcinogenesis involve distinct actions on glutathione S-transferase positive preneoplastic lesions remodeling and DNA damage.

    abstract::Chemopreventive activities of all-trans retinoic acid (AtRA), 9-cis retinoic acid (9cRA), retinol (ROL) and beta-carotene (betaC) were evaluated during hepatocarcinogenesis. Rats received 1 mg/100 g body wt AtRA (AtRA group), 9cRA (9cRA group), ROL (ROL group), 7 mg/100 g body wt betaC (betaC group) or corn oil (CO gr...


    pub_type: 杂志文章


    authors: de Almeida Vasconcelos Fonseca EM,Chagas CE,Mazzantini RP,Heidor R,Ong TP,Moreno FS

    更新日期:2005-11-01 00:00:00

  • Expression of transforming growth factor alpha/epidermal growth factor receptor, hepatocyte growth factor/c-met and acidic fibroblast growth factor/fibroblast growth factor receptors during hepatocarcinogenesis.

    abstract::It is widely believed that abnormal production of polypeptide growth factors, together with other molecular alterations, play an important role in neoplastic development. Transforming growth factor alpha (TGFalpha), hepatocyte growth factor (HGF) and acidic fibroblast growth factor (aFGF) are the three major growth fa...


    pub_type: 杂志文章


    authors: Hu Z,Evarts RP,Fujio K,Omori N,Omori M,Marsden ER,Thorgeirsson SS

    更新日期:1996-05-01 00:00:00

  • miR-15a and miR-16 affect the angiogenesis of multiple myeloma by targeting VEGF.

    abstract::Deregulated microRNAs (miRNAs) and their roles in cancer development have attracted much attention. Two miRNAs, miR-15a and miR-16, which act as putative tumor suppressor by targeting the oncogene BCL2, have been implicated in cell cycle, apoptosis and proliferation. In this study, we investigated the possible role ...


    pub_type: 杂志文章


    authors: Sun CY,She XM,Qin Y,Chu ZB,Chen L,Ai LS,Zhang L,Hu Y

    更新日期:2013-02-01 00:00:00

  • Opium and oesophageal cancer: effect of morphine and opium on the metabolism of N-nitrosodimethylamine and N-nitrosodiethylamine in the rat.

    abstract::The high incidence of oesophageal cancer in Northern Iran has been associated with opium. N-Nitrosamines are the only carcinogens known to induce oesophageal cancer in animals. Ethanol, which is the major influence on oesophageal cancer incidence in the West, inhibits the first pass clearance of N-nitrosodimethylamine...


    pub_type: 杂志文章


    authors: Ribeiro Pinto LF,Swann PF

    更新日期:1997-02-01 00:00:00

  • Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-kappaB in mouse macrophages.

    abstract::Carnosol is a naturally occurring phytopolyphenol found in rosemary. Carnosol functions as antioxidant and anticarcinogen. In the present study, we compared the antioxidant activity of carnosol and other compounds extracted from rosemary. Carnosol showed potent antioxidative activity in alpha,alpha-diphenyl-beta-picry...


    pub_type: 杂志文章


    authors: Lo AH,Liang YC,Lin-Shiau SY,Ho CT,Lin JK

    更新日期:2002-06-01 00:00:00

  • Cell specificity of rat cytokeratin p39 during azo dye-induced hepatocarcinogenesis.

    abstract::Monoclonal or affinity-purified antibodies specific to Novikoff hepatoma cytokeratin p39 were employed to study the origin and fate of p39-containing cell types during hepatocarcinogenesis induced with N,N-dimethyl-p(m-tolylazo)aniline. Frozen sections were obtained from the livers of animals autopsied temporally duri...


    pub_type: 杂志文章


    authors: Schmidt WN,Page DL,McKusick K,Hnilica LS

    更新日期:1985-08-01 00:00:00

  • Comparison of the activity of phorbol 12-myristate 13-acetate and the diglyceride glycerol 1-myristate 2-acetate.

    abstract::Diglycerides function as analogs of the phorbol ester tumor promoters. We compare here the activity of glycerol 1-myristate 2-acetate (GMA) with the corresponding phorbol 12-myristate 13-acetate (PMA). GMA inhibited phorbol ester binding to reconstituted protein kinase C, stimulated protein kinase C enzymatic activity...


    pub_type: 杂志文章


    authors: Sharkey NA,Blumberg PM

    更新日期:1986-04-01 00:00:00