Cyclin D1 gene polymorphism and susceptibility to lung cancer in a Chinese population.

Abstract:

:The objective was to study the relationship between cyclin D1 gene (CCND1) polymorphism and lung cancer in the Chinese population. Blood samples of 182 cases and 185 controls were collected from a hospital based case-control study. PCR-SSCP was used to examine the G/A polymorphism in exon 4 of CCND1. The results showed that the frequencies of the CCND1 AA, GA and GG genotypes were 31.3, 46.7 and 22.0% respectively in cases, and 21.1, 53.0 and 25.9 respectively in controls. Adjusted by age (in years), sex and smoking status, multivariate logistic regression analysis showed that the AA genotype was associated with a significantly increased risk (OR = 1.87, 95% CI 1.01-3.45) for lung cancer. In the stratification analysis, the CCND1 AA variant genotype was associated with increased risk in individuals who were

journal_name

Carcinogenesis

journal_title

Carcinogenesis

authors

Qiuling S,Yuxin Z,Suhua Z,Cheng X,Shuguang L,Fengsheng H

doi

10.1093/carcin/bgg035

keywords:

subject

Has Abstract

pub_date

2003-09-01 00:00:00

pages

1499-503

issue

9

eissn

0143-3334

issn

1460-2180

pii

bgg035

journal_volume

24

pub_type

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