Role of copper accumulation and metallothionein induction in spontaneous liver cancer development in LEC rats.

abstract：:The organochlorine pesticides chlordane and heptachlor were demonstrated to be liver neoplasm promoters in mice. Male B6C3F1 mice exposed to diethylnitrosamine (DEN) for 14 weeks followed by 25 weeks on control diet developed a 40% incidence of liver neoplasms whereas those given chlordane or heptachlor afterwards had...

journal_title：Carcinogenesis

authors： Williams GM,Numoto S

更新日期：1984-12-01 00:00:00

abstract：:Cancer testis antigens (CTAs) are promising targets for T cell-based immunotherapy and studies have shown that certain CT genes are epigenetically depressed in cancer cells through DNA demethylation. Melanoma-associated antigen A11 (MAGE-A11) is a CTA that is frequently expressed in esophageal cancer and is correlated...

journal_title：Carcinogenesis

authors： Wu Y,Sang M,Liu F,Zhang J,Li W,Li Z,Gu L,Zheng Y,Li J,Shan B

更新日期：2020-07-14 00:00:00

abstract：:The rat liver 9000 g supernatant mediated metabolism of the carcinogenic aristolochic acid, which consists of aristolochic acid I (AAI) and aristolochic acid II (AAII), was investigated. Under anaerobic conditions the major metabolites were the corresponding aristolactams for both AAI and AAII. In contrast under aerob...

journal_title：Carcinogenesis

authors： Schmeiser HH,Pool BL,Wiessler M

更新日期：1986-01-01 00:00:00

abstract：:Treatment of human skin fibroblasts in early S-phase with (+-)7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene (BPDE-I) results in more extensive modification of early replicating DNA than parental DNA. We have investigated the effects of benzamide (BZ) and 3-aminobenzamide (3-ABZ), i...

journal_title：Carcinogenesis

authors： Kurian P,Kumari HL,Milo GE

更新日期：1992-03-01 00:00:00

abstract：:The antihistamine methapyrilene (hydrochloride) and four close structural analogs, methaphenilene, methafurylene, thenyldiamine and clorothen, were given to rats at a concentration of 0.1% in drinking water for 34 weeks. Only methapyrilene produced notable histopathological changes in the liver, bile duct hyperplasia ...

journal_title：Carcinogenesis

authors： Hernandez L,Allen PT,Poirier LA,Lijinsky W

更新日期：1989-03-01 00:00:00

abstract：:A single i.p. injection of diethylnitrosamine (DEN) or benzo[a]pyrene (BAP) in 1-day-old female rats produced a high incidence of gamma-glutamyltranspeptidase-(GGT)-positive hepatocyte foci within 4 weeks after the rats were weaned onto a 0.05% phenobarbital diet; the injection of benzo[e]pyrene did not produce foci u...

journal_title：Carcinogenesis

authors： Peraino C,Staffeldt EF,Ludeman VA

更新日期：1981-01-01 00:00:00

abstract：:We have previously demonstrated that betel quid containing safrole induced DNA adducts are highly associated with the development of oral squamous cell carcinoma (OSCC) in Taiwan. Sulfotransferase (SULT) is essential for the formation of these adducts. To elucidate the effects of SULT1A1 haplotypes on OSCC susceptibil...

journal_title：Carcinogenesis

authors： Chung YT,Hsieh LL,Chen IH,Liao CT,Liou SH,Chi CW,Ueng YF,Liu TY

更新日期：2009-02-01 00:00:00

abstract：:Genotoxic carcinogens, including 2-acetylaminofluorene (2-AAF), in addition to exerting their genotoxic effects, often cause a variety of non-genotoxic alterations in cells. It is believed that these non-genotoxic effects may be indispensable events in tumorigenesis; however, there is insufficient knowledge to clarify...

journal_title：Carcinogenesis

authors： Bagnyukova TV,Tryndyak VP,Montgomery B,Churchwell MI,Karpf AR,James SR,Muskhelishvili L,Beland FA,Pogribny IP

更新日期：2008-03-01 00:00:00

abstract：:Genetic variants in multiple cellular pathways have been associated with an altered risk of oesophageal cancer. In this study, eight genes previously associated with an altered risk of oesophageal squamous cell carcinoma (OSCC) in European or Asian populations were investigated in two South African populations. We gen...

journal_title：Carcinogenesis

authors： Bye H,Prescott NJ,Matejcic M,Rose E,Lewis CM,Parker MI,Mathew CG

更新日期：2011-12-01 00:00:00

abstract：:Extracts of human urine were shown to contain substances that strongly inhibited the liver S9-mediated mutagenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in Salmonella typhimurium TA98 strain in a liquid incubation assay. The inhibitory effect was unrelated to cytotoxicity and was similar with urin...

journal_title：Carcinogenesis

authors： Malaveille C,Hautefeuille A,Brun G,Vineis P,Bartsch H

更新日期：1992-12-01 00:00:00

abstract：:Oral squamous cell carcinoma (SCC) is among the most prevalent cancers in the world and is characterized by high morbidity and few therapeutic options. Like most cancers, oral SCC arises from a multistep process involving alterations of genes responsible for balancing proliferation and differentiation. Among these, Kr...

journal_title：Carcinogenesis

authors： Abrigo M,Alvarez R,Paparella ML,Calb DE,Bal de Kier Joffe E,Gutkind JS,Raimondi AR

更新日期：2014-03-01 00:00:00

abstract：:The lipoxygenase catalyzed epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene (BP-7,8-diol) was examined. Epoxidation of the BP-7,8-diol was catalyzed by 5- and 15-lipoxygenase in the presence of either arachidonic acid, gamma-linolenic acid, or 15-hydroperoxyeicosatetraenoic acid (15-HPETE). The anti-9,10-epoxy-7...

journal_title：Carcinogenesis

authors： Hughes MF,Chamulitrat W,Mason RP,Eling TE

更新日期：1989-11-01 00:00:00

abstract：:The induction of aberrant crypt foci (ACF) by irradiation of gamma-rays (60Co), and the effect of dietary sugar beet fiber (SBF) on irradiation-induced ACF were examined. We found that abdominal irradiation of gamma-rays could induce ACF in the rat colon. The irradiation was performed once a week at a dose rate of 2 o...

journal_title：Carcinogenesis

authors： Ishizuka S,Ito S,Onuma M,Kasai T,Aoyama Y,Hara H

更新日期：1999-06-01 00:00:00

abstract：:Cyproterone acetate (CPA), a synthetic steroid hormone widely used as a human pharmaceutical, has recently been shown to induce unscheduled DNA synthesis (UDS) in vitro in primary cultures of rat and human hepatocytes. In the present study CPA was evaluated for its ability to initiate UDS in the liver of female rats i...

journal_title：Carcinogenesis

authors： Kasper P,Mueller L

更新日期：1996-10-01 00:00:00

abstract：:Breast cancer incidence is increased in women with both high and low birth weight. The latter is also associated with hyperglycaemia, insulin resistance and type-2 diabetes, each of which independently increases breast cancer risk. We showed previously in our model of poor early-growth that pregnancy estradiol levels ...

journal_title：Carcinogenesis

authors： Fernandez-Twinn DS,Ekizoglou S,Gusterson BA,Luan J,Ozanne SE

更新日期：2007-03-01 00:00:00

abstract：:Elevated Bcl-xL expression in cancer cells contributes to doxorubicin (DOX) resistance, leading to failure in chemotherapy. In addition, the clinical use of high-dose doxorubicin (DOX) in cancer therapy has been limited by issues with cardiotoxicity and hepatotoxicity. Here, we show that co-treatment with pyrrolidine ...

journal_title：Carcinogenesis

authors： Park SS,Lee DM,Lim JH,Lee D,Park SJ,Kim HM,Sohn S,Yoon G,Eom YW,Jeong SY,Choi EK,Choi KS

更新日期：2018-03-08 00:00:00

abstract：:Common genetic variation may play an important role in altering lung cancer risk. We conducted a pathway-based candidate gene evaluation to identify genetic variations that may be associated with lung cancer in a population-based case-control study in Xuan Wei, China (122 cases and 111 controls). A total of 1260 singl...

journal_title：Carcinogenesis

authors： Hosgood HD 3rd,Menashe I,Shen M,Yeager M,Yuenger J,Rajaraman P,He X,Chatterjee N,Caporaso NE,Zhu Y,Chanock SJ,Zheng T,Lan Q

更新日期：2008-10-01 00:00:00

abstract：:The present study was conducted to clarify the cooperative significance of epigenomic and genomic abnormalities during gastric carcinogenesis. Using 21 samples of normal control gastric mucosa (C), 109 samples of non-cancerous gastric mucosa (N) and 105 samples of cancerous tissue (T) from 109 patients with primary ga...

journal_title：Carcinogenesis

authors： Yang M,Arai E,Takahashi Y,Totsuka H,Chiku S,Taniguchi H,Katai H,Sakamoto H,Yoshida T,Kanai Y

更新日期：2020-11-13 00:00:00

abstract：:Serum selenium (Se) levels were measured before, during and after high-dose induction chemotherapy in 70 patients with acute non-lymphocytic leukemia (ANLL). Pre-treatment serum Se levels were lower in patients than in controls (0.082 +/- 0.033 micrograms/ml versus 0.097 +/- 0.035 micrograms/ml, P less than 0.01). Pre...

journal_title：Carcinogenesis

authors： Beguin Y,Bours V,Delbrouck JM,Robaye G,Roelandts I,Bury J,Fillet G,Weber G

更新日期：1989-11-01 00:00:00

abstract：:To better understand drug and carcinogen metabolism pathways in head and neck squamous cell carcinoma we assayed the principal drug- and carcinogen-metabolizing enzyme systems in both tumors and their corresponding adjacent non-tumoral tissues. Cytochromes P450 (1A1/A2, 2B1/B2, 2C8-10, 2E1, 3A4), epoxide hydrolase and...

journal_title：Carcinogenesis

authors： Janot F,Massaad L,Ribrag V,de Waziers I,Beaune PH,Luboinski B,Parise O Jr,Gouyette A,Chabot GG

更新日期：1993-07-01 00:00:00

abstract：:The mechanism of inactivation of the O6-methylguanine-DNA methyltransferase (MGMT), responsible for repair of mutagenic and cytotoxic O6-alkylguanine, in Mex- tumor cells, is not completely understood. We have examined the role of CpG methylation in the human MGMT promoter in a luciferase (luc) reporter plasmid and as...

journal_title：Carcinogenesis

authors： Bhakat KK,Mitra S

更新日期：2003-08-01 00:00:00

abstract：:Dibenzo[a,l]pyrene (DB[a,l]P) is an extremely potent carcinogen that may be present in environmental samples. Dose-response studies were conducted at low doses in mouse skin by initiation-promotion and repeated application to compare its activity to that of 7,12-dimethylbenz[a]anthracene (DMBA), benzo[a]pyrene (B[a]P)...

journal_title：Carcinogenesis

authors： Higginbotham S,RamaKrishna NV,Johansson SL,Rogan EG,Cavalieri EL

更新日期：1993-05-01 00:00:00

abstract：:In the era of precision oncology, bladder cancer (BlCa) is characterized by generic patient management and lack of personalized prognosis and surveillance. Herein, we have studied the clinical significance of urothelial cancer associated 1 (UCA1) lncRNA in improving patients' risk stratification and prognosis. A scree...

journal_title：Carcinogenesis

authors： Avgeris M,Tsilimantou A,Levis PK,Rampias T,Papadimitriou MA,Panoutsopoulou K,Stravodimos K,Scorilas A

更新日期：2019-08-22 00:00:00

abstract：:Arsenic is an established human carcinogen. Deficiencies in available animal models have inhibited a detailed analysis of the mechanism of arsenic induced cancer. This study sought to determine the role of a methyl-deficient diet in combination with sodium arsenite on the genomic methylation status and Ha-ras methylat...

journal_title：Carcinogenesis

authors： Okoji RS,Yu RC,Maronpot RR,Froines JR

更新日期：2002-05-01 00:00:00

abstract：:Cyclic 1,N2-propanodeoxyguanosine adducts are formed in vitro in DNA treated with alpha-acetoxy-N-nitrosopyrrolidine or its metabolite, crotonaldehyde. However, the in vivo formation of these cyclic adducts in DNA has not been demonstrated due to the lack of a sensitive detection method. In this study, a 32P-postlabel...

journal_title：Carcinogenesis

authors： Chung FL,Young R,Hecht SS

更新日期：1989-07-01 00:00:00

abstract：:The nitrogen heterocycle dibenz[c,h]acridine (DB[c,h]ACR) and the enantiomers of the diastereomeric pair of bay-region 3,4-diol 1, 2-epoxides as well as other bay-region epoxides and dihydrodiol derivatives of this hydrocarbon have been evaluated for tumorigenicity on mouse skin and in the newborn mouse. On mouse skin...

journal_title：Carcinogenesis

authors： Chang RL,Wood AW,Kumar S,Lehr RE,Shirai N,Jerina DM,Conney AH

更新日期：2000-11-01 00:00:00

abstract：:The lymphocyte response to u.v. radiation (254 nm) was investigated by two different methods in 29 unselected patients with multiple epidermal cancer. The u.v.-induced DNA synthesis was determined as the increase in incorporation of [3H]thymidine in irradiated cells compared with nonirradiated cells after incubation f...

journal_title：Carcinogenesis

authors： Munch-Petersen B,Frentz G,Squire B,Wallevik K,Horn CC,Reymann F,Faber M

更新日期：1985-06-01 00:00:00

abstract：:Chemical carcinogens are generally activated enzymatically to electrophiles that form covalently bound carcinogen-DNA adducts. Detoxifying enzymes are competing with the activating enzymes for these procarcinogenic chemical substrates. Wide person-to-person variations in these two types of enzymatic activities are fou...

journal_title：Carcinogenesis

authors： Harris CC

更新日期：1989-09-01 00:00:00

abstract：:4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is the most abundant and carcinogenic tobacco-specific nitrosamine in tobacco and tobacco smoke. The major metabolic pathway for NNK is carbonyl reduction to form the (R) and (S) enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) which, like NNK, is...

journal_title：Carcinogenesis

authors： Ashmore JH,Luo S,Watson CJW,Lazarus P

更新日期：2018-07-30 00:00:00

abstract：:The promoting action of hexachlorocyclohexane (HCH) was evaluated in female Wistar rats by counting the gamma-glutamyltranspeptidase-positive foci which appeared in the liver after diethylnitrosamine (DENA) initiation. Liver tumor promotion by HCH was further confirmed in a long-term tumorigenicity study after DENA pr...

journal_title：Carcinogenesis

authors： Munir KM,Rao KV,Bhide SV

更新日期：1984-04-01 00:00:00