Abstract:
:Serum selenium (Se) levels were measured before, during and after high-dose induction chemotherapy in 70 patients with acute non-lymphocytic leukemia (ANLL). Pre-treatment serum Se levels were lower in patients than in controls (0.082 +/- 0.033 micrograms/ml versus 0.097 +/- 0.035 micrograms/ml, P less than 0.01). Pretreatment serum Se correlated inversely with the absolute peripheral blast cell count (R = -0.62, P less than 0.001) and other measurements of the tumor burden. Seven days after the initiation of chemotherapy, serum Se increased significantly in proportion to the initial tumor burden (P less than 0.01). Thereafter, serum Se levels remained essentially normal in patients entering a complete remission while decreasing gradually in failures. In conclusion, these data do not lend support to the hypothesis that a low selenium status enhances the risk of developing ANLL, but indicate that serum Se levels in patients with acute leukemia are mostly dependent on tumor activity.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Beguin Y,Bours V,Delbrouck JM,Robaye G,Roelandts I,Bury J,Fillet G,Weber Gdoi
10.1093/carcin/10.11.2089subject
Has Abstractpub_date
1989-11-01 00:00:00pages
2089-91issue
11eissn
0143-3334issn
1460-2180journal_volume
10pub_type
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