Metabolism of benzo[a]pyrene and DNA adduct formation in cultured human epidermal keratinocytes.

abstract：:Purified human alpha-thrombin stimulates phosphoinositide turnover as a necessary step in its stimulation of fibroblast cell proliferation. Since phosphoinositide turnover releases diacylglycerol, which activates protein kinase C, we postulated that long-term exposure to thrombin might promote cellular transformation ...

journal_title：Carcinogenesis

authors： Morris DL,Ward JB Jr,Nechay P,Whorton EB Jr,Fenton JW 2nd,Carney DH

更新日期：1992-01-01 00:00:00

abstract：:Silicosis is an inflammatory lung disease induced by the inhalation of silica-containing dust particles. There is conflicting data on whether patients with silicosis are more susceptible to lung cancer induced by cigarette smoke. To examine this issue experimentally, a model was developed in which one of the most abun...

journal_title：Carcinogenesis

authors： Bode C,Kinjo T,Alvord WG,Klinman DM

更新日期：2014-05-01 00:00:00

abstract：:Prepubertal exposure to soy or its biologically active component genistein reduces later breast cancer risk in both animal models and human populations. We investigated whether that might be due to reported estrogenic properties of genistein. Our study indicated that daily prepubertal exposures between postnatal days ...

journal_title：Carcinogenesis

authors： Cabanes A,Wang M,Olivo S,DeAssis S,Gustafsson JA,Khan G,Hilakivi-Clarke L

更新日期：2004-05-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the fifth most common malignancy caused by environmental and genetic factors. MicroRNAs (miRNAs) are a class of short non-coding RNAs with posttranscriptional regulatory functions. They participate in diverse biological pathways and function as gene regulators. Genetic polymorphisms i...

journal_title：Carcinogenesis

authors： Gao Y,He Y,Ding J,Wu K,Hu B,Liu Y,Wu Y,Guo B,Shen Y,Landi D,Landi S,Zhou Y,Liu H

更新日期：2009-12-01 00:00:00

abstract：:Carnosol is a naturally occurring phytopolyphenol found in rosemary. Carnosol functions as antioxidant and anticarcinogen. In the present study, we compared the antioxidant activity of carnosol and other compounds extracted from rosemary. Carnosol showed potent antioxidative activity in alpha,alpha-diphenyl-beta-picry...

journal_title：Carcinogenesis

authors： Lo AH,Liang YC,Lin-Shiau SY,Ho CT,Lin JK

更新日期：2002-06-01 00:00:00

abstract：:The metabolism of benzo[a]pyrene (BP) in cultured human epidermal keratinocytes was investigated using thin layer chromatography, high pressure liquid chromatography and cell-mediated mutagenesis assay. Epidermal keratinocytes were obtained from skin of normal subjects and all experiments were performed on primary cul...

journal_title：Carcinogenesis

authors： Kuroki T,Nemoto N,Kitano Y

更新日期：1980-07-01 00:00:00

abstract：:Covalent binding to haemoglobin, plasma proteins and DNA was determined after intraperitoneal administration of radiolabelled diethylnitrosamine to mice. The level of alkylation of DNA in liver--the main site of activation--was found to be about two orders of magnitude higher than the level of alkylation of haemoglobi...

journal_title：Carcinogenesis

authors： Osterman-Golkar S,Bergmark E

更新日期：1988-11-01 00:00:00

abstract：:Ataxia-telangiectasia (A-T), which is due to mutations in the ATM gene, is a rare autosomal recessive genomic instability syndrome characterized by radiosensitivity and predisposition to cancer. Epidemiological studies have suggested that relatives of A-T patients (A-T carriers) have increased risks of developing brea...

journal_title：Carcinogenesis

authors： Lu S,Shen K,Wang Y,Santner SJ,Chen J,Brooks SC,Wang YA

更新日期：2006-04-01 00:00:00

abstract：:Adducts produced by modification of DNA with benzo[a]pyrene diolepoxide (BPDE) are known to inhibit both DNA and RNA synthesis. This phenomenon has been used as a method for determining the distribution of carcinogen binding within defined DNA sequences. A critical comparison of different enzyme activities on adducted...

journal_title：Carcinogenesis

authors： Thrall BD,Mann DB,Smerdon MJ,Springer DL

更新日期：1992-09-01 00:00:00

abstract：:I-compounds are endogenous bulky DNA modifications which are detected by nuclease P1-enhanced 32P-post-labeling in tissue DNA of animals not knowingly exposed to carcinogens. Their profiles and levels depend inter alia on animal age, species, strain, tissue, gender, diet and exposure to chemicals such as cytochrome P4...

journal_title：Carcinogenesis

authors： Zhou GD,Vulimiri SV,Randerath E,Randerath K

更新日期：1998-10-01 00:00:00

abstract：:The effect of phenobarbital (PB), p,p'-dichlorodiphenyltrichloroethane (DDT) or carbon tetrachloride (CCl4) on dimethylnitrosamine (DMN)-induced hepatocarcinogenesis in Syrian golden hamsters was examined. Hamsters were given a single injection of DMN (6 mg/kg body wt) followed by either PB or DDT in the diet or repea...

journal_title：Carcinogenesis

authors： Tanaka T,Mori H,Williams GM

更新日期：1987-09-01 00:00:00

abstract：:Apoptosis is a morphologically and biochemically distinct form of cell death which determines specific patterns of tissue size and shape and balances cell proliferation. In the present study, the sequence of cellular proliferative alterations in urinary bladder epithelium associated with uracil-induced reversible urin...

journal_title：Carcinogenesis

authors： Otori K,Yano Y,Takada N,Lee CC,Hayashi S,Otani S,Fukushima S

更新日期：1997-08-01 00:00:00

abstract：:Diglycerides function as analogs of the phorbol ester tumor promoters. We compare here the activity of glycerol 1-myristate 2-acetate (GMA) with the corresponding phorbol 12-myristate 13-acetate (PMA). GMA inhibited phorbol ester binding to reconstituted protein kinase C, stimulated protein kinase C enzymatic activity...

journal_title：Carcinogenesis

authors： Sharkey NA,Blumberg PM

更新日期：1986-04-01 00:00:00

abstract：:Colorectal tumors are continuously exposed to an inflammatory environment, which together with mitogenic signals sustain several cancer hallmarks. Nuclear factor-kappa B (NFκB) is a major regulator of inflammation and variation in NFκB-associated genes could potentially be used as biomarkers to identify patients with ...

journal_title：Carcinogenesis

authors： Ungerbäck J,Belenki D,Jawad ul-Hassan A,Fredrikson M,Fransén K,Elander N,Verma D,Söderkvist P

更新日期：2012-11-01 00:00:00

abstract：:The modifying effects of oltipraz on induction of glandular stomach carcinogenesis by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) were investigated in a total of 120 male 6-week-old Wistar rats, divided into six groups. Groups 1-3 (30 animals each) were given 100 p.p.m. MNNG in their drinking water for 10 weeks as an ...

journal_title：Carcinogenesis

authors： Nishikawa A,Tanakamura Z,Furukawa F,Lee IS,Kasahara K,Ikezaki S,Takahashi M

更新日期：1998-02-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of galacto-oligosaccharides (GOS, Elix'or) on the development of aberrant crypt foci (ACF) and colorectal tumours in rats treated with azoxymethane (AOM). Two groups of 102 male Fischer 344 rats were injected twice with AOM to induce colorectal tumours, and f...

journal_title：Carcinogenesis

authors： Wijnands MV,Schoterman HC,Bruijntjes JB,Hollanders VM,Woutersen RA

更新日期：2001-01-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer-related death, with non-small cell lung cancer (NSCLC) being the predominant form of the disease. Most lung cancer is caused by the accumulation of genomic alterations due to tobacco exposure. To uncover its mutational landscape, we performed whole-exome sequencing in 31 NSCL...

journal_title：Carcinogenesis

authors： Liu P,Morrison C,Wang L,Xiong D,Vedell P,Cui P,Hua X,Ding F,Lu Y,James M,Ebben JD,Xu H,Adjei AA,Head K,Andrae JW,Tschannen MR,Jacob H,Pan J,Zhang Q,Van den Bergh F,Xiao H,Lo KC,Patel J,Richmond T,Watt MA,

更新日期：2012-07-01 00:00:00

abstract：:Peroxisome proliferator activated receptor(alpha) (PPARalpha) mediates the liver's responses to peroxisome proliferator compounds. These responses include induction of specific hepatic enzymes, peroxisome proliferation and hepatocyte proliferation. PPARalpha null mice, which lack receptor in all cells of the body, do ...

journal_title：Carcinogenesis

authors： Weglarz TC,Sandgren EP

更新日期：2004-01-01 00:00:00

abstract：:Fifty-five types of commercial cigarettes on the West German market were analyzed for tobacco-specific nitrosamines (TSNA) in mainstream smoke. The cigarettes included filter and nonfilter cigarettes with very high, high, medium, low and ultra-low tar and nicotine yields. The observed range for N'-nitrosonornicotine w...

journal_title：Carcinogenesis

authors： Fischer S,Spiegelhalder B,Preussmann R

更新日期：1989-01-01 00:00:00

abstract：:The physiological state of pregnancy confers significant resistance to polycyclic aromatic hydrocarbon (PAH)-induced mammary tumorigenesis. We have tested the abilities of primary mammary cells from pregnant and virgin rats cultured on collagen-coated plates to metabolize PAHs and convert these carcinogens to mutageni...

journal_title：Carcinogenesis

authors： Moore CJ,Gould MN

更新日期：1984-01-01 00:00:00

abstract：:Observational studies and animal evidence suggest an association between coffee consumption and the risk of prostate cancer. However, the results are inconsistent. We evaluated the association by conducting a meta-analysis of prospective cohort studies. PubMed and Embase were searched through June 2013 to identify stu...

journal_title：Carcinogenesis

authors： Cao S,Liu L,Yin X,Wang Y,Liu J,Lu Z

更新日期：2014-02-01 00:00:00

abstract：:Stimulation of cell proliferation caused by peroxisome proliferators was blocked by antibodies against TNF alpha and agents that inactivate Kupffer cells, a rich source of TNF alpha, which supports the hypothesis that Kupffer cells play a pivotal role in peroxisome proliferator-induced hyperplasia. Here, the ability o...

journal_title：Carcinogenesis

authors： Rusyn I,Tsukamoto H,Thurman RG

更新日期：1998-07-01 00:00:00

abstract：:A diet deficient in choline when fed to rats for as few as 3 days resulted in liver DNA damage. The damage could be monitored as alkali-labile lesions using alkaline-sucrose gradients as well as alkaline elution technique. The DNA damage disappeared when the choline-deficient diet was replaced by a choline-supplemente...

journal_title：Carcinogenesis

authors： Rushmore TH,Farber E,Ghoshal AK,Parodi S,Pala M,Taningher M

更新日期：1986-10-01 00:00:00

abstract：:The DNA double-strand breaks (DSBs) repair pathway has been implicated in maintaining genomic integrity via suppression of chromosomal rearrangements. DNA-dependent protein kinase (DNA-PK) has an important role with DNA DSBs repair. In this study, 93 of untreated cancer patients and 41 of cancer-free healthy volunteer...

journal_title：Carcinogenesis

authors： Someya M,Sakata K,Matsumoto Y,Yamamoto H,Monobe M,Ikeda H,Ando K,Hosoi Y,Suzuki N,Hareyama M

更新日期：2006-01-01 00:00:00

abstract：:Benzoquinones (BQ) are genotoxic species that stem from metabolism of phenolic compounds. We have developed a method for measuring adducts of 1,2- and 1,4-benzoquinone (1,2-BQ and 1,4-BQ) with cysteine residues of hemoglobin (Hb) and albumin (Alb). The method employs a reductive catalyst (Raney nickel) to selectively ...

journal_title：Carcinogenesis

authors： McDonald TA,Waidyanatha S,Rappaport SM

更新日期：1993-09-01 00:00:00

abstract：:The reactive metabolites of the carcinogenic N-acetyl-2-aminofluorene (AAF) form adducts with the guanine base of DNA. The fluorescence emission characteristics of N-(deoxy-guanosin-8-yl)-N-acetyl-2-aminofluorene (dGuo-C8-AAF), N-(deoxyguanosin-8-yl)-2-aminofluorene (dGuo-C8-AF) and the two N7 = C8 imidazole ring-open...

journal_title：Carcinogenesis

authors： van Houte LP,Retèl J,Westra JG,van Grondelle R

更新日期：1990-04-01 00:00:00

abstract：:Epidemiologic studies have suggested that aromatic amines (and nitroaromatic hydrocarbons) may be carcinogenic for human pancreas. Pancreatic tissues from 29 organ donors (13 smokers, 16 non-smokers) were examined for their ability to metabolize aromatic amines and other carcinogens. Microsomes showed no activity for ...

journal_title：Carcinogenesis

authors： Anderson KE,Hammons GJ,Kadlubar FF,Potter JD,Kaderlik KR,Ilett KF,Minchin RF,Teitel CH,Chou HC,Martin MV,Guengerich FP,Barone GW,Lang NP,Peterson LA

更新日期：1997-05-01 00:00:00

abstract：:The effect of co-administration of diethylnitrosamine (DEN) and Clophen A 50, a commercial mixture of polychlorinated biphenyls (PCB), on pre-neoplastic enzyme-altered islands in livers of female Sprague-Dawley rats was studied. The islands were identified by the loss of adenosine-5'-triphosphatase (ATPase), emergence...

journal_title：Carcinogenesis

authors： Deml E,Oesterle D

更新日期：1986-10-01 00:00:00

abstract：:We have measured the levels of thymine glycol (TG) and thymidine glycol (dTG) in human urine, using an HPLC method. The results show that all 30 specimens examined (including 10 non-neoplastic and 20 neoplastic human urines) contained significant amounts of TG and dTG, average levels (mean +/- SEM) were 0.376 +/- 0.02...

journal_title：Carcinogenesis

authors： Cao EH,Wang JJ

更新日期：1993-07-01 00:00:00

abstract：:This study presents the physical characterization of mutants induced in mammalian cells by high linear energy transfer alpha-particle radiation that simulates exposure to radon daughters. Alpha-Particles from accelerated 4He at 150 keV/microns were used to induce 20 Chinese hamster ovary mutants that are deficient in ...

journal_title：Carcinogenesis

authors： Jin Y,Yie TA,Carothers AM

更新日期：1995-08-01 00:00:00