Highly purified human alpha-thrombin promotes morphological transformation of BALB/c 3T3 cells.

abstract：:The metabolism of N-nitrosobis(2-oxopropyl)amine (BOP) was examined in microsomes from uninduced F-344 rats. Even when the conditions were varied, no metabolism of this compound was detected. On the other hand, freshly isolated hepatocytes from F-344 rats metabolized BOP efficiently to CO2. The kinetics of conversion ...

journal_title：Carcinogenesis

authors： Farrelly JG,Saavedra JE,Kupper RJ,Stewart ML

更新日期：1987-08-01 00:00:00

abstract：:One of the most widely studied ultimate carcinogens, 7r,8t-dihydroxy-9t,10t-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE-I), is fairly stable in organic solvents but hydrolyses rapidly in the presence of water. Routine use of BPDE-I stock solutions involves multiple cycles of warming to room temperature and return to f...

journal_title：Carcinogenesis

authors： MacLeod MC,Lew L

更新日期：1988-11-01 00:00:00

abstract：:DNA polymerase beta (polbeta) is a major contributor to mammalian DNA damage repair through its gap-filling DNA synthesis and 5'-deoxyribose phosphate lyase activities. In this way, polbeta plays pivotal roles in the repair of oxidative DNA damage, replication, embryonic survival, neuronal development, meiosis, apopto...

journal_title：Carcinogenesis

authors： Wang L,Bhattacharyya N,Rabi T,Wang L,Banerjee S

更新日期：2007-06-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor (PPAR) gamma is a ligand-activated nuclear receptor that plays a key role in adipogenesis and adipocyte gene expression, and has recently been linked with possible antineoplastic effects in colonic carcinogenesis. PPARgamma2 and gamma3 are two transcripts arising from the PPA...

journal_title：Carcinogenesis

authors： Koh WP,Yuan JM,Van Den Berg D,Ingles SA,Yu MC

更新日期：2006-09-01 00:00:00

abstract：:Insulin-like growth factor-II (IGF-II) may be a prognostic marker in ovarian cancer, and its intronic single nucleotide polymorphism (SNP) rs4320932 has been associated with risk of the disease. We determined whether rs4320932 is associated with IGF-II expression and patient survival in ovarian cancer, and explored wh...

journal_title：Carcinogenesis

authors： Lu L,Risch E,Deng Q,Biglia N,Picardo E,Katsaros D,Yu H

更新日期：2013-09-01 00:00:00

abstract：:Maternal nutrition during pregnancy influences the development and metabolism of the fetus. Recent studies suggest that the cancer risk of offspring later in life is associated with maternal diet, but little is known about the effect of a maternal diet high in methyl nutrients on breast cancer risk. Lipotropes are met...

journal_title：Carcinogenesis

authors： Cho K,Mabasa L,Bae S,Walters MW,Park CS

更新日期：2012-05-01 00:00:00

abstract：:Celastrol is an anti-inflammatory natural triterpenoid, isolated from the herb Tripterygium wilfordii or thunder god vine. Here, we define mechanisms mediating anti-inflammatory activity of celastrol and demonstrate efficacy of a dietary celastrol supplement for chemoprevention of inflammation-driven carcinogenesis in...

journal_title：Carcinogenesis

authors： Barker EC,Kim BG,Yoon JH,Tochtrop GP,Letterio JJ,Choi SH

更新日期：2018-01-12 00:00:00

abstract：:1,3-Butadiene (BD) is an indirect alkylating agent that has greater cancer potency in the mouse than in the rat. The purpose of the present study was to compare the mutagenic potency of BD at the hprt locus of T-lymphocytes of exposed mice and rats and to determine whether mutations induced in this marker gene can be ...

journal_title：Carcinogenesis

authors： Meng Q,Recio L,Reilly AA,Wong BA,Bauer M,Walker VE

更新日期：1998-06-01 00:00:00

abstract：:The metabolism of benzo[a]pyrene (BP) in cultured human epidermal keratinocytes was investigated using thin layer chromatography, high pressure liquid chromatography and cell-mediated mutagenesis assay. Epidermal keratinocytes were obtained from skin of normal subjects and all experiments were performed on primary cul...

journal_title：Carcinogenesis

authors： Kuroki T,Nemoto N,Kitano Y

更新日期：1980-07-01 00:00:00

abstract：:Telomerase activity is observed in approximately 90% of human cancer including esophageal squamous cell cancer. Normal somatic cells do not display telomerase activity on a regular basis. The major mechanism to regulate telomerase activity in human cells is the transcriptional control of the catalytic subunit, the hum...

journal_title：Carcinogenesis

authors： Quante M,Heeg S,von Werder A,Goessel G,Fulda C,Doebele M,Nakagawa H,Beijersbergen R,Blum HE,Opitz OG

更新日期：2005-11-01 00:00:00

abstract：:The three-dimensional structure of the product of the reaction of a diol epoxide of the carcinogen 5-methylchrysene with methanol has been determined by an X-ray diffraction analysis. The diol epoxide used to obtain this compound contains a stereochemically hindered bay region because of the location of the 5-methyl g...

journal_title：Carcinogenesis

authors： Afshar CE,Carrell CJ,Carrell HL,Harvey RG,Kiselyov AS,Amin S,Glusker JP

更新日期：1996-11-01 00:00:00

abstract：:Previous studies have shown that platinum-DNA adduct level in leukocyte DNA (measured by antibody methodology) is directly related to disease response in ovarian cancer and testicular cancer. To determine if this principle could be more broadly applied, platinum-DNA damage was studied in a blinded fashion in leukocyte...

journal_title：Carcinogenesis

authors： Parker RJ,Gill I,Tarone R,Vionnet JA,Grunberg S,Muggia FM,Reed E

更新日期：1991-07-01 00:00:00

abstract：:Garcinol, a polyisoprenylated benzophenone, from the fruit rind of Garcinia spp., has been shown to have anti-inflammatory and anticarcinogenic activities. To study its mechanism of action, we analyzed the effects of garcinol and its derivatives, including cambogin, garcim-1 and garcim-2, on arachidonic acid metabolis...

journal_title：Carcinogenesis

authors： Hong J,Sang S,Park HJ,Kwon SJ,Suh N,Huang MT,Ho CT,Yang CS

更新日期：2006-02-01 00:00:00

abstract：:The rat liver microsomal metabolism of 3-deutero-6-nitrobenzo(a)pyrene ([3-2H]6-NO2-BaP) was studied. The metabolites were separated by h.p.l.c. The 500 MHz 1H n.m.r. spectral analysis of the metabolites indicated that the 3-hydroxy-6-NO2-BaP and 6-NO2-BaP-3,9-hydroquinone each retained 33% of the deuterium label at t...

journal_title：Carcinogenesis

authors： Chou MW,Evans FE,Yang SK,Fu PP

更新日期：1983-01-01 00:00:00

abstract：:Tea polyphenolic constituents induce apoptosis in cancer cells but not in normal cells. To study the mechanism of this selective effect, we used the ornithine decarboxylase (ODC)/Ras double transgenic mouse model that develops spontaneous skin tumors due to over-expression of ODC and a v-Ha-ras transgene. Administrati...

journal_title：Carcinogenesis

authors： Paul B,Hayes CS,Kim A,Athar M,Gilmour SK

更新日期：2005-01-01 00:00:00

abstract：:Adduct formation has been considered to be a major causal factor of DNA damage by carcinogenic heterocyclic amines. By means of experiments with an electrochemical detector coupled to a high-performance liquid chromatograph, we revealed that N-hydroxy metabolite of 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (Ph...

journal_title：Carcinogenesis

authors： Murata M,Kawanishi S

更新日期：2002-05-01 00:00:00

abstract：:The coordinate regulation of DNA synthesis and suppression of apoptosis was investigated in a rat hepatocyte cell culture system which supports high level induction of DNA synthesis by the peroxisome proliferator, methylclofenapate (MCP) (Plant, N.J. et al., 1998, Carcinogenesis, 19, 925-931). The peroxisome prolifera...

journal_title：Carcinogenesis

authors： Plant NJ,Horley NJ,Dickins M,Hasmall S,Elcombe CR,Bell DR

更新日期：1998-09-01 00:00:00

abstract：:The O6-methylguanine-DNA methyltransferase gene (MGMT) encodes the direct reversal DNA repair protein that removes alkyl adducts from the O6 position of guanine. Several single-nucleotide polymorphisms (SNPs) exist in the MGMT promoter/enhancer (P/E) region. However, the haplotype structure encompassing these SNPs and...

journal_title：Carcinogenesis

authors： Xu M,Nekhayeva I,Cross CE,Rondelli CM,Wickliffe JK,Abdel-Rahman SZ

更新日期：2014-03-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a significant risk factor for lung cancer. One potential mechanism through which COPD contributes to lung cancer development could be through generation of an immunosuppressive microenvironment that allows tumor formation and progression. In this study, we compared the s...

journal_title：Carcinogenesis

authors： Narayanapillai SC,Han YH,Song JM,Kebede ME,Upadhyaya P,Kassie F

更新日期：2020-11-13 00:00:00

abstract：:Male outbred Sprague-Dawley rats were fed a choline-deficient diet containing 0.10% DL-ethionine for up to 30 weeks. Liver slices from rats killed 4, 6, 10, 14, 22 and 30 weeks after starting the treatment were histochemically analyzed for the following parameters: basophilia, expression of cytokeratin 19 (which in th...

journal_title：Carcinogenesis

authors： Steinberg P,Hacker HJ,Dienes HP,Oesch F,Bannasch P

更新日期：1991-02-01 00:00:00

abstract：:Aberrant crypt foci (ACF), putative preneoplastic lesions, are early morphological changes induced by the colon carcinogen azoxymethane (AOM). Although inbred mice differ markedly in their susceptibility to AOM carcinogenesis, we have previously shown that ACF develop in both resistant and sensitive mouse strains afte...

journal_title：Carcinogenesis

authors： Papanikolaou A,Wang QS,Papanikolaou D,Whiteley HE,Rosenberg DW

更新日期：2000-08-01 00:00:00

abstract：:The possibility that alpha-tocopherol (vitamin E) inhibits the formation of nitrosomorpholine (NMOR) in vivo was investigated in mice orally pretreated with alpha-tocopherol (2.5-100 mg/kg body wt) once daily for 6 days. Twenty-four hours later, the animals were injected i.p. with 2 mg of morpholine (MOR) per animal f...

journal_title：Carcinogenesis

authors： Norkus EP,Kuenzig WA,Chau J,Mergens WJ,Conney AH

更新日期：1986-03-01 00:00:00

abstract：:In addition to genetic changes, epigenetic aberrations also play important roles in radiation- and chemical-induced disorders and carcinogenesis. The present study investigated whether epigenetic therapy with a histone deacetylase (HDAC) inhibitor has dual benefits for radiation-induced oral mucositis and chemical-ind...

journal_title：Carcinogenesis

authors： Chung YL,Lee MY,Pui NN

更新日期：2009-08-01 00:00:00

abstract：:Hypoxia-inducible factors (HIFs), in particular HIF-1alpha, have been implicated in tumor biology. However, HIF target genes in the esophageal tumor microenvironment remain elusive. Gene expression profiling was performed upon hypoxia-exposed non-transformed immortalized human esophageal epithelial cells, EPC2-hTERT, ...

journal_title：Carcinogenesis

authors： Lee JJ,Natsuizaka M,Ohashi S,Wong GS,Takaoka M,Michaylira CZ,Budo D,Tobias JW,Kanai M,Shirakawa Y,Naomoto Y,Klein-Szanto AJ,Haase VH,Nakagawa H

更新日期：2010-03-01 00:00:00

abstract：:The liver-derived human cell line, Hep G2, has high benzo[a]pyrene-metabolizing activity and converts benzo[a]pyrene to intermediates that are mutagenic and that bind to DNA. This cell line will be useful for studying metabolic activation of polycyclic aromatic hydrocarbons and other xenobiotics by human tissue and as...

journal_title：Carcinogenesis

authors： Diamond L,Kruszewski F,Aden DP,Knowles BB,Baird WM

更新日期：1980-01-01 00:00:00

abstract：:Gene-environment interactions play an important role in folate metabolism, with a potential impact on human health. Deficiencies in the uptake of key micronutrients and variant genotypes can affect the folic acid cycle, modulating methyl group transfer in key processes and leading to increased cancer risk and Down syn...

journal_title：Carcinogenesis

authors： Zijno A,Andreoli C,Leopardi P,Marcon F,Rossi S,Caiola S,Verdina A,Galati R,Cafolla A,Crebelli R

更新日期：2003-06-01 00:00:00

abstract：:Resveratrol (RSVL) is a well-established chemopreventive agent in human breast cancer models. The molecular basis of its action is far less characterized. We investigated the effects of RSVL on activity of adenylate- and guanylate-cyclase (AC, GC) enzymes; two known cytostatic cascades in MCF-7 breast cancer cells. RS...

journal_title：Carcinogenesis

authors： El-Mowafy AM,Alkhalaf M

更新日期：2003-05-01 00:00:00

abstract：:The metabolism of 7,12-dimethylbenz[a]anthracene (DMBA), benzo[a]pyrene (BP) and benz[a]anthracene (BA) by epithelial cell aggregates and fibroblasts in culture has been investigated using mammary tissue obtained from female Wistar rats. The results show that: (a) both types of mammary cells metabolise all three hydro...

journal_title：Carcinogenesis

authors： Cooper CS,Pal K,Hewer A,Grover PL,Sims P

更新日期：1982-01-01 00:00:00

abstract：:The NIH3T3 cell line undergoes transformation when the cells are maintained at high densities for extended periods. In an effort to define the physiological status of the cells before and during the transformation process, they were seeded in medium containing 2, 5 or 10% calf serum (CS) and growth was monitored by me...

journal_title：Carcinogenesis

authors： Rubin AL,Ellison BJ

更新日期：1991-10-01 00:00:00

abstract：:O6-Alkylguanine-DNA alkyltransferase (AGAT) activity was determined in macroscopically normal peripheral lung tissues from 122 patients undergoing lung surgery. AGAT activity of smokers was 1.4-fold higher than that of lifetime non-smokers (P = 0.030). Less than one year of abstinence from smoking did not cause a sign...

journal_title：Carcinogenesis

authors： Drin I,Schoket B,Kostic S,Vincze I

更新日期：1994-08-01 00:00:00