Peroxisome proliferator-activated receptor (PPAR) gamma gene polymorphisms and colorectal cancer risk among Chinese in Singapore.

abstract：:The promoting action of hexachlorocyclohexane (HCH) was evaluated in female Wistar rats by counting the gamma-glutamyltranspeptidase-positive foci which appeared in the liver after diethylnitrosamine (DENA) initiation. Liver tumor promotion by HCH was further confirmed in a long-term tumorigenicity study after DENA pr...

journal_title：Carcinogenesis

authors： Munir KM,Rao KV,Bhide SV

更新日期：1984-04-01 00:00:00

abstract：:A 32P-postlabeling assay was employed for detection and quantitation of DNA adducts formed with carcinogenic 1-phenylazo-2-hydroxynaphthalene (Sudan I, Solvent Yellow 14) activated by a peroxidase system. Enrichment of adducts by digestion with nuclease P1 or by extraction into n-butanol prior to 32P-labeling was used...

journal_title：Carcinogenesis

authors： Stiborová M,Frei E,Schmeiser HH,Wiessler M

更新日期：1992-07-01 00:00:00

abstract：:Intake of dietary factors that serve as methyl group donors may influence promoter hypermethylation in colorectal carcinogenesis. We investigated whether dietary folate, vitamin B2 and vitamin B6, methionine and alcohol were associated with mutL homologue 1 (MLH1) hypermethylation and the related molecular phenotypes ...

journal_title：Carcinogenesis

authors： de Vogel S,Bongaerts BW,Wouters KA,Kester AD,Schouten LJ,de Goeij AF,de Bruïne AP,Goldbohm RA,van den Brandt PA,van Engeland M,Weijenberg MP

更新日期：2008-09-01 00:00:00

abstract：:We have investigated the activity of insoluble and soluble lead compounds in inducing mutagenesis, cell transformation and sister chromatid exchange in mammalian cells. Insoluble lead sulfide, readily phagocytized, was more than four times as toxic to V79 cells on a microM basis, than two moderately soluble lead compo...

journal_title：Carcinogenesis

authors： Zelikoff JT,Li JH,Hartwig A,Wang XW,Costa M,Rossman TG

更新日期：1988-10-01 00:00:00

abstract：:We examined allelic loss in colon tumors induced by 1,2-dimethylhydrazine (DMH) in F1 hybrid mice, using sequence-tagged microsatellite site (STMS) primers derived from the chromosomal region closely linked to the p53 locus. Polymerase chain reaction--single-strand conformation polymorphism (PCR-SSCP) analysis of 155 ...

journal_title：Carcinogenesis

authors： Okamoto M,Ohtsu H,Miyaki M,Yonekawa H

更新日期：1993-07-01 00:00:00

abstract：:Metabolism and macromolecular interaction of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) were studied in human buccal mucosa in vitro. Microautoradiographic analysis of [5-3H]NNK-exposed explant cultures demonstrated a uniform distribution of bound radioactivity in the mucosal ...

journal_title：Carcinogenesis

authors： Liu Y,Sundqvist K,Belinsky SA,Castonguay A,Tjälve H,Grafström RC

更新日期：1993-11-01 00:00:00

abstract：:A diet deficient in choline when fed to rats for as few as 3 days resulted in liver DNA damage. The damage could be monitored as alkali-labile lesions using alkaline-sucrose gradients as well as alkaline elution technique. The DNA damage disappeared when the choline-deficient diet was replaced by a choline-supplemente...

journal_title：Carcinogenesis

authors： Rushmore TH,Farber E,Ghoshal AK,Parodi S,Pala M,Taningher M

更新日期：1986-10-01 00:00:00

abstract：:The role of BRCA1 in sporadic breast and ovarian cancers remains elusive. Direct involvement of BRCA1 in the development of breast and ovarian cancer is suggested by the finding that the BRCA1 promoter region CpG island is methylated in a proportion of breast and ovarian cancers. The aim of this study was to compare t...

journal_title：Carcinogenesis

authors： Bianco T,Chenevix-Trench G,Walsh DC,Cooper JE,Dobrovic A

更新日期：2000-02-01 00:00:00

abstract：:The metabolism in mouse epidermis of benzo[b]fluoranthene (BbF) was studied. [3H]BbF was applied topically, mice were killed at various intervals, and metabolites were extracted from the epidermis and analyzed by h.p.l.c. The major metabolites were identified by comparisons to standards as 4-, 5-, and 6-hydroxyBbF. Su...

journal_title：Carcinogenesis

authors： Geddie JE,Amin S,Huie K,Hecht SS

更新日期：1987-11-01 00:00:00

abstract：:Carcinogenesis develops in stages that have been operationally defined as initiation, promotion and progression. Although morphological end points have been described for detection and quantitation of these stages, to date initiation has been assessed only in the context of clonal growth in response to certain promoti...

journal_title：Carcinogenesis

authors： Dragan YP,Campbell HA,Baker K,Vaughan J,Mass M,Pitot HC

更新日期：1994-11-01 00:00:00

abstract：:Cryptic deletions at chromosome 6q are common cytogenetic abnormalities in T-cell lymphoblastic leukemia/lymphoma (T-LBL), but the target genes have not been formally identified. Our results build on detection of specific chromosomal losses in a mouse model of γ-radiation-induced T-LBLs and provide interesting clues f...

journal_title：Carcinogenesis

authors： López-Nieva P,Vaquero C,Fernández-Navarro P,González-Sánchez L,Villa-Morales M,Santos J,Esteller M,Fernández-Piqueras J

更新日期：2012-02-01 00:00:00

abstract：:Nitrosamine-induced hepatocarcinogenesis has been used to investigate the regulation and expression of different drug-metabolizing enzymes in preneoplastic and neoplastic lesions in the female Wistar rat. The enzymes investigated were two phenobarbital-inducible cytochrome P-450 (cyt. P-450) isoenzymes (PB1 and PB2, m...

journal_title：Carcinogenesis

authors： Buchmann A,Kuhlmann W,Schwarz M,Kunz W,Wolf CR,Moll E,Friedberg T,Oesch F

更新日期：1985-04-01 00:00:00

abstract：:The androgen receptor (AR) is involved in the development and progression of prostate cancer. In order to find new compounds that may present novel mechanisms to attenuate the function of AR, we investigated the effect of a natural flavonoid chemical, quercetin, on androgen action in an androgen-responsive LNCaP prost...

journal_title：Carcinogenesis

authors： Xing N,Chen Y,Mitchell SH,Young CY

更新日期：2001-03-01 00:00:00

abstract：:Vinyl chloride (VC) is a carcinogen associated with human and animal cancers. The ultimate carcinogenic form of VC, 2-chloroacetaldehyde (CAA), has been suspected to be mutagenic and we confirmed the mutagenicity of CAA using a modified shuttle vector plasmid. Base sequence analyses of 109 mutant plasmids with mutatio...

journal_title：Carcinogenesis

authors： Matsuda T,Yagi T,Kawanishi M,Matsui S,Takebe H

更新日期：1995-10-01 00:00:00

abstract：:One of the most widely studied ultimate carcinogens, 7r,8t-dihydroxy-9t,10t-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE-I), is fairly stable in organic solvents but hydrolyses rapidly in the presence of water. Routine use of BPDE-I stock solutions involves multiple cycles of warming to room temperature and return to f...

journal_title：Carcinogenesis

authors： MacLeod MC,Lew L

更新日期：1988-11-01 00:00:00

abstract：:The extracellular matrix (ECM) is known to play an active role in numerous biological processes such as differentiation, apoptosis and cancer. Extensive alterations of epithelial basement membranes and of interstitial ECM are known to occur during the progression of most invasive carcinomas. Collagen, which represents...

journal_title：Carcinogenesis

authors： Pucci-Minafra I,Andriolo M,Basiricò L,Alessandro R,Luparello C,Buccellato C,Garbelli R,Minafra S

更新日期：1998-04-01 00:00:00

abstract：:Oxidative DNA damage may be implicated in ageing, carcinogenesis and other degenerative diseases. Oxidative DNA damage can be assessed in humans in vivo from the urinary excretion of the DNA-repair product 8-hydroxydeoxyguanosine (8OHdG). We investigated factors influencing the excretion of 8OHdG in 24 h urine from 83...

journal_title：Carcinogenesis

authors： Loft S,Vistisen K,Ewertz M,Tjønneland A,Overvad K,Poulsen HE

更新日期：1992-12-01 00:00:00

abstract：:Expression of the human placental form of glutathione S-transferase (GST-pi), an enzyme proposed as a marker for human and experimental neoplasia, was immunohistochemically evaluated in 51 samples of 'normal' and diseased adult human uterine cervix. Five fetal uteri were also studied. GST-pi positivity was detected in...

journal_title：Carcinogenesis

authors： de Camargo JL,Tsuda H,Tatematsu M,Rodrigues MA,Yamada M,Tzuji K,Ito N

更新日期：1989-12-01 00:00:00

abstract：:Telomerase activity is observed in approximately 90% of human cancer including esophageal squamous cell cancer. Normal somatic cells do not display telomerase activity on a regular basis. The major mechanism to regulate telomerase activity in human cells is the transcriptional control of the catalytic subunit, the hum...

journal_title：Carcinogenesis

authors： Quante M,Heeg S,von Werder A,Goessel G,Fulda C,Doebele M,Nakagawa H,Beijersbergen R,Blum HE,Opitz OG

更新日期：2005-11-01 00:00:00

abstract：:The role of rat O6-alkylguanine-DNA alkyltransferase (AGT) in modulating mutagenesis by O6-substituted guanines in the rat H-ras gene was examined. Rat4 cells were transfected with vectors carrying O6-methyl-, O6-ethyl- or O6-benzylguanine residues in place of the normal guanines at either the first, second, or both t...

journal_title：Carcinogenesis

authors： Bishop RE,Dunn LL,Pauly GT,Dolan ME,Moschel RC

更新日期：1993-04-01 00:00:00

abstract：:Alterations of epigenetic modifications are promising targets for cancer therapy, and several epigenetic drugs are now being clinically utilized. At the same time, individual epigenetic modifications have physiological functions in normal cells, and cancer cell specificity is considered difficult to achieve using a dr...

journal_title：Carcinogenesis

authors： Takeshima H,Wakabayashi M,Hattori N,Yamashita S,Ushijima T

更新日期：2015-02-01 00:00:00

abstract：:raf oncogenes have been implicated in hepatic carcinogenesis. We studied the effects of the v-raf of murine retrovirus 3611-MSV on the growth and differentiation of a simian virus 40 (SV40)-immortalized rat liver cell line (ALB-8) which maintained many of characteristics of differentiated hepatocytes. Cells were co-tr...

journal_title：Carcinogenesis

authors： Fang XJ,Keating A,Flowers M,Liew CC,Gupta H,Mills GB,Sherman M

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:Analysis of candidate genes in individual studies has had only limited success in identifying particular gene variants that are conclusively associated with lung cancer risk. In the International Lung Cancer Consortium (ILCCO), we conducted a coordinated genotyping study of 10 common variants selected becaus...

journal_title：Carcinogenesis

authors： Truong T,Sauter W,McKay JD,Hosgood HD 3rd,Gallagher C,Amos CI,Spitz M,Muscat J,Lazarus P,Illig T,Wichmann HE,Bickeböller H,Risch A,Dienemann H,Zhang ZF,Naeim BP,Yang P,Zienolddiny S,Haugen A,Le Marchand L,Hong YC

更新日期：2010-04-01 00:00:00

abstract：:Animal studies demonstrated that females are more susceptible than males to benzo[a]pyrene (BaP)-induced toxicities, including lung carcinogenesis. Elevation of cyclooxygenase-2 (COX-2) expression has been shown to increase the risk of cancer development. BaP induces COX-2 expression, and an interaction between BaP an...

journal_title：Carcinogenesis

authors： Chang LW,Chang YC,Ho CC,Tsai MH,Lin P

更新日期：2007-07-01 00:00:00

abstract：:The HSP70 family of heat shock proteins consists of molecular chaperones of approximately 70kDa in size that serve critical roles in protein homeostasis. These adenosine triphosphatases unfold misfolded or denatured proteins and can keep these proteins in an unfolded, folding-competent state. They also protect nascent...

journal_title：Carcinogenesis

authors： Murphy ME

更新日期：2013-06-01 00:00:00

abstract：:The crosstalk between microRNAs (miRNAs) and other epigenetic factors may lead to novel hypotheses about carcinogenesis identifying new targets for research. Because a single miRNA can regulate multiple downstream target genes, its altered expression may potentially be a sensitive biomarker to detect early malignant t...

journal_title：Carcinogenesis

authors： Cordero F,Ferrero G,Polidoro S,Fiorito G,Campanella G,Sacerdote C,Mattiello A,Masala G,Agnoli C,Frasca G,Panico S,Palli D,Krogh V,Tumino R,Vineis P,Naccarati A

更新日期：2015-10-01 00:00:00

abstract：:Junctional adhesion molecule-A (JAM-A) is preferentially concentrated at tight junctions and influences epithelial cell morphology and migration. Epithelial-to-mesenchymal transition (EMT) is the conversion process of epithelial cells into mesenchymal cells, and it plays an important role in the invasiveness and metas...

journal_title：Carcinogenesis

authors： Tian Y,Tian Y,Zhang W,Wei F,Yang J,Luo X,Zhou T,Hou B,Qian S,Deng X,Qiu Y,Yao K

更新日期：2015-01-01 00:00:00

abstract：:DNA mismatch repair (MMR) deficiency results in a strong mutator phenotype and high-frequency microsatellite instability (MSI-H), which are the hallmarks of tumors arising within Lynch syndrome. MSI-H is characterized by length alterations within simple repeated sequences, microsatellites. Lynch syndrome is primarily ...

journal_title：Carcinogenesis

authors： Imai K,Yamamoto H

更新日期：2008-04-01 00:00:00

abstract：:Whole-body autoradiography of [3H]aflatoxin B1 ([3H]AFB1) in lamb showed a localization of bound labelling, in addition to the liver, in the nasal olfactory and respiratory mucosa, in the mucosa of the nasopharynx, pharynx, oesophagus, larynx, trachea, bronchi and bronchioles and in the palpebral and bulbar conjunctiv...

journal_title：Carcinogenesis

authors： Larsson P,Busk L,Tjälve H

更新日期：1994-05-01 00:00:00

abstract：:Two mutagenic compounds have been isolated and purified from commercial beef extract. These two compounds have chemical, chromatographic, spectroscopic and biological behavior indistinguishable from those of the two known mutagens 2-amino-3-methyl-imidazo-[4,5-f]-quinoline and 2-amino-3,8-dimethyl-imidazo-[4,5-f]-quin...

journal_title：Carcinogenesis

authors： Turesky RJ,Wishnok JS,Tannenbaum SR,Pfund RA,Buchi GH

更新日期：1983-01-01 00:00:00