Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics.

abstract：:Previous metabolism and DNA-binding studies indicated that 5,6-dimethylchrysene (5,6-diMeC) is metabolically activated in mouse skin through formation of its 1,2-dihydrodiol (5,6-diMeC-1,2-diol) and bay region diol-epoxide (anti-5,6-diMeC-1,2-diol-3,4-epoxide). These metabolites were tested as tumor initiators on mous...

journal_title：Carcinogenesis

authors： Amin S,Desai D,Hecht SS

更新日期：1993-10-01 00:00:00

abstract：:Dose response studies regarding the cancer initiating potential of fumonisin B1 (FB1) were conducted as a function of time. Feeding studies over 21 days indicated that FB1 induced a feed refusal effect in rats at dietary levels of 250, 500 and 750 mg FB1/kg diet. This effect was overcome after 14 days and the feed int...

journal_title：Carcinogenesis

authors： Gelderblom WC,Cawood ME,Snyman SD,Marasas WF

更新日期：1994-02-01 00:00:00

abstract：:Colorectal cancer is the second leading cause of cancer deaths worldwide with diet playing a prominent role in disease initiation and progression. Flavonoids are secondary plant compounds that are suggested as protective ingredients of a diet rich in fruits and vegetables. We here tested whether flavone, a flavonoid t...

journal_title：Carcinogenesis

authors： Winkelmann I,Diehl D,Oesterle D,Daniel H,Wenzel U

更新日期：2007-07-01 00:00:00

abstract：:Sulfur-containing substances derived from garlic and onion have been shown to prevent experimental carcinogenesis. One of the hypotheses explaining the mechanisms of the chemopreventive activity of these substances is that they activate detoxification systems such as glutathione S-transferase (GST). In this study the ...

journal_title：Carcinogenesis

authors： Hatono S,Jimenez A,Wargovich MJ

更新日期：1996-05-01 00:00:00

abstract：:Caffeine is sequentially metabolized by cytochrome P4501A2 (CYP1A2), N-acetyltransferase (NAT) and/or xanthine oxidase (XO). In the present study the activity of these three enzymes was estimated from ratios of the metabolites formed from dietary caffeine and excreted into the urine collected as spot samples. In the u...

journal_title：Carcinogenesis

authors： Vistisen K,Poulsen HE,Loft S

更新日期：1992-09-01 00:00:00

abstract：:To test the hypothesis that nucleotide excision repair (NER) plays a protective role in chemical carcinogenesis in internal organs, xeroderma pigmentosum group A gene-deficient (XPA(-/-)) mice, heterozygous (XPA(+/-)) and wild-type (XPA(+/+)) mice were orally administered 0.001% 4-nitroquinoline 1-oxide (4NQO) in thei...

journal_title：Carcinogenesis

authors： Ide F,Oda H,Nakatsuru Y,Kusama K,Sakashita H,Tanaka K,Ishikawa T

更新日期：2001-04-01 00:00:00

abstract：:The association between prostate cancer risk and dietary fat consumption is well documented and explained partly by accelerated lipid peroxidation. We explored the possible effects of high dietary cholesterol on carcinogenesis and oxidative stress in the prostate of ACI/Seg rats. The rats develop prostate cancer spont...

journal_title：Carcinogenesis

authors： Homma Y,Kondo Y,Kaneko M,Kitamura T,Nyou WT,Yanagisawa M,Yamamoto Y,Kakizoe T

更新日期：2004-06-01 00:00:00

abstract：:Female inbred C3H/St mice infected with the Bittner Milk Particle, develop mammary adenocarcinoma with 27% incidence if maintained on a Torula Yeast diet supplemented with 1 ppm of selenium (organically bound, in yeast). Animals switched from the 1 ppm Se diet to a diet containing only 0.15 ppm Se after reaching the a...

journal_title：Carcinogenesis

authors： Schrauzer GN,McGinness JE,Kuehn K

更新日期：1980-02-01 00:00:00

abstract：:In order to investigate the modulatory effect of the immune response induced by recurrent carcinogen exposure, anti-2-acetylaminofluorene (anti-2-AAF) IgG were elicited in Swiss mice before subsequent carcinogen administration. The immunization schedule consisted of three weekly i.p. injections of 2-acetylaminofluoren...

journal_title：Carcinogenesis

authors： Verdina A,Zito R,Cortese G,Leopardi P,Marcon F,Zijno A,Crebelli R

更新日期：1996-08-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of galacto-oligosaccharides (GOS, Elix'or) on the development of aberrant crypt foci (ACF) and colorectal tumours in rats treated with azoxymethane (AOM). Two groups of 102 male Fischer 344 rats were injected twice with AOM to induce colorectal tumours, and f...

journal_title：Carcinogenesis

authors： Wijnands MV,Schoterman HC,Bruijntjes JB,Hollanders VM,Woutersen RA

更新日期：2001-01-01 00:00:00

abstract：:The MDM2 protein negatively regulates p53 expression level in modulating DNA repair, cell-cycle control, cell growth and apoptosis. Polymorphisms in the promoter region of the MDM2 gene have been shown to alter protein expression and may, thus, play a role in carcinogenesis. To test our hypothesis that the MDM2 promot...

journal_title：Carcinogenesis

authors： Li G,Zhai X,Zhang Z,Chamberlain RM,Spitz MR,Wei Q

更新日期：2006-10-01 00:00:00

abstract：:XB2 cells, a teratocarcinoma derived cell line of keratinocyte lineage, have been shown to proliferate and differentiate in low calcium medium (0.03 mM Ca2+) at a density of 500 cells/9.6 cm2 without the need for fibroblast feeder layers or conditioned medium. The degree of differentiation can be assessed by measureme...

journal_title：Carcinogenesis

authors： Hewitt SD,Duffy PA,Orton TC,Garner RC

更新日期：1990-03-01 00:00:00

abstract：:We investigated whether the addition of d-limonene to the diets of rats would modify the process of mammary tumor induction by 7,12-dimethylbenz[a]anthracene (DMBA). When diets containing 1000 or 10 000 p.p.m. d-limonene were fed to rats from one week before DMBA administration to the end of the experiment (27 weeks p...

journal_title：Carcinogenesis

authors： Elegbede JA,Elson CE,Qureshi A,Tanner MA,Gould MN

更新日期：1984-05-01 00:00:00

abstract：:Cyproterone acetate (CPA) is a synthetic steroid which is used in oral contraceptive and anti-androgen formulations. It has previously been classified as a tumor promoter in rat liver. Recent studies have shown that CPA induces DNA repair synthesis in isolated hepatocytes, and this implies that CPA is genotoxic. We st...

journal_title：Carcinogenesis

authors： Deml E,Schwarz LR,Oesterle D

更新日期：1993-06-01 00:00:00

abstract：:Flow cytometric analysis of fibroblasts, normal breast epithelial cells and breast or other cancer cell lines identified variation in the abilities of cell lines to undergo cell cycle arrest as a response to hypoxia. Human mammary epithelial cells (HMEC), normal fibroblasts (Hs68 and WI38), HeLa cervical carcinoma and...

journal_title：Carcinogenesis

authors： Box AH,Demetrick DJ

更新日期：2004-12-01 00:00:00

abstract：:It is now unanimously accepted that neoplastic cells tend to become less susceptible to the growth regulatory effects of transforming growth factor-beta1 (TGF-beta1), mainly because of reduced expression and/or activity of TGF-beta1-specific receptors, as reported for many human cancers including colon cancer. Consequ...

journal_title：Carcinogenesis

authors： Biasi F,Mascia C,Poli G

更新日期：2008-05-01 00:00:00

abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a mammary gland carcinogen present in the human diet. Herein, the expression of estrogen receptor alpha (ERalpha), estrogen receptor beta (ER beta) and progesterone receptor (PR) was examined in mammary gland carcinomas induced by PhIP in female Sprague-Dawley ...

journal_title：Carcinogenesis

authors： Qiu C,Shan L,Yu M,Snyderwine EG

更新日期：2005-04-01 00:00:00

abstract：:The G protein-coupled formylpeptide receptor (FPR), known to mediate phagocytic leucocyte chemotaxis in response to bacterial- and host-derived agonists, was expressed by tumor cells in specimens of surgically removed more highly malignant human gliomas. In human glioblastoma cell lines, FPR activation increased cell ...

journal_title：Carcinogenesis

authors： Huang J,Chen K,Huang J,Gong W,Dunlop NM,Howard OM,Bian X,Gao Y,Wang JM

更新日期：2009-02-01 00:00:00

abstract：:We have studied the influence of genetic polymorphisms in the xenobiotic-metabolizing genes GSTM1, GSTP1, GSTT1, EPHX1, NAT1 and NAT2 and the folate-metabolizing genes MTR and MTHFR on the frequencies of cells with chromosomal aberrations (CAs) in peripheral lymphocytes of Norwegian men. Log-linear Poisson regression ...

journal_title：Carcinogenesis

authors： Skjelbred CF,Svendsen M,Haugan V,Eek AK,Clausen KO,Kure EH,Tuimala JT,Svendsen MV,Norppa H,Hansteen IL

更新日期：2011-03-01 00:00:00

abstract：:Okadaic acid is both a potent inhibitor of protein serine/threonine phosphatases and a tumor promoter in the mouse skin model. We have previously shown that at non-toxic nanomolar concentrations okadaic acid reversibly inhibits induction (promotion) by PDGF of transformed cells by the 'complete' and 'two-stage' protoc...

journal_title：Carcinogenesis

authors： Dean NM,Mordan LJ,Tse K,Mooberry SL,Boynton AL

更新日期：1991-04-01 00:00:00

abstract：:Alternative splicing regulators have emerged as new players in cancer development, modulating the activities of many tumor suppressors and oncogenes and regulating the signaling pathways. However, little is known about the mechanisms by which these oncogenic splicing factors lead to cellular transformation. We have sh...

journal_title：Carcinogenesis

authors： Shimoni-Sebag A,Lebenthal-Loinger I,Zender L,Karni R

更新日期：2013-11-01 00:00:00

abstract：:Formation and removal of hepatic DNA adducts was studied in male Sprague-Dawley rats following single injections of two hepatocarcinogens, N-hydroxy-2-acetylaminofluorene (N-OH-AAF) and N-hydroxy-4-acetylaminobiphenyl (N-OH-AABP) and a nonhepatocarcinogen, N-hydroxy-2-acetylaminophenanthrene (N-OH-AAP) at 0.5 h, 1.5 h...

journal_title：Carcinogenesis

authors： Gupta RC,Dighe NR

更新日期：1984-03-01 00:00:00

abstract：:N2-ethylidene-2'-deoxyguanosine (N2-ethylidene-dG) is a major DNA adduct induced by acetaldehyde. Although it is unstable in the nucleoside form, it is relatively stable when present in DNA. In this study, we analyzed three acetaldehyde-derived DNA adducts, N2-ethylidene-dG, N2-ethyl-2'-deoxyguanosine (N2-Et-dG) and a...

journal_title：Carcinogenesis

authors： Matsuda T,Matsumoto A,Uchida M,Kanaly RA,Misaki K,Shibutani S,Kawamoto T,Kitagawa K,Nakayama KI,Tomokuni K,Ichiba M

更新日期：2007-11-01 00:00:00

abstract：:7-Hydroxymethylbenz[a]anthracene (7-HBA) showed potent mutagenicity towards Salmonella typhimurium TA 98 in the presence of untreated rat liver cytosol fortified with the PAPS-generating system, sodium sulphate and ATP. No mutagenic activity was observed either when the cytosol was boiled or when sodium sulphate or AT...

journal_title：Carcinogenesis

authors： Watabe T,Hakamata Y,Hiratsuka A,Ogura K

更新日期：1986-02-01 00:00:00

abstract：:Whether single cells immunohistochemically positive for glutathione S-transferase P1-1 (GSTP1-1) induced in the female mouse liver by DEN (Hatayama et al., Carcinogenesis, 14, 537-538, 1993) are precursor initiated cells of preneoplastic foci, is of importance in chemical hepatocarcinogenesis. Nrf2 transactivates a wi...

journal_title：Carcinogenesis

authors： Satoh K,Itoh K,Yamamoto M,Tanaka M,Hayakari M,Ookawa K,Yamazaki T,Sato T,Tsuchida S,Hatayama I

更新日期：2002-03-01 00:00:00

abstract：:Benzidine diimine (BZDI), a reactive intermediate in the metabolic peroxidation of the carcinogen benzidine, has been reported to bind covalently to cellular proteins and nucleic acids. We have examined the nature of this interaction with DNA and have identified a major carcinogen-nucleoside adduct. BZDI (20-50 microM...

journal_title：Carcinogenesis

authors： Yamazoe Y,Roth RW,Kadlubar FF

更新日期：1986-01-01 00:00:00

abstract：:The use of naturally occurring botanicals with substantial antioxidant activity to afford protection to human skin against UV damage is receiving increasing attention. The green tea constituent (-)-epigallocatechin-3-gallate (EGCG) is a potent antioxidant and has shown remarkable preventive effects against photocarcin...

journal_title：Carcinogenesis

authors： Katiyar SK,Afaq F,Perez A,Mukhtar H

更新日期：2001-02-01 00:00:00

abstract：:Ovarian cancer is developed from a single layer of thin epithelial cells covering the surface of ovary, named human ovarian surface epithelial cells. Like all primary human cells, human ovarian surface epithelial cells have a finite life span and will go into senescence and eventually die when cultured in vitro. Immor...

journal_title：Carcinogenesis

authors： Yang G,Rosen DG,Mercado-Uribe I,Colacino JA,Mills GB,Bast RC Jr,Zhou C,Liu J

更新日期：2007-01-01 00:00:00

abstract：:We previously characterized a clone of CHO cells, clone B, that displayed tolerance to the cytotoxic effects of N-methylnitrosourea (MNU) and 6-thioguanine (6-TG). To determine whether this phenotype affected the mutagenic response of the cells, MNU-induced mutation to 8-azaadenine resistance (8-AAr) was measured in t...

journal_title：Carcinogenesis

authors： Aquilina G,Biondo R,Dogliotti E,Bignami M

更新日期：1993-10-01 00:00:00

abstract：:An earlier study indicated that ozone (O3), a major pollutant in our atmosphere, acts as a carcinogen as well as a synergistic co-carcinogen with radiation in cultured hamster embryo cells and in mouse C3H10T1/2 cells. In this investigation we further characterize the oncogenic action of ozone, alone or in combination...

journal_title：Carcinogenesis

authors： Borek C,Ong A,Zaider M

更新日期：1989-08-01 00:00:00