The suppression of aberrant crypt multiplicity in colonic tissue of 1,2-dimethylhydrazine-treated C57BL/6J mice by dietary flavone is associated with an increased expression of Krebs cycle enzymes.

abstract：:The aim of the present study was to investigate the impact of four different lactobacillus (LB) strains, namely Lactobacillus bulgaricus 291, Streptococcus thermophilus F4, S.thermophilus V3 and Bifidobacterium longum BB536, which are used for the production of yogurt, on the DNA-damaging effects of heterocyclic aroma...

journal_title：Carcinogenesis

authors： Zsivkovits M,Fekadu K,Sontag G,Nabinger U,Huber WW,Kundi M,Chakraborty A,Foissy H,Knasmüller S

更新日期：2003-12-01 00:00:00

abstract：:Hairless mice were given 5 topical applications of 470 nmol 20-methylcholanthrene (MCA) at one week intervals. In one experimental group the MCA was dissolved in reagent grade acetone alone, in another group it was dissolved in a mixture consisting of 50% acetone and 50% dimethyl sulfoxide (DMSO). A control group rece...

journal_title：Carcinogenesis

authors： Iversen OH,Thorud E,Volden G

更新日期：1981-01-01 00:00:00

abstract：:Woodchuck (Marmota monax) hepatic cells, which were immortalized by the simian virus 40 large T antigen (SV40 Tag) produced nitric oxide (NO; measured as nitrite) in vitro from L-arginine (L-Arg) after lipopolysaccharide (LPS) treatment. NO synthesis was related to L-Arg and LPS concentration and plateaued at 1.0 mM L...

journal_title：Carcinogenesis

authors： Liu RH,Jacob JR,Hotchkiss JH,Tennant BC

更新日期：1993-08-01 00:00:00

abstract：:Spindle cell carcinomas were identified using polyacrylamide gel electrophoresis and immunoblotting of proteins extracted from paraffin-embedded tissue sections. Immunohistochemistry using rabbit monospecific antisera against the mouse 55 kd keratin polypeptide also identified these tumors. A group of 53 SENCAR mice i...

journal_title：Carcinogenesis

authors： Klein-Szanto AJ,Larcher F,Bonfil RD,Conti CJ

更新日期：1989-11-01 00:00:00

abstract：:A decreased incidence of squamous cell carcinoma of the head and neck (SCCHN) associated with fruit and vegetable intake may act through chemopreventive compounds, which may be more available to persons homozygous for the deletion genotypes of the glutathione S-transferase (GST). We evaluated interactions between frui...

journal_title：Carcinogenesis

authors： Gaudet MM,Olshan AF,Poole C,Weissler MC,Watson M,Bell DA

更新日期：2004-05-01 00:00:00

abstract：:The effect of exposing mice to both a chemical carcinogen and leukemia virus with and without an inhibitor of DNA repair were compared. The data indicated that benzo[a]pyrene (BP) could exert a potentiating effect of Friend viral leukemogenesis in mice, which was dependent on the relative times of administration of th...

journal_title：Carcinogenesis

authors： Raikow RB,Okunewick JP,Buffo MJ,Jones DL,Brozovich BJ,Seeman PR,Koval TM

更新日期：1981-01-01 00:00:00

abstract：:The mutagen sensitivity assay is an in vitro measure of DNA repair capacity used to evaluate intrinsic susceptibility for cancer. The high heritability of mutagen sensitivity to different mutagens validates the use of this phenotype to predict cancer susceptibility. However, genetic determinants of mutagen sensitivity...

journal_title：Carcinogenesis

authors： Leng S,Stidley CA,Bernauer AM,Picchi MA,Sheng X,Frasco MA,Van Den Berg D,Gilliland FD,Crowell RE,Belinsky SA

更新日期：2008-07-01 00:00:00

abstract：:High intake of red meat is associated with an increased risk of colon cancer. It has been suggested that fat from red meat is responsible, because high fat intake increases the concentration of cytotoxic lipids in the colon. Experimental studies have not unequivocally supported such a role for fat, however. Recently, ...

journal_title：Carcinogenesis

authors： Sesink AL,Termont DS,Kleibeuker JH,Van Der Meer R

更新日期：2000-10-01 00:00:00

abstract：:The natural flavonoid quercetin has been suggested by epidemiological studies to have preventive activity against lung cancer; however, the mechanism of which has not been well elucidated. In this report, we demonstrate that quercetin significantly enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAI...

journal_title：Carcinogenesis

authors： Chen W,Wang X,Zhuang J,Zhang L,Lin Y

更新日期：2007-10-01 00:00:00

abstract：:Poly(ADP-ribose) polymerase, which catalyzes the formation of poly(ADP-ribose) polymers, is an enzyme involved in cell proliferation, differentiation and transformation as well as in recovery from DNA damage. Poly(ADP-ribose) polymers are rapidly synthesized from the ADP-ribose moieties from intracellular NAD+, which,...

journal_title：Carcinogenesis

authors： Stierum RH,van Herwijnen MH,Hageman GJ,Kleinjans JC

更新日期：1994-04-01 00:00:00

abstract：:In order to investigate specific DNA damage caused by nitric oxide (NO) induced lipid peroxidation, levels of promutagenic etheno adducts 1,N6-ethenodeoxyadenosine (epsilondA) and 3,N4-ethenodeoxycytidine (epsilondC) were measured in spleen DNA of SJL mice induced to produce high levels of NO by injection of RcsX (pre...

journal_title：Carcinogenesis

authors： Nair J,Gal A,Tamir S,Tannenbaum SR,Wogan GN,Bartsch H

更新日期：1998-12-01 00:00:00

abstract：:Monoclonal antibodies were produced that recognized alkali-stabilized modifications of DNA formed by the anticancer drug melphalan in order to permit measurement of melphalan-DNA adducts in individual cells by immunofluorescent staining. Antibody Amp4/42 did not bind to alkali-treated control DNA or to DNA that had be...

journal_title：Carcinogenesis

authors： Tilby MJ,McCartney H,Cordell J,Frank AJ,Dean CJ

更新日期：1995-08-01 00:00:00

abstract：:Chemopreventive activities of all-trans retinoic acid (AtRA), 9-cis retinoic acid (9cRA), retinol (ROL) and beta-carotene (betaC) were evaluated during hepatocarcinogenesis. Rats received 1 mg/100 g body wt AtRA (AtRA group), 9cRA (9cRA group), ROL (ROL group), 7 mg/100 g body wt betaC (betaC group) or corn oil (CO gr...

journal_title：Carcinogenesis

authors： de Almeida Vasconcelos Fonseca EM,Chagas CE,Mazzantini RP,Heidor R,Ong TP,Moreno FS

更新日期：2005-11-01 00:00:00

abstract：:DNA-methyltransferase-3B (DNMT3B) plays an important role in the generation of aberrant methylation in carcinogenesis. Polymorphisms and haplotypes of the DNMT3B gene may influence DNMT3B activity on DNA methylation, thereby modulating the susceptibility to lung cancer. To test this hypothesis, we investigated the ass...

journal_title：Carcinogenesis

authors： Lee SJ,Jeon HS,Jang JS,Park SH,Lee GY,Lee BH,Kim CH,Kang YM,Lee WK,Kam S,Park RW,Kim IS,Cho YL,Jung TH,Park JY

更新日期：2005-02-01 00:00:00

abstract：:Chondrosarcoma is a form of malignant skeletal tumor of cartilaginous origin. The non-malignant form of the disease is termed chondroma. Correctly distinguishing between the two forms is essential for making therapeutic decisions. However, due to their similar histological appearances and the lack of a reliable diagno...

journal_title：Carcinogenesis

authors： Kumari R,Li H,Haudenschild DR,Fierro F,Carlson CS,Overn P,Gupta L,Gupta K,Nolta J,Yik JH,Di Cesare PE

更新日期：2012-11-01 00:00:00

abstract：:Dietary resistant starch (RS), as a high amylose maize starch (HAMS), prevents dietary protein-induced colonocyte genetic damage in rats, possibly through the short-chain fatty acid (SCFA) butyrate produced by large bowel bacterial RS fermentation. Increasing butyrate availability may improve colonic health and dietar...

journal_title：Carcinogenesis

authors： Bajka BH,Clarke JM,Cobiac L,Topping DL

更新日期：2008-11-01 00:00:00

abstract：:The breast cancer gene BRCA1 has previously been cloned from both human and mouse. We cloned a fragment of the rat Brca1 homologue in order to map it and explore its biological function. Partial cDNA fragments of the rat Brca1 homologue were isolated by RT-PCR. Sequence analysis revealed that the RING-finger domain is...

journal_title：Carcinogenesis

authors： Chen KS,Shepel LA,Haag JD,Heil GM,Gould MN

更新日期：1996-08-01 00:00:00

abstract：:Previous studies have shown that in addition to serving as a target for covalent adduct formation, purified DNA catalyzes the detoxification of (+/-)-7r,8t-dihydroxy-9t,10t-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE). To begin to relate these in vitro findings with the processes important in carcinogenesis in vivo, w...

journal_title：Carcinogenesis

authors： Dock L,MacLeod MC

更新日期：1986-04-01 00:00:00

abstract：:Targeting tumor-initiating, drug-resistant populations of cancer stem cells (CSC) with phytochemicals is a novel paradigm for cancer prevention and treatment. We herein employed a phenotypic drug discovery approach coupled to mechanism-of-action profiling and target deconvolution to identify phenolic components of ext...

journal_title：Carcinogenesis

authors： Corominas-Faja B,Cuyàs E,Lozano-Sánchez J,Cufí S,Verdura S,Fernández-Arroyo S,Borrás-Linares I,Martin-Castillo B,Martin ÁG,Lupu R,Nonell-Canals A,Sanchez-Martinez M,Micol V,Joven J,Segura-Carretero A,Menendez JA

更新日期：2018-04-05 00:00:00

abstract：:Cytochrome P450 1B1 (CYP1B1) is an enzyme that has a unique tumor-specific pattern of expression and is capable of bioactivating a wide range of carcinogenic compounds. We have reported previously that coordinated upregulation of CYP1B1 by inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and the aryl hy...

journal_title：Carcinogenesis

authors： Smerdová L,Šmerdová J,Kabátková M,Kohoutek J,Blažek D,Machala M,Vondráček J

更新日期：2014-11-01 00:00:00

abstract：:A single i.p. injection of diethylnitrosamine (DEN) or benzo[a]pyrene (BAP) in 1-day-old female rats produced a high incidence of gamma-glutamyltranspeptidase-(GGT)-positive hepatocyte foci within 4 weeks after the rats were weaned onto a 0.05% phenobarbital diet; the injection of benzo[e]pyrene did not produce foci u...

journal_title：Carcinogenesis

authors： Peraino C,Staffeldt EF,Ludeman VA

更新日期：1981-01-01 00:00:00

abstract：:The influence of the enzymatic inducer beta-naphthoflavone (BNF) and of the inhibitors alpha-naphthoflavone (ANF) and 2-diethylaminoethyl-2,2-diphenylvalerate HCl (SKF 525-A) on the frequency of sister chromatid exchanges (SCE) induced by cyclophosphamide (CPA) was studied in vivo in C57BL/6J male mice. Neither induce...

journal_title：Carcinogenesis

authors： Dragani TA,Sozzi G,Della Porta G

更新日期：1983-01-01 00:00:00

abstract：:DNA double-strand break (DSB) repair is an important mechanism underlying chemotherapy resistance in human cancers. Dicer participates in DSB repair by facilitating homologous recombination. However, whether Dicer is involved in non-homologous end joining (NHEJ) remains unknown. Here, we addressed whether Dicer regula...

journal_title：Carcinogenesis

authors： Chen X,Li WF,Wu X,Zhang HC,Chen L,Zhang PY,Liu LY,Ma D,Chen T,Zhou L,Xu Y,Zhou MT,Tang KF

更新日期：2017-09-01 00:00:00

abstract：:Basal cell carcinoma (BCC) of the skin is the most common neoplasm among the Caucasian population of the Western world. Inflammation may result in oxidative stress and contribute to promotion and progression of tumors, including BCC. The role of cytokines, which are inflammatory modulators, in the biology of tumors ha...

journal_title：Carcinogenesis

authors： Rizzato C,Canzian F,Rudnai P,Gurzau E,Stein A,Koppova K,Hemminki K,Kumar R,Campa D

更新日期：2011-12-01 00:00:00

abstract：:N-Hydroxy-2-acetylaminofluorene (N-OH-AAF), N-hydroxy-4'-fluoro-4-acetylaminobiphenyl (N-OH-FAABP) and N-hydroxy-4-acetylaminobiphenyl (N-OH-AABP) were compared for their initiation and promotion activity in the rat liver using a modified Solt-Farber system. N-OH-AAF, N-OH-FAABP and N-OH-AABP showed comparable initiat...

journal_title：Carcinogenesis

authors： van de Poll ML,van der Hulst DA,Tates AD,Meerman JH

更新日期：1990-02-01 00:00:00

abstract：:BTG3/ANA/APRO4 has been reported to be a tumor suppressor gene in some malignancies. It constitutes important negative regulatory mechanism for Src-mediated signaling, a negative regulator of the cell cycle and inhibits transcription factor E2F1. We report that BTG3 is downregulated in renal cancer and that the mechan...

journal_title：Carcinogenesis

authors： Majid S,Dar AA,Ahmad AE,Hirata H,Kawakami K,Shahryari V,Saini S,Tanaka Y,Dahiya AV,Khatri G,Dahiya R

更新日期：2009-04-01 00:00:00

abstract：:Breast cancer is a leading cause of cancer-related mortality in women. Triple-negative breast cancer (TNBC; HER2-, ER-/PR-) is an aggressive subtype prone to drug resistance and metastasis, which is characterized by high intratumor microvascular density (iMVD) resulting from angiogenesis. However, the mechanisms contr...

journal_title：Carcinogenesis

authors： Kumar N,Prasad P,Jash E,Jayasundar S,Singh I,Alam N,Murmu N,Somashekhar SP,Goldman A,Sehrawat S

更新日期：2018-10-08 00:00:00

abstract：:One of the peaks present in HPLC profiles of [3H]benzo[a]-pyrene (BaP)-deoxyribonucleosides prepared by enzymatic degradation of [3H]BaP-DNA isolated from Wistar rat embryo cell cultures exposed to [G-3H]BaP was found to be r-7,c-9,c-10,t-8-tetrahydroxy-7,8,9,10-tetrahydroBaP, a BaP-DNA adduct decomposition product (P...

journal_title：Carcinogenesis

authors： Pruess-Schwartz D,Mauthe RJ,Baird WM

更新日期：1988-10-01 00:00:00

abstract：:Genetically modified mice with overexpressed and/or deleted genes have been used extensively to model human cancer. However, it is uncertain as to what extent the mouse models reproduce the corresponding cancers in humans. We have compared the global gene expression patterns in human and mouse hepatocellular carcinoma...

journal_title：Carcinogenesis

authors： Lee JS,Grisham JW,Thorgeirsson SS

更新日期：2005-06-01 00:00:00

abstract：:Phorbol ester-sensitive EL4 murine thymoma cells respond to phorbol 12-myristate 13-acetate with activation of ERK mitogen-activated protein kinases, synthesis of interleukin-2, and death, whereas phorbol ester-resistant variants of this cell line do not exhibit these responses. Additional aspects of the resistant phe...

journal_title：Carcinogenesis

authors： Sansbury HM,Wisehart-Johnson AE,Qi C,Fulwood S,Meier KE

更新日期：1997-09-01 00:00:00