Induction of death receptor 5 and suppression of survivin contribute to sensitization of TRAIL-induced cytotoxicity by quercetin in non-small cell lung cancer cells.

abstract：:We investigated, in a cloned hamster tracheal epithelial cell line HTE-B, the effects of inhibitors of DNA topoisomerase, novobiocin and nalidixic acid; of DNA polymerase, 1-beta-arabinofuranosylcytosine (ara-C) and 2',3'-dideoxythymidine; of ribonucleotide reductase, hydroxyurea; and of poly(ADP-ribose)synthetase, 3-...

journal_title：Carcinogenesis

authors： Ireland CM,Eastman A,Bresnick E

更新日期：1984-02-01 00:00:00

abstract：:Use of supercritical carbon dioxide extraction in the analysis of smokeless tobacco for tobacco-specific N-nitrosamines revealed the presence of higher levels of 4-(methylnitros-amino)-1-(3-pyridyl)-1-butanone (NNK) than had been determined with conventional methods. Whether human saliva may be similarly capable of re...

journal_title：Carcinogenesis

authors： Prokopczyk B,Wu M,Cox JE,Hoffmann D

更新日期：1992-05-01 00:00:00

abstract：:The activation of 2-nitrofluorene (2-NF) to reactive intermediates that bind covalently to DNA, RNA and protein has been investigated both in vitro and in the rat in vivo. In vitro, such binding was catalyzed by the hepatic microsomal fraction, was NADPH dependent and could be inhibited by SKF 525A, an inhibitor of cy...

journal_title：Carcinogenesis

authors： Wierckx FC,Wedzinga R,Meerman JH,Mulder GJ

更新日期：1990-01-01 00:00:00

abstract：:Sulforaphane (SFN), an isothiocyanate first isolated from broccoli, exhibits chemopreventive properties in prostate cancer cells through mechanisms that are poorly understood. We recently reported on a novel mechanism of chemoprotection by SFN in human colon cancer cells, namely the inhibition of histone deacetylase (...

journal_title：Carcinogenesis

authors： Myzak MC,Hardin K,Wang R,Dashwood RH,Ho E

更新日期：2006-04-01 00:00:00

abstract：:A method was devised to quantitate N-acetoxy-N-acetyl-2-aminofluorene (N-AcO-AAF) induced crosslinking of the ionic complex between [methyl-3H]thymidine labeled pBR322 DNA and lysozyme. This involved chromatography of the modified complex on Sephadex CM 25 with a high salt buffer that dissociated the non-covalently bo...

journal_title：Carcinogenesis

authors： Rayshell M,Ross J,Werbin H

更新日期：1983-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor (PPAR) gamma is a ligand-activated nuclear receptor that plays a key role in adipogenesis and adipocyte gene expression, and has recently been linked with possible antineoplastic effects in colonic carcinogenesis. PPARgamma2 and gamma3 are two transcripts arising from the PPA...

journal_title：Carcinogenesis

authors： Koh WP,Yuan JM,Van Den Berg D,Ingles SA,Yu MC

更新日期：2006-09-01 00:00:00

abstract：:Breast cancer is the most common cancer and the second most frequent cause of cancer death in women. Despite extensive research, the precise mechanisms of breast carcinogenesis remain unclear. One of the reasons for this is due, at least in part, to a lack of a suitable animal model which can closely mimic the breast ...

journal_title：Carcinogenesis

authors： Xie B,Tsao SW,Wong YC

更新日期：1999-06-01 00:00:00

abstract：:We examined the genotypes of two polymorphic genes involved in the detoxification of several mutagenic and carcinogenic compounds in relation to tobacco smoking-associated urinary mutagenicity. The genes studied were the glutathione S-transferase-encoding GSTM1 gene and acetyltransferase-encoding NAT2 gene. Smokers wi...

journal_title：Carcinogenesis

authors： Hirvonen A,Nylund L,Kociba P,Husgafvel-Pursiainen K,Vainio H

更新日期：1994-05-01 00:00:00

abstract：:The metabolism of 7,12-dimethylbenz[a]anthracene (DMBA), benzo[a]pyrene (BP) and benz[a]anthracene (BA) by epithelial cell aggregates and fibroblasts in culture has been investigated using mammary tissue obtained from female Wistar rats. The results show that: (a) both types of mammary cells metabolise all three hydro...

journal_title：Carcinogenesis

authors： Cooper CS,Pal K,Hewer A,Grover PL,Sims P

更新日期：1982-01-01 00:00:00

abstract：:The skin tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and the chlorinated insecticide, endosulfan, are two potent inhibitors of gap junctional intercellular communication. In the present study the effects of TPA and endosulfan on cell communication have been investigated in IAR 20 rat liver epithelial ce...

journal_title：Carcinogenesis

authors： Kenne K,Fransson-Steen R,Honkasalo S,Wärngård L

更新日期：1994-06-01 00:00:00

abstract：:The incidence and mortality statistics for oral squamous cell carcinoma (OSCC) were 10th and 12th, respectively, in human cancers diagnosed worldwide in 2008. In this study, to identify novel tumor-suppressive microRNAs (TS-miRNAs) and their direct targets in OSCC, we performed methylation-based screening for 43 miRNA...

journal_title：Carcinogenesis

authors： Endo H,Muramatsu T,Furuta M,Uzawa N,Pimkhaokham A,Amagasa T,Inazawa J,Kozaki K

更新日期：2013-03-01 00:00:00

abstract：:Monoclonal or affinity-purified antibodies specific to Novikoff hepatoma cytokeratin p39 were employed to study the origin and fate of p39-containing cell types during hepatocarcinogenesis induced with N,N-dimethyl-p(m-tolylazo)aniline. Frozen sections were obtained from the livers of animals autopsied temporally duri...

journal_title：Carcinogenesis

authors： Schmidt WN,Page DL,McKusick K,Hnilica LS

更新日期：1985-08-01 00:00:00

abstract：:4-Hydroxyphenylretinamide (4-HPR) is a synthetic retinoid with minimal toxicity and favorable pharmacokinetics during long-term administration to patients in clinical trials. Since 4-HPR binds poorly to the retinoic acid receptors, the issue of whether 4-HPR exerts its biological actions via classical retinoid recepto...

journal_title：Carcinogenesis

authors： Giandomenico V,Andreola F,Rodriguez de la Concepcion ML,Collins SJ,De Luca LM

更新日期：1999-06-01 00:00:00

abstract：:In this report we describe results showing that both arachidonic acid (20:4) release and prostaglandin (PG) synthesis in herpes simplex virus type 2 (HSV-2)-transformed tumor-derived rat fibrosarcoma (RFS) cells are inhibited by indomethacin (cyclooxygenase inhibitor). These data suggest that cyclooxygenase (prostagla...

journal_title：Carcinogenesis

authors： Heitman CR,Waite M,Kucera LS

更新日期：1989-11-01 00:00:00

abstract：:The role of nitric oxide (NO) in colon cancer remains controversial. Inducible nitric oxide synthase (iNOS) has been reported to be up regulated and down regulated in colorectal cancer in both animal models and patient tissue samples. Cyclooxygenase-2 (COX-2) is important in colorectal carcinogenesis but its relations...

journal_title：Carcinogenesis

authors： Liu Q,Chan ST,Mahendran R

更新日期：2003-04-01 00:00:00

abstract：:Isoflavone genistein is a specific inhibitor of protein tyrosine kinase (PTK) and has been shown to have a variety of anticancer activities in cultured cells and animal models. We report here that genistein significantly inhibits 7,12-dimethylbenz[a]anthracene (DMBA)-initiated and 12-O-tetradecanoyl phorbol-13-acetate...

journal_title：Carcinogenesis

authors： Wei H,Bowen R,Zhang X,Lebwohl M

更新日期：1998-08-01 00:00:00

abstract：:Following intraperitoneal administration of [3H] aflatoxin B1 (AFB1) to young adult male rats, there is rapid uptake of the carcinogen by the liver, the target organ for carcinogenesis, leading to DNA covalent binding. Acid hydrolysis of this DNA shows that after 2h, the major DNA adduct is trans 8,9-dihydro-8-(7-guan...

journal_title：Carcinogenesis

authors： Hertzog PJ,Lindsay Smith JR,Garner RC

更新日期：1980-09-01 00:00:00

abstract：:To study the roles of DNA polymerases alpha and beta during replication and repair of damaged DNA, use was made of the fact that during chronic treatment with carcinogens, replication and repair do not necessarily follow the same time sequence. Early cell damage and restorative hyperplasia cause a transient wave of DN...

journal_title：Carcinogenesis

authors： Craddock VM

更新日期：1981-01-01 00:00:00

abstract：:The effects of dietary administration of green tea catechins (GTC) were examined using a multi-organ carcinogenesis model. Groups of 15 F344 male rats were initially treated with a single i.p. administration of 100 mg/kg body wt N-diethyl-nitrosamine, 4 i.p. administrations of 20 mg/kg body wt N-methylnitrosourea, 4 s...

journal_title：Carcinogenesis

authors： Hirose M,Hoshiya T,Akagi K,Takahashi S,Hara Y,Ito N

更新日期：1993-08-01 00:00:00

abstract：:When exogenous [(3)H]retinol (vitamin A) was added to culture medium, normal human epithelial cells from the oral cavity, skin, lung and breast took up and esterified essentially all of the [(3)H]retinol within a few hours. As shown by [(3)H]retinol pulse-chase experiments, normal epithelial cells then slowly hydrolyz...

journal_title：Carcinogenesis

authors： Guo X,Ruiz A,Rando RR,Bok D,Gudas LJ

更新日期：2000-11-01 00:00:00

abstract：:Oncogenic pathogens can disturb tissue homeostasis and initiate immune responses for oncogenicity clearance and homeostasis restoration, while failed clearance and chronic inflammation may result in tumorigenesis. The primary tumor development will undergo a cancer immunoediting process, including three phases, termed...

journal_title：Carcinogenesis

authors： Tao Y,Shen H,Liu Y,Li G,Huang Z,Liu Y

更新日期：2020-06-12 00:00:00

abstract：:Hepatocellular carcinoma (HCC), one of the most prevalent and lethal cancers, has shown an alarming rise in the USA. Without effective therapy for HCC, novel chemopreventive strategies may effectively circumvent the current morbidity and mortality. Oxidative stress predisposes to hepatocarcinogenesis and is the major ...

journal_title：Carcinogenesis

authors： Bishayee A,Bhatia D,Thoppil RJ,Darvesh AS,Nevo E,Lansky EP

更新日期：2011-06-01 00:00:00

abstract：:Reduced DNA repair capacity of carcinogen-induced DNA damage is now thought to significantly influence inherent susceptibility to lung cancer. DNA-dependent protein kinase (DNA-PK) is a serine-threonine kinase activated by the presence of double-strand breaks in DNA that appears to play a major role in non-homologous ...

journal_title：Carcinogenesis

authors： Auckley DH,Crowell RE,Heaphy ER,Stidley CA,Lechner JF,Gilliland FD,Belinsky SA

更新日期：2001-05-01 00:00:00

abstract：:Telomeres are critical in maintaining chromosome and genomic stability. Arsenic, a human carcinogen as well as an anticancer agent, is known for its clastogenicity. To better understand molecular mechanisms of arsenic actions, we investigated arsenite effects on telomere and telomerase and determined cell growth and a...

journal_title：Carcinogenesis

authors： Zhang TC,Schmitt MT,Mumford JL

更新日期：2003-11-01 00:00:00

abstract：:Adduct formation has been considered to be a major causal factor of DNA damage by carcinogenic heterocyclic amines. By means of experiments with an electrochemical detector coupled to a high-performance liquid chromatograph, we revealed that N-hydroxy metabolite of 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (Ph...

journal_title：Carcinogenesis

authors： Murata M,Kawanishi S

更新日期：2002-05-01 00:00:00

abstract：:4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is the most abundant and carcinogenic tobacco-specific nitrosamine in tobacco and tobacco smoke. The major metabolic pathway for NNK is carbonyl reduction to form the (R) and (S) enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) which, like NNK, is...

journal_title：Carcinogenesis

authors： Ashmore JH,Luo S,Watson CJW,Lazarus P

更新日期：2018-07-30 00:00:00

abstract：:S-Adenosyl-L-methionine (SAM) is a strong chemopreventive agent of rat liver carcinogenesis. Examination was made to determine whether inhibition by SAM of the development of preneoplastic liver lesions persists to SAM withdrawal in diethylnitrosamine-initiated F344 rats promoted with thiobenzamide (TB). The rats were...

journal_title：Carcinogenesis

authors： Simile MM,Saviozzi M,De Miglio MR,Muroni MR,Nufris A,Pascale RM,Malvaldi G,Feo F

更新日期：1996-07-01 00:00:00

abstract：:Male Ah-responsive C57BL/10ScSn mice received a single dose of iron-dextran (600 mg Fe/kg) and were fed a diet containing 0.01% of the PCBs mixture Aroclor 1254 for up to 12 months. Iron caused a marked synergistic increase in liver size from 2 months with greatly elevated mitotic rates, numbers of basophilic foci and...

journal_title：Carcinogenesis

authors： Smith AG,Francis JE,Carthew P

更新日期：1990-03-01 00:00:00

abstract：:The potential importance of prostaglandin H synthase (PGHS) in the genotoxicity of fecapentaene-12 (fec-12) has been indicated by the finding that non-steroidal anti-inflammatory agents (NSAIDs) block the induction of oxidative DNA base damage by fec-12 in HeLa cells. To further investigate the role of PGHS in the met...

journal_title：Carcinogenesis

authors： Plummer SM,Hall M,Faux SP

更新日期：1995-05-01 00:00:00

abstract：:The phospholipid (PL) content was 4-fold higher while the triacylglycerol (TG) content tended to be 65% lower in human breast cancer tissues as compared with non-cancerous reference parts from excised breast tissues. The variation in TG content among breast tissues was very large while that of PL was relatively small....

journal_title：Carcinogenesis

authors： Sakai K,Okuyama H,Yura J,Takeyama H,Shinagawa N,Tsuruga N,Kato K,Miura K,Kawase K,Tsujimura T

更新日期：1992-04-01 00:00:00