IL-23R in laryngeal cancer: a cancer immunoediting process that facilitates tumor cell proliferation and results in cisplatin resistance.

abstract：:The objective was to study the relationship between cyclin D1 gene (CCND1) polymorphism and lung cancer in the Chinese population. Blood samples of 182 cases and 185 controls were collected from a hospital based case-control study. PCR-SSCP was used to examine the G/A polymorphism in exon 4 of CCND1. The results showe...

journal_title：Carcinogenesis

authors： Qiuling S,Yuxin Z,Suhua Z,Cheng X,Shuguang L,Fengsheng H

更新日期：2003-09-01 00:00:00

abstract：:Epigenetic silencing of tumor suppressor genes commonly occurs in human cancers via increasing DNA methylation and repressive histone modifications at gene promoters. However, little is known about how pathogenic environmental factors contribute to cancer development by affecting epigenetic regulatory mechanisms. Prev...

journal_title：Carcinogenesis

authors： Chen H,Kluz T,Zhang R,Costa M

更新日期：2010-12-01 00:00:00

abstract：:The pyrene-like fluorescence of adducts derived from the covalent binding of (+/-)-trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9, 10-tetrahydrobenzo[a]pyrene [+/-]-anti-BPDE] to DNA increases in intensity by factors of 20 or more as the temperature is lowered from ambient to approximately 100 K. This effect is primarily a...

journal_title：Carcinogenesis

authors： Zhao R,Liu TM,Kim SK,MacLeod MC,Geacintov NE

更新日期：1992-10-01 00:00:00

abstract：:We have previously reported the disposition of benzo[a]pyrene (B[a]P) and its metabolites in male Sprague-Dawley rats following intratracheal instillation of [3H]B[a]P [Weyand, E.H. and Bevan, D.R. (1986) Cancer Res., 46, 5655-5661]. In some experiments, cannulas were implanted in the bile duct of the animals prior to...

journal_title：Carcinogenesis

authors： Bevan DR,Weyand EH

更新日期：1988-11-01 00:00:00

abstract：:Estrogen production and metabolism play critical roles in the development and pathogenesis of endometrial carcinoma. Cytochrome P450 1B1 (CYP1B1) and catechol-O-methyltransferase (COMT) are two key enzymes in the estrogen metabolism pathway that result in the hydroxylation and conjugation of estradiol, respectively. W...

journal_title：Carcinogenesis

authors： McGrath M,Hankinson SE,Arbeitman L,Colditz GA,Hunter DJ,De Vivo I

更新日期：2004-04-01 00:00:00

abstract：:Female inbred C3H/St mice infected with the Bittner Milk Particle, develop mammary adenocarcinoma with 27% incidence if maintained on a Torula Yeast diet supplemented with 1 ppm of selenium (organically bound, in yeast). Animals switched from the 1 ppm Se diet to a diet containing only 0.15 ppm Se after reaching the a...

journal_title：Carcinogenesis

authors： Schrauzer GN,McGinness JE,Kuehn K

更新日期：1980-02-01 00:00:00

abstract：:Mutagenicity and carcinogenicity of the ubiquitous environmental pollutant benzo[a]pyrene is mediated via its reactive diol epoxide metabolite, anti-BPDE, with the predominant formation of N(2)-deoxyguanine adducts in genomic DNA. Polyclonal and monoclonal antibodies specific for (+/-)-anti-BPDE DNA adducts were used ...

journal_title：Carcinogenesis

authors： Venkatachalam S,Denissenko M,Wani AA

更新日期：1995-09-01 00:00:00

abstract：:Nitric oxide (NO) has been shown to induce double strand DNA breaks in Barrett's oesophagus (BO) and in other cancers has a role in invasion. The specific aims of this study were to investigate whether NO can induce invasion in cells representative of different stages of Barrett's progression and to determine possible...

journal_title：Carcinogenesis

authors： Clemons NJ,Shannon NB,Abeyratne LR,Walker CE,Saadi A,O'Donovan ML,Lao-Sirieix PP,Fitzgerald RC

更新日期：2010-09-01 00:00:00

abstract：:Observational studies have been largely consistent in showing an inverse association between vitamin D and an individual's risk of developing colorectal cancer. Vitamin D protection is further supported by a range of preclinical colon cancer models, including carcinogen, genetic and dietary models. A large number of m...

journal_title：Carcinogenesis

authors： Giardina C,Madigan JP,Tierney CA,Brenner BM,Rosenberg DW

更新日期：2012-03-01 00:00:00

abstract：:Alcohol is a major risk factor for oesophageal squamous cell carcinoma (OSCC), the most prevalent histological subtype of oesophageal cancer (OC) worldwide. The metabolism of alcohol is regulated by specific enzymes whose activity and expression is influenced by genetic polymorphisms. We conducted a systematic review ...

journal_title：Carcinogenesis

authors： Matejcic M,Gunter MJ,Ferrari P

更新日期：2017-09-01 00:00:00

abstract：:Recent studies have examined and demonstrated the potential cancer chemopreventive activity of freeze-dried berries including strawberries and black raspberries. Although ellagic acid, an abundant component in these berries, has been shown to inhibit carcinogenesis both in vivo and in vitro, several studies have repor...

journal_title：Carcinogenesis

authors： Xue H,Aziz RM,Sun N,Cassady JM,Kamendulis LM,Xu Y,Stoner GD,Klaunig JE

更新日期：2001-02-01 00:00:00

abstract：:The N-hydroxylamine of the carcinogen 2-amino-3-methylimidazolo[4,5-f]quinoline (IQ) covalently bound to calf thymus DNA at pH 7, and the binding was 11% higher under acidic conditions (pH 5). The extent of N-hydroxy-IQ binding to single-stranded polynucleotides at neutral pH was in the following order: polyguanylic a...

journal_title：Carcinogenesis

authors： Snyderwine EG,Roller PP,Adamson RH,Sato S,Thorgeirsson SS

更新日期：1988-06-01 00:00:00

abstract：:In order to find potentially effective compounds that could prevent the covalent binding of the carcinogen N-hydroxy-2-acetylaminofluorene (N-OH-AAF) to rat liver macromolecules in vivo, the prevention of the covalent binding to RNA of the sulfate ester of the carcinogen N-OH-AAF by a series of thioethers was investig...

journal_title：Carcinogenesis

authors： van den Goorbergh JA,de Wit H,Tijdens RB,Mulder GJ,Meerman JH

更新日期：1987-02-01 00:00:00

abstract：:We have explored the induction of DNA repair synthesis in monocyte/B- and T-lymphocyte enriched cell fractions from 12 different human mononuclear blood cell populations. Unscheduled DNA synthesis was measured in monocyte/B- and T-cells after exposure to the DNA-damaging agents dimethylsulfate (DMS) and N-acetoxy-N-ac...

journal_title：Carcinogenesis

authors： Knudsen LE,Ryder LP,Wassermann K

更新日期：1992-07-01 00:00:00

abstract：:The mutagenicities of 2-aminodipyrido [1,2-a:3',2'-d] imidazole (Glu-P-2, a mutagen obtained from pyrolysate of glutamic acid) and six methyl substituted derivatives of Glu-P-2 were tested with Salmonella typhimurium TA98 and TA100 with S-9 mix. Glu-P-1 (6-Me-Glu-P-2) was the strongest mutagen to TA98 and TA100. 3-Me-...

journal_title：Carcinogenesis

authors： Takeda K,Shudo K,Okamoto T,Nagao M,Wakabayashi K,Sugimura T

更新日期：1980-01-01 00:00:00

abstract：:The effects of retinol and retinoic acid on cytotoxicity and mutation expression at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus in Chinese hamster ovary (CHO) cells with or without exogenous metabolic activation were studied in the presence and absence of known chemical mutagens. Neither retinol ...

journal_title：Carcinogenesis

authors： Budroe JD,Schol HM,Shaddock JG,Casciano DA

更新日期：1988-07-01 00:00:00

abstract：:Cyclin D1 is believed to play an important role in the genesis and/or progression of transitional cell cancer (TCC) of the urinary bladder. Cyclin D1 gene (CCND1) mRNA is alternatively spliced to produce two transcripts, and the splicing pattern may be modulated by a G to A single nucleotide polymorphism within the sp...

journal_title：Carcinogenesis

authors： Wang L,Habuchi T,Takahashi T,Mitsumori K,Kamoto T,Kakehi Y,Kakinuma H,Sato K,Nakamura A,Ogawa O,Kato T

更新日期：2002-02-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is the leading cause of cancer mortality worldwide. Despite progress in developing chemotherapeutics for the treatment of NSCLC, primary and secondary resistance limits therapeutic success. NSCLC cells exhibit multiple mutations in the epidermal growth factor receptor (EGFR), which c...

journal_title：Carcinogenesis

authors： Kim MO,Lee MH,Oi N,Kim SH,Bae KB,Huang Z,Kim DJ,Reddy K,Lee SY,Park SJ,Kim JY,Xie H,Kundu JK,Ryoo ZY,Bode AM,Surh YJ,Dong Z

更新日期：2014-03-01 00:00:00

abstract：:Male ICR Swiss mice, weighing 16-20 g, were fed ad libitum either a fat-free diet or a diet containing 10% corn oil. After three weeks on these diets, the rates of benzo[a]pyrene (B[a]P) metabolite formation and metabolism to products which covalently bind with macromolecules were compared using hepatic nuclei and mic...

journal_title：Carcinogenesis

authors： Baker MT,Karr SW,Wade AE

更新日期：1983-01-01 00:00:00

abstract：:Two samples of 4-amino-2-nitrophenol were tested for mutagenicity in Salmonella typhimurium strains TA1535, TA1537, TA1538, TA98, and TA100. Significant mutagenic activity was detected with a sample of this compound obtained from Aldrich (technical grade (Aldrich), TGA) both in the presence and in the absence of a rat...

journal_title：Carcinogenesis

authors： Shahin MM,Bugaut A,Junino A,Kalopissis G

更新日期：1982-01-01 00:00:00

abstract：:The age-dependence of the induction of pre-neoplastic enzyme-altered hepatic foci was investigated. Rats were exposed (8 h/day, 7 days/week) to 2000 p.p.m. vinyl chloride (VC) either 'transplacentally' (exposure of pregnant females), or immediately after birth for different time intervals (5, 11, 17, 47, 83 days) or f...

journal_title：Carcinogenesis

authors： Laib RJ,Klein KP,Bolt HM

更新日期：1985-01-01 00:00:00

abstract：:DNA-methyltransferase-3B (DNMT3B) plays an important role in the generation of aberrant methylation in carcinogenesis. Polymorphisms and haplotypes of the DNMT3B gene may influence DNMT3B activity on DNA methylation, thereby modulating the susceptibility to lung cancer. To test this hypothesis, we investigated the ass...

journal_title：Carcinogenesis

authors： Lee SJ,Jeon HS,Jang JS,Park SH,Lee GY,Lee BH,Kim CH,Kang YM,Lee WK,Kam S,Park RW,Kim IS,Cho YL,Jung TH,Park JY

更新日期：2005-02-01 00:00:00

abstract：:Previous studies have shown that decorin expression is significantly reduced in colorectal cancer tissues and cancer cells, and genetic deletion of the decorin gene is sufficient to cause intestinal tumor formation in mice, resulting from a downregulation of p21, p27(kip1) and E-cadherin and an upregulation of β-caten...

journal_title：Carcinogenesis

authors： Bi X,Pohl NM,Qian Z,Yang GR,Gou Y,Guzman G,Kajdacsy-Balla A,Iozzo RV,Yang W

更新日期：2012-02-01 00:00:00

abstract：:This study was designed to investigate the role of the epidermal growth factor receptor (EGFR) and its ligands in chemically induced mouse bladder cancer. Bladder tumours were induced in C57Bl/6 and B6D2F1 mice by treatment with the carcinogen, N:-butyl-N:-(4-hydroxybutyl) nitrosamine (BBN). The levels of mRNA for EGF...

journal_title：Carcinogenesis

authors： el-Marjou A,Delouvée A,Thiery JP,Radvanyi F

更新日期：2000-12-01 00:00:00

abstract：:We examined the effects of the aliphatic amides isopropyl-valeramide (IVA) and allylisopropylacetamide (AIA) on oncogenic transformation and sister chromatid exchanges (SCE) induced by cyclopenta[cd]pyrene (CPP) and benzo[a]pyrene (B[a]P) in C3H/10T1/2 cells and on B[a]Pdiol-epoxide (BPDE)-induced mutation at the HGPR...

journal_title：Carcinogenesis

authors： Krolewski B,Nagasawa H,Little JB

更新日期：1986-10-01 00:00:00

abstract：:Non-steroidal anti-inflammatory drugs prevent colorectal cancer by inhibiting cyclooxygenase (COX) enzymes that synthesize tumor-promoting prostaglandins. 15-hydroxyprostaglandin dehydrogenase (15-PGDH) is a tumor suppressor that degrades tumor-promoting prostaglandins. Murine knockout of 15-PGDH increases susceptibil...

journal_title：Carcinogenesis

authors： Fink SP,Dawson DM,Zhang Y,Kresak A,Lawrence EG,Yang P,Chen Y,Barnholtz-Sloan JS,Willis JE,Kopelovich L,Markowitz SD

更新日期：2015-02-01 00:00:00

abstract：:We have previously shown that addition of short chain fructo-oligosaccharides (indigestible carbohydrates) to food prevented colon tumors in C57BL/6-Apc(Min/+) mice, a model for human colon cancer. As gut-associated lymphoid tissue was concomitantly developed, we suggested that the immune response generated by this fo...

journal_title：Carcinogenesis

authors： Pierre F,Perrin P,Bassonga E,Bornet F,Meflah K,Menanteau J

更新日期：1999-10-01 00:00:00

abstract：:Colorectal cancer (CRC) is the fourth leading cause of cancer mortality worldwide. Genome-wide association studies (GWAS) identified more than 50 CRC loci. However, most of the previous studies were conducted in European population, and host genetic factors among Japanese population are largely remained to be identifi...

journal_title：Carcinogenesis

authors： Tanikawa C,Kamatani Y,Takahashi A,Momozawa Y,Leveque K,Nagayama S,Mimori K,Mori M,Ishii H,Inazawa J,Yasuda J,Tsuboi A,Shimizu A,Sasaki M,Yamaji T,Sawada N,Iwasaki M,Tsugane S,Naito M,Wakai K,Koyama T,Takezaki T

更新日期：2018-05-03 00:00:00

abstract：:We previously reported that 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) at the second position of codon 12 of the c-Ha-ras gene induces many types of mutations in NIH3T3 cells. In this study we incorporated the modified base into the first and second positions of codon 12 in the coding strand and into the first positi...

journal_title：Carcinogenesis

authors： Kamiya H,Murata-Kamiya N,Koizume S,Inoue H,Nishimura S,Ohtsuka E

更新日期：1995-04-01 00:00:00

abstract：:The effects of dietary Brussels sprouts and indole-3-carbinol (I3C) on xenobiotic-metabolizing enzyme activities and hepatic aflatoxin B1 (AFB1)-DNA binding were determined in rats. Animals were dosed intraperitoneally (i.p.) or intragastrically (i.g.) with [3H]AFB1 and killed 2 (i.p.) or 3 (i.g.) h later. Brussels sp...

journal_title：Carcinogenesis

authors： Salbe AD,Bjeldanes LF

更新日期：1989-04-01 00:00:00