Cytochrome P450 1B1 and catechol-O-methyltransferase polymorphisms and endometrial cancer susceptibility.

abstract：:The 80%-ethanol extract of lemon grass (Cymbopogon citratus Stapf), a medicinal plant in Thailand, has been reported to be antimutagenic against various known mutagens in the Salmonella mutation assay. To investigate chemoprevention in an animal carcinogenesis model, we examined inhibitory effects of the lemon grass e...

journal_title：Carcinogenesis

authors： Suaeyun R,Kinouchi T,Arimochi H,Vinitketkumnuen U,Ohnishi Y

更新日期：1997-05-01 00:00:00

abstract：:The breast cancer gene BRCA1 has previously been cloned from both human and mouse. We cloned a fragment of the rat Brca1 homologue in order to map it and explore its biological function. Partial cDNA fragments of the rat Brca1 homologue were isolated by RT-PCR. Sequence analysis revealed that the RING-finger domain is...

journal_title：Carcinogenesis

authors： Chen KS,Shepel LA,Haag JD,Heil GM,Gould MN

更新日期：1996-08-01 00:00:00

abstract：:Vinyl chloride (VC) is a carcinogen associated with human and animal cancers. The ultimate carcinogenic form of VC, 2-chloroacetaldehyde (CAA), has been suspected to be mutagenic and we confirmed the mutagenicity of CAA using a modified shuttle vector plasmid. Base sequence analyses of 109 mutant plasmids with mutatio...

journal_title：Carcinogenesis

authors： Matsuda T,Yagi T,Kawanishi M,Matsui S,Takebe H

更新日期：1995-10-01 00:00:00

abstract：:The purpose of this study was to determine if decreasing dietary protein from 24% (high protein) to 5% casein (low protein), substituting sucrose and cornstarch isocalorifically for casein, would modify the activity of protein kinase C (PKC) alpha and beta isoenzymes, as well as the expression of PKC alpha, beta, delt...

journal_title：Carcinogenesis

authors： La Porta CA,Comolli R

更新日期：1995-05-01 00:00:00

abstract：:Groups of male Fischer-344 rats were fed two pairs of semi-purified choline-devoid and choline-supplemented diets, one set containing 5% corn oil and 10% partially hydrogenated fat, and the other only corn oil (15%). Analyses were performed on lipids extracted from whole liver, liver nuclei and adipose tissue of the r...

journal_title：Carcinogenesis

authors： Banni S,Salgo MG,Evans RW,Corongiu FP,Lombardi B

更新日期：1990-11-01 00:00:00

abstract：UNLABELLED:Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2) is recognized as oncogenic and simulative role on tumorigenesis by virtue of abnormal expression in cancer including nasopharyngeal carcinoma (NPC). We hypothesized that the copy number variation (CNV)-30450, which duplicates the MAPKAPK2...

journal_title：Carcinogenesis

authors： Yang L,Liu B,Qiu F,Huang B,Li Y,Huang D,Yang R,Yang X,Deng J,Jiang Q,Zhou Y,Lu J

更新日期：2014-01-01 00:00:00

abstract：:The polysubstituted benzamide derivative metoclopramide (MCA) has previously been shown to enhance the effect of cisplatin and ionizing radiation treatment of xenografted human squamous cell carcinomas from the head and neck region. In the present work we show that MCA decreases the nucleoid sedimentation rate, indica...

journal_title：Carcinogenesis

authors： Lybak S,Pero RW

更新日期：1991-09-01 00:00:00

abstract：:O6-Methylguanine-DNA methyltransferase (MT)-proficient Chinese hamster ovary cells were grown in the presence of low, gradually increasing levels of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) with the aim of selecting MNNG-resistant cell lines. Six resistant clones with two levels of resistance were isolated. A 3-fol...

journal_title：Carcinogenesis

authors： Aquilina G,Frosina G,Zijno A,Di Muccio A,Dogliotti E,Abbondandolo A,Bignami M

更新日期：1988-07-01 00:00:00

abstract：:Spices and flavoring plants part rich in supposedly health-promoting phytochemicals are currently receiving much attention as a possible source of cancer chemopreventive compounds. Clove, the sun-dried unopened flower bud from the plant Syzygium aromaticum L. is a commonly used spice and food flavor. In the present wo...

journal_title：Carcinogenesis

authors： Banerjee S,Panda CK,Das S

更新日期：2006-08-01 00:00:00

abstract：:The human XPBC/ERCC-3 DNA repair gene specifically corrects the repair defect of xeroderma pigmentosum (XP) complementation group B and rodent repair mutant cell lines of group 3. The gene encodes a presumed DNA- and chromatin-binding helicase involved in early steps of the excision repair pathway. To study the evolut...

journal_title：Carcinogenesis

authors： Weeda G,Ma L,van Ham RC,Bootsma D,van der Eb AJ,Hoeijmakers JH

更新日期：1991-12-01 00:00:00

abstract：:Gastrointestinal tumours are among the most common malignancies in Western society, the majority of which are associated with dietary and lifestyle factors. Many dietary or lifestyle factors have been identified which may have toxic or carcinogenic properties. However, several dietary compounds also able to reduce gas...

journal_title：Carcinogenesis

authors： van der Logt EM,Roelofs HM,Nagengast FM,Peters WH

更新日期：2003-10-01 00:00:00

abstract：:The oxidative stress induced in vivo by benzoyl peroxide (BzPo) or 12-O-tetradecanoylphorbol-13-acetate (TPA) was evaluated in terms of chemiluminescence (CL) emitted by SENCAR mouse skin, a non-invasive method that allows an estimation of overall oxidative stress. The ability of a biomimetic superoxide dismutase, cop...

journal_title：Carcinogenesis

authors： Durán HA,de Rey BM

更新日期：1991-11-01 00:00:00

abstract：:DNAs from fourteen fibrosarcomas induced by 3-methylcholanthrene (MCA) in BALB/c mice were analyzed for the presence of transforming oncogenes following transfection on NIH3T3 cells. Six transfection-positive DNAs contained an activated ras gene: four c-K-ras and two c-N-ras. These results demonstrate that c-K-ras is ...

journal_title：Carcinogenesis

authors： Borrello MG,Carbone G,Pierotti MA,Molla A,Della Porta G

更新日期：1988-08-01 00:00:00

abstract：:This study analyzes the mechanism by which the tumor promoter 12-0-tetradecanoyl-phorbol 13-acetate (TPA) inhibits binding of epidermal growth factor (EGF) to its membrane receptors in HeLa cells. Kinetic studies indicate that inhibition of EGF binding occurs within a few minutes after exposure of cells to TPA; delaye...

journal_title：Carcinogenesis

authors： Lee LS,Weinstein IB

更新日期：1980-08-01 00:00:00

abstract：:DNA methylation affects the aggressiveness of human malignancies. Cancers with CpG island methylator phenotype (CIMP), a distinct group with extensive DNA methylation, show characteristic features in several types of tumors. In this study, we initially defined the existence of CIMP in 41 lung adenocarcinomas (AdCas) t...

journal_title：Carcinogenesis

authors： Shinjo K,Okamoto Y,An B,Yokoyama T,Takeuchi I,Fujii M,Osada H,Usami N,Hasegawa Y,Ito H,Hida T,Fujimoto N,Kishimoto T,Sekido Y,Kondo Y

更新日期：2012-07-01 00:00:00

abstract：:The effect of the aromatic amines 2-acetylaminofluorene (AAF), 2-acetylaminophenanthrene (AAP) and trans-4-acetylaminostilbene (AAS) on the rat hepatic aromatic hydrocarbon (Ah) receptor level was studied. 3-Methylcholanthrene (MC), as a known receptor ligand, was used as a control. The complete liver carcinogen AAF a...

journal_title：Carcinogenesis

authors： Göttlicher M,Cikryt P

更新日期：1987-07-01 00:00:00

abstract：:Yeasts were isolated from 12 cases of oral precancerous lesions (leukoplakia and erythroleukoplakia) by sampling the lesion as well as normal mucosa of each patient, yielding 21 strains of Candida albicans belonging to 15 biotypes, two strains of C. tropicalis, one strain of C. parapsilosis and two strains of Torulops...

journal_title：Carcinogenesis

authors： Krogh P,Hald B,Holmstrup P

更新日期：1987-10-01 00:00:00

abstract：:Conjugated linoleic acid (CLA) is a class of commercially available fatty acids that have been associated with anticancer properties in rodent models of chemical carcinogenesis. We conducted a pilot study to examine the antitumor effect of dietary CLA in a polyoma virus-middle T antigen (PyMT) mouse model of invasive ...

journal_title：Carcinogenesis

authors： Flowers M,Schroeder JA,Borowsky AD,Besselsen DG,Thomson CA,Pandey R,Thompson PA

更新日期：2010-09-01 00:00:00

abstract：:Male ICR Swiss mice, weighing 16-20 g, were fed ad libitum either a fat-free diet or a diet containing 10% corn oil. After three weeks on these diets, the rates of benzo[a]pyrene (B[a]P) metabolite formation and metabolism to products which covalently bind with macromolecules were compared using hepatic nuclei and mic...

journal_title：Carcinogenesis

authors： Baker MT,Karr SW,Wade AE

更新日期：1983-01-01 00:00:00

abstract：:The metabolic activation of the heterocyclic food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) by two human cytochrome P450 monoxygenases (P4501A1 and P4501A2) and two human N-acetyltransferases (NAT1 and NAT2) was investigated. Various combinations of these enzymes were functionally expressed in COS-1 cell...

journal_title：Carcinogenesis

authors： Probst MR,Blum M,Fasshauer I,D'Orazio D,Meyer UA,Wild D

更新日期：1992-10-01 00:00:00

abstract：:Pancreatic cancer has remained refractory to treatment. In large part, this results from the lack of an animal model that mimics pancreatic cancer in man. We describe a novel experimental model of pancreatic cancer that shares the genetic background, histologic features and natural history of human mixed acinar-ductal...

journal_title：Carcinogenesis

authors： Doiron B,DeFronzo RA

更新日期：2018-02-09 00:00:00

abstract：:3,3'-Diindolylmethane (DIM), an indole derivative produced on consumption of broccoli and other cruciferous vegetables, has been shown to have multiple anticancer effects in both in vivo and in vitro models. The present study was carried out to clarify the mechanism of DIM's antiangiogenic activity. We found that DIM ...

journal_title：Carcinogenesis

authors： Chang X,Firestone GL,Bjeldanes LF

更新日期：2006-03-01 00:00:00

abstract：:Dietary-related indoles, isothiocyanates, and the allyl isothiocyanate glucosinolate, sinigrin, were administered to F344 rats in the diet for 2 weeks (chronic protocol) or by gavage 2 h before sacrifice (acute protocol) and the effects of these pretreatments on the alpha-hydroxylation of two carcinogenic nitrosamines...

journal_title：Carcinogenesis

authors： Chung FL,Wang MY,Hecht SS

更新日期：1985-04-01 00:00:00

abstract：:The ability of dietary retinyl palmitate, canthaxanthin or the combination of both, to prevent induction of immunosuppression by UVB irradiation was tested by passive transfer of splenocytes. The basal diet was the American Institute of Nutrition diet 76A, containing 4 IU retinyl palmitate/g diet. Groups of 55 mice we...

journal_title：Carcinogenesis

authors： Gensler HL

更新日期：1989-01-01 00:00:00

abstract：:An elevation in total MAP kinase activity and expression has been observed in breast cancer tissue. However, the mechanisms underlying these changes in kinase activity and regulation by growth factors are not well characterized. In these studies, the effect of the potent mammary mitogen, epidermal growth factor (EGF),...

journal_title：Carcinogenesis

authors： Xing C,Imagawa W

更新日期：1999-07-01 00:00:00

abstract：:Pretreatment of Fischer 344 rats with the antioxidant ethoxyquin (EQ), followed by administration of aflatoxin B1 (AFB1) in the continuing presence of EQ was used to examine the effect of the antioxidant on liver and kidney. EQ (0.5% in diet) completely prevented the formation of AFB1-induced preneoplastic liver lesio...

journal_title：Carcinogenesis

authors： Manson MM,Green JA,Driver HE

更新日期：1987-05-01 00:00:00

abstract：:Sulindac, a widely used non-steroidal anti-inflammatory drug (NSAID), has been shown to inhibit chemically induced carcinogenesis in animal models. In the present study, we have investigated the molecular mechanism by which sulindac affects the activity and expression of the enzymes that mediate the initial detoxifica...

journal_title：Carcinogenesis

authors： Ciolino HP,MacDonald CJ,Memon OS,Bass SE,Yeh GC

更新日期：2006-08-01 00:00:00

abstract：:Alternative splicing regulators have emerged as new players in cancer development, modulating the activities of many tumor suppressors and oncogenes and regulating the signaling pathways. However, little is known about the mechanisms by which these oncogenic splicing factors lead to cellular transformation. We have sh...

journal_title：Carcinogenesis

authors： Shimoni-Sebag A,Lebenthal-Loinger I,Zender L,Karni R

更新日期：2013-11-01 00:00:00

abstract：:Administration of methylglyoxal at doses of 300-600 mg/kg body weight by gastric tube to male F344 rats induced 100-fold increase in ornithine decarboxylase activity (formation of 682 pmol CO2/30 min/mg protein) within 7 h, 26-fold increase in DNA synthesis (incorporation of 17 800 d.p.m. of [3H]thymidine/microgram DN...

journal_title：Carcinogenesis

authors： Furihata C,Sato Y,Matsushima T,Tatematsu M

更新日期：1985-01-01 00:00:00

abstract：:Recently, TWIST, a basic helix-loop-helix transcription factor, is suggested to be an oncogene because of its over-expression in many types of human cancer and its positive role in promoting cell survival. The aim of this study was to investigate the role of TWIST on the growth of human epithelial cells. Using two imm...

journal_title：Carcinogenesis

authors： Kwok WK,Ling MT,Yuen HF,Wong YC,Wang X

更新日期：2007-12-01 00:00:00