The nonmutagenicity of purified 4-amino-2-nitrophenol in Salmonella typhimurium.


:Two samples of 4-amino-2-nitrophenol were tested for mutagenicity in Salmonella typhimurium strains TA1535, TA1537, TA1538, TA98, and TA100. Significant mutagenic activity was detected with a sample of this compound obtained from Aldrich (technical grade (Aldrich), TGA) both in the presence and in the absence of a rat-liver S9 metabolic activation mixture. When toluene-insoluble contaminants of the TGA product were separated and tested for mutagenicity, they were found to be mutagenic in the same strains as the TGA sample. After removal of these major contaminants from the TGA product its mutagenicity was reduced; a nonmutagenic sample was obtained by further purification. The other sample of 4-amino-2-nitrophenol, which was synthesized and purified in our laboratory, was nonmutagenic. H.p.l.c. profiles of the unpurified TGA sample and the purified samples revealed a large number of contaminants in the TGA product. Likewise, t.l.c. revealed the presence of contaminants in the TGA product.






Shahin MM,Bugaut A,Junino A,Kalopissis G




Has Abstract


1982-01-01 00:00:00












  • Clinical potential role of circulating microRNAs in early diagnosis of colorectal cancer patients.

    abstract::Current procedures for diagnosis and biomarker examination of colorectal cancer (CRC) are invasive and unpleasant. There is a great need to identify sensitive and specific biomarkers for early diagnosis of CRC. Circulating microRNAs (miRNAs) are promising molecular markers for CRC prediction. We performed a comprehens...


    pub_type: 杂志文章,随机对照试验


    authors: Du M,Liu S,Gu D,Wang Q,Zhu L,Kang M,Shi D,Chu H,Tong N,Chen J,Adams TS,Zhang Z,Wang M

    更新日期:2014-12-01 00:00:00

  • WY-14 643 rapidly activates nuclear factor kappaB in Kupffer cells before hepatocytes.

    abstract::Stimulation of cell proliferation caused by peroxisome proliferators was blocked by antibodies against TNF alpha and agents that inactivate Kupffer cells, a rich source of TNF alpha, which supports the hypothesis that Kupffer cells play a pivotal role in peroxisome proliferator-induced hyperplasia. Here, the ability o...


    pub_type: 杂志文章


    authors: Rusyn I,Tsukamoto H,Thurman RG

    更新日期:1998-07-01 00:00:00

  • miR-9 targets CXCR4 and functions as a potential tumor suppressor in nasopharyngeal carcinoma.

    abstract::MicroRNA deregulation and pathway alterations have been implicated in nasopharyngeal carcinoma (NPC), a highly invasive and metastatic cancer widely prevalent in Southern China. In this study, we report that miR-9 is commonly downregulated in NPC specimens and NPC cell lines with important functional consequences. The...


    pub_type: 杂志文章


    authors: Lu J,Luo H,Liu X,Peng Y,Zhang B,Wang L,Xu X,Peng X,Li G,Tian W,He ML,Kung H,Li XP

    更新日期:2014-03-01 00:00:00

  • Differentiation of oval cells into duct-like cells in preneoplastic liver of rats placed on a choline-deficient diet supplemented with ethionine.

    abstract::Feeding male Wistar rats a choline-deficient diet containing 0.07% DL-ethionine (CDE diet) for up to 5 weeks results in the production of two distinct non-parenchymal cell populations, oval and duct-like cells. These cells can undergo replication and display different patterns of expression of glutathione S-transferas...


    pub_type: 杂志文章


    authors: Tee LB,Kirilak Y,Huang WH,Morgan RH,Yeoh GC

    更新日期:1994-12-01 00:00:00

  • Chemopreventive effects of phenethyl isothiocyanate on lung and pancreatic tumorigenesis in N-nitrosobis(2-oxopropyl)amine-treated hamsters.

    abstract::The chemopreventive effects of phenethyl isothiocyanate (PEITC) were investigated in N-nitrosobis(2-oxopropyl)-amine (BOP)-treated hamsters. Female 5-week-old Syrian golden hamsters were divided into six groups. Animals in groups 1-3, each consisting of 30 hamsters, were given BOP by two subcutaneous injections 7 days...


    pub_type: 杂志文章


    authors: Nishikawa A,Furukawa F,Uneyama C,Ikezaki S,Tanakamaru Z,Chung FL,Takahashi M,Hayashi Y

    更新日期:1996-06-01 00:00:00

  • Carcinogenicity of catechol in F344 rats and B6C3F1 mice.

    abstract::Carcinogenicity of catechol, a naturally occurring and industrial chemical which has been shown to have strong cell proliferating potential on rat glandular stomach epithelium, was investigated in male and female F344 rats and B6C3F1 mice. Groups of 30 male and female F344 rats and B6C3F1 mice were treated with 0.8% c...


    pub_type: 杂志文章


    authors: Hirose M,Fukushima S,Tanaka H,Asakawa E,Takahashi S,Ito N

    更新日期:1993-03-01 00:00:00

  • Modulation of the PD-1/PD-L1 immune checkpoint axis during inflammation-associated lung tumorigenesis.

    abstract::Chronic obstructive pulmonary disease (COPD) is a significant risk factor for lung cancer. One potential mechanism through which COPD contributes to lung cancer development could be through generation of an immunosuppressive microenvironment that allows tumor formation and progression. In this study, we compared the s...


    pub_type: 杂志文章


    authors: Narayanapillai SC,Han YH,Song JM,Kebede ME,Upadhyaya P,Kassie F

    更新日期:2020-11-13 00:00:00

  • Ingestion of sugar beet fiber enhances irradiation-induced aberrant crypt foci in the rat colon under an apoptosis-suppressed condition.

    abstract::The induction of aberrant crypt foci (ACF) by irradiation of gamma-rays (60Co), and the effect of dietary sugar beet fiber (SBF) on irradiation-induced ACF were examined. We found that abdominal irradiation of gamma-rays could induce ACF in the rat colon. The irradiation was performed once a week at a dose rate of 2 o...


    pub_type: 杂志文章


    authors: Ishizuka S,Ito S,Onuma M,Kasai T,Aoyama Y,Hara H

    更新日期:1999-06-01 00:00:00

  • EGFR pathway polymorphisms and bladder cancer susceptibility and prognosis.

    abstract::The epidermal growth factor receptor (EGFR) pathway has recently been appreciated as a central mediator of tumorigenesis and an important drug target; however, the influence of genetic variation in this pathway on bladder cancer is not understood. Pathway activation leads to cell proliferation, angiogenesis and is ant...


    pub_type: 杂志文章


    authors: Mason RA,Morlock EV,Karagas MR,Kelsey KT,Marsit CJ,Schned AR,Andrew AS

    更新日期:2009-07-01 00:00:00

  • Immunohistochemical localization of transforming growth factor-alpha, epidermal growth factor receptor and c-erbB-2 protein in hyperplastic human prostates.

    abstract::Transforming growth factor-alpha (TGF-alpha) is a potent mitogenic factor which acts by binding to the epidermal growth factor (EGF). c-erbB-2 is a member of the EGF receptor family and is known to be associated with cellular growth and differentiation. The roles played by these factors in benign prostatic hyperplasia...


    pub_type: 杂志文章


    authors: Giri DK,Pal R,Wadhwa SN,Talwar GP

    更新日期:1995-04-01 00:00:00

  • Comparative dosimetry of O6-methylguanine in humans and rodents treated with procarbazine.

    abstract::The accumulation of O6-methylguanine (O6-meG) in the DNA of blood leukocytes of 21 Hodgkin's lymphoma patients (followed for up to 12 cycles of treatment) treated in the context of MOPP combination chemotherapy with 150 mg procarbazine daily for 10 days was examined and compared to that observed in rats treated with d...


    pub_type: 杂志文章


    authors: Souliotis VL,Valavanis C,Boussiotis VA,Pangalis GA,Kyrtopoulos SA

    更新日期:1994-08-01 00:00:00

  • Effect of dietary galacto-oligosaccharides on azoxymethane-induced aberrant crypt foci and colorectal cancer in Fischer 344 rats.

    abstract::The aim of the present study was to investigate the effects of galacto-oligosaccharides (GOS, Elix'or) on the development of aberrant crypt foci (ACF) and colorectal tumours in rats treated with azoxymethane (AOM). Two groups of 102 male Fischer 344 rats were injected twice with AOM to induce colorectal tumours, and f...


    pub_type: 杂志文章


    authors: Wijnands MV,Schoterman HC,Bruijntjes JB,Hollanders VM,Woutersen RA

    更新日期:2001-01-01 00:00:00

  • The transition of tissue inhibitor of metalloproteinases from -4 to -1 induces aggressive behavior and poor patient survival in dedifferentiated liposarcoma via YAP/TAZ activation.

    abstract::Liposarcoma (LS) is the most common soft-tissue sarcoma. Dedifferentiated liposarcoma (DDLS) shows more aggressive biological behavior than that of well-differentiated liposarcoma (WDLS), so advanced therapeutic agents based on molecular mechanism are urgently needed. Here we show that tissue inhibitors of metalloprot...


    pub_type: 杂志文章


    authors: Shrestha M,Ando T,Chea C,Sakamoto S,Nishisaka T,Ogawa I,Miyauchi M,Takata T

    更新日期:2019-10-16 00:00:00

  • Rapid induction of uterine tumors with p53 point mutations in heterozygous p53-deficient CBA mice given a single intraperitoneal administration of N-ethyl-N-nitrosourea.

    abstract::To investigate the sensitivity of heterozygous p53-deficient CBA mice to carcinogens, 20 female mice [p53(+/-)] and 20 wild-type littermates [p53(+/+)] were given an intraperitoneal injection of 120 mg/kg body wt of N-ethyl-N-nitrosourea (ENU) and were maintained without any other treatment for a further 26 weeks. His...


    pub_type: 杂志文章


    authors: Mitsumori K,Onodera H,Shimo T,Yasuhara K,Takagi H,Koujitani T,Hirose M,Maruyama C,Wakana S

    更新日期:2000-05-01 00:00:00

  • Increased risk of prostate cancer and benign prostatic hyperplasia associated with transforming growth factor-beta 1 gene polymorphism at codon10.

    abstract::Transforming growth factor-beta 1 (TGF-beta1) plays a significant role in regulating the proliferation and apoptosis of prostate epithelial and stromal cells. We explored the association between the T (Leu) to C (Pro) polymorphism at codon10 of the TGF-beta1 gene (TGFB1) and the risk of prostate cancer (PCa) or benign...


    pub_type: 杂志文章


    authors: Li Z,Habuchi T,Tsuchiya N,Mitsumori K,Wang L,Ohyama C,Sato K,Kamoto T,Ogawa O,Kato T

    更新日期:2004-02-01 00:00:00

  • The p53 target gene desmocollin 3 acts as a novel tumor suppressor through inhibiting EGFR/ERK pathway in human lung cancer.

    abstract::Desmosomes are intercellular junctions that confer strong cell-cell adhesion. Altered expression of desmocollin 3 (DSC3), a member of the desmosomal cadherin family, was found in various cancers; however, its functional involvement in carcinogenesis has not yet been elucidated. Expression/localization of DSC3 was anal...


    pub_type: 杂志文章


    authors: Cui T,Chen Y,Yang L,Knösel T,Huber O,Pacyna-Gengelbach M,Petersen I

    更新日期:2012-12-01 00:00:00

  • Metabolic activation of N-hydroxy-4-acetylaminobiphenyl by cultured human breast epithelial cell line MCF 10A.

    abstract::Metabolism and nucleic acid binding of the mammary gland carcinogen N-hydroxy-4-acetylaminobiphenyl (N-OH-AABP) was investigated using the human mammary epithelial cell line MCF 10A. Chromatographic analysis of the ethyl acetate extract of the media from cultured MCF 10A after 24 h exposure to N-OH-AABP revealed the f...


    pub_type: 杂志文章


    authors: Swaminathan S,Frederickson SM,Hatcher JF

    更新日期:1994-04-01 00:00:00

  • Enhanced glycolysis, regulated by HIF-1α via MCT-4, promotes inflammation in arsenite-induced carcinogenesis.

    abstract::Arsenite is well established as a human carcinogen, but the molecular mechanisms leading to arsenite-induced carcinogenesis are complex and elusive. Accelerated glycolysis, a common process in tumor cells called the Warburg effect, is associated with various biological phenomena. However, the role of glycolysis induce...


    pub_type: 杂志文章


    authors: Luo F,Zou Z,Liu X,Ling M,Wang Q,Wang Q,Lu L,Shi L,Liu Y,Liu Q,Zhang A

    更新日期:2017-06-01 00:00:00

  • Red meat and colon cancer: dietary haem, but not fat, has cytotoxic and hyperproliferative effects on rat colonic epithelium.

    abstract::High intake of red meat is associated with an increased risk of colon cancer. It has been suggested that fat from red meat is responsible, because high fat intake increases the concentration of cytotoxic lipids in the colon. Experimental studies have not unequivocally supported such a role for fat, however. Recently, ...


    pub_type: 杂志文章


    authors: Sesink AL,Termont DS,Kleibeuker JH,Van Der Meer R

    更新日期:2000-10-01 00:00:00

  • Synthesis of 6-methylchrysene-1,2-diol-3,4-epoxides and comparison of their mutagenicity to 5-methylchrysene-1,2-diol-3,4-epoxides.

    abstract::The syn- and anti-isomers of 1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydro-6-methylchrysene (6-MeC-1,2-diol-3,4-epoxide) were synthesized and their mutagenic activities in Salmonella typhimurium were compared with those of the syn- and anti-isomers of 1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydro-5-methylchrysene (5-MeC-1,2...


    pub_type: 杂志文章


    authors: Amin S,Huie K,Hecht SS,Harvey RG

    更新日期:1986-12-01 00:00:00

  • LIFR functions as a metastasis suppressor in hepatocellular carcinoma by negatively regulating phosphoinositide 3-kinase/AKT pathway.

    abstract::Hepatocellular carcinoma (HCC) is one of the leading causes for cancer related mortality worldwide. Poor prognosis of HCC patients is mainly due to frequent metastasis and recurrence. Deregulation of metastasis suppressors in malignant cells plays critical roles during cancer metastasis. Thus, novel metastasis suppres...


    pub_type: 杂志文章


    authors: Luo Q,Wang C,Jin G,Gu D,Wang N,Song J,Jin H,Hu F,Zhang Y,Ge T,Huo X,Chu W,Shu H,Fang J,Yao M,Gu J,Cong W,Qin W

    更新日期:2015-10-01 00:00:00

  • Nucleotide excision repair core gene polymorphisms and risk of second primary malignancy in patients with index squamous cell carcinoma of the head and neck.

    abstract::The nucleotide excision repair (NER) pathway is central in response to damage induced by environmental carcinogens. Efficiency of this pathway, probably genetically determined, may modulate individual risk of developing squamous cell carcinoma of the head and neck (SCCHN) as well as second primary malignancy (SPM) aft...


    pub_type: 杂志文章


    authors: Zafereo ME,Sturgis EM,Liu Z,Wang LE,Wei Q,Li G

    更新日期:2009-06-01 00:00:00

  • Simple methods for quantifying mutagenic heterocyclic aromatic amines in food products.

    abstract::Two solid-phase extraction methods were developed for the determination of mutagenic heterocyclic aromatic amines in heated meat products. The copper phthalocyanine (CPC) tandem extraction was performed on coupled cartridges of diatomaceous earth and CPC-derivatized Sephasorb HP, followed by further clean-up on Sephas...


    pub_type: 杂志文章


    authors: Gross GA

    更新日期:1990-09-01 00:00:00

  • Effects of green tea catechins in a rat multi-organ carcinogenesis model.

    abstract::The effects of dietary administration of green tea catechins (GTC) were examined using a multi-organ carcinogenesis model. Groups of 15 F344 male rats were initially treated with a single i.p. administration of 100 mg/kg body wt N-diethyl-nitrosamine, 4 i.p. administrations of 20 mg/kg body wt N-methylnitrosourea, 4 s...


    pub_type: 杂志文章


    authors: Hirose M,Hoshiya T,Akagi K,Takahashi S,Hara Y,Ito N

    更新日期:1993-08-01 00:00:00

  • Carcinogenicity in rats of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.

    abstract::Carcinogenicity of 2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline (MeIQx), which is a potent mutagen first isolated from fried beef and widely present in various cooked foods, was tested in both sexes of F344 rats. Rats were continuously given a diet containing 0.04% MeIQx or basal diet and the experiment was finished...


    pub_type: 杂志文章


    authors: Kato T,Ohgaki H,Hasegawa H,Sato S,Takayama S,Sugimura T

    更新日期:1988-01-01 00:00:00

  • Polymorphisms in glutathione S-transferases and non-melanoma skin cancer risk in Australian renal transplant recipients.

    abstract::Caucasian renal transplant recipients from Queensland, Australia have the highest non-melanoma skin cancer (NMSC) risk worldwide. Although ultraviolet light (UVR) exposure is critical, genetic factors also appear important. We and others have shown that polymorphism in the glutathione S-transferases (GST) is associate...


    pub_type: 杂志文章


    authors: Fryer AA,Ramsay HM,Lovatt TJ,Jones PW,Hawley CM,Nicol DL,Strange RC,Harden PN

    更新日期:2005-01-01 00:00:00

  • Inhibition of ultraviolet B (UVB)-induced c-fos and c-jun expression in vivo by a tyrosine kinase inhibitor genistein.

    abstract::We reported the inhibitory effects of genistein, an inhibitor of tyrosine protein kinase (TPK), on ultraviolet B (UVB)-induced expression of c-fos and c-jun in SENCAR mouse skin. UVB irradiation substantially increased transcript levels of c-fos and c-jun mRNA in mouse skin. Topical application of genistein 60 min bef...


    pub_type: 杂志文章


    authors: Wang Y,Zhang X,Lebwohl M,DeLeo V,Wei H

    更新日期:1998-04-01 00:00:00

  • Tissue distribution and macromolecular binding of extremely low doses of [14C]-benzene in B6C3F1 mice.

    abstract::The tissue distribution and macromolecular binding of benzene was studied over a dose range spanning nine-orders of magnitude to determine the nature of the dose-response and to establish benzene's internal dosimetry at doses encompassing human environmental exposures. [14C]-Benzene was administered to B6C3F1 male mic...


    pub_type: 杂志文章


    authors: Creek MR,Mani C,Vogel JS,Turteltaub KW

    更新日期:1997-12-01 00:00:00

  • N-acetylbenzidine and N,N'-diacetylbenzidine formation by rat and human liver slices exposed to benzidine.

    abstract::The extent to which N-acetylbenzidine and N,N'-diacetylbenzidine are formed may influence benzidine-induced carcinogenesis. This study compared the formation of these metabolites by rat and human liver slices. The relationship between the NAT2 genotype and the formation of these acetylated products was also evaluated ...


    pub_type: 杂志文章


    authors: Lakshmi VM,Bell DA,Watson MA,Zenser TV,Davis BB

    更新日期:1995-07-01 00:00:00

  • Activity of triphenylselenonium chloride in mammary cancer prevention.

    abstract::The present study was designed to evaluate the tolerance and cancer chemopreventive activity of triphenylselenonium chloride in female Sprague-Dawley rats. No information is available in the literature on the anticarcinogenic efficacy of a lipophilic cationic selenium compound as exemplified by the triphenylselenonium...


    pub_type: 杂志文章


    authors: Ip C,Thompson H,Ganther H

    更新日期:1994-12-01 00:00:00