Suppression of azoxymethane-induced rat colon carcinogenesis by dietary administration of naturally occurring xanthophylls astaxanthin and canthaxanthin during the postinitiation phase.


:The modulating effects of dietary feeding of two xanthophylls, astaxanthin (AX) and canthaxanthin (CX) during the postinitiation phase on colon carcinogenesis initiated with azoxymethane (AOM) were investigated in male F344 rats. Animals were initiated with AOM by weekly s.c. injections of 15 mg/kg body wt for 3 weeks and then they were fed the diets containing AX or CX at concentrations of 100 and 500 p.p.m. for 34 weeks. The others contained the groups of rats treated with AX or CX alone and untreated. At the end of the study (week 37), the incidence and multiplicity of neoplasms (adenoma and adenocarcinoma) in the large intestine of rats initiated with AOM and followed by AX or CX containing diet at a high dose (500 p.p.m.) were significantly smaller than those of rats given AOM alone (P < 0.001). In addition, AX or CX feeding significantly inhibited the development of aberrant crypt foci induced by AOM. Dietary exposure to AX or CX also decreased cell proliferation activity as revealed by measuring 5'-bromodeoxyuridine-labeling index as crypt cells, colonic mucosal ornithine decarboxylase activity and blood polyamine levels. These results indicate that AX and CX are possible chemopreventers for carcinogenesis of colon in addition to urinary bladder and oral cavity and such effects may be partly due to suppression of cell proliferation.






Tanaka T,Kawamori T,Ohnishi M,Makita H,Mori H,Satoh K,Hara A




Has Abstract


1995-12-01 00:00:00












  • Staurosporine is chemoprotective by inducing G1 arrest in a Chk1- and pRb-dependent manner.

    abstract::Chemotherapeutic agents have been the mainstay of cancer therapy for years. However, their effectiveness has been limited by toxicities they impart on normal cells. Staurosporine (ST) has been shown to arrest normal, but not breast cancer, cells in G1. Therefore, ST may become a chemoprotective agent, arresting normal...


    pub_type: 杂志文章


    authors: Murray MM,Bui T,Smith M,Bagheri-Yarmand R,Wingate H,Hunt KK,Keyomarsi K

    更新日期:2013-10-01 00:00:00

  • Identification of genes whose expression is altered during mitosuppression in livers of ethinyl estradiol-treated female rats.

    abstract::In this study, our goal was to identify genes whose expression in liver is altered in female F-344 rats during mitosuppression induced by 42 days of ethinyl estradiol (EE) treatment (Yager et al., Carcinogenesis, 15, 2117-2123, 1994). Northern analysis demonstrated that the mRNA levels for transforming growth factor-b...


    pub_type: 杂志文章


    authors: Chen J,Schwartz DA,Young TA,Norris JS,Yager JD

    更新日期:1996-12-01 00:00:00

  • Promotion, but not progression, effects of tamoxifen on uterine carcinogenesis in mice initiated with N-ethyl-N'-nitro-N-nitrosoguanidine.

    abstract::Effects of tamoxifen (TAM) on development of uterine endometrial carcinogenesis were studied in intact and ovariectomized (OVX) mice initiated with N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG). In experiment I, animals were implanted with cholesterol (ChL, controls) or TAM (5% w/w) and/or 17beta-oestradiol (E(2), 0.5% w...


    pub_type: 杂志文章


    authors: Takahashi M,Shimomoto T,Miyajima K,Iizuka S,Watanabe T,Yoshida M,Kurokawa Y,Maekawa A

    更新日期:2002-09-01 00:00:00

  • Inhibition of methylcholanthrene-induced skin carcinogenesis in hairless mice by dimethyl sulfoxide.

    abstract::Hairless mice were given 5 topical applications of 470 nmol 20-methylcholanthrene (MCA) at one week intervals. In one experimental group the MCA was dissolved in reagent grade acetone alone, in another group it was dissolved in a mixture consisting of 50% acetone and 50% dimethyl sulfoxide (DMSO). A control group rece...


    pub_type: 杂志文章


    authors: Iversen OH,Thorud E,Volden G

    更新日期:1981-01-01 00:00:00

  • In vitro chemopreventive effects of plant polysaccharides (Aloe barbadensis miller, Lentinus edodes, Ganoderma lucidum and Coriolus versicolor).

    abstract::A plant polysaccharide, Aloe gel extract, was reported to have an inhibitory effect on benzo[a]pyrene (B[a]P)-DNA adduct formation in vitro and in vivo. Hence, chemopreventive effects of plant polysaccharides [Aloe barbadensis Miller (APS), Lentinus edodes (LPS), Ganoderma lucidum (GPS) and Coriolus versicolor (CPS)] ...


    pub_type: 杂志文章


    authors: Kim HS,Kacew S,Lee BM

    更新日期:1999-08-01 00:00:00

  • Comparison of hepatic carcinogen initiation-promotion systems.

    abstract::A number of model systems have been developed to study the initiating and promoting phases of neoplastic development in rats liver. Four of these protocols use diethylnitrosamine (DEN) initiation, but employ different methods of promotion. The present studies were designed to evaluate these systems under standardized ...


    pub_type: 杂志文章


    authors: Leonard TB,Dent JG,Graichen ME,Lyght O,Popp JA

    更新日期:1982-01-01 00:00:00

  • Expression of cytochrome P450 in yeast after different chemical treatments.

    abstract::In Saccharomyces cerevisiae a number of chemical agents induce synthesis of cytochrome P450. A cytochrome P450 gene has been well characterized in this yeast: CYP51, which codes for a constitutive enzyme involved in the 14 alpha-demethylation of lanosterol, a key step in the biosynthesis of ergosterol. In this work, w...


    pub_type: 杂志文章


    authors: Del Carratore R,Morichetti E,Cecchini E,Bronzetti G,Gallo E,Galeotti CL

    更新日期:1992-11-01 00:00:00

  • The rat liver foci bioassay: I. Age-dependence of induction by vinyl chloride of ATPase-deficient foci.

    abstract::The age-dependence of the induction of pre-neoplastic enzyme-altered hepatic foci was investigated. Rats were exposed (8 h/day, 7 days/week) to 2000 p.p.m. vinyl chloride (VC) either 'transplacentally' (exposure of pregnant females), or immediately after birth for different time intervals (5, 11, 17, 47, 83 days) or f...


    pub_type: 杂志文章


    authors: Laib RJ,Klein KP,Bolt HM

    更新日期:1985-01-01 00:00:00

  • DNA adduct formation and unscheduled DNA synthesis in rat esophagus in vivo after treatment with N-methyl-N-nitrosourea.

    abstract::An in vivo method for assessment of DNA adduct formation and unscheduled DNA synthesis (UDS) in the esophagus of rats was devised. Small ventral incisions were made in the neck and upper abdomen regions of 6 week old F344 rats and ligation of the esophagus with thread at the two extreme ends performed to make an esoph...


    pub_type: 杂志文章


    authors: Qin XS,Nakatsuru Y,Kohyama K,Ishikawa T

    更新日期:1990-02-01 00:00:00

  • Enhancement of the invasive ability of a transformed human bronchial epithelial cell line by 12-O-tetradecanoyl-phorbol-13-acetate and diacylglycerol.

    abstract::The effect of the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was studied using an immortalized human bronchial epithelial cell line, BEAS-2B, both in vivo and in vitro. The in vivo model consisted of tracheas reconstituted with an epithelium of BEAS-2B cells xenotransplanted into athymic nude mice. Int...


    pub_type: 杂志文章


    authors: Bonfil RD,Momiki S,Fridman R,Reich R,Reddel R,Harris CC,Klein-Szanto A

    更新日期:1989-12-01 00:00:00

  • Induction of hepatic heme oxygenase-1 and ferritin in rats by cancer chemopreventive dithiolethiones.

    abstract::Treatment of rats with the cancer chemopreventive agent 1,2-dithiole-3-thione (D3T) resulted in a significant increase in hepatic heme oxygenase (HO) activity, which corresponded to increased protein levels of HO-1. Upon further analysis of proteins related to heme metabolism, the level of ferritin, the major iron sto...


    pub_type: 杂志文章


    authors: Primiano T,Kensler TW,Kuppusamy P,Zweier JL,Sutter TR

    更新日期:1996-11-01 00:00:00

  • The effect of fibre source and fermentation on the apparent hydrophobic binding properties of wheat bran preparations for the mutagen 2-amino-3,8- dimethylimidazo[4,5-f]quinoxaline (MeIQx).

    abstract::Preparations of dietary fibre have an ability to bind potentially toxic compounds in vitro, but it is unclear how the measured binding properties are a reflection of either the relative affinity of such compounds for fibre or the saturation binding capacity of the fibre. Cooking and processing of foods and fermentatio...


    pub_type: 杂志文章


    authors: Ryden P,Robertson JA

    更新日期:1995-02-01 00:00:00

  • Synthesis of the prototype DNA-protein cross-link, 1-(guan-1-yl)-2-(cysteine-S-yl)ethane, and its role in the reactions of the haloethylnitrosoureas.

    abstract::The haloethylnitrosoureas form a cytotoxic DNA cross-link in a series of reactions which involves initial alkylation of the O6 position of guanine and rearrangement to the intermediate, 1,O6-ethanoguanine; 1,O6-ethanoguanine then reacts with a neighboring cytosine base. O6-Alkylguanine-DNA alkyltransferase can interru...


    pub_type: 杂志文章


    authors: Niu T,Yu D,Kirk MC,Ludlum DB

    更新日期:1993-02-01 00:00:00

  • Pancreatic cancer cells express 25-hydroxyvitamin D-1 alpha-hydroxylase and their proliferation is inhibited by the prohormone 25-hydroxyvitamin D3.

    abstract::The steroid hormone 1,25-dihydroxyvitamin D(3), [1,25(OH)(2)D(3), calcitriol], the active metabolite of vitamin D, exerts pleiotropic antitumor effects against several malignancies. However, the clinical use of this hormone is limited by hypercalcemia. 25-Hydroxyvitamin D(3), the prohormone of 1,25(OH)(2)D(3), is hydr...


    pub_type: 杂志文章


    authors: Schwartz GG,Eads D,Rao A,Cramer SD,Willingham MC,Chen TC,Jamieson DP,Wang L,Burnstein KL,Holick MF,Koumenis C

    更新日期:2004-06-01 00:00:00

  • In vitro enzymatic recognition of DNA modified by O,O'-diacetyl or O-acetyl derivatives of the carcinogen 4-hydroxyaminoquinoline-1-oxide.

    abstract::Purified DNA was modified in vitro by 3H-labelled O-acetyl or O,O'-diacetyl-4-hydroxyaminoquinoline-1-oxide (Ac4HAQO or di Ac-4HAQO). It was then subjected to the action of the single-stranded DNA specific nuclease S1 and the digested fractions were analysed. For both types of modified DNA, the release of non-modified...


    pub_type: 杂志文章


    authors: Galiègue S,Bailleul B,Loucheux-Lefebvre MH,Laval J

    更新日期:1982-01-01 00:00:00

  • Formation and removal of DNA adducts in rat liver treated with N-hydroxy derivatives of 2-acetylaminofluorene, 4-acetylaminobiphenyl, and 2-acetylaminophenanthrene.

    abstract::Formation and removal of hepatic DNA adducts was studied in male Sprague-Dawley rats following single injections of two hepatocarcinogens, N-hydroxy-2-acetylaminofluorene (N-OH-AAF) and N-hydroxy-4-acetylaminobiphenyl (N-OH-AABP) and a nonhepatocarcinogen, N-hydroxy-2-acetylaminophenanthrene (N-OH-AAP) at 0.5 h, 1.5 h...


    pub_type: 杂志文章


    authors: Gupta RC,Dighe NR

    更新日期:1984-03-01 00:00:00

  • Diethylnitrosamine administration in vivo increases hepatic poly(ADP-ribose) levels in rats: results of a modified technique for poly(ADP-ribose) measurement.

    abstract::Poly(ADP-ribose) (polymer) is enzymatically synthesized on nuclear proteins in response to DNA strand breaks. NAD+ is the substrate for this reaction, which is catalyzed by poly(ADP-ribose)polymerase. This post-translational modification occurs in response to DNA strand breaks and is thought to play an important role ...


    pub_type: 杂志文章


    authors: Rawling JM,Driscoll ER,Poirier GG,Kirkland JB

    更新日期:1993-12-01 00:00:00

  • U.v.-enhanced reactivation of u.v.-irradiated herpes virus by primary cultures of rat hepatocytes.

    abstract::Carcinogen treatment of cultured mammalian cells prior to infection with u.v.-irradiated virus results in enhanced virus survival and mutagenesis suggesting the induction of SOS-type processes. In this paper, we report the development of a primary rat hepatocyte culture system to investigate cellular responses to DNA ...


    pub_type: 杂志文章


    authors: Zurlo J,Yager JD

    更新日期:1984-04-01 00:00:00

  • The v-raf oncogene enhances tumorigenicity and suppresses differentiation in vivo in a rat hepatocyte cell line.

    abstract::raf oncogenes have been implicated in hepatic carcinogenesis. We studied the effects of the v-raf of murine retrovirus 3611-MSV on the growth and differentiation of a simian virus 40 (SV40)-immortalized rat liver cell line (ALB-8) which maintained many of characteristics of differentiated hepatocytes. Cells were co-tr...


    pub_type: 杂志文章


    authors: Fang XJ,Keating A,Flowers M,Liew CC,Gupta H,Mills GB,Sherman M

    更新日期:1993-04-01 00:00:00

  • Integrated analysis of genetic and epigenetic alterations reveals CpG island methylator phenotype associated with distinct clinical characters of lung adenocarcinoma.

    abstract::DNA methylation affects the aggressiveness of human malignancies. Cancers with CpG island methylator phenotype (CIMP), a distinct group with extensive DNA methylation, show characteristic features in several types of tumors. In this study, we initially defined the existence of CIMP in 41 lung adenocarcinomas (AdCas) t...


    pub_type: 杂志文章


    authors: Shinjo K,Okamoto Y,An B,Yokoyama T,Takeuchi I,Fujii M,Osada H,Usami N,Hasegawa Y,Ito H,Hida T,Fujimoto N,Kishimoto T,Sekido Y,Kondo Y

    更新日期:2012-07-01 00:00:00

  • The non-genotoxic hepatocarcinogen nafenopin suppresses rodent hepatocyte apoptosis induced by TGFbeta1, DNA damage and Fas.

    abstract::The suppression of apoptosis may contribute to the carcinogenicity of the peroxisome proliferators (PPs), a class of non-genotoxic rodent hepatocarcinogens. Our previous work demonstrated that the PP nafenopin suppressed both spontaneous and transforming growth factor beta1 (TGFbeta1)-induced hepatocyte apoptosis both...


    pub_type: 杂志文章


    authors: Gill JH,James NH,Roberts RA,Dive C

    更新日期:1998-02-01 00:00:00

  • Superoxide generation from Kupffer cells contributes to hepatocarcinogenesis: studies on NADPH oxidase knockout mice.

    abstract::We hypothesized that superoxide from Kupffer cells (KC) contributes to hepatocarcinogenesis. p47phox(-/-) mice, deficient in phagocyte NADPH oxidase and superoxide generation, received a single dose of the hepatocarcinogen diethylnitrosamine (DEN). The following hepatic effects were observed at time points between 30 ...


    pub_type: 杂志文章


    authors: Teufelhofer O,Parzefall W,Kainzbauer E,Ferk F,Freiler C,Knasmüller S,Elbling L,Thurman R,Schulte-Hermann R

    更新日期:2005-02-01 00:00:00

  • Changes in essential fatty acid patterns associated with normal liver regeneration and the progression of hepatocyte nodules in rat hepatocarcinogenesis.

    abstract::Changes in lipid metabolism were monitored in rat hepatocyte nodules at certain time points over 9 months. Tissue obtained from partially hepatectomized rats, collected over a period of 7 days, were included as a control for normal hepatocyte cell proliferation. Two important features regarding the lipid profiles of h...


    pub_type: 杂志文章


    authors: Abel S,Smuts CM,de Villiers C,Gelderblom WC

    更新日期:2001-05-01 00:00:00

  • NF-kappaB inhibition radiosensitizes Ki-Ras-transformed cells to ionizing radiation.

    abstract::Most cancer cells show resistance to ionizing radiation (IR)-induced cell death. Recently, Ki-Ras was reported to be responsible for the increased radioresistance. We report here that inhibition of IR-induced activaton of nuclear transcription factor kappa B (NF-kappaB) but not of either Akt or MAPK kinase (MEK), incr...


    pub_type: 杂志文章


    authors: Kim BY,Kim KA,Kwon O,Kim SO,Kim MS,Kim BS,Oh WK,Kim GD,Jung M,Ahn JS

    更新日期:2005-08-01 00:00:00

  • cAMP regulated EPAC1 supports microvascular density, angiogenic and metastatic properties in a model of triple negative breast cancer.

    abstract::Breast cancer is a leading cause of cancer-related mortality in women. Triple-negative breast cancer (TNBC; HER2-, ER-/PR-) is an aggressive subtype prone to drug resistance and metastasis, which is characterized by high intratumor microvascular density (iMVD) resulting from angiogenesis. However, the mechanisms contr...


    pub_type: 杂志文章


    authors: Kumar N,Prasad P,Jash E,Jayasundar S,Singh I,Alam N,Murmu N,Somashekhar SP,Goldman A,Sehrawat S

    更新日期:2018-10-08 00:00:00

  • MiR-196a binding-site SNP regulates RAP1A expression contributing to esophageal squamous cell carcinoma risk and metastasis.

    abstract::Polymorphisms in 3' untranslated region (UTR) of cancer-related genes might affect regulation by microRNA (miRNA) and contribute to carcinogenesis. In this study, we screened several single nucleotide polymorphisms (SNPs) in 3'UTR of cancer-related genes and investigated their effects on the risk of esophageal squamou...


    pub_type: 杂志文章


    authors: Wang K,Li J,Guo H,Xu X,Xiong G,Guan X,Liu B,Li J,Chen X,Yang K,Bai Y

    更新日期:2012-11-01 00:00:00

  • Use of a TGFbeta type I receptor inhibitor in mouse skin carcinogenesis reveals a dual role for TGFbeta signaling in tumor promotion and progression.

    abstract::Pharmacological inhibitors of the transforming growth factor β (TGFβ) type I receptor (ALK5) have shown promise in blocking growth of xenotransplanted cancer cell lines but the effect on a multistage cancer model is not known. To test this, we treated mouse skin with SB431542 (SB), a well-characterized ALK5 inhibitor,...


    pub_type: 杂志文章


    authors: Mordasky Markell L,Pérez-Lorenzo R,Masiuk KE,Kennett MJ,Glick AB

    更新日期:2010-12-01 00:00:00

  • Absence of mutations in the functional parts of the p120-GAP gene in carcinogen-induced mouse liver tumors.

    abstract::The GTPase activating proteins (GAP) stimulate the intrinsic GTPase activity of ras-p21 thus converting the protein into its inactive form. We have now analyzed carcinogen-induced mouse liver tumors for the possible occurrence of mutational changes in one of the two known GAP genes, namely p120-GAP. RNA from a total o...


    pub_type: 杂志文章


    authors: Müller O,Kress S,Schwarz M

    更新日期:1992-10-01 00:00:00

  • Platinum-DNA damage in leukocyte DNA of patients receiving carboplatin and cisplatin chemotherapy, measured by atomic absorption spectrometry.

    abstract::Previous studies have shown that platinum-DNA adduct level in leukocyte DNA (measured by antibody methodology) is directly related to disease response in ovarian cancer and testicular cancer. To determine if this principle could be more broadly applied, platinum-DNA damage was studied in a blinded fashion in leukocyte...


    pub_type: 临床试验,杂志文章


    authors: Parker RJ,Gill I,Tarone R,Vionnet JA,Grunberg S,Muggia FM,Reed E

    更新日期:1991-07-01 00:00:00

  • 32P-postlabelling/HPLC assay reveals an enantioselective adduct formation in N7 guanine residues in vivo after 1,3-butadiene inhalation exposure.

    abstract::We have established a protocol that allows qualitative and quantitative determination of butadiene monoepoxide-DNA adducts formed as a result of inhalation exposure to 1,3-butadiene. We observed that in this particular case in vivo samples required extensive sample purification to facilitate a low background. Sample p...


    pub_type: 杂志文章


    authors: Koivisto P,Sorsa M,Pacchierotti F,Peltonen K

    更新日期:1997-02-01 00:00:00